請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78558
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林劭品 | zh_TW |
dc.contributor.author | 許溥昇 | zh_TW |
dc.contributor.author | Pu-Sheng Hsu | en |
dc.date.accessioned | 2021-07-11T15:03:55Z | - |
dc.date.available | 2024-08-19 | - |
dc.date.copyright | 2019-08-26 | - |
dc.date.issued | 2019 | - |
dc.date.submitted | 2002-01-01 | - |
dc.identifier.citation | Aapola, U., K. Kawasaki, H.S. Scott, J. Ollila, M. Vihinen, M. Heino, A. Shintani, K. Kawasaki, S. Minoshima, K. Krohn, S.E. Antonarakis, N. Shimizu, J. Kudoh, and P. Peterson. 2000. Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family. Genomics. 65:293-298.
Allen, T.A., S. Von Kaenel, J.A. Goodrich, and J.F. Kugel. 2004. The SINE-encoded mouse B2 RNA represses mRNA transcription in response to heat shock. Nat Struct Mol Biol. 11:816-821. Bale, T.L., and C.N. Epperson. 2015. Sex differences and stress across the lifespan. Nat Neurosci. 18:1413-1420. Barazzoni, R., K.R. Short, and K.S. Nair. 2000. Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart. J Biol Chem. 275:3343-3347. Borghese, B., P. Santulli, D. Hequet, G. Pierre, D. de Ziegler, D. Vaiman, and C. Chapron. 2012. Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis. Am J Pathol. 180:1781-1786. Bourc'his, D., and T.H. Bestor. 2004. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature. 431:96-99. Bourc'his, D., G.L. Xu, C.S. Lin, B. Bollman, and T.H. Bestor. 2001. Dnmt3L and the establishment of maternal genomic imprints. Science. 294:2536-2539. Bundo, M., M. Toyoshima, Y. Okada, W. Akamatsu, J. Ueda, T. Nemoto-Miyauchi, F. Sunaga, M. Toritsuka, D. Ikawa, A. Kakita, M. Kato, K. Kasai, T. Kishimoto, H. Nawa, H. Okano, T. Yoshikawa, T. Kato, and K. Iwamoto. 2014. Increased l1 retrotransposition in the neuronal genome in schizophrenia. Neuron. 81:306-313. Burton, G.J., A.L. Fowden, and K.L. Thornburg. 2016. Placental Origins of Chronic Disease. Physiol Rev. 96:1509-1565. Capone, S., K.M. Connor, A. Colombo, X. Li, T.J. Triche, Jr., and G. Ramsingh. 2018. Senescent human hematopoietic progenitors show elevated expression of transposable elements and inflammatory genes. Exp Hematol. 62:33-38 e36. Carone, B.R., L. Fauquier, N. Habib, J.M. Shea, C.E. Hart, R. Li, C. Bock, C. Li, H. Gu, P.D. Zamore, A. Meissner, Z. Weng, H.A. Hofmann, N. Friedman, and O.J. Rando. 2010. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell. 143:1084-1096. Charradi, K., S. Elkahoui, F. Limam, and E. Aouani. 2013. High-fat diet induced an oxidative stress in white adipose tissue and disturbed plasma transition metals in rat: prevention by grape seed and skin extract. J Physiol Sci. 63:445-455. Chen, H. W., Chang, Y. I., 2018. The molecular mechanism of DNA methyltransferase 3-like gene in megakaryocytic differentiation. Master thesis, Institute of Physiology, National Yang-Ming University. Chiappinelli, K.B., P.L. Strissel, A. Desrichard, H. Li, C. Henke, B. Akman, A. Hein, N.S. Rote, L.M. Cope, A. Snyder, V. Makarov, S. Budhu, D.J. Slamon, J.D. Wolchok, D.M. Pardoll, M.W. Beckmann, C.A. Zahnow, T. Merghoub, T.A. Chan, S.B. Baylin, and R. Strick. 2015. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 162:974-986. Cho, J.H., G.Y. Kim, B.C. Mansfield, and J.Y. Chou. 2018. Hepatic glucose-6-phosphatase-alpha deficiency leads to metabolic reprogramming in glycogen storage disease type Ia. Biochem Biophys Res Commun. 498:925-931. Cho, J.H., G.Y. Kim, C.J. Pan, J. Anduaga, E.J. Choi, B.C. Mansfield, and J.Y. Chou. 2017. Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia. PLoS Genet. 13:e1006819. Chow, J.C., C. Ciaudo, M.J. Fazzari, N. Mise, N. Servant, J.L. Glass, M. Attreed, P. Avner, A. Wutz, E. Barillot, J.M. Greally, O. Voinnet, and E. Heard. 2010. LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation. Cell. 141:956-969. Corominas, J., J.A. Marchesi, A. Puig-Oliveras, M. Revilla, J. Estelle, E. Alves, J.M. Folch, and M. Ballester. 2015. Epigenetic regulation of the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs. Genet Sel Evol. 47:20. Crichton, J.H., D.S. Dunican, M. Maclennan, R.R. Meehan, and I.R. Adams. 2014. Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline. Cell Mol Life Sci. 71:1581-1605. Criscione, S.W., N. Theodosakis, G. Micevic, T.C. Cornish, K.H. Burns, N. Neretti, and N. Rodic. 2016. Genome-wide characterization of human L1 antisense promoter-driven transcripts. BMC Genomics. 17:463. Cruickshanks, H.A., and C. Tufarelli. 2009. Isolation of cancer-specific chimeric transcripts induced by hypomethylation of the LINE-1 antisense promoter. Genomics. 94:397-406. De Cecco, M., S.W. Criscione, A.L. Peterson, N. Neretti, J.M. Sedivy, and J.A. Kreiling. 2013. Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. Aging (Albany NY). 5:867-883. El-Maarri, O., M.S. Kareta, T. Mikeska, T. Becker, A. Diaz-Lacava, J. Junen, N. Nusgen, F. Behne, T. Wienker, A. Waha, J. Oldenburg, and F. Chedin. 2009. A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation. Hum Mol Genet. 18:1755-1768. Fan, T., A. Schmidtmann, S. Xi, V. Briones, H. Zhu, H.C. Suh, J. Gooya, J.R. Keller, H. Xu, J. Roayaei, M. Anver, S. Ruscetti, and K. Muegge. 2008. DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development. Epigenetics. 3:134-142. Farkash, E.A., G.D. Kao, S.R. Horman, and E.T. Prak. 2006. Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay. Nucleic Acids Res. 34:1196-1204. Faulkner, G.J., Y. Kimura, C.O. Daub, S. Wani, C. Plessy, K.M. Irvine, K. Schroder, N. Cloonan, A.L. Steptoe, T. Lassmann, K. Waki, N. Hornig, T. Arakawa, H. Takahashi, J. Kawai, A.R. Forrest, H. Suzuki, Y. Hayashizaki, D.A. Hume, V. Orlando, S.M. Grimmond, and P. Carninci. 2009. The regulated retrotransposon transcriptome of mammalian cells. Nat Genet. 41:563-571. Feil, R., and M.F. Fraga. 2012. Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet. 13:97-109. Ferreira, P.G., P. Jares, D. Rico, G. Gomez-Lopez, A. Martinez-Trillos, N. Villamor, S. Ecker, A. Gonzalez-Perez, D.G. Knowles, J. Monlong, R. Johnson, V. Quesada, S. Djebali, P. Papasaikas, M. Lopez-Guerra, D. Colomer, C. Royo, M. Cazorla, M. Pinyol, G. Clot, M. Aymerich, M. Rozman, M. Kulis, D. Tamborero, A. Gouin, J. Blanc, M. Gut, I. Gut, X.S. Puente, D.G. Pisano, J.I. Martin-Subero, N. Lopez-Bigas, A. Lopez-Guillermo, A. Valencia, C. Lopez-Otin, E. Campo, and R. Guigo. 2014. Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia. Genome Res. 24:212-226. Fish, E.N. 2008. The X-files in immunity: sex-based differences predispose immune responses. Nat Rev Immunol. 8:737-744. Flitton, M., N. Rielly, R. Warman, D. Warden, A.D. Smith, I.A. Macdonald, and H.M. Knight. 2019. Interaction of nutrition and genetics via DNMT3L-mediated DNA methylation determines cognitive decline. Neurobiol Aging. 78:64-73. Fusco, S., and G. Pani. 2013. Brain response to calorie restriction. Cell Mol Life Sci. 70:3157-3170. Garcia-Perez, J.L., T.J. Widmann, and I.R. Adams. 2016. The impact of transposable elements on mammalian development. Development. 143:4101-4114. Gensous, N., C. Franceschi, A. Santoro, M. Milazzo, P. Garagnani, and M.G. Bacalini. 2019. The Impact of Caloric Restriction on the Epigenetic Signatures of Aging. Int J Mol Sci. 20. Guffanti, G., S. Gaudi, T. Klengel, J.H. Fallon, H. Mangalam, R. Madduri, A. Rodriguez, P. DeCrescenzo, E. Glovienka, J. Sobell, C. Klengel, M. Pato, K.J. Ressler, C. Pato, and F. Macciardi. 2016. LINE1 insertions as a genomic risk factor for schizophrenia: Preliminary evidence from an affected family. Am J Med Genet B Neuropsychiatr Genet. 171:534-545. Guo, J., V. Bakshi, and A.L. Lin. 2015. Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice. Front Aging Neurosci. 7:213. Hadem, I.K.H., T. Majaw, B. Kharbuli, and R. Sharma. 2019. Beneficial effects of dietary restriction in aging brain. J Chem Neuroanat. 95:123-133. Hatori, M., C. Vollmers, A. Zarrinpar, L. DiTacchio, E.A. Bushong, S. Gill, M. Leblanc, A. Chaix, M. Joens, J.A. Fitzpatrick, M.H. Ellisman, and S. Panda. 2012. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab. 15:848-860. Hawrylycz, M.J., E.S. Lein, A.L. Guillozet-Bongaarts, E.H. Shen, L. Ng, J.A. Miller, L.N. van de Lagemaat, K.A. Smith, A. Ebbert, Z.L. Riley, C. Abajian, C.F. Beckmann, A. Bernard, D. Bertagnolli, A.F. Boe, P.M. Cartagena, M.M. Chakravarty, M. Chapin, J. Chong, R.A. Dalley, B. David Daly, C. Dang, S. Datta, N. Dee, T.A. Dolbeare, V. Faber, D. Feng, D.R. Fowler, J. Goldy, B.W. Gregor, Z. Haradon, D.R. Haynor, J.G. Hohmann, S. Horvath, R.E. Howard, A. Jeromin, J.M. Jochim, M. Kinnunen, C. Lau, E.T. Lazarz, C. Lee, T.A. Lemon, L. Li, Y. Li, J.A. Morris, C.C. Overly, P.D. Parker, S.E. Parry, M. Reding, J.J. Royall, J. Schulkin, P.A. Sequeira, C.R. Slaughterbeck, S.C. Smith, A.J. Sodt, S.M. Sunkin, B.E. Swanson, M.P. Vawter, D. Williams, P. Wohnoutka, H.R. Zielke, D.H. Geschwind, P.R. Hof, S.M. Smith, C. Koch, S.G.N. Grant, and A.R. Jones. 2012. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 489:391-399. Hsieh, H. T., Lin, S. P., 2018. The stringency of transposable elements modulation correlates to the reduced speed of aging and aging-related diseases. Master thesis, Institute of Biotechnology, College of Bio-Resources and Agriculture, National Taiwan University. Huen, K., A.M. Calafat, A. Bradman, P. Yousefi, B. Eskenazi, and N. Holland. 2016. Maternal phthalate exposure during pregnancy is associated with DNA methylation of LINE-1 and Alu repetitive elements in Mexican-American children. Environ Res. 148:55-62. Hummel, B., E.C. Hansen, A. Yoveva, F. Aprile-Garcia, R. Hussong, and R. Sawarkar. 2017. The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses. Nat Struct Mol Biol. 24:234-242. Hunt, C.R., J.E. Sim, S.J. Sullivan, T. Featherstone, W. Golden, C. Von Kapp-Herr, R.A. Hock, R.A. Gomez, A.J. Parsian, and D.R. Spitz. 1998. Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress. Cancer Res. 58:3986-3992. Hunter, R.G., and B.S. McEwen. 2013. Stress and anxiety across the lifespan: structural plasticity and epigenetic regulation. Epigenomics. 5:177-194. Iskow, R.C., M.T. McCabe, R.E. Mills, S. Torene, W.S. Pittard, A.F. Neuwald, E.G. Van Meir, P.M. Vertino, and S.E. Devine. 2010. Natural mutagenesis of human genomes by endogenous retrotransposons. Cell. 141:1253-1261. Jacob-Hirsch, J., E. Eyal, B.A. Knisbacher, J. Roth, K. Cesarkas, C. Dor, S. Farage-Barhom, V. Kunik, A.J. Simon, M. Gal, M. Yalon, S. Moshitch-Moshkovitz, R. Tearle, S. Constantini, E.Y. Levanon, N. Amariglio, and G. Rechavi. 2018. Whole-genome sequencing reveals principles of brain retrotransposition in neurodevelopmental disorders. Cell Res. 28:187-203. Jia, Y., R. Cong, R. Li, X. Yang, Q. Sun, N. Parvizi, and R. Zhao. 2012. Maternal low-protein diet induces gender-dependent changes in epigenetic regulation of the glucose-6-phosphatase gene in newborn piglet liver. J Nutr. 142:1659-1665. Kaer, K., and M. Speek. 2013. Retroelements in human disease. Gene. 518:231-241. Kalish, B.T., G.L. Fell, P. Nandivada, and M. Puder. 2015. Clinically Relevant Mechanisms of Lipid Synthesis, Transport, and Storage. JPEN J Parenter Enteral Nutr. 39:8S-17S. Kochmanski, J., E.H. Marchlewicz, and D.C. Dolinoy. 2018. Longitudinal effects of developmental bisphenol A, variable diet, and physical activity on age-related methylation in blood. Environ Epigenet. 4:dvy017. Lanza, I.R., P. Zabielski, K.A. Klaus, D.M. Morse, C.J. Heppelmann, H.R. Bergen, 3rd, S. Dasari, S. Walrand, K.R. Short, M.L. Johnson, M.M. Robinson, J.M. Schimke, D.R. Jakaitis, Y.W. Asmann, Z. Sun, and K.S. Nair. 2012. Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis. Cell Metab. 16:777-788. Lapp, H.E., and R.G. Hunter. 2019. Early life exposures, neurodevelopmental disorders, and transposable elements. Neurobiol Stress. 11:100174. Lavie, L., E. Maldener, B. Brouha, E.U. Meese, and J. Mayer. 2004. The human L1 promoter: variable transcription initiation sites and a major impact of upstream flanking sequence on promoter activity. Genome Res. 14:2253-2260. Lee, S.M., Y.G. Lee, J.B. Bae, J.K. Choi, C. Tayama, K. Hata, Y. Yun, J.K. Seong, and Y.J. Kim. 2014. HBx induces hypomethylation of distal intragenic CpG islands required for active expression of developmental regulators. Proc Natl Acad Sci U S A. 111:9555-9560. Levine, M.E., J.A. Suarez, S. Brandhorst, P. Balasubramanian, C.W. Cheng, F. Madia, L. Fontana, M.G. Mirisola, J. Guevara-Aguirre, J. Wan, G. Passarino, B.K. Kennedy, M. Wei, P. Cohen, E.M. Crimmins, and V.D. Longo. 2014. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 19:407-417. Li, Y., M. Daniel, and T.O. Tollefsbol. 2011. Epigenetic regulation of caloric restriction in aging. BMC Med. 9:98. Liang, Y., C. Liu, M. Lu, Q. Dong, Z. Wang, Z. Wang, W. Xiong, N. Zhang, J. Zhou, Q. Liu, X. Wang, and Z. Wang. 2018. Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves. Sci Rep. 8:5779. Liao, H.F., C.F. Mo, S.C. Wu, D.H. Cheng, C.Y. Yu, K.W. Chang, T.H. Kao, C.W. Lu, M. Pinskaya, A. Morillon, S.S. Lin, W.T. Cheng, D. Bourc'his, T. Bestor, L.Y. Sung, and S.P. Lin. 2015. Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. Reproduction. 150:245-256. Liao, H.F., K.Y. Tai, W.S. Chen, L.C. Cheng, H.N. Ho, and S.P. Lin. 2012. Functions of DNA methyltransferase 3-like in germ cells and beyond. Biol Cell. 104:571-587. Liu, B., Q. Du, L. Chen, G. Fu, S. Li, L. Fu, X. Zhang, C. Ma, and C. Bin. 2016a. CpG methylation patterns of human mitochondrial DNA. Sci Rep. 6:23421. Liu, L., J. Souto, W. Liao, Y. Jiang, Y. Li, R. Nishinakamura, S. Huang, T. Rosengart, V.W. Yang, M. Schuster, Y. Ma, and J. Yang. 2013. Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells. J Biol Chem. 288:34719-34728. Liu, S., T. Du, Z. Liu, Y. Shen, J. Xiu, and Q. Xu. 2016b. Inverse changes in L1 retrotransposons between blood and brain in major depressive disorder. Sci Rep. 6:37530. Lu, J., M. McCarter, G. Lian, G. Esposito, E. Capoccia, L.C. Delli-Bovi, J. Hecht, and V. Sheen. 2016. Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression. Hum Mol Genet. 25:1714-1727. Lu, S., Z. Niu, Y. Chen, Q. Tu, Y. Zhang, W. Chen, W. Tong, and Z. Zhang. 2018. Repetitive Element DNA Methylation is Associated with Menopausal Age. Aging Dis. 9:435-443. Lucas, A. 1991. Programming by early nutrition in man. Ciba Found Symp. 156:38-50; discussion 50-35. Lunyak, V.V., G.G. Prefontaine, E. Nunez, T. Cramer, B.G. Ju, K.A. Ohgi, K. Hutt, R. Roy, A. Garcia-Diaz, X. Zhu, Y. Yung, L. Montoliu, C.K. Glass, and M.G. Rosenfeld. 2007. Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis. Science. 317:248-251. Martens, J.H., R.J. O'Sullivan, U. Braunschweig, S. Opravil, M. Radolf, P. Steinlein, and T. Jenuwein. 2005. The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J. 24:800-812. Martin, B., M. Pearson, L. Kebejian, E. Golden, A. Keselman, M. Bender, O. Carlson, J. Egan, B. Ladenheim, J.L. Cadet, K.G. Becker, W. Wood, K. Duffy, P. Vinayakumar, S. Maudsley, and M.P. Mattson. 2007. Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. Endocrinology. 148:4318-4333. Matsuoka, T., K. Kawai, S. Ando, S. Sugita, S. Kandori, T. Kojima, J. Miyazaki, and H. Nishiyama. 2016. DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor. Jpn J Clin Oncol. 46:475-481. Mechta, M., L.R. Ingerslev, O. Fabre, M. Picard, and R. Barres. 2017. Evidence Suggesting Absence of Mitochondrial DNA Methylation. Front Genet. 8:166. Medina, K.L., K.P. Garrett, L.F. Thompson, M.I. Rossi, K.J. Payne, and P.W. Kincade. 2001. Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen. Nat Immunol. 2:718-724. Meischl, C., M. Boer, A. Ahlin, and D. Roos. 2000. A new exon created by intronic insertion of a rearranged LINE-1 element as the cause of chronic granulomatous disease. Eur J Hum Genet. 8:697-703. Ming, M., L. Guanhua, Y. Zhanhai, C. Guang, and Z. Xuan. 2009. Effect of the Lycium barbarum polysaccharides administration on blood lipid metabolism and oxidative stress of mice fed high-fat diet in vivo. Food Chemistry. 113:872-877. Mirzaei, H., J.A. Suarez, and V.D. Longo. 2014. Protein and amino acid restriction, aging and disease: from yeast to humans. Trends Endocrinol Metab. 25:558-566. Morse, B., P.G. Rotherg, V.J. South, J.M. Spandorfer, and S.M. Astrin. 1988. Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma. Nature. 333:87-90. Muotri, A.R., M.C. Marchetto, N.G. Coufal, R. Oefner, G. Yeo, K. Nakashima, and F.H. Gage. 2010. L1 retrotransposition in neurons is modulated by MeCP2. Nature. 468:443-446. Muotri, A.R., C. Zhao, M.C. Marchetto, and F.H. Gage. 2009. Environmental influence on L1 retrotransposons in the adult hippocampus. Hippocampus. 19:1002-1007. Nakada, D., H. Oguro, B.P. Levi, N. Ryan, A. Kitano, Y. Saitoh, M. Takeichi, G.R. Wendt, and S.J. Morrison. 2014. Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy. Nature. 505:555-558. Ollinger, R., J. Reichmann, and I.R. Adams. 2010. Meiosis and retrotransposon silencing during germ cell development in mice. Differentiation. 79:147-158. Pal, S., and J.K. Tyler. 2016. Epigenetics and aging. Sci Adv. 2:e1600584. Papsdorf, K., and A. Brunet. 2019. Linking Lipid Metabolism to Chromatin Regulation in Aging. Trends Cell Biol. 29:97-116. Parikh, I., J. Guo, K.H. Chuang, Y. Zhong, R.G. Rempe, J.D. Hoffman, R. Armstrong, B. Bauer, A.M. Hartz, and A.L. Lin. 2016. Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions. Aging (Albany NY). 8:2814-2826. Reik, W., W. Dean, and J. Walter. 2001. Epigenetic reprogramming in mammalian development. Science. 293:1089-1093. Rohleder, N., N.C. Schommer, D.H. Hellhammer, R. Engel, and C. Kirschbaum. 2001. Sex differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress. Psychosom Med. 63:966-972. Roman-Gomez, J., A. Jimenez-Velasco, X. Agirre, J.A. Castillejo, G. Navarro, E. San Jose-Eneriz, L. Garate, L. Cordeu, F. Cervantes, F. Prosper, A. Heiniger, and A. Torres. 2008. Repetitive DNA hypomethylation in the advanced phase of chronic myeloid leukemia. Leuk Res. 32:487-490. Roulois, D., H. Loo Yau, R. Singhania, Y. Wang, A. Danesh, S.Y. Shen, H. Han, G. Liang, P.A. Jones, T.J. Pugh, C. O'Brien, and D.D. De Carvalho. 2015. DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts. Cell. 162:961-973. Ruetenik, A., and A. Barrientos. 2015. Dietary restriction, mitochondrial function and aging: from yeast to humans. Biochim Biophys Acta. 1847:1434-1447. Santos, F., and W. Dean. 2004. Epigenetic reprogramming during early development in mammals. Reproduction. 127:643-651. Saradalekshmi, K.R., N.V. Neetha, S. Sathyan, I.V. Nair, C.M. Nair, and M. Banerjee. 2014. DNA methyl transferase (DNMT) gene polymorphisms could be a primary event in epigenetic susceptibility to schizophrenia. PLoS One. 9:e98182. Seisenberger, S., S. Andrews, F. Krueger, J. Arand, J. Walter, F. Santos, C. Popp, B. Thienpont, W. Dean, and W. Reik. 2012. The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells. Mol Cell. 48:849-862. Shpyleva, S., S. Melnyk, O. Pavliv, I. Pogribny, and S. Jill James. 2018. Overexpression of LINE-1 Retrotransposons in Autism Brain. Mol Neurobiol. 55:1740-1749. Slotkin, R.K., and R. Martienssen. 2007. Transposable elements and the epigenetic regulation of the genome. Nat Rev Genet. 8:272-285. Sluczanowska-Glabowska, S., M. Laszczynska, K. Piotrowska, M. Grabowska, K. Grymula, and M.Z. Ratajczak. 2015. Caloric restriction increases ratio of estrogen to androgen receptors expression in murine ovaries--potential therapeutic implications. J Ovarian Res. 8:57. Solyom, S., A.D. Ewing, D.C. Hancks, Y. Takeshima, H. Awano, M. Matsuo, and H.H. Kazazian, Jr. 2012. Pathogenic orphan transduction created by a nonreference LINE-1 retrotransposon. Hum Mutat. 33:369-371. St Laurent, G., 3rd, N. Hammell, and T.A. McCaffrey. 2010. A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage? Mech Ageing Dev. 131:299-305. Stover, P.J., W.P.T. James, A. Krook, and C. Garza. 2018. Emerging concepts on the role of epigenetics in the relationships between nutrition and health. J Intern Med. 284:37-49. Sun, D., M. Luo, M. Jeong, B. Rodriguez, Z. Xia, R. Hannah, H. Wang, T. Le, K.F. Faull, R. Chen, H. Gu, C. Bock, A. Meissner, B. Gottgens, G.J. Darlington, W. Li, and M.A. Goodell. 2014. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell. 14:673-688. Suomalainen, A., and P. Isohanni. 2010. Mitochondrial DNA depletion syndromes--many genes, common mechanisms. Neuromuscul Disord. 20:429-437. Swindell, W.R. 2009. Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse. BMC Genomics. 10:585. Tang, D., S. Tao, Z. Chen, I.O. Koliesnik, P.G. Calmes, V. Hoerr, B. Han, N. Gebert, M. Zornig, B. Loffler, Y. Morita, and K.L. Rudolph. 2016. Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging. J Exp Med. 213:535-553. Teng, L.L., G.L. Lu, L.C. Chiou, W.S. Lin, Y.Y. Cheng, T.E. Hsueh, Y.C. Huang, N.H. Hwang, J.W. Yeh, R.M. Liao, S.Z. Fan, J.H. Yen, T.F. Fu, T.F. Tsai, M.S. Wu, and P.Y. Wang. 2019. Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement. PLoS Biol. 17:e2007097. Testori, A., L. Caizzi, S. Cutrupi, O. Friard, M. De Bortoli, D. Cora, and M. Caselle. 2012. The role of Transposable Elements in shaping the combinatorial interaction of Transcription Factors. BMC Genomics. 13:400. Tobi, E.W., J.J. Goeman, R. Monajemi, H. Gu, H. Putter, Y. Zhang, R.C. Slieker, A.P. Stok, P.E. Thijssen, F. Muller, E.W. van Zwet, C. Bock, A. Meissner, L.H. Lumey, P. Eline Slagboom, and B.T. Heijmans. 2014. DNA methylation signatures link prenatal famine exposure to growth and metabolism. Nat Commun. 5:5592. Tower, J. 2015. Mitochondrial maintenance failure in aging and role of sexual dimorphism. Arch Biochem Biophys. 576:17-31. Uhlen, M., L. Fagerberg, B.M. Hallstrom, C. Lindskog, P. Oksvold, A. Mardinoglu, A. Sivertsson, C. Kampf, E. Sjostedt, A. Asplund, I. Olsson, K. Edlund, E. Lundberg, S. Navani, C.A. Szigyarto, J. Odeberg, D. Djureinovic, J.O. Takanen, S. Hober, T. Alm, P.H. Edqvist, H. Berling, H. Tegel, J. Mulder, J. Rockberg, P. Nilsson, J.M. Schwenk, M. Hamsten, K. von Feilitzen, M. Forsberg, L. Persson, F. Johansson, M. Zwahlen, G. von Heijne, J. Nielsen, and F. Ponten. 2015. Proteomics. Tissue-based map of the human proteome. Science. 347:1260419. Upton, K.R., D.J. Gerhardt, J.S. Jesuadian, S.R. Richardson, F.J. Sanchez-Luque, G.O. Bodea, A.D. Ewing, C. Salvador-Palomeque, M.S. van der Knaap, P.M. Brennan, A. Vanderver, and G.J. Faulkner. 2015. Ubiquitous L1 mosaicism in hippocampal neurons. Cell. 161:228-239. Van Meter, M., M. Kashyap, S. Rezazadeh, A.J. Geneva, T.D. Morello, A. Seluanov, and V. Gorbunova. 2014. SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. Nat Commun. 5:5011. Vaquero, A., and D. Reinberg. 2009. Calorie restriction and the exercise of chromatin. Genes Dev. 23:1849-1869. Wahlfors, J., H. Hiltunen, K. Heinonen, E. Hamalainen, L. Alhonen, and J. Janne. 1992. Genomic hypomethylation in human chronic lymphocytic leukemia. Blood. 80:2074-2080. Wang, J., L. Ho, W. Qin, A.B. Rocher, I. Seror, N. Humala, K. Maniar, G. Dolios, R. Wang, P.R. Hof, and G.M. Pasinetti. 2005. Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. FASEB J. 19:659-661. Waterland, R.A., and R.L. Jirtle. 2003. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 23:5293-5300. White, C.L., P.J. Pistell, M.N. Purpera, S. Gupta, S.O. Fernandez-Kim, T.L. Hise, J.N. Keller, D.K. Ingram, C.D. Morrison, and A.J. Bruce-Keller. 2009. Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiol Dis. 35:3-13. Witte, A.V., M. Fobker, R. Gellner, S. Knecht, and A. Floel. 2009. Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci U S A. 106:1255-1260. Wolff, E.M., H.M. Byun, H.F. Han, S. Sharma, P.W. Nichols, K.D. Siegmund, A.S. Yang, P.A. Jones, and G. Liang. 2010. Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer. PLoS Genet. 6:e1000917. Wood, J.G., B.C. Jones, N. Jiang, C. Chang, S. Hosier, P. Wickremesinghe, M. Garcia, D.A. Hartnett, L. Burhenn, N. Neretti, and S.L. Helfand. 2016. Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila. Proc Natl Acad Sci U S A. 113:11277-11282. Xie, M., C. Hong, B. Zhang, R.F. Lowdon, X. Xing, D. Li, X. Zhou, H.J. Lee, C.L. Maire, K.L. Ligon, P. Gascard, M. Sigaroudinia, T.D. Tlsty, T. Kadlecek, A. Weiss, H. O'Geen, P.J. Farnham, P.A. Madden, A.J. Mungall, A. Tam, B. Kamoh, S. Cho, R. Moore, M. Hirst, M.A. Marra, J.F. Costello, and T. Wang. 2013. DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet. 45:836-841. Yang C. Y., Lin, S. P., 2018. DNMT3L mediated legacy has long term effect on bone-marrow-derived mesenchymal stem/stromal cell. Master thesis, Institute of Molecular and cellular biology, college of Life Science, National Taiwan University. Yang, N., and H.H. Kazazian, Jr. 2006. L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells. Nat Struct Mol Biol. 13:763-771. Yu C. Y., Hui Z. K., Kao T. H., Liao H.F., Yang C. Y., Hou C. C., Hsieh H. T., Pinskaya M., Yan K. C., Chen Y. R., Morillon A., Tsai M. H., Lin S. P., 2019. DNMT3L reinforces chromatin surveillance to halt senescence progression. Unpublished paper. Ziech, D., R. Franco, A. Pappa, and M.I. Panayiotidis. 2011. Reactive oxygen species (ROS)--induced genetic and epigenetic alterations in human carcinogenesis. Mutat Res. 711:167-173. | - |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78558 | - |
dc.description.abstract | 跳躍子的適度調控在發育、生理與心智行為上扮演重要的角色。跳躍子調控機制的損害將會造成不孕、老化、老化相關的神經退化疾病與癌症的發生。飲食的組成與多寡會透過表觀遺傳的修飾作用去進一步調控染色體結構,而染色體結構的改變將會影響跳躍子的表現。飲食節制具有延緩老化相關疾病並且具有延長壽命甚至於更好的生理機能,而在小鼠與果蠅的研究上,也觀察到了飲食節制可以抑制跳躍子的表現。此外,類三號DNA甲基化酶(DNMT3L) 在發育中的生殖細胞具有抑制跳躍子表現的作用,其在體細胞的功能性還未有人紀載,但唐氏症患者由於額外的第21染色體造成過量DNMT3L表現,已被連結到造成心智能力受損的可能原因之一。在我的研究中,主要探討飲食的組成、質量對於跳躍子的表現與行為測試的結果有什麼樣的影響,也會對跳躍子的表現與行為實驗的結果進行分析來判斷血液裡的跳躍子表現量是否與腦部功能有所關聯,以及類三號DNA甲基化酶的基因型對與飲食調控的血液跳躍子表現和體細胞的表現型有何影響。
在實驗中,我使用高脂飼料與育種飼料搭配飲食節制與時間的調控來觀察小鼠血液中跳躍子表現的變化與行為的改變。結果顯示兩種飼料在飲食節制的情況下,皆能夠抑制血液中跳躍子的表現。但是進行飲食節制與任意飲食的轉換之後,採食育種飼料的小鼠會隨著飲食的改變而調控血液中跳躍子的表現,但食用高脂飼料的小鼠不論有無進行飲食節制,對於跳躍子表現的調控都需要較長的時間作出調整。而在行為測試中,以育種飼料飼育的小鼠在轉換至飲食節制之後可以提升對新物件的偏好性,而採食高脂飼料的小鼠在轉換至節制飲食之後,在曠野試驗中的運動活性會有顯著的改善。而現階段血液中跳躍子的表現和腦部功能的連結仍不夠明確,需要更深入的研究與探討。另一方面,飲食節制引起的抑制跳躍子表現作用,同樣可以在類三號DNA甲基化酶剔除的老鼠中觀察到。此外,類三號DNA甲基化酶剔除的老鼠在餵飼高脂飼糧與時區轉換的複合實驗中,肝臟中的脂質新生基因、醣類代謝基因以及粒線體數目也皆有顯著的下降。 總結來說,血液中跳躍子的靜默與食物組成、採食量有關,飲食節制可提升老鼠在行為實驗中的表現,不過這些反應具有性別差異性。而因為類三號DNA甲基化酶在成鼠體細胞中的表現尚未完全明朗,我以大家熟知的類三號DNA甲基化酶主要於胚胎發育時期協助DNA甲基化的建立為基礎,來假設類三號DNA甲基化酶剔除鼠在胚胎發育的過程中,由於喪失了類三號DNA甲基化酶主導的表觀遺傳特徵,而造成類三號DNA甲基化酶剔除鼠對不良環境與飲食的組成有更為顯著的反應。 | zh_TW |
dc.description.abstract | Proper regulation of transposable elements (TEs) is critical for development, physiology and mental activities. Impairment of TE modulation resulted in infertility, aging, aging related neurodegenerative disorders and cancer formation. Dietary composition and quantity could regulate chromatin structure via epigenetic modulation, and that contribute in part to the dynamics of TE expression. In mouse and Drosophila, dietary restriction (DR) has also been introduced to alleviate aging related disease, and to increase lifespan and heath span, correlating to repress TEs. DNA methyltransferase 3 like (DNMT3L) is required for TE repression in developing germ cells. However, no obvious phenotype in somatic lineages have been documented in Dnmt3l KO mice, despite the suggestion that excessive DNMT3L expression from the extra chromosome 21 may be responsible for impaired cognition ability for Down syndrome patients. In my study, I aim to clarify the effect of dietary composition, quantity and duration on TE expression and behavior outcome. Furthermore, I wanted to exam the potential link between peripheral blood TEs expression and behavior test result in order to evaluate the feasibility of using whole blood TEs expression as brain diseases biomarker. Lastly, I wanted to know whether Dnmt3l genotype would influence the dietary effect on TE modulation and phenotype in somatic lineages.
For these purposes, I used a 2-month-switching between DR and ad libitum (AL) with high fat diet (HFD) or breeding diet to observe TEs expression in mouse whole blood. I also used behavior test to demonstrate cognitive function. The result showed that DR with both HFD and breeding diet resulted in repressing TEs expression in whole blood. However, only switching between AL and DR with breeding diet demonstrated fluctuation of food quantity-associated TEs expression pattern. After taking HFD without limitation (AL) for 2-month resulted in resistance of TEs re-repression in blood after switching to DR treatment. In behavior test, DR with breeding diet improved novel object preference and DR with HFD improved locomotorability in open filed test. But I could not associate whole blood TEs expression with brain function so far. On the other hand, DR-mediated TEs expression were also demonstrated in Dnmt3l mutant mice as it did in the wild type (WT) littermate. In addition, Dnmt3l KO mice after 6 weeks of time zone shifting and HFD treatment demonstrated decreased expression level of lipogenesis and carbohydrate metabolism related genes, and decreased mitochondrial copy number in liver. In conclusion, modulation of whole blood TEs expression is associated with dietary choice. DR in general improves cognition and motor related behavior test results. In addition, gender differences are clearly demonstrated in diet associated TEs regulation and behavior test results. Since the expression of DNMT3L is not easily detectable in somatic cells, I hypothesize that loss of DNMT3L dependent epigenetic signature in embryonic stem cells/progenitor cells may eventually enhanced the sensitivity of metabolic genes and transposable elements in adult DNMT3L mutants. | en |
dc.description.provenance | Made available in DSpace on 2021-07-11T15:03:55Z (GMT). No. of bitstreams: 1 ntu-108-R06642008-1.pdf: 2241217 bytes, checksum: abdec49baf4559c8a89d38399586601f (MD5) Previous issue date: 2019 | en |
dc.description.tableofcontents | 口試委員會審定書 #
誌謝 i 中文摘要 ii ABSTRACT iv CONTENTS vi LIST OF FIGURES ix LIST OF TABLES xi Abbreviations xii Chapter 1 Introduction 1 1.1 Dynamics of Transposable element (TEs) modulation during embryonic development, physiology, aging and disease 1 1.1.1 TEs modulation in embryonic development 2 1.1.2 TEs modulated gene expression 3 1.1.3 TEs de-repression in aging 4 1.1.4 TEs deregulation and disease 5 1.2 TEs expression could be influenced by environment 7 1.3 Dietary restriction (DR) represses TEs in organismal aging 8 1.4 Dnmt3l knock-out model change chromatin structure in somatic lineages 9 1.5 Epigenetic alterations cause long-term effect on metabolism 11 1.6 Experimental design 12 Chapter 2 Materials and Methods 16 2.1 Mouse keeping and diets 16 2.2 Submandibular blood and organs collection 17 2.3 RNA extraction 18 2.4 Real-time quantification polymerase chain reaction (RT-qPCR) 19 2.5 Behavior test 20 2.5.1 Marble burying 20 2.5.2 Tail suspension 21 2.5.3 Rotarod performance test 21 2.5.4 Open field test and novel object recognition (NOR) 22 2.5.5 Three-chamber test 23 2.6 ATP production test 24 2.7 Glucose tolerance test 25 Chapter 3 Results 26 3.1 The effect of dietary composition on DR associated behavior and TEs expression 26 3.1.1 Continues DR cause TEs repression, regardless of diets composition 28 3.1.2 DR re-repress breeding diet AL-induced TEs de-repression 30 3.1.3 HFD inhibit the DR mediated TE silencing after prior HFD AL treatment 33 3.1.4 DR with breeding diet elevate novel object preference compared with familiar object 35 3.1.5 DR treatment with HFD improve behavior outcome in open field test 37 3.1.6 Gender and genotype effect on DR mediated TE repression in breeding diet 39 3.2 Dnmt3l knock-out mice showed metabolic defect under drastic environmental changes 44 3.2.1 Dnmt3l-KO mice reduce daily metabolizable energy regardless of age, sex and dietary composition 44 3.2.2 Gender effect on DR-induced mitochondrial copy number loss in Dnmt3l-KO mice 46 3.2.3 HFD and time zone shifting affect metabolism in Dnmt3l-KO male 48 3.2.4 HFD dysregulate TEs expression in female 50 3.2.5 HFD increased the blood glucose in both Dnmt3l WT and KO female 52 3.3 Future work 54 Chapter 4 Discussion 55 4.1 The implications of dynamic whole blood TEs expression 55 4.2 Dietary composition and quantity cause the disparate resulted in TEs expression and behavior test 57 4.3 Gender differences affect DR outcome in whole blood TEs and behavior test 60 4.4 DNMT3L’s legacy may prevent metabolic defect 61 4.5 Conclusion 63 4.6 Perspective 64 Appendix 65 REFERENCE 68 | - |
dc.language.iso | en | - |
dc.title | 營養、代謝和跳躍子的調控與行為的關連 | zh_TW |
dc.title | Nutrition, Metabolism, Transposable Element Control and Behavior | en |
dc.type | Thesis | - |
dc.date.schoolyear | 107-2 | - |
dc.description.degree | 碩士 | - |
dc.contributor.oralexamcommittee | 陳靜宜;王培育;陳示國;張原翊 | zh_TW |
dc.contributor.oralexamcommittee | ;;; | en |
dc.subject.keyword | 跳躍子,飲食節制,類三號DNA甲基化?,行為測試,代謝作用, | zh_TW |
dc.subject.keyword | Transposable element,Diet,DNMT3L,Behavior,Metabolism, | en |
dc.relation.page | 76 | - |
dc.identifier.doi | 10.6342/NTU201903724 | - |
dc.rights.note | 未授權 | - |
dc.date.accepted | 2019-08-16 | - |
dc.contributor.author-college | 生物資源暨農學院 | - |
dc.contributor.author-dept | 生物科技研究所 | - |
dc.date.embargo-lift | 2024-08-26 | - |
顯示於系所單位: | 生物科技研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-107-2.pdf 目前未授權公開取用 | 2.19 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。