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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.author | San-Tai Shen | en |
| dc.contributor.author | 沈三泰 | zh_TW |
| dc.date.accessioned | 2021-07-01T08:14:04Z | - |
| dc.date.available | 2021-07-01T08:14:04Z | - |
| dc.date.issued | 1985 | |
| dc.identifier.citation | REFERENCE 1. Lea, C. Y. (1979) Recent advances in chemistry and pharmacology of snake toxin Advanced in Cytopharmacology, 3, 1-11. 2. Tu, A. T. (1982) Rattlesnake Venoms, (New York; Marcel Dekker Inc.) 3. Kondo, K., Narita, K., and Lee, C.Y. (1978) Chemical properties and amino acid composition of β-bungarotoxin from the venom of Bungarus multicictus. J. Biochem. (Tokyo), 91-99. 4. Kondo, K., Narita, K., and Lee, C. Y. (1978) Amino acid sequence of two polypeptide chains in β-bungarotoxin from the venom of Buncarus multicictus. J. Biochem. (Tokyo), 85, 101-115. 5. Fonlman, J., Eaker, D., Harlsson, E., and Thesleff, S. (1976) Taipoxin, an extremely potent presynaptic neurotoxin from venom of Australian snake Taipan. Bur. J. Biochem., 68, 457-49. 6. Lind, I., and baker, D. (1982) Amino acid sequence of the α-subunit of Taipoxin. Bur. J. Biochem., 124, 441-447. 7. Lind, F (1982) Amino acid sequence of the β-isosubunit of Taipoxin. J. Biochem., 128, 71-75. 8. Harlsson, .E, Eaker, B, and Ryden, L. (1972) Poxicon, 10, 405-413. 9. Halpert, J., and Eaker, D. (1975) Amino acid Sequence of a presynaptic neurotoxin from the venom of Notechis scutatus scutatus (Australian Tiger Snake) J. Biol. Chem., 250, 6990-6997. 10. Haloert, J., and Eaker, D. (1976) Isolation and amino acid sequence of a neurotoxic phospholipase A from the venom of the Australian Tiger :Snake (Notechis scutatus scutatus). J. Biol. Chem., 251, 7343_7347. 11. Hendon, R. A., and Fraenkel-Conrat, H. (1971) Fiolcica1 role of the two component of Crotoxin. Froc. Natn. Acad. Sci. USA, 68, 1560. 12. Habermann, L., and Breithaupt, H. (1978) The crotoxin complex - an example of biochemical and pharmacological protein complementation. Poxicon, 16, 19-50. 13. Praenkel-Conrat, H., Jeng, T. W., and Hsiang, M: Biological activities of crotoxin and amino acid sequence of crotoxin B. Natural Toxin. 14. Preithaupt, H., Rubsamen, K., and. zermann, E. (1974) Biochemistry and pharmacology of the crctoxin complex. Bur. J. BiocheM., 49, 333-345. 15. Bieber, A. L., Tu, T., and Tu, □.□ (1975) Studies of an acidic cardiotoxin isolated from the venom of Mojave rattlesnake (Crotalus scutulstue) Biochem. Biophys. Acta., 400, 178 16. Hendon, R.A. (1975) Preliminary studies on the neurotoxin in the venom of Mojave rattlesnake (Crotclus soutulatus) Poxiocn, 13, 477. 17. Pattabbiraman, T. R., and Russell, F. E. (1975) Isolation and purification of the toxic fractions of Mojave rattlesnake venom. Toxicon, 13, 291. 18. Cate, R.L., and Bieber, A. L. (1978) Purification and characterization of Mojave( Crotalus S. scutulatus) toxin and its subunits. Archs. Biochem. Biophys., 189, 397. 19. Rael, L. Knight, R. A., and Zepeda, H. (1984) Electrephoretic variation of Mojave rattlesnake venom and migrationdifferences of Mojave toxin. Toxicon, 22, 980-985. 20. Hardy, R. L. (1985) Envenomation by the Mojave rattlesnake in southern Arizona,U. S. A. Toxicon, 21, 111-116. 21. Gleen, J. L., Straight, H. C., Wolfe, N. C., and Hardy, D. D. (1983) Ceographical variation in Mojave rattlesnake venor properties. Toxicon, 21, 19-151. 22. Neridle, D. N. (1971) Molecular weight determination of protein-Dodecyl sulfate complex by gel electrophoresis in a discontinous buffer syster. J. Biol. Chem., 246, 6328. 23. Crestifield, A. M., Moore, S., and Stein, W. H. (1963) Preparation and enzymatic hydrolysis of reduced and □-carboxymethylated protein. J. Biol. Chem., 238, 622-629. 24. Grose. B. (1967) The cyanogen bromide reaction. Methods in Enzymology, 11, 238-255. 25. Ing1is, A. S. (1983) Single hydrolysis method for all amino acid including cystein and tryptophan. Methods in Enzymology, 91, 26-36. 26. Simrson, R. T., Neuberger, N. R., and Liu, T. Y. (1976) Complete amino acid analysis of protein from a single hydrolyaia. J. Biol. Chem., 251, 1936-1940. 27. Chang., J. Y., Erauer, D. Z., and Wittmann-Leibolid, B. (1978) Microsequence analyois of pertudes and. proteins using 4-N, N-dimethylaminoazobenzene-4-isothiceyanate/phenylisc-thiocyanate double coupling method.□□□S lett. 93, 205-214 28. Chang, J. Y. (1963) Manual micro-sequence analysis of :pelypeptise using . □□methylaminoazobenzene-4-iscthiceyanate. Nethoas in Enzymology, 91, 455-483. 29. Yang, C. Y. (1979) Horse-seylers. 2. Physiol. Chem., □, 1873-1875. 30. Chang, C. C., and Lee, J. D. (1977) Crotoxin, the neurotoxin of South American rattlesnake venom is a presynaptic toxin acting as like -bungarctoxin. Naunyn-Sahmeidebergs Arch. Pharmac., 295, 159-168. 31. Hawgooa, B, J., and Smith, J. W. (1977) The mode of action at the mouse neuromuseluar junction of the phospholipase A-Orotapotin complex isolated from the venom of the South American rattlesnake. Er. J. Pharmac., 61, 577-606. 32. Tu, A.T. (1980) Sites of action of Mojave toxin isolated from the venom of the Mojave rattlesnake. Br. J. Pharmac., 69, 421-431. 33. Cmor-Satch, T.., Lang, J., Breithaupt, H., and Habermann, L. (1975) Partial amino acid sequence of the basic crotalus phospholipase A. Toxicon, 13, 69-71. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75593 | - |
| dc.description.abstract | 摘要 具有致死性的蛇毒蛋白，Mojave toxin, 是由美洲響尾蛇(Mojave rattlesnake, Crotaluo Acutulatuo cutulatuo)的毒液純化得到，再經由陽離子交換樹脂，Sp-Sephadex C-25，可將其兩個次單元分離。具有毒性與磷脂?活性的酸性次單元，稱?Mojave toxin A，經由還原烷化將雙硫鍵打斷，以析柱Sephadex G-50，得到兩個部份。整個酸性單元及經由Sephoder G-50的兩個部分，本實驗D ABITC/PITC 雙偶合的方法，決定其N-端胺酸排列順序與比較。 具有毒性與磷脂?活性的鹼性次單元，稱?Mojave toxin B，與還原烷化後的鹼性次單元R(M-Mojave-toxin B)。同作N-端胺基酸排列順序為：His-Leu-Leu-Gln-Phe-Asn-Lys-Met-Ile-Lys-Phe。Mojave toxin B以BRCN切判後，以Sephadex G-25分離得到兩個部分為：CNBI 及CNBII/III，而其中CNBII/III含雙硫鍵，還原烷化後，同樣以Sephadex G-25得CNBII及CNBIII兩個部分；而它們的部分胺酸排列順序被決定出來。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-07-01T08:14:04Z (GMT). No. of bitstreams: 0 Previous issue date: 1985 | en |
| dc.description.tableofcontents | 目錄 1 摘要......................1 2 圖表目錄......................3 3 序言......................4 4 材料、藥品......................8 5 儀器......................9 6 實驗方法......................10 7 結果......................16 8 討論......................40 9 參考文獻......................42 | |
| dc.language.iso | zh-TW | |
| dc.title | 北美洲響尾蛇神經蛇毒蛋白的部份胺基酸排列順序 | zh_TW |
| dc.title | Partial Amino Acid Sequence of Mojove Toxin(Crotalus Scutulatus Scutulatus) | en |
| dc.date.schoolyear | 74-2 | |
| dc.description.degree | 碩士 | |
| dc.relation.page | 45 | |
| dc.rights.note | 未授權 | |
| dc.contributor.author-dept | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科學研究所 | zh_TW |
| 顯示於系所單位： | 生化科學研究所 | |
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