請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78045完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 邱文英(Wen-Yin Chiu) | |
| dc.contributor.author | Mei-Fei Lin | en |
| dc.contributor.author | 林美斐 | zh_TW |
| dc.date.accessioned | 2021-07-11T14:40:34Z | - |
| dc.date.available | 2020-02-21 | |
| dc.date.copyright | 2017-02-21 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-10-25 | |
| dc.identifier.citation | 1.W. Z. Hong, R. X. Chen; “The introduction of Cosmetic Science”, 1993, 3-13.
2.J. F. Dice, “Cellular and Molecular Mechanisms of Aging”, Phys. Rev. 1993 , 73, 149. 3.L. Hayfick, “Current Theories of Biotogical Aging”, Federation Proc. 1975, 34, 9. 4.T. Dweck, “axing Natural”, SPC, 1993, 11, 37-49. 5.T. Mitsui, “New Cosmetic Science”, Elsevier 1997, 14-20. 6.I. E. Danhof, Cosm. & Toil. 1987, 102, 6, 62. 7.G. J. Arndt, Cosm. & Toil. 1987, 102, 6, 68. 8.D. F. Williams, W. H. Schmitt, Chemistry and Technology of the Cosmetics and Toiletries Industry. Frist edition, U.S.A, 1992, 20-26. 9.T. G. Polefka, Cosm. & Toil. 1989, 104, 2, 67. 10.Kunzmann, “Surfactants in Cosmetics”, 1956, 82, 747. 11.J. S. Jellinek, “Formulation and Function of Cosmetics”, U.S.A, 1974, 32-74. 12.M. M. Rieger, “Surfactants in Cosmetics” Marcel Deeker Inc, 1985. 13.J. L. Knowlton, E. M. Pearce, “Handbook of Cosmetic Science and Technology”, First edition, Elsevier Advanced Technology, UK, 1993. 14.D. C. Steinberg, Cosm. & Toil. 1992, 197, 9, 77. 15.J. J. Rogers, “Oils, Essential”, Encyclopaedia of Chemical Technology 3rd Edn. Vol.16, 307-332. 16.G. G. Bauerk, S. Surburg, “Common fragrance and Flavour Materials Preparation, properties and Users”, 2nd Edn., 1990. 17.R. Y. Uochhead, W R. Fron, “Ecyclopedia of Polymers and Thickeners for Cosmetics”, 1993,108, 5, 95. 18.J. A. Wenninger, G. N. McEwen, Jr. “lnternational Cosmetic lnqredient Dictionary” 5th Edn. CTFA, 1993. 19.B. Francis, J. soc. Cosmet. Chem., 1963, 14,117. 20.W. P. Smith, Cosm. & Toil. 1994, 109, 9, 41. 21.A. C. Dweck, Cosm. & Toil. 1992, 197, 5, 89. 22.H. Moller, A. Ansmann, A. Wallat, Fat Sci Technol. 1989, 91 295-305. 23.R. Record, I. E. Dreosti, M. Konstantinopoulos, R. A. Buckley, Nutr Cancer. 1991, 16, 219-225. 24.E. Niki, Free Radical Biology and Medicine, Elsevier, 2014, 66, 3–12. 25.F. Lucas, J. T. B. Shaw, S. G. Smith, The sillk fibroins, in Advances in Protein Chemistry XIII, CB Anfinsen et al, eds. New York:Academic Press lnc, 1958, 107-242. 26.R. Marks, D. Black, I. Hamani, A. Caunt, R. J. Marshal, Br. J. Dermatol 111, 1984, 265-270. 27.B. D. Ridge, M. D. Batt, H. E. Palmer, and A. Jarrett, Br. J. Dermatol., 1988,118, 164-174. 28.M. L. Groves, J. Am. Chem. Soc. 1960, 82(13), 3345-3350. 29.S. Jalkanen, M. Perola, O. Raitakari, V. Salomaa, M. Ala-Korpela, Cell systems, 2015, 1, 4, 293–301. 30.N. Naidu, “Lactoferrin: Natural-Multifunctional-Antimicrobial”, CRC Press 2000. 31.L. Adlerova, A. Bartoskova, M. Faldyna, “Lactoferrin: a review, Veterinarni Medicina”, 2008, 53, 9, 457-468. 32.Y. A. Suzuki, V. Lopez, B. Lönnerda, Cellular and Molecular Life Sci., 2005, 62, 2560. 33.B. W. A. Van der Strate, L. Beljaars, G. Molema, M. C. Harmsen, D. K. F. Meijer, Antiviral Res., 2001, 52, 3, 225-239. 34.H. Wakabayashi, K. Uchida, K. Yamauchi, S. Teraguchi, H. Hayasawa, H. Yamaguchi, J. Antimicrob. Agents Chemother. 2000, 46, 4, 595-602. 35.K. Hu, Y. Shi, W. Jiang, J. Hana, S. Huang, X. Jiang, International J. Pharma., 2011, 415, 273– 283. 36.C. Bengoechea , I. Peinado, D. J. McClements, Food Hydrocolloids, 25, 5, 2011, 1354–1360. 37.V. M. Balcão, C. I. Costa, C. M. Matos, C. G. Moutinho, M. Amorim, M. E. Pintado, A. P. Gomes, M. M. Vila, J. A. Teixeira, Food Hydrocolloids, 2013, 32, 2, 425–431. 38.楊仲平，博士論文，嘉南藥理科技大學：化妝品科技研究所,民國97年。 39.陳紀慶、謝昌衛、易光輝，弘光學報，2012，67期 40.陳彙淳, 博士論文， 嘉南藥理科技大學：化妝品科技研究所，民國99年。 41.徐珮清、陳崇裕，美容科技學刊；2009，6，1，119–143。 42.J. W. Lin, H. M. Chiang, Y. C. Lin, K. C. Wen, Journal of Food and Drug Analysis, 2008, 16, 2 . 43.J. H. Ryu, J. K. Seok, S. M. An, J. H. Baek, J. S. Koh, Y. C. Boo, Archives of Dermatological Research, 2015, 307, 3, 239–247. 44.S. S. Davis, J. Hadgraft, K. J. Palin, P. Becher, “Encyclopedia of emulsion technology”, 1985, 2, 159. 45.M. Frenkel, R. Shwartz, N. Garti, J. Colloid Interface Sci. 1983, 94, 1, 174-178. 46.M. H. Lee, S. G. Oh, S. K. Moon, S. Y. Bae, J. Colloid Interface Sci. 2001, 240, 1, 83-89. 47.C. M. Chang, R. Bodmeier, Int. J. Pharm. 1996, 130, 2, 187-194. 48.M. F. Ficheux, L. Bonakdar, F. Leal-Calderon, J. Bibette, “Food Emulsions”, 1998, 14, 10, 2702-2706. 49.C. H. Villa, L. B. Lawson, Y. Li, K. D. Papadopoulos, Langmuir, “Encyclopedia of Surface and Colloid Science”, 2003, 19, 2, 244-249. 50.S. Benita, J. P. Benoit, F. Puisieux, C. Thies, J. Pharm. Sci., 1984, 73,12, 1721-1724. 51.Y. Y. Yang, T. S. Chung, N. P. Ng, Biomaterials, 2001, 22, 3, 231-241. 52.N. Nihant, C. Grandfils, R. Jérôme, P. Teyssie, J. Controlled Release, 1995, 35, 2, 117-125. 53.W. Hou, K. D. Papadopoulos, Chemical Engin. Sci., 1996, 51, 22, 5043-5051. 54.W. Hou, K. D. Papadopoulos, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 1997,125, 181-187. 55.A. S. Cunha, M. Cheron, J. L. Grossiord, F. Puisieux, M. Seiller, International J. Pharma., 1998, 169, 1, 33-44. 56. C. Y. Lin, K. H. Wang, Fuel, 2003, 82, 11, 1367–1375. 57.M. S. Gamal, M. M. Elshafei, E. H. Said, A.E. Attia, T. G. M. Mohammed, Industrial Crops and Products, 2010, 31, 1, 99–106. 58.J. Pan, Y. Yin, M. Gan, M. Meng, X. Dai , R. Wu, W. Shi, Y. Yan, Chemical Engineering Journal, 2015, 266, 0, 299-308. 59.R. Lutz, A. Aserin, Wiley, 2008, 85-120. 60.A. Y. Khan , S. Talegaonkar , Z. Iqbal , F. J. Ahmed , R. K. Khar, Current Drug Delivery, 2006, 3, 429-443. 61.Figiel, Chemical Engineering Research and Design, 2007, 85, 5, 730-734. 62.J. C. Francisco, Food Research International, 2013, 52, 1, 64–74. 63.N. Prichapan, U. Klinkesorn, Songklanakarin J. Sci. Tec., 2014, 26, 6, 651-661. 64.L. Bahloul, F. Bendebane, M. Djenouhat, H. Meradi, F. Ismail, J. Taiwan Institute of Chemical Engineers, 2016, 59, 26–32. 65.莊仲揚，博士論文，國立臺灣大學高分子科學與工程學研究所，民國九十九年七月。 66.H. G. Schild, Prog. Polym. Sci., 1992, 17, 163-249. 67.T. Aoyagi, M. Ebara, K. Sakai, Y. Sakurai, T. Okano. J. Biomater. Sci., Polym. Ed. 2000, 1, 101-110. 68.T. Aoki, M. Muramatsu, T. Torii, K. Sanui, N. Ogata, Macromolecules, 2001, 34, 3118-3119. 69.L. H. Gan, Y.Y. Gan, G. R. Deen. Macromolecules, 2000, 33, 7893-7897. 70.L. H. Gan, G. R. Deen, X. J. Loh, Y. Y. Gan. Polymer, 2001, 42, 65-69. 71.E. S. Gil, S. M. Hudson, Prog. Polym. Sci., 2004, 29, 1173-1222. 72.H. G. Schild, Prog. Polym. Sci., 1992,17, 163-249. 73.M. Annaka, C. Tanaka, T. Nakahira, M. Sugiyama, T. Aoyagi, T. Okano, Macromolecules, 2002, 35, 8173-8179. 74.R. Yoshida, K. Uchida, Y. Kaneko, K. Sakai, A. Kikuchi, Y. Sakurai, T. Okano, Nature, 1995, 374, 240-242. 75.M. Matsukata, T. Aoki, K. Sanui, N. Ogata, A. Kikuchi, Y. Sakurai, T. Okano, Bioconjug. Chem., 1996, 7, 96-101. 76.Y. G. Takei, T. Aoki, K. Sanui, N. Ogata, Y. Sakurai, T. Okano, Macromolecules, 1994, 27, 6163-6166. 77.Y. Kaneko, S. Nakamura, K. Sakai, T. Aoyagi, A. Kikuchi, Y. Sakurai, T. Okano, Macromolecules, 1998, 31, 6099-6105. 78.W. Tscharnuter, Photon correlation spectroscopy in particle sizing, “Encyclopedia of analytical chemistry”, 2000. 79.W. Y. Chiu, T. M. Don, J. Applied Polym. Sci., 1989, 37, 10, 2973-2986. 80. C. H. Wildemuth and M. C. Williams, Rheol. Acta, 1984, 23, 627. 81.J. Happel, H. Brenner, Low Reynolds Number Hydrodyunamics, Prentice-Hall, Englewood Cliffa, NJ, 1965. 82.J. Hu, H. Meng, G. Li, S. I. Ibckwe. Smarl Mater. Strucl. 2012, 21, 05301. 83.B. Jeong, A. Gutowska, Trends Biotechnol. 2002, 20, 305-311. 84.R. Gomes, D. Azevedo, L. P. N. Rebelo, A. M. Ramos, J. Szydlowski, H. C. de Sousa, J. Klein. Fluid Phase Equilib. 2001, 185, 189-198. 85.J. T. Zhang, S. Petersen, M. Thunga, E. Leipold, R. Weidisch, X. Liu, A. fahr, K. D. Jandt, Actd Biomater., 2010, 6, 1297-1306. 86.X. Z. Zhang, D. Q.Wu, C. C. Chu, Biomaterials, 2004, 25, 3793-3805. 87.林佳龍，博士論文，國立台灣大學材料科學與工程學研究所，民國九十四年七月。 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78045 | - |
| dc.description.abstract | 本研究主要以乳鐵蛋白作為化粧品的機能性有效成份，採用多重乳化法(W1/O/W2)研發乳化之皮膚保養品。
本論文分成三部分，第一部分是第四章，本章描述以多重乳化法(W1/O/W2) 製備含乳鐵蛋白的乳化產品及探討其影響乳膠顆粒性質的因素，經由FTIR、UV-Vis及測導電度儀器找尋乳化溫度，調整乳鐵蛋白的濃度、乳化溫度、攪拌速率、油相與水相成分之含量比率、油相成分中乳化劑的種類及含量、水相(W2)成分中乳化劑的含量等因素，調製出不同配方的乳化保養品。將各產品置分別裝入20ml的樣品瓶中，再分別放於4℃冰箱、室溫25℃及烘箱40℃中，觀察產品的耐候性，以TEM探討乳膠顆粒之形態，DLS (Dynamic light scattering) 探討乳膠顆粒粒徑大小及分佈，黏度計測量產品的黏度等及其性質分析。 第二部分是第五章，我們提出一個「黏度模型」描述油水混合乳化過程，乳膠顆粒結構隨時間增加的變化情形，經乳化一段時間後，乳膠顆粒結構會隨不同的變因而呈現不同的穩定狀態；乳化結束，靜置過程中，乳膠顆粒結構再度隨時間增加而變化，不久又呈現另一個不同的穩定狀態；用黏度計測黏度，所得的黏度與剪切速率值是實驗值，再設定不同的、合理的參數條件，所得的黏度與剪切速率值是理論值，從圖表說明不同乳化溫度、攪拌速率、Tween 80濃度之乳液乳霜的實驗值與理論值彼此消長情形。最後藉「黏度模型」模型解釋乳液的黏度與乳膠顆粒結構之關連性。 第三部分是第六章，我們成功地以多重乳化法(W1/O/W2)製備具溫感性的乳化產品及對其特性做分析。在外層水相(W2)中，以Poly(NIPAAm-co-MBA)溶液:去離子水=7:3取代原去離子水部分。因為乳化產品加入少許微凝膠(microgel) Poly(NIPAAm-co-MBA)而有保水的功能，相對穩定。 本研究之原創性及成果貢獻於: 一、首次以以多重乳化法(W1/O/W2) 製備含乳鐵蛋白的乳化產品，並且藉由調整乳鐵蛋白的濃度、乳化溫度、攪拌速率、油相與水相成分之含量比率、油相成分中乳化劑的種類及含量、外層水相(W2)成分中乳化劑的含量等變數，調製出不同配方的穩定乳化保養品。 二、提出一個「黏度模型」解釋乳化產品的黏度與乳膠顆粒結構之關連性。 三、利用Poly(NIPAAm-co-MBA)的溫度感應性，成功地以多重乳化法(W1/O/W2)製備具溫感性的穩定乳化產品。 | zh_TW |
| dc.description.abstract | In this study, skin-care products of double emulsion cream were synthesized via two-step emulsification process (W1/O/W2), where lactoferrin was used as a functional component in the emulsions.
There are three parts in this research. The first part is chapter 4. In Chapter 4, it showed the preparation and characterization of a novel W1/O/W2 emulsion containing lactoferrin. FT-IR, UV-Vis spectroscopy, and conductivity measuring instrument were used to determine the appropriate emulsification temperature. The influence of W1/O/W2 emulsion factors are the different concentration of lactoferrin, emulsification temperature, stirring rate, the composition ratio of oil and water, the type and content of emulsifier in oil phase, and the different concentration of emulsifier in the water phase (W2) etc.. Emulsions were then stored at three temperatures (4°C, 25°C, 40°C) to observe the stabilities of the emulsion particles. Morphology of emulsion particles, particle diameters and distributions, and viscosities of emulsions were determined by TEM images, DLS measurements, and viscometer, respectively. The second part is the fifth chapter. In chapter 5, we proposed a viscosity model to calculate theoretical value of viscosity as a function of shear rate under different emulsification temperatures (50°C, 70°C), stirring rates (600 rpm, 700 rpm), and the quantities of Tween80 in water phase (W2) (Tween80 = 1.67%, 3%) and further compared to experimental values. This viscosity model was then used to explain the correlation of viscosity and aggregation structure of emulsion particles. The third part is the sixth chapter. In chapter 6, it showed the preparation of the thermo-responsive emulsion which is in the outer water phase (W2), the weight ratio of the Poly(NIPAAm-co-MBA) solution : Deionized water = 7:3 by two-step emulsification process (W1/O/W2) and we did the analysis on its characteristics. Because the thermo-responsive emulsion with a little Poly (NIPAAm-co-MBA) microgel remained water, the emulsion was relatively stable. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-11T14:40:34Z (GMT). No. of bitstreams: 1 ntu-105-D00527008-1.pdf: 3794795 bytes, checksum: eb4b8d5392147d265d9f917fc47a96bb (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 第一章 緒論 1
第二章 文獻回顧 2 2-1 化妝品科技概論 2 2-2 機能性成份及應用 7 2-2-1乳鐵蛋白的功能及應用 7 2-2-2 其他機能性成份及應用 8 2-3 乳液或乳霜的製造技術 10 2-4 多重乳化法 12 2-5溫度敏感型高分子材料簡介 13 第三章 實驗藥品與實驗儀器 16 3-1 實驗藥品 16 3-2 實驗儀器 22 第四章 以乳鐵蛋白作為機能性有效成份製備乳化保養品和探討影響產品因素及其特性分析 24 4-1 簡介 24 4-2實驗流程 25 4-3 實驗方法 25 4-3-1 產品的製備 25 4-3-1-1 乳鐵蛋白水溶液的製備 25 4-3-1-2 W1/O/W2乳化產品的製備 26 4-3-1-3 找尋適合的乳化溫度 26 4-3-1-4 油相材料的熔點 28 4-3-2 特性分析 28 4-3-2-1 耐候性 28 4-3-2-2 乳膠顆粒粒徑大小及分佈 28 4-3-2-3 乳膠顆粒的形態 29 4-3-2-4 乳化產品的黏度 29 4-4 結果與討論 29 4-4-1乳化溫度 29 4-4-2 油相材料的熔點 32 4-4-3 乳鐵蛋白濃度對乳化產品中乳膠顆粒性質的影響 33 4-4-3-1 耐候性 33 4-4-3-2 產品乳膠顆粒之形態(TEM) 34 4-4-3-3 黏度分析 36 4-4-4 乳化溫度對乳化產品中乳膠顆粒性質的影響 38 4-4-4-1 耐候性 38 4-4-4-2 乳膠顆粒之形態、粒徑大小及分佈(TEM & DLS) 39 4-4-4-3 黏度分析 39 4-4-5 攪拌速率對乳化產品中乳膠顆粒性質的影響 42 4-4-5-1 耐候性 42 4-4-5-2 乳膠顆粒之形態、粒徑大小及分佈(TEM & DLS) 43 4-4-5-3 黏度分析 44 4-4-6 油相與水相成分之含量比率對乳化產品顆粒性質的影響 46 4-4-6-1 耐候性 46 4-4-6-2 乳膠顆粒之粒徑大小及分佈(DLS) 48 4-4-6-3 黏度分析 49 4-4-7 油相成分中乳化劑的種類及含量對乳化產品中乳膠顆粒性質的影響 50 4-4-7-1 耐候性 50 4-4-7-2 乳膠顆粒之粒徑大小及分佈(DLS) 51 4-4-7-3 黏度分析 53 4-4-8 水相成分(W2)中乳化劑的含量對乳化產品中乳膠顆粒性質的影響 54 4-4-8-1 耐候性 54 4-4-8-2 乳膠顆粒之形態、粒徑大小及分佈(TEM & DLS) 55 4-4-8-3 黏度分析 57 4-5 結論 58 第五章 乳化產品之黏度 60 5-1 簡介 60 5-2 黏度模型 61 5-2-1 基本原理 61 5-2-2 黏度模型 62 5-3 結果與討論 63 5-3-1 乳化階段 64 5-3-2 靜置階段 66 5-3-3 使用黏度計測黏度(25℃) 67 5-4 結論 71 第六章 多重乳化法W1/O/W2製備具溫感性的乳液或乳霜及其特性分析 72 6-1 簡介 72 6-2 實驗 73 6-2-1 智慧型微凝膠的製備 73 6-2-2 具溫感性乳液或乳霜的製備 73 6-2-3 性質分析 75 6-2-3-1 最低臨界溶液溫度(LCST;Lower Critical Solution Temperature) 75 6-2-3-2 微凝膠(microgel)的結構分析 76 6-2-3-3 保水率 76 6-2-3-4 粒徑大小及分佈檢定 76 6-2-3-5 溫感性的乳液或乳霜乳膠顆粒的形態觀察 76 6-2-3-6 乳化產品的黏度 77 6-3 結果與討論 77 6-3-1 微凝膠(microgel)的性質分析 77 6-3-1-1 微凝膠Poly(NIPAAm-co-MBA) (microgel)的結構分析 77 6-3-1-2 微凝膠(microgel)的LCST 78 6-3-2 溫感性乳液或乳霜的LCST 79 6-3-2溫感性乳液或乳霜的耐候性 82 6-3-3 溫感性乳液或乳霜的保水率 82 6-3-4 溫感性乳液或乳霜的形態、粒徑大小及分布 83 6-3-5 溫感性乳液或乳霜的黏度 85 6-4 結論 89 第七章 結論 90 第八章 參考文獻 92 | |
| dc.language.iso | zh-TW | |
| dc.subject | W1/O/W2 | zh_TW |
| dc.subject | 多重乳化法 | zh_TW |
| dc.subject | 黏度模型 | zh_TW |
| dc.subject | 微凝膠(microgel) | zh_TW |
| dc.subject | 溫感性的乳化產品 | zh_TW |
| dc.subject | (W1/O/W2) | en |
| dc.subject | two-step emulsification process | en |
| dc.subject | microgel | en |
| dc.subject | viscosity model | en |
| dc.subject | thermo-responsive | en |
| dc.subject | emulsion | en |
| dc.title | 多重乳化法W1/O/W2製備含乳鐵蛋白的乳液或乳霜及其特性分析 | zh_TW |
| dc.title | Preparation and characterization of a novel W/O/W emulsion containing lactoferrin | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 105-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 許克瀛,廖文斌,戴子安,王勝仕,董崇民 | |
| dc.subject.keyword | 多重乳化法,W1/O/W2,黏度模型,微凝膠(microgel),溫感性的乳化產品, | zh_TW |
| dc.subject.keyword | two-step emulsification process,microgel,thermo-responsive,emulsion,(W1/O/W2),viscosity model, | en |
| dc.relation.page | 97 | |
| dc.identifier.doi | 10.6342/NTU201603703 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2016-10-25 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 材料科學與工程學研究所 | zh_TW |
| 顯示於系所單位： | 材料科學與工程學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-105-D00527008-1.pdf 未授權公開取用 | 3.71 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。