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標題: | 腦部連結與句法處理能力側化的關係 Linking Brain Connectivity to Lateralized Processing of Syntax |
作者: | Wan-Ting Lin 林婉婷 |
指導教授: | 李佳霖 |
關鍵字: | 句法處理,側化,腦電波,結構性連結,功能性連結, syntactic processing,lateralization,ERPs,structural connectivity,functional connectivity, |
出版年 : | 2018 |
學位: | 碩士 |
摘要: | 過去研究認為語言處理能力有左側化的傾向,其中以句法處理能力最為左側化。但語言功能性側化背後的腦部神經機制則尚未有定論,本研究以分視野 (Split Visual Field Paradigm) 的方式呈現中文詞組結合成的片語為媒介,並結合三種不同類型的測量工具 — 事件關聯電位(Event-Related Potential, ERP)、擴散磁振造影(Diffusion Tensor Imaging, DTI)、靜息狀態功能性磁振造影(Resting-state Functional Magnetic Resonance Imaging, RS-fMRI),更全面地從處理句法時的即時腦部功能性反應、腦部白質徑結構密度、腦部靜息態的功能性連結,來探討健康的年輕人中,腦部結構性與功能性連結與側化的句法處理能力之間的關聯。
本研究包括24位慣用右手且家族史也皆為右利手的年輕人,所有受試者 們皆在七個月內進行了三個部分的實驗 — 實驗一是ERP腦波實驗,實驗二與三 則是DTI腦部結構與RS-fMRI靜態功能造影。實驗ㄧ過程中,受試者將先閱讀呈 現在視野中央的語詞,然後閱讀出現在左或右視野的目標詞後,判斷片語通順 與否,在這當中同時利用腦波紀錄右腦和左腦優勢處理句法錯誤的歷程,如同 先前研究,我們發現句法處理的效果(P600 grammaticality effect)側化至左腦。 實驗二與三的過程中,受試者平躺靜止,以得到腦部掃掃瞄影像。 透過結構方程模型(Structural Equation Modeling, SEM),我們嘗試結合 腦部結構、功能性連結,與側化的句法處理策略三種不同類型的資料之間的關 聯。我們發現在句法處理上左腦還是主要的優勢半腦,這會受到中後區左右半 腦的靜息態功能性連結強弱所影響。而前區半腦間溝通則與右腦的句法處理反 應以及右腦半腦內額葉顳葉間的連結性互相影響。總體而論,我們的發現對於 側化的語言能力影響因素,提供了更全面的了解。 Syntactic processing has been known as one of the most left-lateralized of brain cognitive functions. However, the underlying mechanism of the functional lateralization seems uncertain. We combined three kind of measurements, event-related potentials (ERP), diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (RS-fMRI) to measure the correlations between structural connectivity (SC) of white matter tracts, resting-state functional connectivity (FC) within and between hemispheres, and online functional ERP responses during the processing of Chinese grammatical judgements at the phrase level in a split visual field paradigm. We investigated the relationships between intra- and inter-hemispheric connectivity and the lateralization of syntactic processing in younger adults. Twenty-four right-handed young adults without familial sinistrality were recruited in this experiment involving ERP, DTI and rs-fMRI data, with the MRI scan at resting state conducted within 7 months of the ERP experiment. By the spilt visual field presentation, we could collect the hemisphere-biasd ERP responses. Consistent to prior researches, we found the left-lateralized ERP response. We further analyzed the role of functional connectivity in the associations between language-processing-related white-matter structures and ERP indices of syntax processing by structural equation modeling (SEM). Our main finding is that there is a dominant role of LH in syntax processing which may associated with the functional connectivity between middle-posterior part of CC connected area. Functional connectivity between anterior part of CC connected area has bidirectional association with the functional response and frontal-temporal connection of RH. Overall, through analyzing these multimodal data jointly, we bridge some knowledge gaps in our understanding of the critical factors driving a left-lateralized language processing network. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78876 |
DOI: | 10.6342/NTU201804275 |
全文授權: | 有償授權 |
電子全文公開日期: | 2028-11-14 |
顯示於系所單位: | 腦與心智科學研究所 |
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