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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 何佳安 | zh_TW |
| dc.contributor.advisor | Ja-an Annie Ho | en |
| dc.contributor.author | 曾敬婷 | zh_TW |
| dc.contributor.author | Ching-Ting Tzeng | en |
| dc.date.accessioned | 2021-07-10T21:49:21Z | - |
| dc.date.available | 2024-08-23 | - |
| dc.date.copyright | 2019-08-28 | - |
| dc.date.issued | 2019 | - |
| dc.date.submitted | 2002-01-01 | - |
| dc.identifier.citation | 1 林金富、潘志寬、黃郁珺、吳思嫺、林蘭砡. 106年食品中毒發生與防治年報. 衛生福利部食品藥物管理署, (2017).
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Multiple topological isomerism of three-connected networks in silver-based metal–organoboron frameworks. Chemical Communications 46, 2608-2610, (2010). 39 Wyszogrodzka, G., Marszałek, B., Gil, B. & Dorożyński, P. Metal-organic frameworks: mechanisms of antibacterial action and potential applications. Drug Discovery Today 21, 1009-1018, (2016). 40 Ladnorg, T., Welle, A., Heissler, S., Woll, C. & Gliemann, H. Site-selective growth of surface-anchored metal-organic frameworks on self-assembled monolayer patterns prepared by AFM nanografting. Beilstein J Nanotechnol 4, 638-648, (2013). 41 Chui, S. S.-Y., Lo, S. M.-F., Charmant, J. P. H., Orpen, A. G. & Williams, I. D. A Chemically Functionalizable Nanoporous Material [Cu3(TMA)2(H2O)3]n. Science 283, 1148-1150, (1999). 42 Xiong, Y., Su, L., Yang, H., Zhang, P. & Ye, F. Fabrication of copper sulfide using a Cu-based metal organic framework for the colorimetric determination and the efficient removal of Hg2+ in aqueous solutions. 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In Situ Probing of Newly Synthesized Peptidoglycan in Live Bacteria with Fluorescent D-Amino Acids. Angewandte Chemie International Edition 51, 12519-12523, (2012). | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/77172 | - |
| dc.description.abstract | 位於亞熱帶地區的台灣終年溫暖潮濕，食物保存不當，微生物容易大量繁殖並產生毒素，因此食品中毒事件發生頻率高。研發新型抗菌材料，使之具有更佳抗菌效果並提高其應用性為刻不容緩的目標。過去研究指出奈米金屬粒子對抑制革蘭氏陽性菌及陰性菌的生長皆有功效，而殺菌的原因可能為氧化壓力之提高、金屬離子之釋出及非氧化機制。金屬有機骨架材料由有機配位基與金屬離子所組成，具有多孔洞及大表面積的特性。本計畫中我們選用以銅金屬離子為節點的HKUST-1、鋁金屬離子為節點的MIL-53、MIL-68、MOG及鐵金屬離子為節點的MIL-88B、MIL-100，以MIC、MBC Assay及Disk diffusion test針對引起食物中毒的主要病原菌作為研究對象：革蘭氏陽性菌的蠟樣芽孢桿菌與金黃色葡萄球菌；革蘭氏陰性菌的大腸桿菌以及對抗生素抗性高的綠膿桿菌進行抗菌能力檢測，藉由H2DCF-DA螢光探針檢測細菌體內氧化壓力，以及FDAAs螢光探針檢測細胞壁合成活性。實驗結果顯示HKUST-1對本研究所選用的目標菌種具有最佳的抗菌效果，菌體內部氧化壓力增加，細胞壁合成能力受到抑制，僅於以上我們可以發現HKUST-1是經由多重機制以達到抗菌效果。 | zh_TW |
| dc.description.abstract | The subtropical climate of Taiwan makes food preservation difficult to achieve. Microorganisms tend to multiply and produce toxins in warm and humid environment, causing high frequency of food poisoning incidents. In this study, we aimed to develop a new nanomaterial with better antibacterial effect and improved applicability. Previous studies revealed that metallic nanoparticles (NPs) exhibited antibacterial properties against both Gram-positive and Gram-negative bacteria. The underlined mechanism for their antibacterial activities include elevated oxidation pressure, metal ion release and non-oxidation mechanism. Metal-organic frameworks (MOFs) are comprising nanomaterials consisting of metal ions and organic binding ligands, that are highly porous with large surface area. Three metal organic framework materials: (1) HKUST-1 with copper metal ion as the node, (2) MOF-53, MOF-68 and MOG with aluminum metal ions as the node and (3) MIL-88B and MIL-100 with iron metal ion as the node, were under investigation for their antibacterial activities, while four bacteria were selected for study, including Gram-positive bacteria Bacillus cereus and Staphylococcus aureus, and Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa with high resistance to antibiotics. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) of the MOFs were determined by visual turbidity analysis, optical density analysis and disk diffusion test, respectively. The oxidative pressure in the bacteria was detected by H2DCF-DA fluorescent probe, and the cell wall synthesis activity was detected by FDAAs fluorescent probe. Our results showed that copper-containing HKUST-1 demonstrated the best antibacterial effect among all, including increased internal oxidative stress, inhibited cell wall synthesis, and change in average size of bacteria. Taken all together, antibacterial effects of the HKUST-1 may involve multiple mechanisms of action. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-10T21:49:21Z (GMT). No. of bitstreams: 1 ntu-108-R06b22008-1.pdf: 4476930 bytes, checksum: 43485bb40c6a5acfbcf00295d533e4d8 (MD5) Previous issue date: 2019 | en |
| dc.description.tableofcontents | 中文摘要 i
Abstract ii 目錄 iv 圖目錄 vi 第一章 緒論 1 第二章 文獻回顧 2 2.1 食品中毒之發生 2 2.2 常見引起食品中毒之細菌 3 2.3 金屬/金屬氧化物奈米粒子之抗菌機制 9 2.4 食品包裝材料 11 2.5 金屬有機骨架材料應用 12 2.6 六種金屬有機骨架材料之結構與性質 16 第三章 實驗材料與方法21 3.1 實驗材料 21 3.1.1 藥品 21 3.1.2 抗菌實驗耗材 21 3.1.3 儀器 22 3.1.4 細菌株 23 3.1.5 金屬有機骨架材料 23 3.2 實驗方法 24 3.2.1 金屬有機骨架材料製備 24 3.2.2 細菌培養液/培養基製備 26 3.2.3 細菌培養方法(bacteria culture) 27 3.2.4 序列稀釋法(Dilution method) - 最小抑菌濃度(MIC) 28 3.2.5 序列稀釋法(Dilution method) - 最小殺菌濃度(MBC) 30 3.2.6 無菌紙錠製備 30 3.2.7 紙錠擴散法(Disk diffusion) 31 3.2.8 細菌氧化壓力(Bacteria oxygen stress) 32 第四章 實驗結果與討論 34 4.1 序列稀釋法(Dilution method) - 最小抑菌濃度(MIC) 34 4.2 序列稀釋法(Dilution method) - 最小殺菌濃度(MBC) 51 4.3 紙錠擴散法(Disk diffusion) 60 4.4 細菌體內氧化壓力(Reactive oxygen stress，ROS) 65 4.5 細菌細胞壁合成活性 (Bacterial cell wall synthesis activity) 69 第五章 結論 73 第六章 參考文獻 74 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 抗菌 | zh_TW |
| dc.subject | 氧化壓力 | zh_TW |
| dc.subject | 細胞壁合成 | zh_TW |
| dc.subject | 金屬有機骨架材料 | zh_TW |
| dc.subject | Metal-organic frameworks (MOFs) | en |
| dc.subject | Antibacterial | en |
| dc.subject | Oxidation stress | en |
| dc.subject | Cell wall synthesis | en |
| dc.title | 金屬有機骨架材料之抗菌能力與機制研究 | zh_TW |
| dc.title | Antibacterial activity and mechanism of action of the metal-organic frameworks (MOFs) | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 107-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.coadvisor | 蕭寧馨 | zh_TW |
| dc.contributor.coadvisor | Ning-Sing Shaw | en |
| dc.contributor.oralexamcommittee | 劉婉舲;吳立真;沈偉強 | zh_TW |
| dc.contributor.oralexamcommittee | Wan-Ling Liu;Li-chen Wu;Wei-Chiang Shen | en |
| dc.subject.keyword | 金屬有機骨架材料,抗菌,氧化壓力,細胞壁合成, | zh_TW |
| dc.subject.keyword | Metal-organic frameworks (MOFs),Antibacterial,Oxidation stress,Cell wall synthesis, | en |
| dc.relation.page | 79 | - |
| dc.identifier.doi | 10.6342/NTU201903185 | - |
| dc.rights.note | 未授權 | - |
| dc.date.accepted | 2019-08-20 | - |
| dc.contributor.author-college | 生命科學院 | - |
| dc.contributor.author-dept | 生化科技學系 | - |
| Appears in Collections: | 生化科技學系 | |
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