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標題: | 半乳糖凝集素-3與介白素-22訊號傳遞對於腸表皮細胞表現抗菌胜肽之影響 The Effect of Galectin-3 and IL-22 Signaling on Antimicrobial Peptides Gene Expression in Intestinal Epithelial Cells |
作者: | Guei-Yun Cheng 鄭貴云 |
指導教授: | 朱清良(Ching-Liang Chu) |
關鍵字: | 半乳糖凝集素-3,介白素-22,炎症性腸病,抗菌胜?,Reg3b,Reg3g,S100A8,S100A9, galectin-3,Interleukin-22,nflammatory bowel disease,antimicrobial peptides,Reg3b,Reg3g,S100A8,S100A9, |
出版年 : | 2017 |
學位: | 碩士 |
摘要: | Galectin-3 (Gal-3) 在生理反應上調控許多生物活性功能。在腸炎症患者中,腸道中的Gal-3 表現量明顯較健康人低。在腸道發炎情況下,Interleukin-22 (IL-22) 能透過表現抗菌蛋白,如Reg3β/3γ 及 S100A8/A9,來保護腸道避免遭受病原菌侵犯。IL-22結合到IL-22受器後,會活化下游Jak1/Tyk2-STAT3、Akt 及 MAPK 訊號路徑。許多研究顯示 Gal-3 及 IL-22 對於維持腸道生理平衡扮演重要角色,故我們假設 Gal-3 也許參與在IL-22/IL-22R 訊號傳遞,並調控腸表皮細胞的功能。我們研究中發現,Gal-3似乎不參與在IL-22/IL-22R下游主要的三條訊號路徑。在動物實驗的大腸組織中,雖然Gal-3不參與在調控 Reg3b/3g 的表現,但Gal-3會負調控 IL-22 所誘導表現的 S100A8/A9。 Galectin-3 (Gal-3) is known to exert a lot of biological function. Expression of Gal-3 is significantly downregulated in the gut of patients with inflammatory bowel disease (IBD). Interleukin-22 (IL-22) is known to protect against colitis through enhancing the production of antimicrobial peptides (AMP), such as Reg3β/3γ and S100A8/A9. Binding of IL-22 to its receptor activates Jak1/Tyk2-STAT3, Akt and MAPK signaling pathways. It has been reported that Gal-3 and IL-22 are important to maintain the intestinal homeostasis. We hypothesize that Gal-3 may participate in IL-22 signaling and regulate the functions in intestinal epithelial cells (IECs). In our study, Gal-3 seems not regulate the three major IL-22 signaling pathways. Although Gal-3 is not involved in regulating Reg3b/3g expression, it negatively regulates IL-22-induced S100A8/A9 expression in colon. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/7661 |
DOI: | 10.6342/NTU201704125 |
全文授權: | 同意授權(全球公開) |
顯示於系所單位: | 免疫學研究所 |
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