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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 謝旭亮(Hsu-Liang Hsieh) | |
dc.contributor.author | You-Huei Huang | en |
dc.contributor.author | 黃友慧 | zh_TW |
dc.date.accessioned | 2021-07-10T21:56:19Z | - |
dc.date.available | 2021-07-10T21:56:19Z | - |
dc.date.copyright | 2019-08-06 | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019-08-04 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/77323 | - |
dc.description.abstract | 植物透過光以及各種植物賀爾蒙協同感知外界環境變化,以促成生長與適應。在阿拉伯芥中,具有雙重功能的蛋白質FIN219/JAR1,會被遠紅光 (FR)激發並作為將茉莉酸 (JA)轉換成活化態茉莉酸-異白胺酸 (JA-isoleucine)之酵素,參與在茉莉酸訊息傳遞。為更加了解FIN219/JAR1如何調節遠紅光與茉莉酸訊息傳遞,透過微陣列分析(microarray analysis)顯示FIN219調控了許多鹼性螺旋-環-螺旋(basic helix-loop-helix, bHLH)轉錄因子的表現量。在這些被調控的基因之中,bHLH27 與bHLH51被FIN219所正調控。進一步的研究顯示,在低遠紅光、高遠紅光、藍光、紅光、白光與甚至黑暗當中,bHLH27 與bHLH51突變株的幼苗,對於外加的甲基化茉莉酸處理,表現出了與野生型相比顯著性地更低的下胚軸抑制率,顯示出bHLH27與bHLH51參與在光型態發生、暗型態發生與茉莉酸訊息傳遞當中。不僅是地上部的下胚軸延長,地下部的初級根根長的量測結果指出bHLH27與bHLH51突變株具有比野生型更短的根,顯示bHLH27與bHLH51作為初級根發育的正調控者。另外,如同對於茉莉酸抑制下胚軸較不敏感的反應,bHLH27與bHLH51突變株的也表現出了與Col-0相比,對甲基茉莉酸抑制根長現象較不敏感。此外,bHLH27與bHLH51正向調控了種子發育,兩者的突變株也有晚開花的現象。不僅如此,花青素累積、葉綠素含量以及許多茉莉酸反應的標識基因,也都受到bHLH27與bHLH51的突變、以及外加甲基茉莉酸與否的影響。這些證據都顯示,bHLH27與bHLH51參與在茉莉酸訊息傳遞鏈當中。除此之外,bHLH27與bHLH51次細胞定位位於細胞核,並具有彼此形成異型二聚體與同型二聚體的能力,這可能暗示了這兩個蛋白質、可能作為轉錄因子並透過不同結合形式調控不同目標基因。總結而言,bHLH27與bHLH51作為FIN219整合之光與茉莉酸訊息傳遞之下游因子,調控轉錄網絡與生理發育。 | zh_TW |
dc.description.abstract | Plants integrate light and several phytohormones to monitor environmental changes and accomplish growth for adaptation. In Arabidopsis, a dual function protein FIN219/JAR1 is activated by far-red (FR) light and also participates in the jasmonate (JA) signaling pathway by enzymatically converting JA to an active form JA-isoleucine. To further understand how FIN219/JAR1 mediates FR and JA signaling pathways, a microarray analysis was performed and revealed that FIN219 regulated the expression levels of many basic helix-loop-helix (bHLH) transcription factors. Among those affected genes, bHLH27 and bHLH51 were confirmed to be positively regulated by FIN219. Further studies indicated that hypocotyl length measurement of the seedlings under low FR, high FR, blue, red and white light and also in the dark, with MeJA treatments showed that bHLH27 and bHLH51 mutants exhibited significantly lower inhibition rates of hypocotyl elongation than wild type, suggesting the vital roles of bHLH27 and bHLH51 in photo- and skoto-morphogenesis and JA signaling pathways. In addition to the overground part of hypocotyl elongation, the underground root lengths were also measured. Both bhlh27 and bhlh51 mutants have much shorter root lengths than wild type, which indicates that bHLH27 and bHLH51 positively regulate primary root development. Besides, bhlh27 and bhlh51 displayed significantly lower MeJA-mediated inhibition of root elongation than Col-0, which showed a similar response of both mutants to MeJA-mediated inhibition of hypocotyl elongation. Additionally, bHLH27 and bHLH51 positively regulated seeds germination and both mutants showed a delayed flowering. Moreover, anthocyanin accumulation, chlorophyll content and several JA responsive marker genes, were all affected by bhlh27 and bhlh51 mutants with or without MeJA treatment. These results provide further evidence that bHLH27 and bHLH51 are involved in JA signaling pathways. In addition, bHLH27 and bHLH51 are localized in the nucleus and able to form not only homo- but also hetero-dimers with each other, which implies that they can act as active transcription factors and regulate their target genes in various ways. Taken together, bHLH27 and bHLH51 are important downstream components of FIN219-mediated light and JA signaling pathways in regulation of transcriptional networks and physiological development. | en |
dc.description.provenance | Made available in DSpace on 2021-07-10T21:56:19Z (GMT). No. of bitstreams: 1 ntu-108-R01b42005-1.pdf: 2979046 bytes, checksum: 571839e6226152203c9d061c69842e31 (MD5) Previous issue date: 2019 | en |
dc.description.tableofcontents | 1 Introduction 1
1.1 Light and seedling development 1 1.2 Light and jasmonate (JA) in plant growth and development 3 1.3 FIN219 (FAR-RED INSENSITIVE 219) 5 1.4 Basic helix-loop-helix (bHLH) transcription factors 6 1.5 The purpose of this study 8 2 Materials and Methods 10 2.1 Plant materials and growth conditions 10 2.2 Hypocotyl and root length measurements 11 2.3 Anthocyanin and chlorophyll content measurements 11 2.4 Flowering-time measurements 12 2.5 RNA isolation and analysis of gene expression 12 2.6 Protoplasts transfection for subcellular localization and Bimolecular Fluorescence Complementation (BiFC) Analysis 13 3 Results 15 3.1 bhlh27 and bhlh51 mutants showed longer hypocotyls than Col-0 under low FR light and less sensitive to exogenous MeJA. 15 3.2 Both bhlh27 and bhlh51 exhibited less sensitivity to MeJA-mediated inhibition of hypocotyl elongation under high FR light. 16 3.3 bhlh27 and bhlh51 mutants showed a hypersensitive short-hypocotyl phenotype under blue light and less sensitive to MeJA-mediated inhibition of hypocotyl elonation. 17 3.4 bhlh27 and bhlh51 mutants showed slightly short hypocotyls under red light and a comparable hypocotyl phenotype with Col-0 under red light with MeJA treatment 17 3.5 bhlh27 and bhlh51 mutants showed comparable hypocotyl phenotype with wild type under white light 18 3.6 bHLH27 and bHLH51 may play vital roles in the regulation of seedling development in the dark 19 3.7 bhlh27 and bhlh51 mutants showed short primary root phenotype 19 3.8 The germination of bhlh27 and bhlh 51 mutants was greatly decreased 20 3.9 bhlh27 and bhlh51 exhibited a late-flowering phenotype 20 3.10 Both bhlh27 and bhlh51 showed decreased anthocyanin accumulation under FR and FR blockage of chlorophyll greening 21 3.11 FIN219 but not COI1 differentially regulated the levels of bHLH27 and bHLH51 expression under low FR light 22 3.12 Both bhlh27 and bhlh51 resulted in a great reduction of light-responsive gene expression under low FR light 22 3.13 Both bhlh27 and bhlh51 mutants resulted in a great decrease of JA-responsive gene expression under low FR light 23 3.14 Both bhlh27 and bhlh51 mutants largely led to an increase of light-responsive gene expression under blue light 23 3.15 Both bhlh27 and bhlh51 mutants differentially affected the expression of JA-responsive genes under blue light condition 24 3.16 Both bHLH27 and bHLH5 1 are localized in the nucleus. 25 3.17 Bimolecular Fluorescence Complementation (BiFC) studies revealed that bHLH27 and bHLH51 could form homodimers as well as heterodimers 25 4 Discussion 27 5 Conclusion 31 6 References 55 | |
dc.language.iso | en | |
dc.title | 阿拉柏芥bHLH27和bHLH51基因參與遠紅光及茉莉酸訊息調控幼苗發育之功能性研究 | zh_TW |
dc.title | Functional studies of bHLH27 and bHLH51 genes in regulation of seedling development under far-red light and JA signaling in Arabidopsis | en |
dc.type | Thesis | |
dc.date.schoolyear | 107-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 涂世隆(Shih-Long Tu),張英?(Ing-Feng Chang),吳克強(Keqiang Wu) | |
dc.subject.keyword | bHLH27,bHLH51,光型態發生,FIN219/JAR1,茉莉酸, | zh_TW |
dc.subject.keyword | bHLH27,bHLH51,photomorphogenesis,FIN219/JAR1,Jasmonates, | en |
dc.relation.page | 68 | |
dc.identifier.doi | 10.6342/NTU201902511 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2019-08-05 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 植物科學研究所 | zh_TW |
顯示於系所單位: | 植物科學研究所 |
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