請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80515完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 王尚麟(Shang-Lin Wang) | |
| dc.contributor.author | Pei-Chi Shih | en |
| dc.contributor.author | 石佩琪 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:08:19Z | - |
| dc.date.available | 2022-01-01 | |
| dc.date.available | 2022-11-24T03:08:19Z | - |
| dc.date.copyright | 2021-11-03 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-27 | |
| dc.identifier.citation | [1] Shepherd, A. J. (2012). US pet ownership demographics sourcebook. American Veterinary Medical Association, Schaumburg, Illinois. [2] Volk, J. O., Felsted, K. E., Thomas, J. G., Siren, C. W. (2011). Executive Summary of the Bayer Veterinary Care Usage Study. Journal of the American Veterinary Medical Association, 238(10), 1275-1282. [3] Vogt, A. H., Rodan, I., Brown, M., Brown, S., Buffington, C. T., Forman, M. L., Neilson, J., Sparkes, A. (2010). AAFP-AAHA: Feline life stage guidelines. [4] Little, S. (2015). August's Consultations in Feline Internal Medicine (Vol. 7): Elsevier Health Sciences. [5] Rodan, I. (2010). Understanding Feline Behavior and Application for Appropriate Handling and Management. Topics in Companion Animal Medicine, 25(4), 178-188. [6] Quimby, J. M., Smith, M. L., Lunn, K. F. (2011). Evaluation of the Effects of Hospital Visit Stress on Physiologic Parameters in the Cat. Journal of Feline Medicine and Surgery, 13(10), 733-737. [7] Rand, J. S., Kinnaird, E., Baglioni, A., Blackshaw, J., Priest, J. (2002). Acute Stress Hyperglycemia in Cats Is Associated with Struggling and Increased Concentrations of Lactate and Norepinephrine. Journal of Veterinary Internal Medicine, 16(2), 123-132. [8] Rodan, I. (2012). Understanding the cat and feline-friendly handling. In The Cat (pp. 2-19). WB Saunders. [9] Stevens, B. J., Frantz, E. M., Orlando, J. M., Griffith, E., Harden, L. B., Gruen, M. E., Sherman, B. L. (2016). Efficacy of a Single Dose of Trazodone Hydrochloride Given to Cats Prior to Veterinary Visits to Reduce Signs of Transport- and Examination-Related Anxiety. Journal of the American Veterinary Medical Association, 249(2), 202. doi:10.2460/javma.249.2.202 [10] Orlando, J. M., Case, B. C., Thomson, A. E., Griffith, E., Sherman, B. L. (2016). Use of Oral Trazodone for Sedation in Cats: A Pilot Study. Journal of Feline Medicine and Surgery, 18(6), 476-482. doi:10.1177/1098612X15587956 [11] Stahl, S. M. (2009). Mechanism of Action of Trazodone: A Multifunctional Drug. CNS Spectrums, 14(10), 536-546. [12] Fries, R. C., Kadotani, S., Vitt, J. P., Schaeffer, D. J. (2019). Effects of Oral Trazodone on Echocardiographic and Hemodynamic Variables in Healthy Cats. Journal of Feline Medicine and Surgery, 21(12), 1080-1085. [13] Bryant, S., Ereshefsky, L. (1982). Antidepressant Properties of Trazodone. Clinical Pharmacy, 1(5), 406-417. [14] Gruen, M. E., Roe, S. C., Griffith, E., Hamilton, A., Sherman, B. L. (2014). Use of Trazodone to Facilitate Postsurgical Confinement in Dogs. JAVMA: Journal of the American Veterinary Medical Association, 245(3), 296-301. doi:10.2460/javma.245.3.296 [15] Pisani, F., Oteri, G., Costa, C., Di Raimondo, G., Di Perri, R. (2002). Effects of Psychotropic Drugs on Seizure Threshold. Drug Safety, 25(2), 91-110. [16] Bossini, L., Casolaro, I., Koukouna, D., Cecchini, F., Fagiolini, A. (2012). Off-Label Uses of Trazodone: A Review. Expert Opinion on Pharmacotherapy, 13(12), 1707-1717. [17] Khouzam, H. R. (2017). A Review of Trazodone Use in Psychiatric and Medical Conditions. Postgraduate Medicine, 129(1), 140-148. [18] Gruen, M. E., Sherman, B. L. (2008). Use of Trazodone as an Adjunctive Agent in the Treatment of Canine Anxiety Disorders: 56 Cases (1995-2007). Journal of the American Veterinary Medical Association, 233(12), 1902. doi:10.2460/javma.233.12.1902 [19] Gruen, M. E., Sherman, B. L. (2012). Animal Behavior Case of the Month. Journal of the American Veterinary Medical Association, 241(10), 1293-1295. [20] Herron, M. E., Shreyer, T. (2014). The Pet-Friendly Veterinary Practice: A Guide for Practitioners. Veterinary Clinics: Small Animal Practice, 44(3), 451-481. [21] Gilbert-Gregory, S. E., Stull, J. W., Rice, M. R., Herron, M. E. (2016). Effects of Trazodone on Behavioral Signs of Stress in Hospitalized Dogs. Journal of the American Veterinary Medical Association, 249(11), 1281. doi:10.2460/javma.249.11.1281 [22] Murphy, L. A., Barletta, M., Graham, L. F., Reichl, L. J., Duxbury, M. M., Quandt, J. E. (2017). Effects of Acepromazine and Trazodone on Anesthetic Induction Dose of Propofol and Cardiovascular Variables in Dogs Undergoing General Anesthesia for Orthopedic Surgery. Journal of the American Veterinary Medical Association, 250(4), 408-416. [23] Halls, V. (2018). Tools for Managing Feline Problem Behaviours: Environmental and Behavioural Modification. Journal of Feline Medicine and Surgery, 20(11), 1005-1014. [24] Jay, A. R., Krotscheck, U., Parsley, E., Benson, L., Kravitz, A., Mulligan, A., Silva, J., Mohammed, H., Schwark, W. S. (2013). Pharmacokinetics, Bioavailability, and Hemodynamic Effects of Trazodone after Intravenous and Oral Administration of a Single Dose to Dogs. American Journal of Veterinary Research, 74(11), 1450. doi:10.2460/ajvr.74.11.1450 [25] Chea, B., Giorgi, M. (2017). Trazodone: A Review of Its Pharmacological Properties and Its Off-Label Use in Dogs and Cats. American Journal of Animal and Veterinary Sciences, 12(4), 188-194. doi:10.3844/ajavsp.2017.188.194 [26] Plumb, D. C. (2018). Trazodone hydrochloride. In Plumb's Veterinary Drug Handbook: Desk (pp. 1627-1630). John Wiley Sons. [27] Perrin, C., Seksel, K., Landsberg, G. M. (2014). Drug Dosage Chart. The Veterinary Clinics of North America. Small Animal Practice, 44(3), 629-632. [28] Landsberg, G., Hunthausen, W., Ackerman, L. (2011). Chapter 8: Pharmacologic intervention in behavioral therapy. In Behavior Problems of the Dog and Cat-E-Book (pp. 133-134). Elsevier Health Sciences. [29] Wilbur, R. L. (2017). The Difference Between Topical and Transdermal Medications. Gensco Pharma, May, 1-2. [30] Das, M., Bhattacharya, A., Ghosal, S. (2006). Transdermal Delivery of Trazodone Hydrochloride from Acrylic Films Prepared from Aqueous Latex. Indian Journal of Pharmaceutical Sciences, 68(1), 41. [31] Das, M. K., Bhattacharya, A., Ghosal, S. K. (2006). Effect of Different Terpene-Containing Essential Oils on Percutaneous Absorption of Trazodone Hydrochloride through Mouse Epidermis. Drug Delivery, 13(6), 425-431. doi:10.1080/10717540500395064 [32] Das, M. K., Bhattacharya, A., Ghosal, S. K. (2006). Effect of Penetration Enhancers on Skin Permeation of Trazodone Hydrochloride from Matrix Type Transdermal Formulation through Mouse and Human Cadaver Epidermis. Acta Poloniae Pharmaceutica, 63, 535-541. [33] Das, M. K., Ghosal, S. K. (2008). Ex Vivo and in Vivo Evaluation of Transdermal Formulation of Trazodone Hydrochloride. Acta Poloniae Pharmaceutica, 65(4), 481-486. [34] Kaminsky, B. M., Bostwick, J. R., Guthrie, S. K. (2015). Alternate routes of administration of antidepressant and antipsychotic medications. Annals of Pharmacotherapy, 49(7), 808-817. [35] Mason, B., Buhules W., Quimby, J., Labelle, D., Jung, D., Poole, M. (2017). Single dose pharmacokinetics following transdermal application and oral administration of mirtazapine ointment in cats. National Harbor, MD [36] Pankratz, K. E., Ferris, K. K., Griffith, E. H., Sherman, B. L. (2018). Use of Single-Dose Oral Gabapentin to Attenuate Fear Responses in Cage-Trap Confined Community Cats: A Double-Blind, Placebo-Controlled Field Trial. Journal of Feline Medicine and Surgery, 20(6), 535-543. doi:10.1177/1098612X17719399 [37] Dybdall, K. J. (2011). Experiment 1: Measuring Stress in Shelter Cats. Measuring Stress, Attachment Behavior, and Adoptability in Domestic Cats at a Local Humane Society (pp. 7-8). University of Nebraska at Omaha. [38] van Haaften, K. A., Forsythe, L. R. E., Stelow, E. A., Bain, M. J. (2017). Effects of a Single Preappointment Dose of Gabapentin on Signs of Stress in Cats During Transportation and Veterinary Examination. Journal of the American Veterinary Medical Association, 251(10), 1175. doi:10.2460/javma.251.10.1175 [39] Hudec, C. P., Griffin, C. E. (2019). Changes in the Stress Markers Cortisol and Glucose before and During Intradermal Testing in Cats after Single Administration of Pre-Appointment Gabapentin. Journal of Feline Medicine and Surgery, 1098612X19830501. doi:10.1177/1098612X19830501 [40] Bayer, A. J., Pathy, M., Ankier, S. (1983). Pharmacokinetic and Pharmacodynamic Characteristics of Trazodone in the Elderly. British Journal of Clinical Pharmacology, 16(4), 371-376. [41] Greenblatt, D. J., Friedman, H., Burstein, E. S., Scavone, J. M., Blyden, G. T., Ochs, H. R., Miller, L. G., Harmatz, J. S., Shader, R. I. (1987). Trazodone Kinetics: Effect of Age, Gender, and Obesity. Clinical Pharmacology Therapeutics, 42(2), 193-200. [42] Bird, D., Ravindra, N. M. (2020). Transdermal Drug Delivery and Patches—an Overview. Medical Devices Sensors, 3(6), e10069. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80515 | - |
| dc.description.abstract | "曲唑酮氫氯化合物是一種普遍用於人類及犬病患的選擇型血清素拮抗劑和重吸收抑制劑，也是一種四環類三唑吡啶抗憂鬱劑。此藥在貓病患越來越常被用作於看診前優先經口投予的抗焦慮劑和鎮靜劑。經口投藥對貓飼主來說經常是困難的挑戰，可能因此限制曲唑酮在貓的實用度。為了發展更便利的投藥方式，本次以單中心、隨機的前瞻性研究，評估一款新型的經皮吸收曲唑酮藥膏使用於貓的藥效和安全性。參與的貓隻被隨機分配至每隻貓使用100毫克(低劑量)或每隻貓使用150毫克(高劑量)經皮吸收曲唑酮藥膏的組別，每隻貓會有用藥前和用藥後共兩次就診，這兩次就診分別就是每隻貓自己的控制組和實驗組，過程中會觀察並記錄貓在來回交通上和檢查操作時的行為。我們根據動物行為學和相關的過去文獻設計出一系列評分系統來評估貓的緊迫程度和易處理性，包含貓緊迫評分(cat stress score, CSS)、整體鎮靜評分(global sedation score, GSS)、行為反應評分(behavioral response score, BRS)和飼主的總體經驗評分(overall experience score, OES)。最後將每隻貓用藥前後的就診數據相互比較，包含上述各項評分以及生理數值(呼吸速率、心跳速率、血壓收縮壓、脈搏速率和耳溫)，也會另外評估血液檢驗變化、副作用和藥效反應時間。總共有20隻室內飼養貓參與本研究，其中7隻被分配至低劑量組，另外13隻被分配至高劑量組。在低劑量組，經皮吸收曲唑酮藥膏顯著降低了貓來醫院路上的CSS (P = 0.042)，但回家路上的CSS沒有顯著差異(P = 0.104)。在高劑量組，經皮吸收曲唑酮藥膏顯著降低了貓來醫院(P = 0.005)和回家(P = 0.005)路上的CSS。兩個組別在門診檢查時的CSS和GSS於用藥後都沒有顯著的改變。門診檢查時的BRS在低劑量組(P = 0.034)和高劑量組(P = 0.018)用藥後皆有顯著下降的情形，意即貓在檢查操作時的易處理性增加，但其顯著性依照不同的檢查操作步驟或行為層面來看有不一致的結果。根據OES問卷調查結果，高劑量組的飼主認為貓在使用此藥膏後於來醫院路上(P = 0.002)、回家路上(P = 0.005)和門診檢查(P = 0.003)的緊迫程度都有顯著地減輕，而低劑量組的飼主認為使用此藥膏後貓的緊迫程度只有在來醫院路上獲得顯著改善(P = 0.020)。本研究顯示此藥膏對生理數值以及血檢數值皆無顯著影響，產生的副作用也只佔少數且程度輕微，可見該族群貓對單次100毫克或150毫克經皮吸收曲唑酮藥膏的耐受度佳。透過本篇研究可知，就診前優先使用足夠劑量的經皮吸收曲唑酮藥膏可以減輕貓的緊迫和焦慮，並改善貓與飼主的就醫經驗。對於經皮吸收曲唑酮藥膏降低貓就診時的恐懼與抗拒，未來仍需要進一步的研究以探討更多資訊。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:08:19Z (GMT). No. of bitstreams: 1 U0001-2710202102553500.pdf: 1499881 bytes, checksum: 664fbf039fec20396f8c0c2a991af76f (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 摘要 i Abstract iii Table of Contents v List of Figures vii List of Tables viii List of Abbreviations ix Chapter 1 Introduction 1 1.1 Stress-associated ethology 1 1.2 Trazodone 2 1.3 Adverse effects and toxicities of trazodone 3 1.4 Transdermal formulation 4 1.5 Hypothesis 5 1.6 Objectives 6 Chapter 2 Materials and Methods 7 2.1 Animals 7 2.2 Dose of transdermal trazodone 8 2.3 Formulation of transdermal trazodone 9 2.4 Procedures and physiologic parameters 9 2.5 Assessment scoring systems 11 2.6 Statistical analysis 12 Chapter 3 Results 14 3.1 Animals and treatment groups 14 3.2 CSS assessed by owners during transportation 14 3.3 CSS and GSS assigned by veterinarian 16 3.4 BRS assessed by veterinarian during examination 17 3.5 OES assessed by owners 18 3.6 Physiologic variables 20 3.7 Drug safety and adverse effects 20 Chapter 4 Discussion 22 Chapter 5 Conclusion 29 References 30 Figures 36 Tables 45 | |
| dc.language.iso | en | |
| dc.subject | 抗焦慮劑 | zh_TW |
| dc.subject | 鎮靜劑 | zh_TW |
| dc.subject | 貓緊迫和焦慮行為 | zh_TW |
| dc.subject | 經皮吸收藥膏 | zh_TW |
| dc.subject | 血清素活性抗憂鬱劑 | zh_TW |
| dc.subject | 曲唑酮 | zh_TW |
| dc.subject | trazodone | en |
| dc.subject | feline stress and anxiety | en |
| dc.subject | sedative | en |
| dc.subject | anxiolytic | en |
| dc.subject | transdermal cream | en |
| dc.subject | serotonergic antidepressant | en |
| dc.title | 就診前使用經皮吸收曲唑酮藥膏減少貓的緊迫和焦慮 | zh_TW |
| dc.title | Use of transdermal trazodone prior to veterinary visits for reducing stress and anxiety in cats | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李繼忠(Hsin-Tsai Liu),王儷蒨(Chih-Yang Tseng),劉以立,廖泰慶 | |
| dc.subject.keyword | 曲唑酮,血清素活性抗憂鬱劑,經皮吸收藥膏,抗焦慮劑,鎮靜劑,貓緊迫和焦慮行為, | zh_TW |
| dc.subject.keyword | trazodone,serotonergic antidepressant,transdermal cream,anxiolytic,sedative,feline stress and anxiety, | en |
| dc.relation.page | 59 | |
| dc.identifier.doi | 10.6342/NTU202104294 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-28 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床動物醫學研究所 | |
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