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標題: | 高血壓及正常血壓大鼠尾端腹側延腦循環呼吸控制區之研究 Comparison of cardiorespiratory control mechanism of caudal ventrolateral region of the medulla in hypertensive and normotensive rats |
作者: | 邱瑞珍 |
出版年 : | 1997 |
學位: | 碩士 |
摘要: | 神經性因素可能是高血壓產生的主因之一,一般相信交感神經活性異常在高血壓的形成與惡化中扮演著重要的角色。本論文研究副交感神經在高血壓個體體內可能扮演的角色。本實驗使用高血壓大鼠SHR及SHRSP,以及正常血壓對照組WKY、Wistar。用α-氯醛醣(α-chloralose)及尿酯(urethane)麻醉,針對疑核與疑核四周的延腦尾端腹側區,利用麩胺酸(glutamate)刺激的方法,找尋大鼠延腦中最大降心跳反應點,比較高血壓大鼠的副交感神經系統是否有所減弱;以及找出在延腦中與循環系統控制區相近的呼吸系統控制區兩者之間的關係。在心跳反應數值上,SP和WKY與Wistar有顯著的差異,但換成百分比變化之後,四種大鼠並無差異。血壓方面,高血壓品系大鼠降血壓的量比正常血壓鼠顯著提高。結果支援高血壓鼠的延腦交感神經控制區活性增強,但副交感抑心區反應活性沒有明顯改變。初步結果顯示血壓、心跳反應與呼吸反應點間有很高的相關性。四種大鼠各種反應點的分佈都極相似。 Neural factor is one of the main cause of hypertension. It is believed that a enhanced sympathetic activity plays a critical role in the development and the maintenance of essential hypertension. This thesis studied the possible involvement of the parasympathetic system. Stroke-prone spontaneously hypertensive rat (SP) and spontaneously hypertensive rat (SHR), two of the most widely used animal models of essential hypertension, were used as hypertensive rat. Wistar Kyoto rat (WKY) and Wistar rat were used as normotensive controls. Rats were anesthetized with urethane and α-chloralose. Microinjections of glutamate solution (110 pmole) in the ventrolateral region of the medulla were used to probe the cardiac vagal area. Heart rate, blood pressure and diaphragm electromyogram responses were recorded. The maximal responses of heart rate decreases were larger in Wistar than either WKY or SP. With percentile scale, however, there were no differences among the four stains. Hypertensive rats had larger depressor responses. The results support that hypertensive rats has an enhanced sympathetic control in the medulla, whereas their parasympathetic cardioinhibitory control is not changed. In the medulla, heart rate, blood pressure, and respiration points were interrelated. There was no difference in the distribution of all three types of control points. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/76259 |
全文授權: | 未授權 |
顯示於系所單位: | 動物學研究所 |
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