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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 葉光勝(Kuang-Sheng Yeh) | |
| dc.contributor.author | Te-Heng Lee | en |
| dc.contributor.author | 李得亨 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:03:44Z | - |
| dc.date.available | 2023-07-01 | |
| dc.date.available | 2022-11-24T03:03:44Z | - |
| dc.date.copyright | 2021-07-23 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-07-02 | |
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Grönthal T, Österblad M, Eklund M, Jalava J, Nykäsenoja S, Pekkanen K, Rantala M: Sharing more than friendship – transmission of NDM-5 ST167 and CTX-M-9 ST69 Escherichia coli between dogs and humans in a family, Finland, 2015. Eurosurveillance 2018, 23(27):1700497. 143. Hammad AM, Hoffmann M, Gonzalez-Escalona N, Abbas NH, Yao K, Koenig S, Allué-Guardia A, Eppinger M: Genomic features of colistin resistant Escherichia coli ST69 strain harboring mcr-1 on IncHI2 plasmid from raw milk cheese in Egypt. Infect Genet Evol 2019, 73:126-131. 144. Zhao S-Y, Wang Y-C, Xiao S-Z, Jiang X-F, Guo X-K, Ni Y-X, Han L-Z: Drug susceptibility and molecular epidemiology of Escherichia coli in bloodstream infections in Shanghai, China, 2011–2013. Infect Dis 2015, 47(5):310-318. 145. Wang S, Zhao SY, Xiao SZ, Gu FF, Liu QZ, Tang J, Guo XK, Ni YX, Han LZ: Antimicrobial resistance and molecular epidemiology of Escherichia coli causing bloodstream infections in three hospitals in Shanghai, China. PLoS One 2016, 11(1):e0147740. 146. Li Y, Ma X, Li C, Dai X, Zhang L: Occurrence and genomic characterization of ESBL-producing Escherichia coli ST29 strains from swine with abundant virulence genes. Microb Pathog 2020, 148:104483. 147. Zweifel C, Cernela N, Stephan R: Detection of the emerging Shiga toxin-producing Escherichia coli O26:H11/H- sequence type 29 (ST29) clone in human patients and healthy cattle in Switzerland. Appl Environ Microbiol 2013, 79(17):5411-5413. 148. Chattaway MA, Jenkins C, Ciesielczuk H, Day M, DoNascimento V, Day M, Rodríguez I, van Essen-Zandbergen A, Schink A-K, Wu G et al: Evidence of evolving extraintestinal enteroaggregative Escherichia coli ST38 clone. Emerging Infect Dis 2014, 20(11):1935-1937. 149. Kuo S-C, Huang W-C, Wang H-Y, Shiau Y-R, Cheng M-F, Lauderdale T-L: Colistin resistance gene mcr-1 in Escherichia coli isolates from humans and retail meats, Taiwan. Antimicrob Agents Chemother 2016, 71(8):2327-2329. 150. Aeksiri N, Toanan W, Sawikan S, Suwannarit R, Pungpomin P, Khieokhajonkhet A, Niumsup PR: First detection and genomic insight into mcr-1 encoding plasmid-mediated colistin-resistance gene in Escherichia coli ST101 isolated from the migratory bird species hirundo rustica in Thailand. Microb Drug Resist 2019, 25(10):1437-1442. 151. Freitag C, Michael GB, Kadlec K, Hassel M, Schwarz S: Detection of plasmid-borne extended-spectrum β-lactamase (ESBL) genes in Escherichia coli isolates from bovine mastitis. Vet Microbiol 2017, 200:151-156."……… | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80278 | - |
| dc.description.abstract | "超廣譜乙內醯胺酶 (extend-spectrum β-lactamase, ESBL) 為一種能夠破壞乙內醯胺類抗生素的酵素，包含第三代頭孢菌素，從而使細菌產生抗藥性。大腸桿菌為常見的共生菌，廣泛存在於動物腸道中，並能透過污染食物鏈的方式影響人體健康。因此，帶有ESBL的大腸桿菌 (ESBL-producing E. coli) 為公共健康的隱患之一。本研究旨在調查2020年間ESBL-producing E. coli在台灣健康產食動物中的盛行率與特性分析。總計共分析490株大腸桿菌，其ESBL-producing E. coli的盛行率在雞、豬及牛分別為10.9% (17/156)、4.27% (7/164) 及8.82% (15/170)。總體盛行率為7.96% (39/490)。ESBL基因型檢測結果顯示，在雞隻檢體中，檢測到CTX-M-1group與TEM group。而豬隻檢體則有CTX-M-1group、CTX-M-2 group、CTX-M-9 group與TEM group。牛隻除了沒有檢測到CTX-M-2 group 以外，其餘的基因型與豬隻檢體相同。綜合三個物種來說，檢出率最高的基因型為CTX-M-1 group (32/46, 69.6%)，而CTX-M-8、CTX-M-25與SHV基因型則均未檢出。針對常見的13種抗生素進行藥物敏感性試驗，包括amoxicillin/clavulanic acid、ampicillin、cephalothin、ceftiofur、nalidixic acid、ciprofloxacin、enrofloxacin、tetracycline、doxycycline、amikacin、streptomycin、gentamicin、sulfamethoxazole/trimethoprim。結果顯示所有的ESBL-producing E. coli都具有多重抗藥性，除了對乙內醯胺類抗生素具有高比例的抗藥性外，對四環黴素、磺胺劑與鏈黴素也同樣具有高比例的抗藥性。這些細菌對於amoxicillin/clavulanic acid、氨基配糖體類 (鏈黴素除外) 與奎諾酮類抗生素，則呈現較高的感受性。另外，接合試驗結果顯示，多數菌株具有水平轉移ESBL基因的能力。在牛隻檢體中100% 均可轉移，而在雞隻與豬隻檢體中，則分別為94.1% 與54.1%。多重序列分型法結果顯示ESBL-producing E. coli的分型具有高度多樣性，共分離出28種不同的序列分型。最常見的為ST162與ST1249，分別各有4株。依照物種進行菌株的親緣樹分析，發現物種內的菌株間無緊密的親緣關係，因此沒有特定的演化趨勢可循。本研究提供了健康產食動物中ESBL-producing E. coli的盛行率與特性分析，可做為流行病學研究或抗藥性監測的初步參考。ESBL-producing microorganism的檢測應持續進行，以便擬定合適的抗生素使用策略並期許能減緩抗藥性細菌的浮現。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:03:44Z (GMT). No. of bitstreams: 1 U0001-3006202119211400.pdf: 3308002 bytes, checksum: 47ad80a3bf47ab78d83248bb81f38d2e (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "中文摘要 i Abstract iii 目錄 v 第一章 文獻探討 1 第一節 抗生素的使用與抗藥性 1 2-1-1 抗生素簡史 1 2-1-2 抗生素在產食動物中的使用 2 2-1-3 抗生素抗藥性的危害 3 2-1-4 抗生素抗藥性的預防措施 5 第二節 β-lactam類抗生素(乙內醯胺類抗生素) 10 第三節 超廣譜乙內醯胺酶 (Extend-Spectrum-β-lactamase) 12 2-3-1 β-lactamase分類 13 2-3-2 ESBLs 基因型分類 16 第四節 大腸桿菌 17 2-4-1 大腸桿菌型態與特徵 17 2-4-2 致病性大腸桿菌分類 18 2-4-3大腸桿菌抗藥性機制 23 第五節 ESBL-producing microorganism流行現況與趨勢 25 2-5-1 ESBLs在人醫領域之流行情況 25 2-5-2 ESBLs在產食動物領域之流行情況 30 第六節 研究目的 33 第二章 材料與方法 34 第一節 菌株來源 34 第二節 ESBL E. coli初步篩選 34 第三節 ESBL E. coli表現型確認試驗 34 第四節 ESBL菌株DNA樣本萃取 35 第五節 β-lactamases基因型檢測及定序分析 36 第六節 multilocus sequence typing (MLST) 分析及親緣樹建構 37 第七節 藥物敏感性試驗 (紙錠擴散法) 38 第八節 接合作用 (conjugation) 試驗 38 第三章 研究結果 40 第一節 各物種ESBL-producing E. coli盛行率 40 第二節 β-lactamase基因型檢測結果 40 第三節 抗微生物藥物敏感性試驗結果 41 第四節 接合試驗結果 42 第五節 MLST分析結果 43 第四章 討論 44 第一節 ESBL-producing E. coli盛行率分析 44 第二節 ESBL基因型分析 47 第三節 藥物敏感性試驗分析 49 第四節 接合試驗分析 51 第五節 MLST親緣樹分析 51 第五章 參考文獻 55 表次 71 Table1. The primers used in this study. 71 Table 2. The prevalence of the ESBL-producing E. coli in chicken, pigs, and cattle. 72 Table 3. The ESBL genes profiles and the sequence types from the 17 chicken ESBL-producing E. coli. 73 Table 4. The ESBL genes profiles and the sequence types from the 7 pigs ESBL-producing E. coli. 74 Table 5. The ESBL genes profiles and the sequence types from the 15 cattle ESBL-producing E. coli. 75 Table 6. The conjugation test result. 76 圖次 78 Figure1. Minimum spanning tree of ESBL-producing E. coli from chicken. 78 Figure2. Minimum spanning tree of ESBL-producing E. coli from pigs. 79 Figure 3. Minimum spanning tree of ESBL-producing E. coli from cattle 80 Figure 4. The antibiotic susceptibility profile of ESBL-producing E. coli from chicken isolates. 81 Figure 5. The antibiotic susceptibility profile of ESBL-producing E. coli from pigs.. 82 Figure 6. The antibiotic susceptibility profile of ESBL-producing E. coli from cattle. 83 附錄 84 Appendix 1. The geographical distribution of the slaughterhouses participating in the present study 84 Appendix 2. The MLST sequencing results of the ESBL-producing E. coli from the chicken samples. 85 Appendix 3. The MLST sequencing results of the ESBL-producing E. coli from the pigs samples. 86 Appendix 4. The MLST sequencing results of the ESBL-producing E. coli from the cattle samples. 87" | |
| dc.language.iso | zh-TW | |
| dc.subject | 接合試驗 | zh_TW |
| dc.subject | 超廣譜乙內醯胺酶 | zh_TW |
| dc.subject | 大腸桿菌 | zh_TW |
| dc.subject | 多重抗藥性 | zh_TW |
| dc.subject | 多重序列分型法 | zh_TW |
| dc.subject | 產食動物 | zh_TW |
| dc.subject | multidrug resistance | en |
| dc.subject | multilocus sequence typing | en |
| dc.subject | conjugation | en |
| dc.subject | food animals | en |
| dc.subject | extend-spectrum β-lactamases | en |
| dc.subject | Escherichia. coli | en |
| dc.title | 2020臺灣產食動物中所分離帶有超廣譜乙內醯胺酶大腸桿菌之盛行率及特性分析 | zh_TW |
| dc.title | The Prevalence and the Characteristics of the Extended-Spectrum β-Lactamases-Producing Escherichia coli from Food Animals in Taiwan in 2020 | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張惠雯(Hsin-Tsai Liu),陳正文(Chih-Yang Tseng) | |
| dc.subject.keyword | 超廣譜乙內醯胺酶,大腸桿菌,多重抗藥性,產食動物,接合試驗,多重序列分型法, | zh_TW |
| dc.subject.keyword | extend-spectrum β-lactamases,Escherichia. coli,multidrug resistance,food animals,conjugation,multilocus sequence typing, | en |
| dc.relation.page | 87 | |
| dc.identifier.doi | 10.6342/NTU202101218 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-07-02 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
| dc.date.embargo-lift | 2023-07-01 | - |
| 顯示於系所單位： | 獸醫學系 | |
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