請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78237
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 歐海仁(Hiran Anjana Ariyawansa) | |
dc.contributor.author | Wei-Yu Chuang | en |
dc.contributor.author | 莊偉裕 | zh_TW |
dc.date.accessioned | 2021-07-11T14:47:15Z | - |
dc.date.available | 2021-08-13 | |
dc.date.copyright | 2020-08-28 | |
dc.date.issued | 2020 | |
dc.date.submitted | 2020-08-17 | |
dc.identifier.citation | Aman, S., Anderson, D. J., Connolly, T. J., Crittall, A. J., and Ji, G. 2000. From adenosine to 30-deoxyadenosine: development and scale up. Org. Process Res. Dev. 4:601–605. Ariyawansa, H. A., Hyde, K. D., Liu, J. K., Wu, S. P., and Liu, Z. Y. 2016. Additions to Karst Fungi 1: Botryosphaeria minutispermatia sp. nov., from Guizhou Province, China. Phytotaxa, 275:35–44. Artjariyasripong, S., Mitchell, J. I., Hywel-Jones, N. L., and Jones, E. B. G. 2001. Relationship of the genus Cordyceps and related genera, based on parsimony and spectral analysis of partial 18S and 28S ribosomal gene sequences. Mycoscience 42:503. Bary, A. 1867. Zur Kenntniss insectentoedtender pilze. Botanische Zeitung, vol. 25:2–28 Barry, C. P., and Lind, S. E. 2000. Adenosine-mediated killing of cultured epithelial cancer cells. Cancer research 60:1887–1894. Bischoff, J. F., and White Jr., J. F. 2003. The plant-infecting clavicipitaleans. In Clavicipitalean fungi: evolutionary biology, chemistry, biocontrol, and cultural impacts, eds. James F. White, Jr., Charles W. Bacon, Nigel L. Hywel-Jones and Joseph W. Spatafora. New York: Marcel Dekker, p. 125–149. Cai, H., Li, J., Gu, B., Xiao, Y., Chen, R., Liu, X., Xie, X., and Cao, L. 2018. Extracts of Cordyceps sinensis inhibit breast cancer cell metastasis via down-regulation of metastasis-related cytokines expression. J. Ethnopharmacol. 214:106–112. Caplins, L., and Halvorson, S. J. 2017. Collecting Ophiocordyceps sinensis: an emerging livelihood strategy in the Garhwal, Indian Himalaya. J. Mt. Sci. 14:390–402. Castlebury, L. A., Rossman, A. Y., Sung, G. H., Hyten, A. S., and Spatafora, J. W. 2004. Multigene phylogeny reveals new lineage for Stachybotrys chartarum, the indoor air fungus. Mycol. Res. 108:864-872. Chaicharoenaudomrung, N., Jaroonwitchawan, T., and Noisa, P. 2018. Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy. Toxicol. In Vitro 46:113–121. Chen, S., Yin, D., Li, L., Zha, X., Shuen, J., and Zhama, C. 2000. Resources and distribution of Cordyceps sinensis in Naqu Tibet. Zhong Yao Cai 23:673–675. Chen, Z. C. 1978. Note on new formosan forest fungi VI. Genus Cordyceps and their distribution in Taiwan. Taiwania 23:153–162. Chu, Z. B., Chang, J., Zhu, Y., and Sun, X. 2015. Chemical constituents of Cordyceps cicadae. Nat. Prod. Commun. 10:2145-6. Crous, P., Wingfield, M., Lombard, L., Roets, F., Swart, W., Alvarado, P., Carnegie, A., Moreno, G., Luangsa-Ard, J., Thangavel, R., Alexandrova, A., Baseia, I., Bellanger, J., Bessette, A., Bessette, A., Delapeña-Lastra, S., García, D., Gené, J., Pham, T., Heykoop, M., Malysheva, E., Malysheva, V., Martín, M., Morozova, O., Noisripoom, W., Overton, B., Rea, A., Sewall, B., Smith, M., Smyth, C., Tasanathai, K., Visagie, C., Adamík, S., Alves, A., Andrade, J., Aninat, M., Araújo, R., Bordallo, J., Boufleur, T., Baroncelli, R., Barreto, R., Bolin, J., Cabero, J., Cabo, M., Cafà, G., Caffot, M., Cai, L., Carlavilla, J., Chávez, R., Decastro, R., Delgat, L., Deschuyteneer, D., Dios, M., Domínguez, L., Evans, H., Eyssartier, G., Ferreira, B., Figueiredo, C., Liu, F., Fournier, J., Galli-Terasawa, L., Gil-Durán, C., Glienke, C., Gonçalves, M., Gryta, H., Guarro, J., Himaman, W., Hywel-Jones, N., Iturrieta-González, I., Ivanushkina, N., Jargeat, P., Khalid, A., Khan, J., Kiran, M., Kiss, L., Kochkina, G., Kolaík, M., Kubátová, A., Lodge, D., Loizides, M., Luque, D., Manjón, J., Marbach, P., Massolajr, N., Mata, M., Miller, A., Mongkolsamrit, S., Moreau, P., Morte, A., Mujic, A., Navarro-Ródenas, A., Németh, M., Nóbrega, T., Nováková, A., Olariaga, I., Ozerskaya, S., Palma, M., Petters-Vandresen, D., Piontelli, E., Popov, E., Rodríguez, A., Requejo, Ó., Rodrigues, A., Rong, I., Roux, J., Seifert, K., Silva, B., Sklená, F., Smith, J., Sousa, J., Souza, H., Desouza, J., Vec, K., Tanchaud, P., Tanney, J., Terasawa, F., Thanakitpipattana, D., Torres-Garcia, D., Vaca, I., Vaghefi, N., Vaniperen, A., Vasilenko, O., Verbeken, A., Yilmaz, N., Zamora, J., Zapata, M., Jurjević, Ž. and Groenewald, J. 2019. Fungal Planet description sheets: 951–1041. Persoonia 43:223–425. Cunningham, A. B., and Long, X. 2019. Linking resource supplies and price drivers: Lessons from Traditional Chinese Medicine (TCM) price volatility and change, 2002–2017. J. Ethnopharmacol. 229:205–214. Cunningham, K. G., Manson, W., Spring, F. S., and Hutchinson, S. A. 1950. Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link. Nature 166:949–949.Dettman, J. R., Jacobson, D. J., Turner, E., Pringle, A., and Taylor, J. W. 2003. Reproductive isolation and phylogenetic divergence in Neurospora: comparing methods of species recognition in a model eukaryote. Evolution 57:2721–2741. Dong, J. Z., Wang, S. H., Ai, X. R., Yao, L., Sun, Z. W., Lei, C., Wang, Y., and Wang, Q. 2013. Composition and characterization of cordyxanthins from Cordyceps militaris fruit bodies. J. Funct. Foods 5:1450–1455. Eltzschig, H. K. 2009. Adenosine: an old drug newly discovered. Anesthesiology 111: 904–915. Eriksson, O. 1982. Cordyceps bifusispora spec. nov. Mycotaxon 15:185–188 Fries E. M. 1818. Observationes Mycologiae. Vol. 2 (Cancellans issue). Hafniae: G. Bonnieri. Gams, W. 2016. Recent changes in fungal nomenclature and their impact on naming of microfungi. In Biology of Microfungi, eds. Li, De. Wei. Cham: Springer, p. 7–23. Gams, W., Hodge, K. T., Samson, R. A., Korf, R. P., and Seifert, K. A. 2005. Proposal to conserve the name Isaria (anamorphic fungi) with a conserved type. Taxon 54:537. Gams, W., O'Donnell, K., Schroers, H. J., and Christensen, M. 1998. Generic classification of some more hyphomycetes with solitary conidia borne on phialides. Can. J. Bot., 76:1570–1583. Guo, C., Zhu, J., Zhang, C., and Zhang, L. 1998. Determination of adenosine and 3'-deoxyadenosine in Cordyceps militaris (L.) Link. by HPLC. Zhongguo Zhong Yao Za Zhi 23:236-7. Guo, P., Kai, Q., Gao, J., Lian, Z. Q., Wu, C. M., Wu, C. A., and Zhu, H. B. 2010. Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J. Pharmacol. Sci. 113:395–403. Haskó, G., and Cronstein, B. N. 2004. Adenosine: an endogenous regulator of innate immunity. Trends Immunol. 25:33–39. Holbein, S., Wengi, A., Decourty, L., Freimoser, F. M., Jacquier, A., and Dichtl, B. 2009. Cordycepin interferes with 3′ end formation in yeast independently of its potential to terminate RNA chain elongation. RNA 15:837–849. Holliday, J. 2017. Cordyceps: a highly coveted medicinal mushroom. In Medicinal Plants and Fungi: Recent Advances in Research and Development. Singapore: Springer, p. 59–91. Hong, I. P., Kang, P. D., Kim, K. Y., Nam, S. H., Lee, M. Y., Choi, Y. S., Kim, N. S., Kim, H. K., Lee, K. G., and Humber, R. A. 2010. Fruit Body Formation on Silkworm by Cordyceps militaris. Mycobiology 38:128–132. Hsu, T. H., Shiao, L. H., Hsieh, C., and Chang, D. M. 2002. A comparison of the chemical composition and bioactive ingredients of the Chinese medicinal mushroom Dong Chong Xia Cao, its counterfeit and mimic, and fermented mycelium of Cordyceps sinensis. Food chemistry 78:463–469. Huang, B., Li, C., Humber, R. A., Hodge, K. T., Fan, M., and Li, Z. 2005. Molecular evidence for the taxonomic status of Metarhizium taii and its teleomorph, Cordyceps taii (Hypocreales, Clavicipitaceae). Mycotaxon 94:137–147. Huang, L. F., Liang, Y. Z., Guo, F. Q., Zhou, Z. F., and Cheng, B. M. 2003. Simultaneous separation and determination of active components in Cordyceps sinensis and Cordyceps militaris by LC/ESI-MS. J. Pharm. Biomed. Anal. 33:1155–1162. Huang, L., Li, Q., Chen, Y., Wang, X., and Zhou, X. 2009. Determination and analysis of cordycepin and adenosine in the products of Cordyceps spp. Afr. J. Microbiol. Res. 3:957–961. Huang, S., Liu, H., Sun, Y., Chen, J., Li, X., Xu, J., Hu, Y., Li, Y., Deng, Z., and Zhong, S. 2017. An effective and convenient synthesis of cordycepin from adenosine. Chem. Zvesti 72:149–160. Humber, R. A. 2008. Evolution of entomopathogenicity in fungi. J. Invertebr. Pathol. 98:262–266. Humber, R. A., Rocha, L. F., Inglis, P. W., Kipnis, A., and Luz, C. 2013. Morphology and molecular taxonomy of Evlachovaea-like fungi, and the status of this unusual conidial genus. Fungal Biol. 117:1–12. Hwang, J. H., Park, S. J., Ko, W. G., Kang, S. M., Lee, D. B., Bang, J., Park, B. J., Wee, C. B., Kim, D. J., Jang, I., S., and Ko, J. H. 2017. Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway. Am. J. Cancer Res. 7:417. Ji, D. B., Ye, J., Li, C. L., Wang, Y. H., Zhao, J., and Cai, S. Q. 2009. Antiaging effect of Cordyceps sinensis extract. Phytother. Res. 23:116–122. Jin, J., Zhong, C., Qin, Y., Cai, Y., Zhen, L., Shen, B., Chen, L., Wan. D., Qin, Y., and Zhang, S. 2017. A new cordycepin-producing caterpillar fungus Ophiocordyceps xuefengensis with artificial infection to the host, cultivation of mycelia and stromata. FEMS Microbiol. Immunol. 364. Kaczka, E. A., Dulaney, E. L., Gitterman, C. O., Woodruff, H. B., and Folkers, K. 1964. Isolation and inhibitory effects on KB cell cultures of 3′-deoxyadenosine from Aspergillus nidulans (Eidam) Wint. Biochem. Biophys. Res. Commun. 14:452–455. Kazemi, M. H., Raoofi Mohseni, S., Hojjat‐Farsangi, M., Anvari, E., Ghalamfarsa, G., Mohammadi, H., and Jadidi‐Niaragh, F. 2018. Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer. J. Cell. Physiol. 233:2032–2057. Kepler, R. M., Sung, G. H., Harada, Y., Tanaka, K., Tanaka, E., Hosoya, T., Bischoff, J. F., and Spatafora, J. W. 2012. Host jumping onto close relatives and across kingdoms by Tyrannicordyceps (Clavicipitaceae). gen. nov. and Ustilaginoidea (Clavicipitaceae). Am. J. Bot. 99:552–561. Kepler, R., Ban, S., Nakagiri, A., Bischoff, J., Hywel-Jones, N., Owensby, C. A., and Spatafora, J. W. 2013. The phylogenetic placement of hypocrealean insect pathogens in the genus Polycephalomyces: an application of One Fungus One Name. Fungal Biol. 117:611–622. Kepler, R. M., Humber, R. A., Bischoff, J. F., and Rehner, S. A. 2014. Clarification of generic and species boundaries for Metarhizium and related fungi through multigene phylogenetics. Mycologia 106:811–829. Knowles, J. R. 1980. Enzyme-catalyzed phosphoryl transfer reactions. Annu. Rev. Biochem. 49:877–919. Kobayasi Y. 1941. The genus Cordyceps and its allies. Science Reports of the Tokyo Bunrika Daigaku Kobayasi, Y., and Shimizu, D. 1963. Monographic studies of Cordyceps 2. Group parasitic on Cicadidae. Bull. Natl. Sci. Mus. 6:286–314. Kobayasi, Y. and Shimizu, D. 1981. The genus Cordyceps and its allies from Taiwan (Formosa). Bull. Natl. Sci. Mus. 7:113–122. Kobayasi, Y. 1982. Keys to the taxa of the genera Cordyceps and Torrubiella. Transaction of the Mycological Society of Japan. Kobayasi, Y. 1983. Cordyceps species from japan 6. Bull. Natl. Sci. Mus. 9:1–21. Kodama, K., Kusakabe, H., Machida, H., Midorikawa, Y., Shibuya, S., Kuninaka, A., and Yoshino, H. 1979. Isolation of 2′-Deoxycoformycin and Cordycepin from Wheat Bran Culture of Aspergillus nidulans Y 176–2. Agric. Biol. Chem. 43:2375–2377. Koh, J. H., Yu, K. W., Suh, H. J., Choi, Y. M., and Anh, T. S. 2002. Activation of macrophages and the intestinal immune system by an orally administered decoction from cultured mycelia of Cordyceps sinensis. Biosci. Biotechnol. Biochem. 66:407–411. Kryukov, V. Y., Yaroslavtseva, O. N., Lednev, G. R., and Borisov, B. A. 2011. Local epizootics caused by teleomorphic cordycipitoid fungi (Ascomycota: Hypocreales) in populations of forest lepidopterans and sawflies of the summer-autumn complex in Siberia. Microbiology, 80:286–295. Lee, S. K., Lee, J. H., Kim, H. R., Chun, Y., Lee, J. H., Yoo, H. Y., Park, C., and Kim, S. W. 2019. Improved cordycepin production by Cordyceps militaris KYL05 using casein hydrolysate in submerged conditions. Biomolecules 9:461. Liang, Z. Q., Liu, A. Y., and Liu, J. L. 1991. A new species of the genus Cordyceps and its Metarhizium anamorph. Acta Mycol. Sin. 10:257–262. Ling, J. Y., Sun, Y. J., Zhang, H., Lv, P., and Zhang, C. K. 2002. Measurement of cordycepin and adenosine in stroma of Cordyceps sp. by capillary zone electrophoresis (CZE). J. Biosci. Bioeng. 94:371–374. Lin, Q., Long, L., Wu, L., Zhang, F., Wu, S., Zhang, W., and Sun, X. 2017. Evaluation of different agricultural wastes for the production of fruiting bodies and bioactive compounds by medicinal mushroom Cordyceps militaris. J. Sci. Food Agric. 97:3476–3480. Liu, H. J., Hu, H. B., Chu, C., Li, Q., and Li, P. 2011. Morphological and microscopic identification studies of Cordyceps and its counterfeits. Acta Pharm. Sin. B 1:189–195. Liu, Y., Wang, J., Wang, W., Zhang, H., Zhang, X., and Han, C. 2015. The chemical constituents and pharmacological actions of Cordyceps sinensis. Evid. Based Complement Alternat. Med. 2015 Liu, Z., Li, P., Zhao, D., Tang, H., and Guo, J. 2011. Anti-inflammation effects of Cordyceps sinensis mycelium in focal cerebral ischemic injury rats. Inflammation 34:639–644. Liu, Z. Y., Liang, Z. Q., Whalley, A. S., Yao, Y. J., and Liu, A. Y. 2001. Cordyceps brittlebankisoides, a new pathogen of grubs and its anamorph, Metarhizium anisopliae var. majus. J. Invertebr. Pathol. 78:178–182. Lo, H. C., Hsieh, C., Lin, F. Y., and Hsu, T. H. 2013. A systematic review of the mysterious caterpillar fungus Ophiocordyceps sinensis in Dong-ChongXiaCao (冬蟲夏草 Dōng Chóng Xià Cǎo) and related bioactive ingredients. J. Tradit. Complement Med. 3:16–32. Luangsa-Ard, J. J., Hywel-Jones, N. L., Manoch, L., and Samson, R. A. 2005. On the relationships of Paecilomyces sect. Isarioidea species. Mycol. Res. 109:581–589. Mains, E. B. 1958. North American entomogenous species of Cordyceps. Mycologia 50:169–222. Ma, Y., Zhang, J., Zhang, Q., Chen, P., Song, J., Yu, S., Liu, H., Liu, F., Song, C., Yang, D., and Liu, J. 2014. Adenosine induces apoptosis in human liver cancer cells through ROS production and mitochondrial dysfunction. Biochem. Biophys. Res. Commun. 448:8–14. Matheny, P. B., Liu, Y. J., Ammirati, J. F., and Hall, B. D. 2002. Using RPB1 sequences to improve phylogenetic inference among mushrooms (Inocybe, Agaricales). Am. J. Bot. 89:688–698. McNeill, J., Turland, N.J., Barrie, F.R., Buck, W.R., Greuter, W., and Wiersema, J.H. 2012. International Code of Nomenclature for Algae, Fungi, and Plants. Konigstein, Germany: Koeltz Scientific Books, p. 208 Meng, Z., Wen, T., Kang, J., Lei, B., and Hyde, K. D. 2014. Cordyceps pruinosa produces cordycepin and N6-(2-hydroxyethyl)-adenosine in culture. Arch. of Biol. Sci. 66:1411–1421. Mongkolsamrit, S., Noisripoom, W., Thanakitpipattana, D., Wutikhun, T., Spatafora, J. W., and Luangsa-ard, J. 2018. Disentangling cryptic species with isaria-like morphs in Cordycipitaceae. Mycologia 110:230–257. Moreau, C., Kirchberger, T., Swarbrick, J. M., Bartlett, S. J., Fliegert, R., Yorgan, T., Bauche, A., Harneit, A., Guse, A. H. and Potter, B. V. 2013. Structure–activity relationship of adenosine 5′-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) channel: Rational design of antagonists. J. Med. Chem. 56:10079–10102. Moreno-Arribas, M.V., and Polo, M.C. 2003. CHROMATOGRAPHY | High-performance Liquid Chromatography. In Encyclopedia of Food Sciences and Nutrition (Second Edition), eds. Benjamin Caballero. United States: Academic Press, p.1274–1280. Ng, T. B., and Wang, H. X. 2005. Pharmacological actions of Cordyceps, a prized folk medicine. J. Pharm. Pharmacol. 57:1509–1519. Nikoh, N., and Fukatsu, T. 2000. Interkingdom host jumping underground: phylogenetic analysis of entomoparasitic fungi of the genus Cordyceps. Mol. Biol. Evol. 17:629–638. Noh, E. M., Jung, S. H., Han, J. H., Chung, E. Y., Jung, J. Y., Kim, B. S., Lee, S. h., Lee, Y. R., and Kim, J. S. 2010. Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK/AP-1 pathway in MCF-7 human breast cancer cells. Int. J. Mol. Med. 25:255–260. Paton, D. M. 1988. Adenosine and adenine nucleotides: physiology and Pharmacology. Basingstoke: Taylor Francis. Pelleg, A., and Belardinelli, L. 1993. Cardiac electrophysiology and pharmacology of adenosine: basic and clinical aspects. Cardiovascular. Res. 27:54–61. Petch, T. 1924. Studies in entomogenous fungi: IV. Some Ceylon Cordyceps. Trans. Brit. Mycol. Soc. 10:28–45. Quandt, C. A., Kepler, R. M., Gams, W., Araújo, J. P., Ban, S., Evans, H. C., Hughes, D., Humber, R., Hywel-Jones, N., Li, Z., Luangsa-ard, J. J., Rehner, S. A., Sanjuan, T., Sato, H., Shrestha, B., Sung, G. H., Yao, Y. J., Zare, R., and Spatafora, J. W. 2014. Phylogenetic-based nomenclatural proposals for Ophiocordycipitaceae (Hypocreales) with new combinations in Tolypocladium. IMA Fungus 5:121. Radwan, M. M., and Wilson, H. R. 1980. The structure of cordycepin. Acta Crystallogr 36: 2185–2187. Ralevic, V., and Burnstock, G. 1998. Receptors for purines and pyrimidines. Pharmacol. Rev. 50:413–492. Ramesh, T., Yoo, S. K., Kim, S. W., Hwang, S. Y., Sohn, S. H., Kim, I. W., and Kim, S. K. 2012. Cordycepin (3′-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats. Exp. Gerontol. 47:979–987. Rehner, S. A., and Buckley, E. 2005. A Beauveria phylogeny inferred from nuclear ITS and EF1-α sequences: evidence for cryptic diversification and links to Cordyceps teleomorphs. Mycologia 97:84–98. Rogerson, C. T. 1970. The hypocrealean fungi (ascomycetes, Hypocreales). Mycologia 62: 865–910. Rottman, F., and Guarino, A. J. 1964. The inhibition of phosphoribosyl-pyrophosphate amidotransferase activity by cordycepin monophosphate. Biochim. Biophys. Acta-Enzymology and Biological Oxidation 89:465–472 Saitoh, M., Nagai, K., Nakagawa, K., Yamamura, T., Yamamoto, S., and Nishizaki, T. 2004. Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. Biochem. Pharmacol. 67:2005–2011. Saito, M., Yaguchi, T., Yasuda, Y., Nakano, T., and Nishizaki, T. 2010. Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A1 adenosine receptors. Cancer let. 290:211–215. Sebastião, A. M., and Ribeiro, J. A. 2000. Fine-tuning neuromodulation by adenosine. Trends Pharmacol. Sci. 21:341–346. Selbmann, L., Isola, D., Fenice, M., Zucconi, L., Sterflinger, K., and Onofri, S. 2012. Potential extinction of Antarctic endemic fungal species as a consequence of global warming. Sci. Total Environ. 438:127-134. Shao, L. W., Huang, L. H., Yan, S., Jin, J. D., and Ren, S. Y. 2016. Cordycepin induces apoptosis in human liver cancer HepG2 cells through extrinsic and intrinsic signaling pathways. Oncol. Lett. 12:995–1000. Sharma, S. 2004. Trade of Cordyceps sinensis from high altitudes of the Indian Himalaya: conservation and biotechnological priorities. Curr. Sci. 86:1614–1618. Sheng, L., Chen, J., Li, J., and Zhang, W. 2011. An exopolysaccharide from cultivated Cordyceps sinensis and its effects on cytokine expressions of immunocytes. Appl. Biochem. Biotechnol. 163:669–678. Shrestha, B., Han, S. K., Sung, J. M., and Sung, G. H. 2012b. Fruiting body formation of Cordyceps militaris from multi-ascospore isolates and their single ascospore progeny strains. Mycobiology 40:100–106. Shrestha, B., Han, S. K., Yoon, K. S., and Sung, J. M. 2005. Morphological characteristics of conidiogenesis in Cordyceps militaris. Mycobiology 33:69–76. Shrestha, B., Sung, G. H., and Sung, J. M. 2017. Current nomenclatural changes in Cordyceps sensu lato and its multidisciplinary impacts. Mycology 8:293–302. Shrestha, B., Tanaka, E., Han, J. G., Oh, J., Han, S. K., Lee, K. H., and Sung, G. H. 2014. A brief chronicle of the genus Cordyceps Fr., the oldest valid genus in Cordycipitaceae (Hypocreales, Ascomycota). Mycobiology 42:93–99. Shrestha, B., Tanaka, E., Hyun, M. W., Han, J. G., Kim, C. S., Jo, J. W., Han, S. K., Oh, J., and Sung, G. H. 2016. Coleopteran and lepidopteran hosts of the entomopathogenic genus Cordyceps sensu lato. J. Mycol. 2016:1–4. Shrestha, B., Zhang, W., Zhang, Y., and Liu, X. 2012a. The medicinal fungus Cordyceps militaris: research and development. Mycol. Prog. 11:599–614. Silvestro, D., and Michalak, I. 2012. RaxmlGUI: a graphical front-end for RAxML. Org. Divers. Evol. 12:335–337. Spatafora, J. W., and Blackwell, M. 1993. Molecular systematics of unitunicate perithecial ascomycetes: the Clavicipitales-Hypocreales connection. Mycologia 85:912–922. Spatafora, J. W., Sung, G. H., Sung, J. M., Hywel‐Jones, N. L., and White Jr, J. F. 2007. Phylogenetic evidence for an animal pathogen origin of ergot and the grass endophytes. Molecular Ecology 16:1701–1711. Sprecher, M., and Sprinson, D. B. 1963. A Reinvestigation of the Structure of “Cordycepic Acid” 1a. J. Org. Chem., 28:2490–2491. Steidinger, B. S., Bhatnagar, J. M., Vilgalys, R., Taylor, J. W., Qin, C., Zhu, K., Bruns, T. D., and Peay, K. G. 2020. Ectomycorrhizal fungal diversity predicted to substantially decline due to climate changes in North American Pinaceae forests. J. Biogeogr. 47:772–782. Stemp, L. I., and Roy, W. L. 1992. Adenosine for the cardioversion of supraventricular tachycardia during general anesthesia and open heart surgery. Anesthesiolog 76:849–852. Stensrud, Ø., Hywel-Jones, N. L., and Schumacher, T. 2005. Towards a phylogenetic classification of Cordyceps: ITS nrDNA sequence data confirm divergent lineages and paraphyly. Mycol. Res. 109:41–56. Su, C. H., and Wang, H. H. 1986. Phytocordyceps, a new genus of the Clavicipitaceae. Mycotaxon 26:337–344. Sung, G. H., Hywel-Jones, N. L., Sung, J. M., Luangsa-ard, J. J., Shrestha, B., and Spatafora, J. W. 2007a. Phylogenetic classification of Cordyceps and the clavicipitaceous fungi. Stud. Mycol. 57: 5–59. Sung, G. H., Spatafora, J. W., Zare, R., Hodge, K. T., and Gams, W. 2001. A revision of Verticillium sect. Prostrata. II. Phylogenetic analyses of SSU and LSU nuclear rDNA sequences from anamorphs and teleomorphs of the Clavicipitaceae. Nova Hedwigia 72:311–328. Sung, G. H., Sung, J. M., Hywel-Jones, N. L., and Spatafora, J. W. 2007b. A multi-gene phylogeny of Clavicipitaceae (Ascomycota, Fungi): Identification of localized incongruence using a combinational bootstrap approach. Mol. Phylogenet. Evol. 44:1204–1223. Taylor, J. W. 2011. One fungus = One Name: DNA and fungal nomenclature twenty years after PCR. IMA Fungus 2:113–120. Trohman, R. G. 2000. Supraventricular tachycardia: implications for the intensivist. Crit. Care Med. 28:N129–N135. Tuli, H. S., Sharma, A. K., Sandhu, S. S., and Kashyap, D. 2013. Cordycepin: a bioactive metabolite with therapeutic potential. Life Sci. 93:863–869. Tzean, S. S., Hsieh, L. S., and Wu, W. J. 1997. Atlas of entomopathogenic fungi from Taiwan Council of Agriculture. Taiwan, ROC. p. 214. Vaillant, S. 1727. Botanicon parisiense. Leiden: Boorhaave. Vilgalys, R., and Hester, M. 1990. Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. J. Bacteriol. 172:4238–4246. Wallisdevries, M. F., and Van Swaay, C. A. 2006. Global warming and excess nitrogen may induce butterfly decline by microclimatic cooling. Global Change Biology, 12:1620–1626. Wang, B. J., Yang, Q. S., Chen, T., Qin, X. D., Ma, J. R., and Zhao, Y. 2017. Optimization of enzyme-assisted extraction of carotenoids antioxidants from Cordyceps militaris using response surface methodology. Int. J. Food Eng. 13:10. Wang, J., Liu, Y. M., Cao, W., Yao, K. W., Liu, Z. Q., and Guo, J. Y. 2012. Anti-inflammation and antioxidant effect of Cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats. Metab. Brain Dis. 27:159–165. Wang, X. L., and Yao, Y. J. 2011. Host insect species of Ophiocordyceps sinensis: a review. ZooKeys 127:43–59. Wang, Y., Guo, Y., Zhang, L., and Wu, J. 2012. Characterizations of a new Cordyceps cicadae isolate and production of adenosine and cordycepin. Braz. J. Microbiol. 43:449–455. Wang, Y. W., Hong, T. W., Tai, Y. L., Wang, Y. J., Tsai, S. H., Pham, K. L. T., Chou, T. H., Lai, J. Y., Chu, R., Ding, S. T., Irie, K., Li, T. K., Tzean, S. S., and Shen, T. L. 2015. Evaluation of an epitypified Ophiocordyceps formosana (Cordyceps s. l.) for its pharmacological potential. Evid. Based Complement Alternat. Med. Wang, Z. N. 1988. Imperfect state of three Cordyceps fungi from Taiwan and their pathogenicity to some insects. Report of the Taiwan Sugar Research Institute 121:17–27 Wei, D. P., Wanasinghe, D. N., Hyde, K. D., Mortimer, P. E., Xu, J., Xiao, Y. P., Bhunjun C. S. and To-anun, C. 2019. The genus Simplicillium. MycoKeys 60:69–92. Wong, Y. Y., Moon, A., Duffin, R., Barthet-Barateig, A., Meijer, H. A., Clemens, M. J., and de Moor, C. H. 2010. Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. J. Biol. Chem. 285:2610–2621. Wong, J. H., Ng, T. B., Wang, H., Sze, S. C. W., Zhang, K. Y., Li, Q., and Lu, X. 2011. Cordymin, an antifungal peptide from the medicinal fungus Cordyceps militaris. Phytomedicine 18:387–392. Yadav, M., Yadav, A., and Yadav, J. P. 2014. In vitro antioxidant activity and total phenolic content of endophytic fungi isolated from Eugenia jambolana Lam. Asian Pac. J. Trop. Med. 7:S256–S261. Yalin, W., Ishurd, O., Cuirong, S., and Yuanjiang, P. 2005. Structure analysis and antitumor activity of (1→ 3)-β-D-glucans (cordyglucans) from the mycelia of Cordyceps sinensis. Planta Med. 71:381–384. Yang, T., and Dong, C. 2011. Cordycepin research and exploitation: progress and problems. Mycosystema 30:180–190. Yoon, S. Y., Park, S. J., and Park, Y. J. 2018. The anticancer properties of cordycepin and their underlying mechanisms. Int. J. Mol. Sci. 19:3027. Yu, R., Song, L., Zhao, Y., Bin, W., Wang, L., Zhang, H., Wu, Y., Ye, W., nd Yao, X. 2004. Isolation and biological properties of polysaccharide CPS-1 from cultured Cordyceps militaris. Fitoterapia, 75:465–472. Yu, R., Yang, W., Song, L., Yan, C., Zhang, Z., and Zhao, Y. 2007. Structural characterization and antioxidant activity of a polysaccharide from the fruiting bodies of cultured Cordyceps militaris. Carbohydr. Polym. 70:430–436. Yuan, J. P., Wang, J. H., Liu, X., Kuang, H. C., and Zhao, S. Y. 2007. Simultaneous determination of free ergosterol and ergosteryl esters in Cordyceps sinensis by HPLC. Food Chem. 105:1755–1759. Zare, R., Gams, W. J. N. H. 2001. A revision of Verticillium section Prostrata. IV. The genera Lecanicillium and Simplicillium gen. nov. Nova Hedwigia 73:1–50. Zha, L. S., Wen, T. C., Huang, S. K., Boonmee, S., and Eungwanichayapant, P. D. 2019. Taxonomy and biology of Cordyceps qingchengensis sp. nov. and its allies. Phytotaxa 416:14–24. Zhang, H., Wu, W., Chen, W., Gao, X., and Tang, L. 2006. Comparative analysis of cordycepin and adenosine contents in fermentation supernatants between Aspergillus nidulans and Cordyceps militaris. Acta Agriculturae Shanghai 22:28. Zhang, J., Yu, Y., Zhang, Z., Ding, Y., Dai, X., and Li, Y. 2011. Effect of polysaccharide from cultured Cordyceps sinensis on immune function and anti-oxidation activity of mice exposed to 60Co. Int. Immunopharmacol. 11:2251–2257. Zhang, Y., Li, E., Wang, C., Li, Y., and Liu, X. 2012. Ophiocordyceps sinensis, the flagship fungus of China: terminology, life strategy and ecology. Mycology 3:2–10. Zhou, X., Gong, Z., Su, Y., Lin, J., and Tang, K. 2009. Cordyceps fungi: natural products, pharmacological functions and developmental products. J. Pharm. Pharmacol. 61:279–291. Zhou, X., Luo, L., Dressel, W., Shadier, G., Krumbiegel, D., Schmidtke, P., Zepp, F., and Meyer, C. U. 2008. Cordycepin is an immunoregulatory active ingredient of Cordyceps sinensis. Am. J. Chin. Med. 36:967–980. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78237 | - |
dc.description.abstract | 蟲草屬類群(Cordyceps-like)真菌廣泛地作為藥用用途或食品添加劑,在中華歷史及西藏中草藥文化中,作為珍貴藥材享譽盛名。一般而言,蟲草屬類群真菌可透過以下特點與其他真菌進行區分:柄狀子囊座、子囊殼排列方式、子囊的形態特徵及寄主。臺灣有關蟲草屬(Cordyceps)真菌之相關研究屈指可數並零星散佈於歷史文獻中。蟲草屬真菌能產生各式生物活性物質,例如: 蟲草素(Cordycepin)、腺苷(Adenosine)和各種酵素,也因此蟲草屬真菌常作為增能劑與民俗藥物,在傳統中醫學中更被認為有利於癌症與糖尿病的治療。本研究目的有三: (一)依據形態與親緣演化評估台灣地區之蟲草屬真菌之自然分類地位。(二)透過高效液相層析儀探討台灣蟲草屬真菌之菌絲溫水萃取液之蟲草素與腺苷含量。(三)比較台灣地區新採集之蟲草屬真菌與市面商用菌株之蟲草素與腺苷含量。研究期間,於臺灣各處採集共獲59株蟲草屬菌株,並於採後進行形態構造紀錄。利用單對與合併的基因序列片段(nrLSU、ITS、tef1-α、rpb1、rpb2)進行親源演化分析並評估自然分類地位。結合親源演化分析與形態鑑定,共發現七種蟲草屬新種(Cordyceps sp. nov. 1–7)與四隻蟲草屬新紀錄種(C. blackwelliae、C. lepidopterorum、C. jakajanicola與C. rosea)。同時,我們還描述了C. rosea完整世代的型態。高效液相層析結果表示所有新採集之蟲草屬菌株皆會產生腺苷。然而,只有三種蟲草屬真菌具有產生蟲草素的能力,分別為C. militaris、Cordyceps sp. nov. 4 (NTUCC 18-144)與Cordyceps sp. nov. 7 (NTUCC 18-145)。此外,我們的結果指出新採集之C. militaris (NTUCC 18-120) 比市售菌株具有更強的蟲草素生合成能力。 | zh_TW |
dc.description.abstract | Cordyceps-like taxa are widely used for medicinal purpose or food additives and have been described as precious herbal medicine in ancient Chinese history and Tibetan social community. Generally, Cordyceps taxa are characterized by well-developed often stipitate stromata, arrangement of perithecia, ascospore morphology and host affiliation. Knowledge of the Cordyceps species in Taiwan is based on relatively few records that are scattered throughout the literature. Cordyceps species produce various bioactive compounds, such as cordycepin, adenosine and enzymes, which have been widely used as energizers and folk medicines that can be conducive to cancer and diabetes treatments in traditional Chinese medicines. The main purposes of this study were 1) to evaluate the natural classification of Cordyceps species in Taiwan based on morphology and phylogeny, 2) to investigate cordycepin and adenosine production of Cordyceps species in Taiwan by high-performance liquid chromatography (HPLC) based on the hot-water extract from its mycelium, 3) to compare the level of cordycepin production of the newly collected Taiwan Cordyceps isolates with commercially available Cordyceps species. A total of 59 fresh Cordyceps strains were collected and their morphological characteristics were recorded. Phylogenetic reconstruction using single and multi-loci (nrLSU+ITS+tef1-α+rpb1+rpb2) DNA sequences data were used to evaluate the natural classification of the new strains. Within this phylogenetic framework and considering the diagnostic morphological characters, seven new species (Cordyceps sp. nov. 1–7) were described. In addition, four new records, namely (C. blackwelliae, C. lepidopterorum, C. jakajanicola and C. rosea) were also made. Furthermore, we illustrated the holomorph of C. rosea for the first time. The results of our HPLC analyses showed that all isolates used in this study produced adenosine. However, only three Cordyceps species, namely C. militaris, Cordyceps sp. nov. 4 (NTUCC 18-144) and Cordyceps sp. nov.7 (NTUCC 18-145) proposed in this study were able to produce cordycepin. Moreover, our results indicated that C. militaris (NTUCC 18-120) collected in this study, produced a higher level of cordycepin compared to commercially available Ophiocordyceps sinensis and C. militaris. | en |
dc.description.provenance | Made available in DSpace on 2021-07-11T14:47:15Z (GMT). No. of bitstreams: 1 U0001-1308202013235100.pdf: 7556152 bytes, checksum: 3ca0f2581833a3cec1a5e5d71156515f (MD5) Previous issue date: 2020 | en |
dc.description.tableofcontents | ACKNOWLEDGEMENTS I 摘要 III ABSTRACT IV LIST OF TABLES VIII LIST OF FIGURES IX CHAPTER ONE: LITERATURE REVIEW 1 Historical outline 1 Molecular studies and modern classification 8 Pharmacological implications of Cordyceps sensu lato 11 Adenosine and Cordycepin compounds 15 CHAPTER TWO: PHYLOGENY AND TAXONOMY 21 Introduction 21 Materials and methods 24 Fungal collecting, isolation and morphological examination 24 DNA extraction and PCR amplification 26 Phylogenetic analyses 29 Results 39 Distribution and fungal isolations 39 Phylogeny 42 Taxonomy 43 Discussions 82 CHAPTER THREE: IDENTIFICATION OF CORDYCEPIN AND ADENOSINE FROM THE Cordyceps spp. IN TAIWAN 86 Introduction 86 Materials and methods 88 Fungal extract preparation 88 HPLC detection 89 Statistical analyses 90 Results 90 Detection and identification of concentrations of Adenosine and Cordycepin 90 Discussion 99 GENERAL CONCLUSION 101 REFERENCES 103 APPENDIX 124 APPENDIX A: Single-gene phylogenetic tree 124 APPENDIX B: Chromatogram of 51 Cordyceps and 1 Ophiocordyceps sinensis 129 APPENDIX C: Media composition 133 APPENDIX D: Sequences of newly introduced Cordyceps species in this study. 136 | |
dc.language.iso | en | |
dc.title | 臺灣蟲草屬真菌之類緣關係及生物活性物質之研究 | zh_TW |
dc.title | Phylogeny of Cordyceps species and their bioactive compounds study in Taiwan | en |
dc.type | Thesis | |
dc.date.schoolyear | 108-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 曾顯雄(Shean-Shong Tzean),沈湯龍(Tang-Long Shen),彭家禮(Ka-Lai Pang),謝松源(Sung-Yuan Hsieh) | |
dc.subject.keyword | 蟲草屬,新種,親緣關係,蟲草素,腺苷, | zh_TW |
dc.subject.keyword | Adenosine,Cordycepin,Cordyceps,Novel species,Phylogeny, | en |
dc.relation.page | 160 | |
dc.identifier.doi | 10.6342/NTU202003233 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2020-08-18 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 植物病理與微生物學研究所 | zh_TW |
顯示於系所單位: | 植物病理與微生物學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
U0001-1308202013235100.pdf 目前未授權公開取用 | 7.38 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。