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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 段維新(Wei-Hsing Tuan) | |
| dc.contributor.author | Po-Chun Shen | en |
| dc.contributor.author | 沈柏均 | zh_TW |
| dc.date.accessioned | 2021-07-11T15:00:28Z | - |
| dc.date.available | 2022-01-14 | |
| dc.date.copyright | 2020-01-14 | |
| dc.date.issued | 2019 | |
| dc.date.submitted | 2019-07-30 | |
| dc.identifier.citation | [1] W. Wang and K.W. Yeung, Bone grafts and biomaterials substitutes for bone defect repair: A review. Bioactive Materials, 2017. 2(4): p. 224-247.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78500 | - |
| dc.description.abstract | 在本研究中，我們透過固態反應法合成β-三鈣磷酸鹽(β-TCP)，並將合成的粉末與半水硫酸鈣(CSH)以不同之重量比例混合、壓錠成生胚。接著透過在高溫下的燒結使生胚緻密化，同時半水硫酸鈣也會轉換為無水硫酸鈣(CSA)。而在本實驗中，我們將會透過檢測相對密度、抗折強度、體外降解行為以及細胞毒性來評估β-TCP/ CSA複合系統作為人工骨替代材之可行性。
結果顯示，透過我們所設計的流程，可以得到高緻密度的β-TCP (96.3%)，且此時的雙軸向抗折強度可達226MPa。而在加入硫酸鈣之後，儘管相對密度仍然能夠維持在90%之上，但即使僅添加了20個重量百分比的硫酸鈣，雙軸向抗折強度卻會大幅下降至62MPa。至於體外降解行為方面，β-TCP的降解速率很慢，而CSA的重量損失則是隨著時間具有上升的趨勢。此外，複合材料的降解行為則主要發生於實驗的初期階段，並且在四至五天後達到飽和，同時伴隨著片狀的微觀結構在表面生成。在細胞毒性的測試中，β-TCP、CSA以及兩者的複合材料都顯示為不具細胞毒性。因此整體而言，將β-TCP與CSA複合是能夠達到調整材料的降解行為，並且也驗證了此複合材料系統作為人工骨替代材之可行性。 | zh_TW |
| dc.description.abstract | In the present study, a β-tricalcium phosphate (TCP) powder has been synthesized through a solid-state reaction at elevated temperature. The powder is then mixed with calcium sulfate hemihydrate (CSH) in various weight ratios, and pressed into green compacts. Densification of the green compacts is conducted by sintering at elevated temperatures, in order to obtain dense bulks with desired compositions. The CSH has transformed into calcium sulfate anhydrate (CSA) during the heat treatment. The relative density, flexural strength, in vitro degradation behavior and cytotoxicity of the composite materials had been examined in order to evaluate the compatibility of the β-TCP/CSA system as synthetic bone graft substitute.
The results showed that for TCP samples, a high relative density (96.3%) was achieved after sintering, along with a high flexural strength (226 MPa). Although the composite materials with CSA maintained high relative densities (>90%), the flexural strength had been reduced to a great extent (62 MPa) even when the addition is as low as only 20wt%. As for the degradation behavior, the degradation of β-TCP in simulated body fluid is slow while the accumulated weight loss of pure CSA samples increases with time. On the other hand, the composite samples degraded only at the early stage and saturated after 4 to 5 days, with the formation of plate-like structures on the surfaces. For cytotoxicity test, the β-TCP and its composite with CSA show low toxicity. In summary, the combination of β-TCP and CSA is able to modify the degradation behavior. The present study has demonstrated that the potential of using β-TCP/CSA composites as synthetic bone graft substitutes is high. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-11T15:00:28Z (GMT). No. of bitstreams: 1 ntu-108-R06527002-1.pdf: 21101769 bytes, checksum: 53fadbce63f83f2e7a167c99c3f04367 (MD5) Previous issue date: 2019 | en |
| dc.description.tableofcontents | 口試委員會審定書 #
致謝 i 中文摘要 ii ABSTRACT iii CONTENTS iv LIST OF FIGURES vii LIST OF TABLES xi Chapter 1 Introduction 1 Chapter 2 Literature review 3 2.1 Bone graft substitutes and bioceramics 3 2.1.1 Bone grafts 3 2.1.2 Bioceramics 5 2.1.3 Calcium phosphates 8 2.2 Physical and biological properties of β-tricalcium phosphate 10 2.2.1 Crystal structure 10 2.2.2 Synthesis of β-TCP 11 2.2.3 Mechanical properties of β-TCP 15 2.2.4 Biological properties of β-TCP 16 2.3 Use of β-tricalcium phosphate as bone graft substitute 18 2.4 Combination of β-tricalcium phosphate and calcium sulfate 21 Chapter 3 Experimental procedures 23 3.1 Synthesis of β-tricalcium phosphate 23 3.1.1 Starting materials 23 3.1.2 Processing 23 3.2 Mixing of β-tricalcium phosphate and calcium sulfate 25 3.3 Preparation of specimens 26 3.4 Characterization 26 3.4.1 Physical properties 26 3.4.1.1 Density 26 3.4.1.2 Phase identification 26 3.4.1.3 Microstructure analysis 26 3.4.2 Mechanical properties 27 3.4.3 Biological properties 28 3.4.3.1 In vitro degradation behavior 28 3.4.3.2 Cytotoxicity 30 Chapter 4 Results 32 4.1 Physical properties 32 4.1.1 Density 32 4.1.2 Phase identification 32 4.1.3 Microstructure observation 34 4.2 Mechanical properties 37 4.3 Biological properties 39 4.3.1 In vitro degradation 39 4.3.1.1 pH value 39 4.3.1.2 Accumulated weight loss 40 4.3.1.3 Microstructure observation 41 4.3.1.4 Phase identification 48 4.3.1.5 Ion concentration investigation 56 4.3.2 Cytotoxicity by MTT assay 58 Chapter 5 Discussion 60 5.1 Sample preparation 60 5.1.1 Synthesis of β-TCP by solid-state reaction 60 5.1.2 Combination of β-TCP and calcium sulfate 60 5.2 Physical properties 63 5.2.1 Microstructure observation 63 5.2.2 Microstructure and density 65 5.2.3 Microstructure and flexural strength 67 5.3 In vitro degradation 68 5.3.1 Degradation of TCP 69 5.3.2 Degradation of 100CS 71 5.3.3 Degradation of 20CS and 40CS 76 5.3.4 Degradation of 60CS and 80CS 81 Chapter 6 Conclusions 86 Chapter 7 Future work 88 REFERENCES 89 Appendix A Toughness 99 Appendix B Deformation behavior 100 | |
| dc.language.iso | en | |
| dc.subject | 人工骨替代材 | zh_TW |
| dc.subject | β-三鈣磷酸鹽 | zh_TW |
| dc.subject | 降解 | zh_TW |
| dc.subject | 硫酸鈣 | zh_TW |
| dc.subject | 生醫陶瓷 | zh_TW |
| dc.subject | degradation | en |
| dc.subject | bone graft substitute | en |
| dc.subject | calcium sulfate | en |
| dc.subject | β-tricalcium phosphate (β-TCP) | en |
| dc.subject | bioceramic | en |
| dc.title | 探討β-三鈣磷酸鹽與硫酸鈣複合材料之性質與降解行為 | zh_TW |
| dc.title | Degradation of β-Tricalcium Phosphate and its Composites with Calcium Sulfate | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 108-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 林?輝,唐政宏,施劭儒 | |
| dc.subject.keyword | β-三鈣磷酸鹽,硫酸鈣,生醫陶瓷,降解,人工骨替代材, | zh_TW |
| dc.subject.keyword | β-tricalcium phosphate (β-TCP),calcium sulfate,bioceramic,degradation,bone graft substitute, | en |
| dc.relation.page | 101 | |
| dc.identifier.doi | 10.6342/NTU201901543 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2019-07-31 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 材料科學與工程學研究所 | zh_TW |
| Appears in Collections: | 材料科學與工程學系 | |
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