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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78261完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 呂東武(Tung-Wu Lu) | |
| dc.contributor.author | Ivan Komala | en |
| dc.contributor.author | 林福豐 | zh_TW |
| dc.date.accessioned | 2021-07-11T14:48:19Z | - |
| dc.date.available | 2025-08-18 | |
| dc.date.copyright | 2020-09-14 | |
| dc.date.issued | 2020 | |
| dc.date.submitted | 2020-08-12 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78261 | - |
| dc.description.abstract | Cycling has been commonly used by people for commuting, exercise, and leisure activity. Additionally, it is frequently used for rehabilitation exercise after knee injury or surgery. It not only strengthens the leg muscles but also reduces the pain, stiffness, and disability caused by osteoarthritis (OA). OA is usually characterized by elevated fluid content, reduced collagen content and lose its collagen network organization. A multi-scale model was developed for analyzing the mechanical behavior of collagen fibril network inside articular cartilage from healthy subjects and patients with OA during cycling The geometry of the knee was obtained from 3D reconstruction of computer tomography scan and the articular cartilage surface was acquired from magnetic resonance imaging scan. The finite element (FE) method was used to analyze microstructures under mechanical loading. The boundary conditions (BC) were gathered from the dynamic fluoroscopy system. Collagen fibrils were modeled as a viscoelastic material that can perform a stress relaxation and the material properties were taken from the literature. Current results showed that the initiation of early OA was probably caused by the stiffening of collagen fibril which may subsequently lead to embrittlement and drive the disease progression. Furthermore, the repetitive movement might cause the fibril to undergo permanent deformation, thus change in material properties and became stiffer. Therefore, it is possible that doing a functional activity for a long time without resting may cause early OA. This study might provide more accurate results for diagnostic basis and reference in the treatment, rehabilitation, or assistive device development for cartilage. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-11T14:48:19Z (GMT). No. of bitstreams: 1 U0001-1208202010422600.pdf: 5599682 bytes, checksum: d8f71352cad9c3460eec5b370d9c92e3 (MD5) Previous issue date: 2020 | en |
| dc.description.tableofcontents | ACKNOWLEDGEMENT II ABSTRACT III LIST OF FIGURES VI LIST OF TABLES IX CHAPTER I – INTRODUCTION 1 1.1. Research Background 1 1.2. Anatomy of Knee Joints 6 1.3. Kinematics of Knee Joints 8 1.4. Composition and Mechanical Properties of Articular Cartilage 10 1.5. Literature Review 14 1.5.1. 2D Model of Collagen Fibril Network 14 1.5.2. 3D Model of Collagen Fibril Network 16 1.6. Research Purposes 18 CHAPTER II – METHODOLOGY 19 2.1. In-vivo Cycling Experiment 19 2.2. Material and Method 19 2.3. Cycling Kinematics Data 22 CHAPTER III – FINITE ELEMENT ANALYSIS 24 3.1. Geometric Model of Knee Joint 25 3.2. Boundary Condition 29 3.3. 2D FE Model of Collagen Fibril Network 30 3.4. 3D FE Model of Collagen Fibril Network 33 3.5. Material Properties of Collagen Fibril 35 3.6. Multi-scale Cartilage FE Model for Cycling 39 CHAPTER IV – RESULTS DISCUSSION 44 4.1. Single Collagen Fibril Validation 44 4.2. 2D Collagen Fibril Network Model 47 4.2.1. 2D Model Validation 47 4.2.2. Collagen Fibril Mechanical Behavior to Cyclic Load 52 4.2.3. Human Collagen Fibril Test 56 4.2.4. Mechanical Response Comparison between Collagen Fibril of Healthy and Patients with early OA 58 4.2.5. Failure Prediction 60 4.3. Macro-Scale Knee Cartilage FEA during Cycling 63 4.4. Micro-Scale Knee Cartilage FEA during Cycling 65 CHAPTER V – CONCLUSION 69 CHAPTER VI – FUTURE WORK 71 REFERENCES 72 | |
| dc.language.iso | en | |
| dc.subject | multi-scale modeling | en |
| dc.subject | Articular cartilage | en |
| dc.subject | cycling | en |
| dc.subject | knee joint | en |
| dc.subject | Finite element method | en |
| dc.subject | collagen fibril | en |
| dc.subject | osteoarthritis | en |
| dc.title | 膝關節軟骨之多尺度有限元素模擬及其於腳踏車踩踏之應用 | zh_TW |
| dc.title | Multi-Scale Finite Element Modeling of Knee Cartilage with Applications to Cycling | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 108-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳祥和(Hsiang-Ho Chen),陳文斌(Weng-Pin Chen),林正忠 | |
| dc.subject.keyword | Finite element method,Articular cartilage,cycling,knee joint,multi-scale modeling,collagen fibril,osteoarthritis, | en |
| dc.relation.page | 76 | |
| dc.identifier.doi | 10.6342/NTU202003055 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2020-08-13 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
| dc.date.embargo-lift | 2025-08-18 | - |
| 顯示於系所單位： | 醫學工程學研究所 | |
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