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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳中明(Chung-Ming Chen) | |
| dc.contributor.author | Chuan-Tsung Su | en |
| dc.contributor.author | 蘇傳宗 | zh_TW |
| dc.date.accessioned | 2022-11-23T09:08:54Z | - |
| dc.date.available | 2021-09-11 | |
| dc.date.available | 2022-11-23T09:08:54Z | - |
| dc.date.copyright | 2021-09-11 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-08-30 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79725 | - |
| dc.description.abstract | "光生物調節作用 (Photobiomodulation, PBM) 已廣泛應用於體內與體外之臨床實務應用。而 PBM 在皮膚上的光學特性及應用已有多年的研究探討，但是PBM在真實皮膚下的劑量及穿透深度探討甚少，也缺乏直接證據。另一方面，抗菌光動力療法 (Antimicrobial photodynamic therapy, aPDT) 已被廣泛用於牙周疾病的治療，牙周疾病影響了全球 20% 至 50% 的人口，同時也構成全球的健康挑戰。然而雷射光型在 aPDT 體外研究的抗菌功效仍需進一步釐清。本論文研究包含 PBM 在牙齦上的定量分析及雷射光源均勻性在 aPDT的重要性探討。本論文發展出非侵入式感測裝置來偵測 PBM 穿透口輪匝肌到牙齦上的真實劑量，其劑量可被準確量測且定義出來。當PBM應用於皮膚下的目標組織時，正確的劑量計算有助於增加臨床上的整體性評估。在aPDT的應用中，本論文發展出低成本的aPDT系統應用在放線共生聚集桿菌和變異鏈球菌並可達到 98% 及 91% 的抗菌效果。研究結果顯示雷射光型的均勻性對於細菌存活率具關鍵的重要性。根據我們研究的結果，牙醫師可正確計算牙齦的照射劑量及有效評估體外抗菌的最佳照射參數。本研究結果預期可擴大 PBM 及 aPDT 的臨床應用並做為光生物刺激研究之重要參考。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-23T09:08:54Z (GMT). No. of bitstreams: 1 U0001-2108202112590100.pdf: 5059945 bytes, checksum: c5e78db02fe9365138e134d4f0e5f2a8 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 誌謝 I 中文摘要 II Abstract III Table of contents IV List of figures VII List of tables XI Chapter 1: Introduction 1 1.1 Photobiomodulation (PBM) 1 1.1.1 The development of PBM in medicine and applications 1 1.1.2 The optical characteristics in skin and dose analysis in vitro/vivo studies 5 1.1.3 The role of mechanisms and physiological effects 9 1.2 Antimicrobial Photodynamic therapy (aPDT) 16 1.2.1 The development of aPDT in dentistry and applications 16 1.2.2 The role of mechanisms and biological effects 20 1.3 Purposes 24 Chapter 2: Materials and methods 26 2.1 Noninvasive sensing system design and optical property in skin 26 2.1.1 Auto current control circuit designed for driving laser diode (LD) 26 2.1.2 Detector system design and calibration method 27 2.1.3 Transparent polyethylene (PE) thin film 28 2.1.4 Stabilized flexible facial fixture appliance (FFFA) and retainer fabrication 29 2.1.5 Simulation of light scattering and light propagation in skin 31 2.2 Low cost aPDT system design 33 2.2.1 aPDT with copper tubes waveguide (CTW) and optical fiber waveguide (OFW) 33 2.2.2 Laser profile simulation 39 2.2.3 Bacterial culture preparation and aPDT procedure 40 Chapter 3: Exact power density analysis of PBM in vivo study 42 3.1 Irradiance of 650 nm/ 830 nm laser on attached gingiva 42 3.1.1 Optical measurement of collimated and uncollimated laser on the orbicularis oris for a male and a female 42 3.2 Optical characteristics of red and NIR in skin 46 3.2.1 Angular distribution versus light scattering angle 46 3.2.2 Laser power with 660 nm in skin layers 46 3.2.3 Laser power with 825 nm in skin layers 47 Chapter 4: Antibacterial Efficiency of aPDT in vitro study 49 4.1 aPDT laser viability and power distribution measurement method 49 4.1.1 Temperature and power decay of 660 nm laser operation 49 4.1.2 Power distribution measurement method 50 4.2 Antibacterial effect of periodontal bacteria by aPDT 51 4.2.1 Antibacterial efficiency of A. actinomycetcmcomitans and S. mutans by aPDT (N=5) 51 4.3 Laser optical profile 52 4.3.1 The laser profile guided with polished CTW and OFW 52 4.4 Antibacterial effect of periodontal bacteria by aPDT with polished CTW 54 4.4.1 Optical density of A. actinomycetcmcomitans by aPDT with CTW (N=10) 54 4.4.2 Optical density of S. mutans by aPDT with CTW (N=10) 55 Chapter 5: Discussion and conclusion 57 Chapter 6: Future work 65 References 66 | |
| dc.language.iso | en | |
| dc.subject | 雷射光型 | zh_TW |
| dc.subject | 光生物調節作用 | zh_TW |
| dc.subject | 光動力療法 | zh_TW |
| dc.subject | 牙周疾病 | zh_TW |
| dc.subject | 抗菌功效 | zh_TW |
| dc.subject | antimicrobial photodynamic therapy | en |
| dc.subject | periodontal disease | en |
| dc.subject | antibacterial efficacy | en |
| dc.subject | laser profile | en |
| dc.subject | photobiomodulation | en |
| dc.title | 紅光與近紅外線雷射劑量在口腔醫學上的應用: 光生物調節作用之功率密度分析及光型分布在光動力治療系統上的設計 | zh_TW |
| dc.title | Dosimetry of red and near-infrared laser in stomatology: Exact dose analysis of photobiomodulation and optical profile analysis of photodynamic therapy | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.coadvisor | 吳季華(Jih-Huah Wu) | |
| dc.contributor.oralexamcommittee | 林文澧(Hsin-Tsai Liu),陳俊呈(Chih-Yang Tseng),馬仕信 | |
| dc.subject.keyword | 光生物調節作用,光動力療法,牙周疾病,抗菌功效,雷射光型, | zh_TW |
| dc.subject.keyword | photobiomodulation,antimicrobial photodynamic therapy,periodontal disease,antibacterial efficacy,laser profile, | en |
| dc.relation.page | 91 | |
| dc.identifier.doi | 10.6342/NTU202102567 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-08-31 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
| 顯示於系所單位： | 醫學工程學研究所 | |
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|---|---|---|---|
| U0001-2108202112590100.pdf | 4.94 MB | Adobe PDF | 檢視/開啟 |
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