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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Dian-Han Kuo | en |
dc.contributor.author | 郭典翰 | zh_TW |
dc.date.accessioned | 2021-07-01T08:20:58Z | - |
dc.date.available | 2021-07-01T08:20:58Z | - |
dc.date.issued | 1998 | |
dc.identifier.citation | 1. Abrieu, A., Lorca, T., Labb?, J.-C., Morin, N., Keyes, S. & Dor?e, M. 1996. MAP kinase does not inactive, but rather prevents the cyclin degradation pathway from being turned on in Xenopus egg extracts. J. Cell Sci. 109, 239-246. 2. Andrews, B. & Measday, V. 1998. The cyclin family of budding yeast: abundant use of a good idea. Trends Genet. 14, 66-72. 3. Araki, K., Naito, K., Haraguchi, S., Suzuki, R., Yokoyama, M., Inoue, M., Aizawa, S., Toyoda, Y & Sato, E. 1996. Meiotic abnormalities of c-mos knockout mouse oocytes: activation after first meiosis or entrance into third meiotic metaphase. Biol. Reprod. 55, 1315-1324. 4. Bai, C., Sen, P., Hofmann, K., Ma, L., Goebl, M., Harper, J.W. & Elledge, S.J. 1996. SKP1 connects cell cycle to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274. 5. Booher, R.N., Alfa, C.E., Hyams, J.S. & Beach, D.H. 1989. The fission yeast cdc2/cdc13/suc1 protein kinase: regulation of catalytic activity and nuclear localization. Cell 58, 485-497. 6. Brizuela, L., Draetta, G. & Beach, D. 1987. p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. EMBO J. 6, 3507-3514. 7. Bueno, A., Richardson, H., Reed, S.I. & Russell, P. 1991. A fission yeast B-type cyclin functioning early in the cell cycle. Cell 66, 149-160. 8. Choi, T., Aoki, F., Mori, M., Yamashita, M., Nagahama, Y. & Kohmoto, K. 1991. Activation of p34cdc2 protein kinase activity in meiotic and mitotic cell cycle in mouse oocytes and embryos. Development 113, 789-795. 9. Ciechanover, A. 1994. The ubiquitin-proteasome proteolytic pathway. Cell 79, 13-21. 10. Clurman, B.E., Sheaff, R.J., Thress, K., Groudine, M. & Roberts, J.M. 1996. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev. 10, 1979-1990. 11. Cohen-Fix, O. & Koshland, D. 1997. The metaphase-to-anaphase transition: avoiding a mid-life crisis. Curr. Opin. Cell Biol. 9, 800-806. 12. Cohen-Fix, O., Peters, J.-M., Kirschner, M.W. & Koshland, D. 1996. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 10, 3081-3093. 13. Colledge, W.H., Carlton, M.B.L., Udy, G.B. & Evans, M.J. 1994. Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs. Nature 370, 65-68. 14. Connelly, C. & Hieter, P. 1996. Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression. Cell 86, 275-285. 15. Crenshaw, D.G., Yang, J., Means, A.R. & Kornbluth, S. 1998. The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. EMBO J. 17, 1315-1327. 16. Cyert, M.S. & Kirschner, M.W. 1988. Regulation of MPF activity in vitro. Cell 53, 185-195. 17. Dasso, M & Newport, J.W. 1990. Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus. Cell 61, 811-823. 18. Dawson, I.A., Roth, S., Akam, M. & Artavanis-Tsakonas, S. 1993. Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos. Development 117, 359-376. 19. Dawson, I.A., Roth, S. & Artavanis-Tsakonas, S. 1995. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclin A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J. Cell Biol. 129, 725-737. 20. De Bondt, H., Rosenblatt, J., Jancarik, J., Jones, H.D., Morgan, D.O. & Kim, S.-H. 1993. Crystal structure of cyclin-dependent kinase 2. Nature 363, 595-602. 21. Descombes, P. & Nigg, E.A. 1998. The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts. EMBO J. 17, 1328-1335. 22. Deshaies, R.J., Chau, V. & Kirschner, M. 1995. Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway. EMBO J 14, 4803-4813. 23. Diehl, J.A., Zindy, F. & Sherr, C.J. 1997. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 11, 957-972. 24. Diffley, J.F.X. 1996. Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells. Genes Dev. 10, 2819-2830. 25. Doheny, K.F., Sorger, P.K., Hyman, A.A., Tugendreich, S., Spencer, F. & Hieter, P. 1993. Identification of essential components of the S. cerevisiae kinetochore. Cell 73, 761-774. 26. Draetta, G., Luca, F., Westendorf, J., Brizuela L., Ruderman, J. & Beach, D. 1989. Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF, a cytoplasmic regulation of mitosis. Cell 54, 423-431. 27. Drury, L.S., Perkins, G. & Diffley, J.F.X. 1997. The Cdc4/34/53 pathway targets Cdc6p for proteolysis in the budding yeast. EMBO J. 16, 5966-5976. 28. Dunphy, W.G. & Kumagai, A. 1991. The cdc25 protein contains an intrinsic phosphatase activity. Cell 67, 189-196. 29. Dunphy, W.G., Brizuela, L., Beach, D. & Newport, J. 1988. The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell 54, 423-431. 30. Eckberg, W.R. 1997. MAP and cdc2 kinase activities at germinal vesicle breakdown in Chaetopterus. Dev. Biol. 191, 182-190. 31. Espinoza, F.H., Farell, A., Erdjument-Bromage, H., Tempts, P. & Morgan, D.O. 1996. A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science 273, 1714-1717. 32. Feldman, R.M.R., Correll, C.C., Kaplan, K.B. & Dashaies, R.J. 1997. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic p. Cell 91, 221-230. 33. Fesquet, D., Labb?, J.-C., Derancourt, J., Capony, J.-P., Galas, S., Girard, F., Lorca, T., Shuttleworth, J., Dor?e, M. & Cavadore, J.C. 1993. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin- dependent kinases (CDKs) through phosphorylation of Thrl61 and its homologues. EMBO J. 12, 3111-3121. 34. Fisher, R.P. & Morgan D.O. 1994. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78, 713-724. 35. Fitzgerald-Hayes, M., Clarke, L. & Carbon, J. 1982. Nucleotide sequence comparison and functional analysis of yeast centromere DNAs. Cell 29, 235-244. 36. Freeman, R.S., Ballantyne, S.M. & Donoghue, D.J. 1991. Meiotic induction by Xenopus cyclin B is accelerated by coexpression with mosxe. Mol. Cell. Biol. 11, 1713-1717. 37. Fry, A.M., Meraldi, P. & Nigg, E.A. 1998. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. EMBO J. 17, 470-481. 38. Funabiki, H., Yamano, H., Kumada, K., Nagao, K., Hunt, T. & Yanagida, M. 1996. Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature 381, 438-441. 39. Funari, B., Rhind, N. & Russell, P. 1997. Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase. Science 277, 1495-1497. 40. Furuno, N., Nishizawa, M., Okazaki, K., Tanaka, H., Iwashita, J., Nakajo, N., Ogawa, Y. & Sagata, N. 1994. Supression of DNA replication via Mos function during meiotic divisions in Xenopus oocytes. EMBO J. 13, 2399-2410. 41. Gabbrielli, B.G., Roy, L.M. & Maller, J.L. 1993. Requirement for Cdk2 in cytostatic factor-mediated metaphase II arrest. Science 259, 1766-1769. 42. Gautier, J. Norbury, C. Lohka M., Nurse, P. & Maller, J. 1988. Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+. Cell 54, 433-439. 43. Gavin, A.C., Cavadore, J.C. & Schorderest, S.S. 1994. Histone H1 kinase activity, germinal vesicle breakdown and M phase entry in mouse oocytes. J. Cell Sci. 107, 275-283. 44. Girard, F., Strausfeld, U., Fernandez, A. & Lamb, N. 1991. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67, 1169-1179. 45. Goebl, M.G., Yochem, J., Jentsch, S., McGrath, J.P., Varshavsky, A. & Byers, B. 1988. The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science 241, 1331-1335. 46. Goh, P.-Y. & Kilmartin, J.V. 1993. NDC10: a gene involved in chromosome segregation in S. cerevisiea. J. Cell Biol. 121, 503-512. 47. Gotoh, Y., Masuyama, N., Dell, K., Shirakabe, K. & Nishida, E. 1995. Initiation of Xenopus oocytes maturation by activation of the mitogen-activated protein kinase cascade. J. Biol. Chem. 270, 25898-25904. 48. Gould, K.L. & Nurse, P. 1989. Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature 342, 39-45. 49. Gould, K.L., Moreno, S., Owen, D.J., Sazer, S. & Nurse, P. 1991. Phosphorylation at Thrl67 is required for Schizosaccharomyces pombe p34cdc2 function. EMBO J. 10, 3297-3309. 50. Gu, Y., Rosenblatt, J. & Morgan, D.O. 1992. Cell cycle regulation of CDK2 activity by phosphorylation of Thrl60 and Tyrl5. EMBO J. 11, 3995-4005. 51. Haccard, O., Sarcevic, B., Lewellyn, A., Hartley, R., Roy, L., Izumi, T., Erikson, E. & Maller, J.L. 1993. Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase. Science 262, 1262-1265. 52. Hadwick, K.G. 1998. The spindle checkpoint. Trends Genet. 14, 1-4. 53. Hardy, C.F. & Pautz, A. 1996. A novel role for Cdc5p in DNA replication. Mol. Cell. Biol. 16, 6775-6782. 54. Harlow, E. & Lane, D. Antibodies: a Laboratory Manual. Cold Spring Harbor Laboratory Press, USA. 55. Hashimoto, N., Watanabe, N., Furuta, Y., Tamemoto, H., Sagata, N., Yokoyama, M., Okazaki, K., Nagayoshi, M., Takeda, N., Ikawa, Y. & Aizawa, S. 1994. Parthenogenetic activation of oocytes in c-mos-deficient mice. Nature 370, 68-71. 56. Hedgemann, J., Shero, J., Cottarel, G., Philippsen, P. & Hieter, P. 1988. Mutational analysis of centromere DNA from chromosome VI of Saccharomyces cerevisiae. Mol. Cell. Biol. 8, 2523-2535. 57. Henchoz, S., Chi, S., Catarin, B., Herskowitz, I. & Deshaies, R.J. 1997. Phosphorylation and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. Genes Dev. 11, 3046-3060. 58. Hershko, A. 1997. Roles of ubiquitin-mediated proteolysis in cell cycle control. Curr. Opin. Cell Biol. 9, 788-799. 59. Hieter, P., Mann, C., Snyder, M. & Davis, R. 1985. Mitotic stability of yeast chromosomes: a colony color assay that measures nondisjuction and chromosome loss. Cell 40, 381-392. 60. Hilt, W. & Wolf, D.H. 1996. Proteasomes: destruction as a programme. Trends Biochem. Sci. 21, 96-102. 61. Hoyt, M.A. 1997. Eliminating all obstacles: regulatied proteolysis in the eukaryotic cell cycle. Cell 91, 149-151. 62. Hwang, L.H., Lau, L.F., Smith, D.L., Mistrot, C.A., Hardwick, K.G., Hwang, E.S., Amon, A. & Murray, A.W. 1998. Budding yeast Cdc20: a target of the spindle checkpoint. Science 279, 1041-1044. 63. Jeffrey, P.D., Russo, A.A., Polyak, K., Gibbs E., Hurwitz, J., Messagu?, J. & Pavletich, N.P. 1995. Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 376, 313-320. 64. Jiang, W., Lechner, J., & Carbon, J. 1993. Isolation and characterization of a gene (CBF2) specifying an essential protein component of the budding yeast kinetochore. J. Cell Biol. 121, 513-519. 65. Juang, Y.-L., Huang, J., Peters, J.-M., McLaughlin, M.E., Tai, C.-Y. & Pellman, D. 1997. APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science 275, 1311-1314. 66. Jung, T., Moor, R.M. & Fulka, J.J. 1993. Kinetics of MPF and histone kinase activity differ during the G2-to M-phase transition in mouse oocytes. Int. J. Dev. Biol. 37, 595-600. 67. Kaldis, P., Sutton, A. & Solomon, M.J. 1996. The Cdk-activating kinase (CAK) from budding yeast. Cell 86, 553-564. 68. Kanki, J.P. & Donoghue, D.J. 1991. Progression from meiosis I to meiosis II in Xenopus oocytes requires de novo translation of the mosxe protooncogene. Proc. Natl. Acad. Sci. USA 88, 5794-5798. 69. Kaplan, K.B., Hyman, A.A. & Sorger, P.K. 1997. Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation. Cell 91, 491-500. 70. Kim, S.H., Lin, D.P., Matsumoto, S., Kitazono, A. & Matsumoto, T. 1998. Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint. Science 279, 1045-1047. 71. King, R.W., Deshaies, R.J., Peters, J.-M. & Kirschner, M.W. 1996. How proteolysis drives the cell cycle. Science 274, 1652-1659. 72. King, R.W., Peters, J.-M., Tugendreich, S., Rolfe, M., Hieter, P. & Kirschner, M.W. 1995. A 20S complex containing CDC27 and CDC 16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81, 279-288. 73. King, R.W., Jackson, P.K. & Kirschner, M.W. 1994. Mitosis in transition. Cell 79, 563-571. 74. Kipreos, E.T., Lander, L.E., Wing, J.P., He, W.W. & Hedgecock, E.M. 1996. Cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Cell 85, 829-839. 75. Kitada, K., Johnson, A.L., Johnston, L.H., Sugino, A. 1993. A multicopy suppressor gene of the Saccharomyces cerevisiae G-1 cell cycle mutant gene Dbf4 encodes a protein kinase and is identified as CDC5. Mol. Cell. Biol. 13, 4445-4457. 76. Kleckner, N. 1996. Meiosis: How could it work Proc. Natl. Acad. Sci. USA 93, 8167-8174. 77. Kominami, K. & Toda, T. 1997. Fission yeast WD-repeat protein Pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase inhibitor Cdc18. Genes Dev. 11, 1548-1560. 78. Kumagai, A. & Dunphy, W.G. 1996. Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts. Science 273, 1377-1380. 79. Kumagai, A. & Dunphy, W.G. 1991. The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system. Cell 64, 903-914. 80. Krude, T., Jackman, M., Pines, J. & Laskey, R.A. 1997. Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system. Cell 88, 109-119. 81. Laemmli, U.K. 1970. Claevage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685. 82. Lamb, J.R., Michaud, W., Sikorski, R.S. & Hieter, P.A. 1994. Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis. EMBO J. 13, 4321-4328. 83. Lane, H.A. & Nigg, E.A. 1997. Cell-cycle control: POLO-like kinases join the outer circle. Trends Cell Biol. 7, 63-68. 84. Lane, H.A. & Nigg, E.A. 1996. Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. J. Cell Biol. 135, 1701-1713. 85. Lanker, S., Valdivieso, M.H. & Wittenberg, C. 1996. Rapid degradation of the G1 cyclin CLN2 induced by Cdk-dependent phosphorylation. Science 271, 1597-1601. 86. Lechner, J. 1994. A zinc finger protein, essential for chromosome segregation, constitutes a putative DNA binding subunit of the Saccharomyces cerevisiae kinetochore complex, CBF3. EMBOJ. 13, 5203-5211. 87. Lechner, J. & Carbon, J. 1991. A 240kD multisubunit protein complex is a major component of the budding yeast centromere. Cell 64, 717-725. 88. Lee, K.S., Yuan, Y.-L., Kuriyama, R. & Erikson, R.L. 1995. Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1. Mol. Cell. Biol. 15, 7143-7151. 89. Letwin, K., Mizzen, L., Motro, B., Ben-David, Y., Bernstein, A. & Pawson, T. 1992. A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells. EMBO J. 11, 3521-3531. 90. Li, F.N. & Johnston, M. 1997. Grr1 of S. cerevisiae is connected to the ubiquitination machinery through Skp1: Coupling glucose sensing to gene expression and cell cycle. EMBO J. 16, 5629-5638. 91. Liu, F., Stanton, J.J., Wu, Z. & Piwnica-Worms, H. 1997. The human Myt1 kinase preferentially phosphorylates Cdc2 on Threonine 14 and localizes to the endoplasmic reticulum and golgi complex. Mol. Cell. Biol. 17, 571-583. 92. Lorca, T., Cruzalegui, F.H., Fesquent, D., Cavadore, J.-C., M?ry, J, Means, A. & Dore?, M. 1993. Calmodulin-dependent prottein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs. Nature 366, 270-274. 93. Lorca, T., Galas, S., Fesquet, D., Devault, A., Cavadore, J.-C. & Dore?, M. 1991. Degradation of the proto-oncogene product p39mos is not necessary for cyclin proteolysis and exit from meiotic metaphase: requirement for a Ca2+-calmodulin dependent event. EMBO J. 10, 2087-2093. 94. Lu, K.P. & Hunter, T. 1995. Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell 81,413-424. 95. Lu, K.P., Hanes, S.D. & Hunter, T. 1996. A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 380, 544-547. 96. Lu, K.P., Osmani, S.A. & Means, A.R. 1993. Properties and regulation of the cell cycle-specific NIMA kinase of Aspergillus nidulans. J. Biol. Chem. 268, 8769-8776. 97. M?kel?, T.P., Tassan, J.P., Nigg, E.A., Frutiger, S., Hughes, G.J. & Weinberg, R.A. 1994. A cyclin associates with the CDK-activating kinase MO15. Nature 371, 254-257. 98. Martin-Castellanos, C. & Moreno, S. 1997. Recent advances on cyclins, CDKs an CDK inhibitors. Trends Cell Biol. 7, 95-98. 99. Mathias, N., Johnson, S.L., Winey, M., Adams, A.E., Goetsch, L., Pringle, J.R. & Goebl, M.G. 1996. Cdc53 acts in concert with Cdc4 and Cdc34 to control the G1 to S phase transition and identifies a conserved family of proteins. Mol. Cell. Biol. 16, 6634-6643. 100. Matsumoto, T. 1997. A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2. Mol. Cell. Biol. 17, 742-750. 101. Matten, W.T., Copeland, T.D., Ahn, N.G. & Vande Woude, G.F. 1996. Positive feedback between MAP kinase and Mos during Xenopus oocyte maturation. Dev. Biol. 179, 485-492. 102. McGarry, T.J. & Kirschner, M.W. 1998. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93, 1043-1053. 103. Mondesert, O., McGowan, C.H. & Russel, P. 1996. Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe. Mol. Cell. Biol. 16, 1527-1533. 104. Moreno, S., Hayles, J. & Nurse, P. 1989. Regulation of p34cdc2 protein kinase during mitosis. Cell 58, 361-372. 105. Muller, P.R., Coleman, T.R., Kumagai, A. & Dunphy, W.G. 1995. Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science 270, 86-90. 106. Murphy, T.D. & Karpen, G.H. 1998. Centromeres take flight: alpha satellite and the quest for the human centromere. Cell 93, 317-320. 107. Murray, A.W. 1998. MAP kinases in meiosis. Cell 92, 157-159. 108. Nagahama, Y., Yoshikuni, M., Yamashita, M., Tokumoto, T. & Katsu, Y. 1995. Regulation of oocyte growth and maturation in fish. Curr. Top. Dev. Biol. 30, 103-145. 109. Nasmyth, K. 1996. At the heart of the budding yeast cell cycle. Trends Genet. 12, 405-412. 110. Nebreda, A.R. & Hunt, T. 1993. The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs. EMBOJ. 12, 1979-1986. 111. Newlon, C.S. 1997. Putting it all together: building a prereplication complex. Cell 91, 717-720. 112. Nicolas, A. 1998. Relationship between transcription and initiation of meiotic recombination: toward chromatin accessibility. Proc. Natl. Acad. Sci. USA 95, 87-89. 113. Nishizawa, M. Furuno, N., Okazaki, K., Tanaka, H., Ogawa, Y. & Sagata, N. 1993. Degradation of Mos by the N-terminal prolin (Pro2)-dependent ubiquitin pathway on fertilization of Xenopus eggs: possible significance of natural selection for Pro2 in Mos. EMBO J. 12, 4021-2027. 114. Nishizawa, M., Okazaki, K., Furuno, N., Watanabe, N. & Sagata, N. 1992. The Second codon rule and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes. EMBO J. 11, 2433-2446. 115. O'Connell, M.J., Norbury, C. & Nurse, P. 1994. Premature chromatin condensation upon accumulation of NIMA. EMBO J. 12, 4926-4937. 116. Ohtsubo, M. & Roberts, J.M. 1993. Cyclin-dependent regulation of G1 in mammalian cells. Science 259, 1908-1912. 117. Ohtsubo, M., Theodoras, A.M., Schumacher, J., Roberts, J.M. & Pagano, M. 1995. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell. Biol. 15, 2612-2624. 118. Okazaki, K., Nishizawa, M., Furuno, N., Yasuda, H. & Sagata, N. 1993. Differential occurance of CSF-like activity and transforming activity of Mos during the cell cycle in fibroblast. EMBO J. 11, 2447-2456. 119. O'Keefe, S.J., Wolfes, H., Kiessling, A.A. & Cooper, G.M. 1989. Microinjection of antisense c-mos oligonuleotides prevents meiosis II in the maturing mouse egg. Proc. Natl. Aca. Sci. USA 86, 7038-7042. 120. Osmani, A.H., McGuire, S.L. & Osmani, S.A. 1991a. Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans. Cell 67, 283-291. 121. Osmani, A.H., O'Donnell, K., Pu, R.T. & Osmani, S.A. 1991b. Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint. EMBO J. 10, 2669-2679. 122. Pagano, M., Pepperkok, R., Verde, F., Ansgorge, W. & Draetta, G. 1992. Cyclin A is required at two points in the human cell cycle. EMBO J. 11, 961-971. 123. Parker. L.L., Atherton-Fessler, S. & Piwnica-Worms, H. 1992. p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc. Natl. Acad. Sci. USA 89, 2917-2921. 124. Paules, R.S., Buccione, R., Moschel, R.C., Vande Woude, G.F. & Eppig, J.J. 1989. Mouse mos protooncogene product is present and functions during oogenesis. Proc. Natl. Acad. Sci. USA 86, 5395-6399. 125. Peng, C.-Y., Graves, P.R., Thoma, R.S., Wu, Z., Shaw, A.S. & Piwnica-Wworms, H. 1997. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501-1505. 126. Peter, M., Garter, A., Horecka, J., Ammerer, G. & Herskowitz, I. 1993. Far1 links the signal transduction pathway to the cell cycle machinery in yeast. Cell 73, 747-760. 127. Peters, J.-M., King, R.W., Hoog, C. & Kirschner, M.W. 1996. Identification of BIME as a subunit of the anaphase-promoting complex. Science 274, 1199-1201. 128. Picard, A., Galas, S., Peaucelier, G. & Dor?e, M. 1996. Newly assembled cyclin B-cdc2 kinase is required to supress DNA replication between meiosis I and meiosis II in starfish oocytes. EMBO J. 15, 3590-3598. 129. Pickham, K.M., Meyer, A.N., Li, J. & Donoghue, D.J. 1992. Requirement of mosxe protein kinase for meiotic maturation of Xenopus oocytes induced by a cdc2 mutant lavking regulatory phosphorylation sites. Mol. Cell. Biol. 12, 3192-3203. 130. Pines, J. 1995. Cyclins and cyclin-dependent kinases: a biochemical view. Biochem. J. 308, 697-711. 131. Pomerance, M., Thang, M.N., Tocque, B. & Pierre, M. 1996. The Ras-GTPase-activating protein SH3 domain is required for cdc2 activation and mos induction by oncogenetic Ras in Xenopus oocytes independently of mitogen-actvated protein kinase activation. Mol. Cell. Biol. 16, 3179-3186. 132. Poon, R.Y.C., Yamashita, K., Adamczewszi, J.P., Hunt, T. & Shuttleworth, J. 1993. The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2. EMBO J. 12, 3123-3132. 133. Posada, J. & Cooper, J.A. 1992. Requirement for phosphorylation of MAP kinase during meiosis in Xenopus oocytes. Science 255, 212-215. 134. Posada, J., Yew, N., Ahn, N.G., Vande Woude, G.F. & Cooper, J.A. 1993. Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro. Mol. Cell. Biol. 13, 2546-2553. 135. Pu, R.T. & Osmani, S.A. 1995.mitotic destruction of the cell cycle regulated NIMA protein kinase of Aspergillus nidulans is required for mitotic exit. EMBO J. 14, 995-1003. 136. Ranganathan, R., Lu, K.P., Hunter, T. & Noel, J.P. 1997. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell 89, 875-886. 137. Renauld, H. & Gasser, S.M. 1997. Heterochromatin: a meiotic matchmaker Trends Cell Biol. 7, 201-205. 138. Resnitzky, D. & Reed, S.I. 1995. Different roles for cyclins D1 and E in regulation of the G1-to-Stransition. Mol. Cell. Biol. 15, 3463-3469. 139. Resnitzky, D., Gossen, M., Bujard, H. & Reed, S.I. 1994. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol. 14, 1669-1679. 140. Rhee, K. & Wolgemuth, D.J. 1997. The NIMA-related kinase 2, Nek2, is expressed in specific stages of the meiotic cell cycle and associates with meiotic chromosomes. Development 124, 2167-2177. 141. Rickert, P., Seghezzi, W., Shanahan, F., Cho, H. & Lees, E. 1996. Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II. Oncogene 12, 2631-2640. 142. Roeder, G.S. 1997. Meiotic chromosomes: it takes two to tango. Genes Dev. 11, 2600-2621. 143. Romanowski, P. & Madine, M.A. 1996. Mechanisms restricting DNA replication to once per cell cycle: MCMs, pre-replicative complexes and kinases. Trends Cell Biol. 6, 184-188. 144. Roy, L.M., Haccard, O., Izumi, T., Lattes, B.G., Lewellyn, A.L. & Maller, J.L. 1996. mos proto-oncogene function during oocyte maturation in Xenopus. Oncogene 12, 2203-2211. 145. Roy, L.M., Singh, B., Gautier, J., Arlinghaus, R.B., Nordeen, S.K. & Maller, J.L. 1990. The cyclin B2 component of MPF is a substrate for the c-mosxe proto-oncogene product. Cell 61, 825-831. 146. Russell, P. & Nurse, P. 1987. Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell 49, 559-567. 147. Sagata, N. 1997. What does Mos do in oocytes and somatic cells. BioEssays 19, 13-21. 148. Sagata, N. 1996. Meiotic metaphase arrest in animal oocytes: its mechanisms and biological significance. Trends Cell Biol. 6, 22-28. 149. Sagata, N., Daar, I., Oskarsson, M., Showalter, S.D. & Vande Woude, G.F. 1989a. The product of the mos proto-oncogene as a candidate initiator for oocyte maturation. Science 245, 643-646. 150. Sagata, N. Wattanabe, N. Vande Woude, G.F. & Ikawa, Y. 1989b. The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs. Nature 342, 512-518. 151. Sagata, N. Oskarsson, M., Copeland, T., Brumbaugh, J. & Vande Woude, G.F. 1988. Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes. Nature 335, 519-525. 152. Sakamoto, I., Takahara, K., Yamashita, M. & Iwao, Y. 1998. Changes in cyclin B during oocyte maturation and early embryonic cell cycle in the newt, Cynops pyrrhogaster: requirement of germinal vesicle for MPF activation. Dev. Biol. 195, 60-69. 153. Sambrook, J., Fritsch, E.F. & Maniatis, T. 1989. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory Press, USA. 154. Sanchez, Y., Wong, C., Thoma, Richman, R., Wu, Z., Piwnica-Worms, H. & Elledge, S.J. 1997. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497-1501. 155. Sch?gger, H. & von Jagow, G. 1987. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the seperation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166, 368-379. 156. Schneider, B.L., Yang, Q.-H. & Futcher, A.B. 1996. Linkage of replication to Start by the Cdk inhibitor Sic1. Science 272, 560-562. 157. Schwab, M., Lutum, A.S. & Seifert, W. 1997. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell 90, 683-693. 158. Schwob, E., Bohm, T., Mendenhall, M.D. & Nasmyth, K. 1994. The B-type cyclin kinase inhibitor p40SICl controls the G1 to S transition in S. cerevisiae. Cell 79, 233-244. 159. Sebastian, B., Kakizuka, A. & Hunter, T. 1993 cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15. Proc. Natl. Acad. Sci. USA 90, 3521-3524. 160. Selman, K., Wallace, R.A., Sarka, A. & Qi, X. 1993. Stages of oocyte development in the zebrafish, Brachydanio rerio. J. Morphol. 218, 203-224. 161. Sethi, N., Montragudo, M.C., Koshland, D., Hogan, E., & Burke, D.J. 1991. The CDC20 gene product of Saccharomyces cerevisiae, a β-transducin homolog, is required for a subset of mircotubule-dependent processes. Mol. Cell. Biol. 11, 5592-5606. 162. Sharon, G. & Simchen, G. 1990. Mixed segregation of chromosomes during single-division meiosis of Saccharomyces cerevisiae. Genetics 125, 475-486. 163. Sheaff, R.J., Groudine, M., Gordon, M., Roberts, J.M. & Clurman, B.E. 1997. Cyclin E -CDK2 is a regulator of p27Kip1. Genes Dev. 11, 1464-1478. 164. Shen, M., Stukenberg, P.T., Kirschner, M.W. & Lu, K.P. 1998. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev. 12, 706-720. 165. Sherr, C.J. & Roberts, J.M. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9, 1149-1163. 166. Sherr, C.J. 1994. G1 phase progression: cycling on cue. Cell 79, 551-555. 167. Shirayama, M., Zachariae, W., Ciosk, R. & Nasmyth, K. 1998. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J 17, 1336-1349. 168. Sigrist, S., Jacobs, H., Startmann, R. & Lehner, C.F. 1995. Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclin A, B and B3. EMBO J. 14, 4827-4838. 169. Sigrist, S.J. & Lehner, C.F. 1997. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90, 671-681. 170. Skowrya, D., Craig, K.L., Tyers, M., Elledge, S.J. & Harper, J.W. 1997. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209-219. 171. Smythe, C. & Newport, J.W. 1992. Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2. Cell 68, 787-797. 172. Solomon, M.J., Glotzer, M., Lee, T.H., Philippe, M. & Kirschner, M.W. 1990. Cyclin activation of p34cdc2. Cell 63, 1013-1024. 173. Solomon, M.J., Harper, J.W. & Shuttleworth, J. 1993. CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15. EMBO J. 12, 3133-3142. 174. Stillman, B. 1996. Cell cycle control of DNA replication. Science 274, 1659-1664. 175. Strunnikov, A.V., Kingsbury, J. & Koshland, D. 1995. CEP3 encodes a centromere protein of Saccharomyces cerevisiae. J. Cell Biol. 128, 749-760. 176. Tavares, A.A., Glover, D.M. & Sunkel, C.E. 1996. The conserved mitotic kinase polo is regulated by phosphorylation and has preferred microtubule-associated substrates in Drosophila embryo extract. EMBO J. 15, 4873-4883. 177. Terada, Y., Tatsuka, M., Jinno, S. & Okayama, H. 1995. Requirement for tyrosine phosphorylation of Cdk4 in G1 arrest induced by ultraviolet irradiation. Nature 376, 358-362. 178. Thibier, C., De Smedt, V., Poulhe, R., Huchon, D., Jessus, C. & Ozon, R. 1997. In vivo regulation of cytostatic activity in Xenopus metaphase II-arrest oocytes. Dev. Biol. 185, 55-66. 179. Thuret, J.-Y., Valay, J.-G., Faye, G. & Mann, C. 1996. Civ1 (CAK in vivo), a novel Cdk-activating kinase. Cell 86, 565-576. 180. Townsley, F.M. & Ruderman, J.V. 1998. Proteolytic ratchets that control progression through mitosis. Trends Cell Biol. 8, 238-244. 181. Uchiumi, T., Longo, D.L. & Ferris, D.K. 1997. Cell cycle regulation of the human polo-like kinase (PLK) promoter. J. Biol. Chem. 272, 9166-9174. 182. Varshavsky, A. 1997. The ubiquitin system. Trends Biochem. Sci. 22, 383-387. 183. Velhac, M.-H., Kubiak, J.Z. Weber, M., G?raud, G., Colledge, W.H., Evans, M.J. & Maro, B. 1996. Mos is required for MAP kinase activation and involved in microtubule organization during meiotic maturation in the mouse. Development 122, 815-822. 184. Verma, R., Annan, R.S., Huddleston, M.J., Carr, S.A., Reynard, G. & Deshaies, R.J. 1997. Phosphorylation of Sic p by G1 Cdk required for its degradation and entry into S phase. Science 278, 455-460. 185. Visintin, R., Prinz, S. & Amon, A. 1997. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278, 460 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/76386 | - |
dc.description.abstract | 細胞週期控制機制的基本架構建立了S期及M期交替出現的順序關係。環環相扣的CDK系統與ubiquitin蛋白質分解系統所構成的迴路形成一個以事件的發生為里程碑的細胞週期進程。一般體細胞的細胞週期進程為G1→S→G2→M,然而在進行減數分裂的細胞中則為G1→S→G2→MI→MII。減數分裂中的MI-MII明顯違背了有絲分裂中S-M交替的基本原則,因此減數分裂細胞中應存在一調控系統以修飾細胞週期的調控迴路。瞭解細胞週期迴路系統在減數分裂的狀態是瞭解減數分裂細胞週期本質的先決條件,而分析這個迴路中的元件則是重要的第一步。控制S期及M期蛋白質分解的ubiquitin蛋白質分解系統分別是SCF系統及APC系統。Skp1及Fzr分別是兩大系統中的重要元件。為調查減數分裂中ubiquitin蛋白質分解系統的狀態,本研究選殖了skp1 cDNA的全長及fzr cDNA的片段。將鯉魚skp1 cDNA的DNA序列翻譯成胺基酸序列後與其他生物中的skp1同源基因胺基酸序列比對,發現鯉魚Skp1與人類及豚鼠的Skp1胺基酸序列幾乎完全相同。以原位雜合反應偵測c-mos、fzr及skp1等細胞週期調控基因mRNA於卵巢中的表現狀態,發現c-mos及fzr的訊號均勻分佈於卵黃未堆積前的小卵細胞質中,而skp1的訊號則僅分佈於小卵外圍。以細菌表現及純化Skp1重組蛋白並以之製作抗血清,並以Skp1的抗血清進行免疫組織化學法以偵測卵巢中Skp1蛋白的表現,結果並無法測得任何預期訊號。 | zh_TW |
dc.description.abstract | Cyclin-dependent kinases (CDKs) and the ubiquitin-dependent proteolysis systems are the principle regulators in the cell cycle. Tight connected cell cycle regulatory mechanisms order the mitotic cell cycle in the succession of G1 → S → G2 → M. However, the cell cycle progression in meiosis is shown to be G1 → S → G2 → MI → MII. The omitting of the S phase between the MI and MII apparently violates the rule set by the cell cycle regulatory mechanisms. During meiosis, a modifying machinery must functions to alter the cell cycle regulatory mechanisms. The ubiquitin-dependent proteolysis systems are the possible targets of the modification mechinery. There are two ubiquitin-dependent proteolysis systems involved in the cell cycle control. The SCF system majorly governs the onset of the S phase and the APC system directs the progression of the M phase. Skp1 protein is an essential part of the SCF complex. Fzr seems to control the substrate specificity in the APC system. To investigate the status of the ubiquitin-dependent proteolysis system in the meiotic cell cycle, the cDNA of SKP1 gene from the carp ovary was cloned and the partial DNA sequence of fzr gene with the same origin was also cloned. The deduced amino sequence of carp SKP1 gene shows extremely high homology to its counterparts in other vertebrates. In situ hybridization was performed to detect the distribution of c-mos, fzr and SKP-1 mRNAs in the carp ovary. It was found that c-mos and fzr mRNA disperses in the cytoplasm of the smaller oocytes before the stage of vitellogenesis while skp1 mRNA distributes peripherally. It is notable that I was never able to detect any signal within oocytes with thick yolk. A bacterial expressed recombinant Skp1 protein was produced to induce antiserum against Skp1 protein. However, Immunohistochemistry and immunoblot failed to detect the expression of endogenous Skp1 protein in fish oocytes. | en |
dc.description.provenance | Made available in DSpace on 2021-07-01T08:20:58Z (GMT). No. of bitstreams: 0 Previous issue date: 1998 | en |
dc.description.tableofcontents | 目錄…………………………………………………………………………………………………i 圖目錄………………………………………………………………………………………………iii 簡寫名詞對照表………………………………………………………………………………………iv 中文摘要………………………………………………………………………………………………ix 英文摘要………………………………………………………………………………………………x 引言……………………………………………………………………………………………………1 第一部分:有絲分裂細胞週期的分子調控機制……………………………………………………1 壹.調控細胞週期的主要系統………………………………………………………………………2 一、CDK系統…………………………………………………………………………………………2 二、Ubiquitin蛋白質分解系統……………………………………………………………………3 貳.細胞週期運轉的分子調控機制…………………………………………………………………4 一、G1-S期的運轉機制………………………………………………………………………………4 1.出芽酵母菌G1/S期CDK系統活性的調控…………………………………………………………5 2.後生動物G1/S期CDK系統活性的調控……………………………………………………………6 二、G2-M期的控制機制………………………………………………………………………………8 1.M期CDK活性的啟始………………………………………………………………………………8 2.APC蛋白質分解系統與M期CDK的活性控制………………………………………………………9 三、CDK與Ubiquitin蛋白質分解系統所驅動的細胞週期………………………………………11 第二部分:減數分裂中的細胞週期機制…………………………………………………………13 壹.進入減數分裂的機制…………………………………………………………………………13 貳.減數分裂中特殊的染色體行為:同源染色體的配對與互換………………………………14 參.減數分裂M期的細胞週期控制…………………………………………………………………16 一、GVBD的誘發……………………………………………………………………………………17 二、減數分裂中連續兩次的特殊M期………………………………………………………………19 三、Metaphase II arrest…………………………………………………………………………20 四、細胞週期蛋白質分解系統在減數分裂中可能的特化………………………………………20 材料與方法…………………………………………………………………………………………24 壹.一般分子生物技術……………………………………………………………………………24 一、勝任細胞(Competent cell)之製作………………………………………………………24 二、細菌轉型(Transformation)………………………………………………………………25 三、質體DNA之抽取…………………………………………………………………………………25 四、自洋菜膠電泳中純化DNA片段…………………………………………………………………25 五、DNA定序…………………………………………………………………………………………26 貳.卵細胞RACE cDNA基因庫之製備………………………………………………………………27 一、卵細胞之分離…………………………………………………………………………………27 二、mRNA之抽取與純化……………………………………………………………………………27 三、RACE cDNA基因庫之製備………………………………………………………………………28 參.以RACE法選殖全長基因………………………………………………………………………28 一、基因片段序列之獲取…………………………………………………………………………29 二、以RACE法決定cDNA全長序列…………………………………………………………………30 肆.skp1表現質體之構築、重組蛋白的表現與純化……………………………………………31 一、表現質體之購築………………………………………………………………………………31 二、表現蛋白的誘發與純化………………………………………………………………………32 伍.抗血清之製備…………………………………………………………………………………33 陸.鯉魚卵萃取液的製備…………………………………………………………………………33 柒.Western Blot…………………………………………………………………………………33 捌.鯉魚卵巢組織石臘切片之製作………………………………………………………………34 玖.原位雜合反應…………………………………………………………………………………35 一、DIG標記探針的製備……………………………………………………………………………35 二、雜合反應………………………………………………………………………………………35 三、DIG呈色反應……………………………………………………………………………………35 拾.免疫組織化學…………………………………………………………………………………36 結果…………………………………………………………………………………………………37 一、鯉魚SKP1 cDNA全長及fzr cDNA片段的選殖…………………………………………………37 1.cDNA片段的選殖…………………………………………………………………………………37 2.SKP1 cDNA全長序列的決定………………………………………………………………………49 二、鯉魚Skp1氨基酸序列及Fzr部分氨基酸序列與其他物種同源基因氨基酸序列的比較……38 三、Skp1細菌表現蛋白的製備及純化………………………………………………………………38 四、原位雜合反應……………………………………………………………………………………40 五、鯉魚卵萃液的Skp1免疫偵測與免疫組織化學…………………………………………………40 討論……………………………………………………………………………………………………64 壹.減數分裂中Ubiquitin蛋白質分解系統可能的狀態……………………………………………52 貳.Skp1與Fzr的結搆在演化上的保守度……………………………………………………………53 參.Skp1在卵細胞中可能的表現狀態………………………………………………………………54 肆.Skp1表現蛋白的製作……………………………………………………………………………56 伍.研究展望…………………………………………………………………………………………57 引用文獻………………………………………………………………………………………………58 | |
dc.language.iso | zh-TW | |
dc.title | 鯉魚卵細胞中SKP1基因的選殖及表現 | zh_TW |
dc.title | Molecular Cloning and Expression of skp1 Gene in the Carp Oocytes. | en |
dc.date.schoolyear | 86-2 | |
dc.description.degree | 碩士 | |
dc.relation.page | 82 | |
dc.rights.note | 未授權 | |
dc.contributor.author-dept | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
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