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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79613完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林信甫(Hsin-Fu Lin) | |
| dc.contributor.author | Chih-Yuan Hsueh | en |
| dc.contributor.author | 薛智元 | zh_TW |
| dc.date.accessioned | 2022-11-23T09:05:14Z | - |
| dc.date.available | 2021-09-17 | |
| dc.date.available | 2022-11-23T09:05:14Z | - |
| dc.date.copyright | 2021-09-17 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-09-11 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79613 | - |
| dc.description.abstract | "背景: 高糖飲食可能會造成氧化壓力提高、動脈硬化，與提升罹患心血管疾病的風險; 單次有氧運動則有助於改善動脈硬化。然而，單次有氧運動對於攝取不同劑量葡萄糖後血管功能之改善效益，以及其他相關心血管因子變化尚不清楚，並且研究對象也僅限於健康成人。目的: 探討執行單次有氧運動後攝取不同劑量葡萄糖補充液，對於高血壓前期男性餐後動脈硬化、氧化壓力、骨鈣素 (osteocalcin, OC) 及交感神經之影響。方法: 12名高血壓前期男性 (28 ± 4歲) 為研究對象，隨機交叉分配為控制組 (安慰劑, Con)、低糖組 (25克葡萄糖, 25g) 與高糖組 (75克葡萄糖, 75g)，每組實驗中間至少間隔一週。運動前測量血管硬化指標 (心跳、血壓、心-肱脈波傳導速度、收縮間隔) 與抽血取樣 (血糖、胰島素) 後，執行30分鐘65%保留心跳率 (heart rate reserve, HRR) 之跑步機慢跑，運動結束立即飲用250克葡萄糖補充液。接著，分別在運動後30、60、90與120分鐘測量血管硬化指標與抽血取樣。此外，在運動前與運動後30分鐘氧化壓力與骨鈣素也會進行採樣分析。結果: 75g組在運動後60分鐘之心-肱脈波傳導速度(heart-brachial pulse wave velocity, hbPWV) 顯著高於Con (75g: 3.35±0.48 m/s; Con: 3.14±0.40 m/s)。超氧化物歧化酶 (superoxide dismutase, SOD) 運動後些微上升，但無顯著差異。丙二醛 (malondialdehyde, MDA) 運動後僅25g組顯著上升 (Pre-test: 8.9±1.7 nmol/mL; 30min: 10.6±2.2 nmol/mL)，75g組接近顯著差異 (Pre-test: 9.0±2.4 nmol/mL; 30min: 11.5±3.1 nmol/mL, p=0.059)。25g與75g組左心室射血時間 (ejection time, ET)、射血前期 (pre-ejection period, PEP) 在運動後30分鐘皆顯著下降。結論: 單次有氧運動對中心動脈硬化改善效果不顯著，但攝取高劑量葡萄糖後60分鐘會導致中心動脈硬化程度保持較高水平，可能與高胰島素濃度造成的心臟交感神經興奮有關，而非MDA或SOD。" | zh_TW |
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| dc.description.tableofcontents | 口試委員會審定書 I 摘要 II Abstract III 目錄 V 圖目錄 VIII 表目錄 IX 附錄 X 第壹章 緒論 1 第一節 研究動機 1 第二節 研究目的 2 第三節 研究假設 2 第四節 名詞操作性定義 2 第五節 研究限制 3 第六節 研究的重要性 3 第貳章 文獻探討 4 第一節 動脈硬化 4 (一) 動脈硬化之機轉 4 (二) 評估動脈硬化之指標 4 第二節 餐後高血糖與動脈硬化 5 第三節 有氧運動與動脈硬化 6 (一) 有氧運動改善動脈硬化之可能機轉 6 (二) 有氧運動變項與改善動脈硬化之關係 6 第四節 動脈硬化與氧化壓力之探討 13 第五節 有氧運動後攝取葡萄糖之血清總骨鈣素反應 13 第六節 動脈硬化與交感神經活動之探討 15 第參章 研究方法 17 第一節 實驗對象 17 第二節 實驗時間與地點 18 第三節 材料與設備 18 (一) 增補劑 18 (二) 儀器與設備 18 第四節 實驗流程 19 第五節 實驗方法與步驟 19 (一) 實驗前準備 19 (二) 運動前檢測 20 (三) 有氧運動與增補 20 (四) 運動後檢測 20 第六節 統計分析 21 第肆章 結果 22 第一節 血液樣本分析 22 (一) 血糖 22 (二) 胰島素 23 (三) 血清總骨鈣素 24 (四) 血清超氧化物歧化酶 25 (五) 血清丙二醛 25 第二節 生理訊號結果分析 25 (一) 心跳 26 (二) 收縮壓 27 (三) 舒張壓 27 (四) 射血時間 28 (五) 射血前期 28 (六) PEP/ET 29 (七) 心-肱脈波傳導速度 30 第三節 變項間之相關性與線性回歸 31 (一) 心跳率與射血時間 31 (二) 胰島素與射血前期 32 (三) PEP/ETc與心-肱脈波傳導速度 32 第伍章 討論與結論 34 第一節 攝取不同濃度葡萄糖後運動恢復期之生理反應 34 第二節 探討運動恢復期影響中心動脈硬化之可能機制 36 第三節 研究結果之應用與限制 38 第四節 結論 39 參考文獻 40 | |
| dc.language.iso | zh-TW | |
| dc.title | 有氧運動後攝取不同劑量葡萄糖對高血壓前期男性氧化壓力、心臟交感神經活動與中心脈波傳導速度之影響 | zh_TW |
| dc.title | "Effects of Glucose Intake Doses after Acute Aerobic Exercise on Oxide Stress, Cardiac Sympathetic Nervous Activity and Central Pulse Wave Velocity in Male Prehypertensives " | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 廖翊宏(Hsin-Tsai Liu),林原佑(Chih-Yang Tseng) | |
| dc.subject.keyword | 動脈功能,收縮間隔,氧化壓力,心臟交感神經活動,胰島素, | zh_TW |
| dc.subject.keyword | arterial function,systole time intervals,oxide stress,cardiac sympathetic nervous activity,insulin, | en |
| dc.relation.page | 56 | |
| dc.identifier.doi | 10.6342/NTU202103097 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-09-11 | |
| dc.contributor.author-dept | 共同教育中心 | zh_TW |
| dc.contributor.author-dept | 運動設施與健康管理碩士學位學程 | zh_TW |
| 顯示於系所單位： | 運動設施與健康管理碩士學位學程 | |
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