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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 林璧鳳 | |
dc.contributor.author | Xiang-Lin Koh | en |
dc.contributor.author | 辜祥霖 | zh_TW |
dc.date.accessioned | 2021-07-11T14:43:23Z | - |
dc.date.available | 2021-11-02 | |
dc.date.copyright | 2016-11-02 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-08-11 | |
dc.identifier.citation | 黃子倩 (2013),營養素及飲食因子對腸道免疫系統的影響,國立台灣大學生化科技學系 碩士論文
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78136 | - |
dc.description.abstract | 台灣的末期腎臟病發生率自2001年十年以上排名世界之冠,現代化生活的飲食型態趨向於高油低蔬果,是否葉酸營養會影響腎健康議題值得探討。有研究指出人體血液葉酸含量與慢性腎衰竭發生率呈負相關,因此,本研究探討葉酸對高油誘發肥胖小鼠的腎臟之影響。實驗方法先以不同葉酸含量培養小鼠腎間膈細胞株MES-13,測定細胞分泌促發炎細胞激素的含量是否受葉酸缺乏影響,並且分析高油誘發肥胖小鼠的腎臟發炎相關基因表現與葉酸的相關性。進而以實驗動物,分別給C57BL/6J公鼠正常油脂 (NF-f1) 組與不同葉酸含量的高油飲食:葉酸缺乏組(HF-f0)、葉酸1倍組(HF-f1)與葉酸10倍組(HF-f10),分組餵飼48週時給予馬兜鈴酸三週後犧牲,測定血液、脾臟與腎臟發炎細胞激素和促纖維化指標TGF-β與galectin-3、及腎臟組織切片觀察。結果顯示,小鼠腎間膈細胞株MES13在LPS (lipopolysaccharide)刺激下,葉酸缺乏時,顯著分泌較高的IL-6與MCP-1。高油誘發肥胖小鼠之腎臟Il-6基因表現量,也與血液葉酸含量呈負相關 (r=-0.69, p=0.002),顯示葉酸缺乏可能促進腎臟發炎反應。並且,葉酸缺乏的高油肥胖小鼠HF-f0組有顯著較高的發炎性細胞激素例如血清IL-6,以及顯著的促纖維化指標,包括血清和腎臟galectin-3含量、血清與腎臟以及脾臟細胞分泌的TGF-β含量。此外, HF-f0組也有顯著較高的尿蛋白比值、腎病理組織染色的腎絲球面積較大、細胞浸潤較多、以及基底膜增厚的現象。綜合以上結果顯示,葉酸缺乏可能促進高油誘發肥胖小鼠的發炎反應與腎臟纖維化進展。 | zh_TW |
dc.description.abstract | End-stage renal disease in Taiwan had the highest prevalence in the world for more than ten years since 2001. To study whether the folate status in high-fat diets with low vegetables and fruits intake in industrialized countries, which may be related to kidney disease. It has been reported that there was a negative correlation between human serum folate concentration and chronic kidney failure. This study aimed to investigate the effects of folate deficiency on kidney in high-fat diet mice. First, MES-13 mesangial cells were used to investigate the influence of different folate status on the secretion of pro-inflammatory cytokines in vitro. Also, analysing the correlation between renal gene expression of inflammation-related cytokines and serum folate concentration in high-fat fed mice. Next, C57BL/6 male mice fed with normal-fat diet (NF-f1) and high-fat diet were divided into three groups randomly: no folate (HF-f0) as folate deficient group, 2 mg folate/kg diet as a control group (HF-f1), and 20 mg folate/kg diet as high folate group (HF-f10). Mice were sacrificed at week 51 after giving 3 weeks aristolochic acid in the high-fat diet and analyzed (1) Cytokines from blood, splenocytes, kidney, and (2) TGF-β, galectin-3 from blood, kidney, (3) Histological sections of the kidney. Results indicated that folate deficiency group had higher secretion of IL-6 and MCP-1 in LPS stimulated MES-13. There was a negative correlation between serum folate concentration and renal il-6 mRNA gene expression in 20 weeks high-fat diet mice (r=-0.69, p=0.002). Also, folate deficiency group had higher serum IL-6, galectin-3 in blood and kidney, TGF-β in blood, splenocytes, kidney and had higher urine protein/creatinine ratio, In addition, glomerular sections were expanded, elevated cellular infiltration and glomerular basement membrane expansion in the folate deficiency group. In conclusion, folate deficiency may promote the inflammatory response and renal fibrosis progression. | en |
dc.description.provenance | Made available in DSpace on 2021-07-11T14:43:23Z (GMT). No. of bitstreams: 1 ntu-105-R03b22054-1.pdf: 3728760 bytes, checksum: f8d7ba71e353cbf17f383bbab6003f07 (MD5) Previous issue date: 2016 | en |
dc.description.tableofcontents | 目錄
摘要 i Abstract ii 圖目錄 v 表目錄 vi 縮寫對照表 vii 第一章、緒論 1 第一節 文獻回顧 1 一、慢性腎臟疾病 1 二、肥胖 9 三、葉酸 11 第二節、研究動機與架構 14 第二章、葉酸含量對腎間膈細胞MES-13與高油飲食小鼠腎臟促發炎細胞激素基因表現量的影響 17 第一節、前言 17 第二節、材料與方法 18 一、細胞實驗 18 二、動物飼養 19 三、腎間膈細胞之細胞激素測定 20 四、腎臟組織基因表現量分析 22 五、統計方法 24 第三節、結果與討論 25 (一) 葉酸含量對MES-13小鼠腎間膈細胞分泌細胞激素的影響 25 (二) 葉酸含量對小鼠腎臟發炎與纖維化相關細胞激素基因表現量的影響 26 第三章、葉酸含量對高油飲食小鼠腎損傷的影響 31 第一節、前言 31 第二節、材料與方法 32 一、動物飼養 32 二、血清葉酸濃度測定 33 三、血糖分析 35 四、血脂質分析 35 五、肝臟脂質萃取與測定 36 六、血液與腎臟組織galectin-3含量測定 36 七、組織細胞單離培養 36 八、組織、血清與細胞之細胞激素測定 37 九、尿液creatinine含量測定 38 十、尿液或腎臟組織蛋白質測定 38 十一、血清BUN測定 39 十二、組織染色切片 39 十三、統計方法 39 第三節、結果與討論 40 (實驗一) 40 (一) 不同葉酸含量之高油飲食小鼠添加AA後的體重與生命期 40 (二) 不同葉酸含量高油飲食小鼠添加AA後的腎臟損傷情形 43 (三) 不同葉酸含量高油飲食小鼠添加AA後的肝臟脂質代謝情形 46 (實驗二) 48 (一) 高油飲食小鼠體重與器官重量 48 (二) 小鼠禁食血糖、血脂及血清葉酸含量 51 (三) 高油飲食小鼠的尿蛋白比值 52 (四) 小鼠血清發炎和纖維化指標以及肌酸酐的含量 53 (五) 小鼠腎臟細胞激素含量與組織切片染色 54 (六) 小鼠脾臟細胞和腹腔細胞分泌細胞激素的能力 56 (七) 小鼠血清葉酸與腎損傷指標的相關性 60 第四章、綜合討論與總結 64 第五章、參考文獻 67 附錄 74 | |
dc.language.iso | zh-TW | |
dc.title | 不同葉酸含量對高油飲食小鼠腎臟的影響 | zh_TW |
dc.title | Effects of high-fat diet and folate status on kidney | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 江伯倫,林水龍,江孟燦,謝佳倩 | |
dc.subject.keyword | 高油誘發肥胖,葉酸缺乏,腎臟纖維化,TGF-β,galectin-3, | zh_TW |
dc.subject.keyword | high-fat-diet induced obesity,folate deficiency,renal fibrosis,TGF-β,galectin-3, | en |
dc.relation.page | 75 | |
dc.identifier.doi | 10.6342/NTU201602312 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2016-08-11 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 生化科技學系 | zh_TW |
顯示於系所單位: | 生化科技學系 |
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