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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 郭彥彬 | zh_TW |
dc.contributor.advisor | Mark Yen-Ping Kuo | en |
dc.contributor.author | 黃振邦 | zh_TW |
dc.contributor.author | Chen-Pang Huang | en |
dc.date.accessioned | 2021-07-11T15:41:37Z | - |
dc.date.available | 2024-02-28 | - |
dc.date.copyright | 2018-10-11 | - |
dc.date.issued | 2018 | - |
dc.date.submitted | 2002-01-01 | - |
dc.identifier.citation | Agrawal, A. A. 2015. 'Gingival enlargements: Differential diagnosis and review of literature', World J Clin Cases, 3: 779-88.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79071 | - |
dc.description.abstract | 實驗目的和背景:轉型生長因子-β (Transforming growth factor-β (TGF-β) ) 在牙齦腫大 (gingival overgrowth, GO)的致病機轉中扮演重要角色。先前研究發現環孢素(Cyclosporin-A, CsA) 在牙齦纖維母細胞可經由TGF-β訊息傳遞路徑引發GO。TGF-β誘導上皮-間質轉換(epithelial to mesenchymal transition (EMT))在GO的致病機轉中亦扮演重要角色。然而CsA於人類牙齦上皮細胞的作用並未完全明瞭。本研究的實驗目的探討環孢素於人類牙齦上皮細胞經由TGF-β訊息傳遞路徑引發GO機轉。
實驗方法:利用西方墨點法檢測環孢素所引發的上皮-間質轉換(epithelial to mesenchymal transition (EMT)) 之表現及活化態TGF-β Enzyme Linked Immunosorbent Assay (ELISA) 檢測環孢素CsA及前處理各種不同抑制劑對於人類牙齦上皮細胞的作用。 實驗結果:本研究發現人類牙齦上皮OECM-1和Ca9-22細胞株在處理環孢素48小時後,有上皮鈣黏蛋白(E-cadherin)表現量下降,slug表現量上升的EMT現象。以TGF-β1的中和抗體前處理後可抑制環孢素所誘導的EMT表現。前處理抗氧化劑N-acetyl-cystenine (ROS抑制劑)、Diphenylene iodonium (NOX抑制劑)、Plumbagin (NOX4抑制劑)、Apocynine (NOX2抑制劑)、薑黃素(Curcumin) 和Lovastatin可以抑制環孢素誘導的活化態TGF-β產生及過氧化物(ROS)生成。另外我們也發現薑黃素劑量依賴性地抑制OECM-1和Ca9-22細胞株中環孢素所誘導的過氧化物生成及活化態TGF-β1的釋放。 結論:環孢素可透過過氧化物誘導活化態TGF-β1的釋放於人類牙齦表皮細胞,薑黃素可以顯著抑制環孢素所誘導的過氧化物生成及活化態TGF-β1的釋放,冀望未來薑黃素可以成為治療牙齦過度增生的潛力藥物。 | zh_TW |
dc.description.abstract | Objectives: Transforming growth factor-β (TGF-β) is a key regulator associated with pathogenesis of gingival overgrowth. Cyclosporin-A (CsA) has been shown to induce gingival overgrowth through TGF-β signaling pathway. However, the mechanism(s) of CsA-induced TGF-β1 activation in human gingival epithelium (hGE) cells is still unknown. The aims of this study were to investigate the mechanisms of CsA-induced TGF-β1 activation in hGE cells.
Materials and Methods: Effects of CsA on EMT and activated-TGF-β1 levels in hGE cells (OECM-1 and CA9-22) were assessed by Western blot analysis and enzyme-linked immunosorbent assay. Results: The expression of E-cadherin decreased and slug increased after 48 hours treatment with CsA in both OECM-1 and CA9-22 cells. Pretreatment with TGF-β1 neutralizing antibody in OECM-1 and CA9-22 cells inhibited the effects of CsA on OECM-1 and CA9-22 cells. Pretreatment with N-acetyl-cystenine (reactive oxygen species (ROS) inhibitor), Diphenylene iodonium (NOX inhibitor), Plumbagin (NOX4 inhibitor), Apocynine (NOX2 inhibitor), Curcumin and Lovastatin in OECM-1 and CA9-22 cells significantly inhibited CsA-induced TGF-β1 activation. Moreover, curcumin dose-dependently inhibited CsA-induced latent TGF-β1 activation in OECM-1 and CA9-22 cells. Conclusion: CsA induced latent TGF-β1 activation via ROS generation in hGE cells. Curcumin significantly inhibited CsA-induced ROS generation and latent TGF-β1 activation in hGE cells and could be a potential therapy of gingival overgrowth. | en |
dc.description.provenance | Made available in DSpace on 2021-07-11T15:41:37Z (GMT). No. of bitstreams: 1 ntu-107-R04422006-1.pdf: 2714834 bytes, checksum: 5a8ec3ba95ac488d8d6f7047b2b7b9f1 (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 口試委員會審定書……………………………………………………………………I
謝誌…………………………………………………………………………………...II 中文摘要…………………………………………………………………………...…III Abstract…………………………………………………………………………...IV 目錄........................................................................................V 導論 第一節 牙齦過度增生 ( Gingival overgrowth )…………………………..1 1-1 牙齦過度增生的簡介 ………1 1-2 牙齦過度增生的流行病學 2 1-3 牙齦過度增生的致病機制 3 1-4 牙齦過度增生的治療 3 第二節 環孢素 (Cyclosporin A, CsA)……………………………………….4 2-1 Cyclosporin A的簡介 4 2-2 Cyclosporin A的作用機轉 4 2-3 Cyclosporin A與牙齦過度增生 5 第三節 轉型生長因子- ß (TGF- ß1)…………………………………………….6 3-1 TGF-β1的簡介 6 3-2 TGF-β1的訊息傳遞路徑 7 3-3 TGF-β1與纖維化 9 第四節 過氧化物 (Reactive oxygen species,ROS)………………………11 4-1 ROS的簡介 11 4-2 ROS與纖維化……………………………………………………..12 4-3 NADPH oxidase 2與纖維化 13 4-4 NADPH oxidase 4與纖維化……………………………………...14 第五節 薑黃素 ( Curcumin )………………………………………………... 15 研究目的…………………………………………………………………………….16 材料與方法……………………………………………………………………….…17 第一節 細胞株與細胞培養…………………………………………………..17 第二節 藥物處理……………………………………………………………..17 第三節 西方墨點法…………………………………………………………..19 第四節 Enzyme Linked Immunosorbent Assay (ELISA)……………………21 第五節DCFDA Cellular ROS Detection Assay ….……………………….…22 第六節 統計與方法…………………………………………………………..22 結果…………………………………………………………………………………..23 Cyclosporin A誘導上皮-間質 轉換………………………………………………..23 TGF-β中和抗體可抑制Cyclosporin A誘導的牙齦上皮細胞上皮-間質 轉換…23 Cyclosporin A誘導牙齦上皮細胞株釋放活化態TGF-β………………………….23 Cyclosporin A經由ROS誘導牙齦上皮細胞株釋放活化態TGF-β……...............24 Curcumin、Lovastatin 可抑制Cyclosporin A釋放活化態TGF-β及ROS……25 討論……………………………………………………………………………….… .26 圖與表………………………………………………………………………….……..28 References List………………………………………………………………………..39 | - |
dc.language.iso | zh_TW | - |
dc.title | 薑黃素抑制環孢素經由活性氧誘導牙齦上皮細胞活化潛伏性TGF-β | zh_TW |
dc.title | Cyclosporin-A activated latent TGF-β through reactive oxygen species in gingival epithelial cells: Suppression by curcumin | en |
dc.type | Thesis | - |
dc.date.schoolyear | 106-2 | - |
dc.description.degree | 碩士 | - |
dc.contributor.oralexamcommittee | 周涵怡;張瑞青 | zh_TW |
dc.contributor.oralexamcommittee | Han-Yi E. Chou;Jenny Zwei-Chieng Chang | en |
dc.subject.keyword | 環孢素,牙齦過度增生,潛在的轉化生長因子,上皮-間質細胞轉換,活性氧化物, | zh_TW |
dc.subject.keyword | Cyclosporin-A,Gingival overgrowth,TGF-β1,EMT,ROS, | en |
dc.relation.page | 47 | - |
dc.identifier.doi | 10.6342/NTU201803047 | - |
dc.rights.note | 未授權 | - |
dc.date.accepted | 2018-08-13 | - |
dc.contributor.author-college | 醫學院 | - |
dc.contributor.author-dept | 臨床牙醫學研究所 | - |
dc.date.embargo-lift | 2023-10-11 | - |
顯示於系所單位: | 臨床牙醫學研究所 |
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