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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 連家瑩(Chia-Ying Lien) | |
| dc.contributor.author | Keng-Yu Chang | en |
| dc.contributor.author | 張耕瑜 | zh_TW |
| dc.date.accessioned | 2022-11-23T09:07:28Z | - |
| dc.date.available | 2022-02-16 | |
| dc.date.available | 2022-11-23T09:07:28Z | - |
| dc.date.copyright | 2022-02-16 | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2022-02-09 | |
| dc.identifier.citation | 中文文獻 劉又嫻（2014）。冬蟲夏草增補與阻力訓練對大鼠骨品質的影響。國立臺灣師範大學運動科學研究所碩士論文，台北市。 取自https://hdl.handle.net/11296/398t22 衛生福利部（2020）。【新聞群組】。取自 https://www.mohw.gov.tw/cp-16-54482-1.html 梁景超、陳柏志（2018）。醫檢小百科：淺談骨質疏鬆檢測因子。【部落格文字資料】。取自http://www.labmed.org.tw/knowledge_1.asp?mno=98 曾慶城（2012）。免疫組織化學染色發展的歷史回顧。生物醫學地5卷第2期：105-111 英文文獻 Brahma, R., Dawson, B., Goodman, C. (2003). The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine, 37(1):45-9; discussion 49. doi: 10.1136/bjsm.37.1.45 Buijs, J. T., Stayrook, K. R., Guise, T. A. (2011). TGF-β in the Bone Microenvironment: Role in Breast Cancer Metastases. Cancer Microenviron, 4(3):261-81. doi: 10.1007/s12307-011-0075-6 Beck, B. R., Daly, R. M., Singh, M. A. F., Taaffe, D. R. (2017). Exercise and Sports Science Australia (ESSA) position statement on exercise prescription for the prevention and management of osteoporosis. 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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79684 | - |
| dc.description.abstract | 過去針對骨質疏鬆之研究多著重於老化族群，而癌症病患因化療藥物導致之骨質疏鬆問題則經常被忽略；多項研究指出Doxorubicin化療藥具造成骨骼損傷之實證，若化療期間進行阻力訓練和攝取增益骨骼之健康食品，則可能保留其骨質密度。目的：本研究選擇安全性高之低強度阻力訓練和骨骼健康食品的介入，探討是否能延緩化療藥物造成之小鼠骨質疏鬆的症狀。 方法：本研究使用20隻8週齡健康ICR小鼠進行為期三週的實驗，隨機分為控制組、化療組、化療運動組、化療食品組、化療運動食品組。需注射化療藥之組別，間隔兩天施打共四次、累積劑量至每公斤小鼠16毫克；使用自製紙板階梯進行每週三次，共九次的低強度阻力訓練；健康食品內含龜板、鹿角、葡萄糖胺和軟骨素，每日以管餵提供每公斤小鼠100毫克的劑量。實驗後犧牲小鼠取其股骨，利用微電腦斷層掃描儀取得三維掃描影像和骨骼參數，以單因子變異數分析檢測實驗結果中骨質流失和緩解的狀況。 結果：根據小鼠三維掃描影像及各骨骼數據之統計分析結果，對小鼠施打化療藥後造成了明顯的骨質流失，僅進行阻力訓練和攝食骨骼健康食品的化療小鼠則沒有與化療小鼠有顯著骨質保留的結果，而在阻力訓練與骨骼健康食品搭配介入下的化療小鼠在統計上與其他化療小鼠組別皆有骨骼保留之顯著差異。 結論：同時進行阻力訓練和攝食健康食品對於延緩化療造成之骨質疏鬆是具可預期性的，僅有阻力訓練的組別可能需再提高強度方能有保留骨質的效用，若提高骨骼健康食品之攝取含量，對於化療小鼠之骨骼保健應有更明顯的作用。 | zh_TW |
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| dc.description.tableofcontents | 口試委員會審定書……………………………………………………………………i 致謝……………………………………………………………………………………ii 中文摘要………………………………………………………………………………iii 英文摘要………………………………………………………………………………v 第壹章、緒論…………………………………………………………………………1 第一節、研究背景與動機………………………………………………………1 第二節、研究問題………………………………………………………………3 第三節、研究目的與重要性……………………………………………………3 第四節、名詞操作性定義………………………………………………………4 第貳章、文獻探討……………………………………………………………………7 第一節、骨質疏鬆………………………………………………………………7 第二節、化療藥物 DOX 造成骨質疏鬆之機轉………………………………9 第三節、阻力訓練對骨質疏鬆程度之影響……………………………………12 第四節、骨骼健康食品對骨質疏鬆改善之效用………………………………15 第五節、阻力訓練搭配骨骼健康食品之補充是否有交互作用………………18 第六節、文獻總結………………………………………………………………18 第參章、研究方法……………………………………………………………………20 第一節、研究對象………………………………………………………………20 第二節、實驗設計………………………………………………………………20 第三節、阻力訓練之設計………………………………………………………22 第四節、研究假設………………………………………………………………23 第五節、分析方法………………………………………………………………24 第肆章、結果…………………………………………………………………………27 第一節、一般染色＆免疫組織染色……………………………………………27 第二節、股骨三維掃描影像……………………………………………………28 第三節、靜態骨骼組織型態學分析……………………………………………29 第伍章、討論…………………………………………………………………………34 第一節、DOX 對骨骼之負面影響 ……………………………………………34 第二節、阻力訓練對化療小鼠骨質之影響……………………………………35 第三節、骨骼健康食品對化療小鼠骨質之影響………………………………35 第四節、阻力訓練與骨骼健康食品搭配對化療小鼠骨質之影響……………36 第五節、結論與建議……………………………………………………………36 參考文獻………………………………………………………………………………38 | |
| dc.language.iso | zh-TW | |
| dc.title | 阻力訓練與補充骨骼健康食品對化療小鼠骨質疏鬆之緩解影響 | zh_TW |
| dc.title | Alleviative Effects of Resistance Training and Bone Health Food on Osteoporosis of Mice Undergoing Chemotherapy | en |
| dc.date.schoolyear | 110-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 吳忠信(Keh-Chia Yeh),莊泰源(Hsun-Chuan Chan) | |
| dc.subject.keyword | 肌力訓練,健康食品,骨質密度,化學治療,癌症, | zh_TW |
| dc.subject.keyword | muscle training,health food,bone mass density,chemotherapy,cancer, | en |
| dc.relation.page | 49 | |
| dc.identifier.doi | 10.6342/NTU202200303 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2022-02-11 | |
| dc.contributor.author-dept | 共同教育中心 | zh_TW |
| dc.contributor.author-dept | 運動設施與健康管理碩士學位學程 | zh_TW |
| 顯示於系所單位： | 運動設施與健康管理碩士學位學程 | |
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| U0001-0602202219285100.pdf | 4.86 MB | Adobe PDF | 檢視/開啟 |
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