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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 賴文崧(Wen-Sung Lai) | |
| dc.contributor.author | Chi-Shieng Peng | en |
| dc.contributor.author | 彭琪聖 | zh_TW |
| dc.date.accessioned | 2022-11-23T08:59:33Z | - |
| dc.date.available | 2021-11-03 | |
| dc.date.available | 2022-11-23T08:59:33Z | - |
| dc.date.copyright | 2021-11-03 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-28 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79393 | - |
| dc.description.abstract | 學習與記憶是個體於變動的環境中謀取生存與競爭的重要能力。迄今，我們已知神經可塑性、神經元群集（neural ensemble）均為重要的基礎神經機制，亦已擁有有力的工具辨認那些參與不同種行為的腦區中的神經元群集（如c-fos基因活化神經元）。因此，使對參與如現實中不確定情境下學習及記憶的多個相關腦區進行腦部神經活動圖譜分析（brain mapping）成為可能。採用可模擬環境中不確定與變動學習情境的行為作業，而且不僅僅針對部分功能而是大範圍地檢驗與整體學習行為有關係腦區參與程度的研究仍然不足。因此，本研究採用具有機率學習（probabilistic learning）設計的小鼠二選項動態覓食作業（two-choice dynamic foraging task）模擬真實環境中不確定且變動的學習情境，並透過初步大範圍檢驗後再針對有潛力腦區進行複驗的方式，整體地檢驗從初始學習至記憶回憶階段小鼠腦部14個與該行為作業有關區域之c-fos基因活化神經元活化表現。研究結果顯示這些腦區的神經活化表現在二選項動態覓食作業不同學習階段間無顯著差異，表示這些腦區參與二選項動態覓食作業特定學習階段之可能性低。本研究可提供後續相關議題研究者更多的研究經驗，特別有助於在研究方法與感興趣區域選取方面的思考。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-23T08:59:33Z (GMT). No. of bitstreams: 1 U0001-2210202117583200.pdf: 2928664 bytes, checksum: 5877b230e14ecc3c577e1ec233d4b995 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | " 目次 第一章 緒論 1 第一節 學習與記憶的基本定義 1 第二節 學習與記憶的基礎神經機制 2 第三節 c-fos基因活化神經元活性檢驗於學習與記憶神經機制相關研究 中的應用 7 第四節 模擬變動情境下的學習與記憶 10 第五節 研究目的 12 第二章 材料與方法 15 第一節 實驗動物 15 第二節 實驗程序及方法 16 第三章 實驗結果 28 第一節 行為作業表現 28 第二節 腦部c-fos基因活化表現初步大範圍檢驗結果 29 第三節 內側前額葉皮質前邊緣部前側（aPrL）及背側齒狀迴區（dDG） 的c-fos基因活化表現複驗結果 32 第四章 討論 35 第一節 實驗結果總結 35 第二節 初步大範圍檢驗與複驗結果差異原因探討 36 第三節 可能參與本研究相關之操作制約學習的感興趣區域 37 第四節 參與或影響其他類型學習、記憶運作的感興趣區域 43 第五節 結語 45 參考文獻 66 表目次 表1 初步大範圍檢驗腦區c-fos基因活化神經元細胞分布密度分析及組間差異 檢定結果說明表 46 表2 初步大範圍檢驗腦區c-fos基因活化神經元細胞分布密度分析與二選項動 態覓食作業最終操作表現之相關性分析結果說明表 48 圖目次 圖1 二選項動態覓食作業訓練流程暨實驗分組參與階段示意圖 ........................50 圖2 腦區aPrL、dDG 左、右側位置c-fos基因活化神經元活化表現情形 .......51 圖3 腦組織樣本處理流程示意圖 ............................................................................52 圖4 一般性自主活動功能表現情形 53 圖5 二選項動態覓食作業初始學習日操作表現情形 54 圖6 二選項動態覓食作業最終操作表現情形(一) 55 圖7 二選項動態覓食作業最終操作表現情形(二) 56 圖8 初步大範圍檢驗腦區位置示意圖（aPrL, OFC） 57 圖9 初步大範圍檢驗腦區位置示意圖（pPrL/ infralimbic(IL), NAc, HPC, AMG） 58 圖10 初步大範圍檢驗c-fos基因活化神經元細胞分布密度分析與二選項 動態覓食作業最終操作表現之線性迴歸分析曲線圖（OFC, PL, IL, NAc） 59 圖11 初步大範圍檢驗c-fos基因活化神經元細胞分布密度分析與二選項動態覓食作業最終操作表現之線性迴歸分析曲線圖（HPC, AMG） 60 圖12 腦區aPrL c-fos基因活化神經元活化表現情形(初步大範圍檢驗) 61 圖13 腦區aPrL c-fos基因活化神經元表現組別比較示意圖 61 圖14 腦區dDG c-fos基因活化神經元活化表現情形(初步大範圍檢驗) 62 圖15 腦區dDG c-fos基因活化神經元表現組別比較示意圖. 62 圖16 腦區aPrL c-fos基因活化神經元活化表現情形(複驗) 63 圖17 腦區aPrL c-fos基因活化神經元表現組別比較示意圖 63 圖18 腦區dDG c-fos基因活化神經元活化表現情形(複驗) 64 圖19 腦區aPrL c-fos基因活化神經元表現組別比較示意圖 64 圖20 複驗腦區c-fos基因活化神經元細胞分布密度分析與二選項動態覓食作業最終操作表現之線性迴歸分析曲線圖（aPrL, dDG） 65 " | |
| dc.language.iso | zh-TW | |
| dc.title | 小鼠進行二選項動態覓食作業學習時腦部c-fos基因活化表現情形 | zh_TW |
| dc.title | Evaluation of the c-fos gene expression in mice while learning two-choice dynamic foraging task | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蔡惠珍(Hsin-Tsai Liu),蕭逸澤(Chih-Yang Tseng),姚皓傑 | |
| dc.subject.keyword | 機率學習,二選項動態覓食作業,神經元群集,c-fos基因,腦部神經活動圖譜分析, | zh_TW |
| dc.subject.keyword | probabilistic learning,two-choice dynamic foraging task,neural ensemble,c-fos gene,brain mapping, | en |
| dc.relation.page | 78 | |
| dc.identifier.doi | 10.6342/NTU202104048 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-10-29 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 心理學研究所 | zh_TW |
| 顯示於系所單位： | 心理學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| U0001-2210202117583200.pdf | 2.86 MB | Adobe PDF | 檢視/開啟 |
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