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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 蕭浩明(Hao-Ming Hsiao) | |
dc.contributor.author | Yu-Han Cheng | en |
dc.contributor.author | 鄭羽涵 | zh_TW |
dc.date.accessioned | 2021-07-11T14:38:24Z | - |
dc.date.available | 2022-08-31 | |
dc.date.copyright | 2017-08-31 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-07-26 | |
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Garcia-Garcia, et al., 'A bioabsorbable everolimus-eluting coronary stent system (ABSORB): 2-year outcomes and results from multiple imaging methods,' The Lancet, vol. 373, pp. 897-910, 2009. [35] H.-M. Hsiao, Y.-H. Chiu, K.-H. Lee, and C.-H. Lin, 'Computational modeling of effects of intravascular stent design on key mechanical and hemodynamic behavior,' Computer-Aided Design, vol. 44, pp. 757-765, 2012. [36] H.-M. Hsiao, K.-H. Lee, Y.-C. Liao, and Y.-C. Cheng, 'Cardiovascular stent design and wall shear stress distribution in coronary stented arteries,' Micro & Nano Letters, vol. 7, pp. 430-433, 2012. [37] U. F. a. D. Administration, 'Non-Clinical Engineering Tests and Recommended Labeling for Intravascular Stents and Associated Delivery Systems Document,' ed, 2010. [38] J. Grogan, S. Leen, and P. 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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/77962 | - |
dc.description.abstract | 生物可吸收式血管模架具有可以被人體吸收,不會在體內留下永久金屬植入物的優點,預期將成為未來治療心血管疾病的趨勢;然而,生物可吸收式血管模架卻普遍有徑向支撐強度不足、回彈率偏高的問題。本研究提出兩種不同概念之自鎖式血管支架設計方向,其一是軸向的自鎖式結構設計,用以限制血管支架Crown的開合角度,其二是圓周向的自鎖式結構設計,利用圓周向的結構變化使血管支架固定在特定直徑。為了提升徑向支撐強度、降低回彈率,本研究希望從血管支架的設計端來改善,並且進行有限元素分析模擬自鎖式血管支架的機械行為,探討設計樣式及材料對自鎖式血管支架機械性質的影響,使用的材料為鈷鉻合金以及聚乳酸。研究結果顯示以圓周向設計的自鎖式結構表現較佳;而機械性質在不同材料上,會產生不同程度的影響,以聚乳酸為材料的自鎖式血管模架所受自鎖式結構的影響較大。本研究所提出的兩種設計概念皆有其可行性,有望改善生物可吸收式血管模架的徑向支撐強度,希望能提供後繼者設計自鎖式血管支架之參考,以進行最佳化設計,為高階醫療器材的開發盡一份心力。 | zh_TW |
dc.description.abstract | Bioresorbable vascular scaffolds offer the possibility of transient scaffolding of the vessel to prevent acute vessel closure and restenosis, which are a tendency of stent treatment. However, bioresorbable vascular scaffolds have weaker radial strength and higher expansion recoil. This problem is sure to be solved with self-locking stents. In this study, there are two design concepts of self-locking mechanism. One is designed to constrain the open and close movement of crowns. The other is designed to fix stent diameter in θ direction. In order to improve radial strength and reduce expansion recoil, it is self-locking mechanism that achieve these goals. In this study, finite element models were developed to investigate the mechanical behaviors of self-locking stents. Computational simulations were performed on different design patterns assigned with two different materials, quantifying individual effects of the self-locking design patterns and materials on the mechanical performance of self-locking stents. In the finite element model, Co-Cr alloy and PLA were used. Simulation results show that the design concept of θ-direction has better performances, and the material properties plays the most significant role in self-locking stents. These two design concepts are both feasible to enhance the mechanical behaviors of self-locking stents. This study provides great insight for the future self-locking design optimization. | en |
dc.description.provenance | Made available in DSpace on 2021-07-11T14:38:24Z (GMT). No. of bitstreams: 1 ntu-106-R04522805-1.pdf: 9153340 bytes, checksum: e9fb548241621bbb099f282e1e35ff80 (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 口試委員審定書 i
誌謝 ii 中文摘要 iii 英文摘要 iv 目錄 v 圖目錄 viii 表目錄 xi 1 第一章 緒論 1 1.1 前言 1 1.1.1 心血管疾病及治療方法 1 1.1.2 血管支架簡介 2 1.1.3 血管支架之設計與製造 3 1.2 研究動機與目的 4 1.3 研究內容 5 2 第二章 文獻回顧 6 2.1 血管支架之有限元素分析 6 2.2 生物可吸收式材料簡介 6 2.3 生物可吸收式血管模架 8 2.3.1 生物可吸收式血管模架之優勢 8 2.3.2 生物可吸收式血管模架簡介 9 3 第三章 研究方法 11 3.1 自鎖式血管支架設計概念 11 3.1.1 血管支架基本設計 11 3.1.2 自鎖式結構發想 13 3.1.3 血管支架幾何參數 13 3.2 機械性質參考指標 15 3.2.1 等效塑性應變(Equivalent Plastic Strain, PEEQ) 15 3.2.2 徑向支撐強度(Radial Strength, RS) 16 3.2.3 擴張回彈(Expansion Recoil, ER) 16 3.2.4 疲勞安全係數(Fatigue Safety Factor, FSF) 17 3.3 有限元素分析-材料參數設定 19 3.3.1 鈷鉻合金(Co-Cr Alloy) 19 3.3.2 聚乳酸(PLA) 20 3.4 有限元素分析-機械性質測試模型設定 21 3.4.1 血管部署及徑向支撐強度測試模型 21 3.4.2 疲勞壽命測試模型 25 4 第四章 自鎖式血管支架研究結果與討論 27 4.1 基本幾何血管支架模擬結果 27 4.1.1 幾何變化 27 4.1.2 部署模擬結果 29 4.1.3 徑向支撐強度模擬結果 31 4.1.4 疲勞壽命模擬結果 33 4.2 自鎖式血管支架模擬結果 34 4.2.1 幾何變化 34 4.2.2 部署模擬結果 38 4.2.3 徑向支撐強度模擬結果 41 4.2.4 疲勞壽命模擬結果 44 4.3 綜合比較 45 4.3.1 機械性質比較 45 4.3.2 自鎖式結構血管部署結果比較 46 4.4 自鎖式血管支架雛型品製造 47 4.4.1 加工模組介紹 48 4.4.2 鈷鉻合金加工參數設定 49 4.4.3 雛型品展示 50 5 第五章 自鎖式血管模架研究結果與討論 51 5.1 基本幾何血管模架模擬結果 51 5.1.1 部署模擬結果 51 5.1.2 徑向支撐強度模擬結果 53 5.2 自鎖式血管模架模擬結果 54 5.2.1 幾何變化 54 5.2.2 部署模擬結果 56 5.2.3 徑向支撐強度模擬結果 58 5.3 綜合比較 60 5.3.1 機械性質比較 60 5.3.2 自鎖式結構血管部署結果比較 61 6 第六章 結論與未來展望 63 參考文獻 65 | |
dc.language.iso | zh-TW | |
dc.title | 自鎖式血管支架之設計概念與可行性評估 | zh_TW |
dc.title | Design Concept and Feasibility Study of Self-Locking Stents | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 李貫銘,廖洺漢 | |
dc.subject.keyword | 自鎖式血管支架,生物可吸收式血管模架,有限元素分析,徑向支撐強度,回彈率, | zh_TW |
dc.subject.keyword | Self-locking stents,Bioresorbable vascular scaffold,Finite element analysis,Radial strength,Expansion recoil, | en |
dc.relation.page | 68 | |
dc.identifier.doi | 10.6342/NTU201701857 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2017-07-27 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 機械工程學研究所 | zh_TW |
顯示於系所單位: | 機械工程學系 |
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