請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75432
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chih-Hung Cheng | en |
dc.contributor.author | 鄭智鴻 | zh_TW |
dc.date.accessioned | 2021-07-01T08:13:10Z | - |
dc.date.available | 2021-07-01T08:13:10Z | - |
dc.date.issued | 2003 | |
dc.identifier.citation | Adams, J. M., and Cory, S. (1998). The Bcl-2 protein family: arbiters of cell survival. Science 281, 1322-6. Aladjem, M. I., Spike, B. T., Rodewald, L. W., Hope, T. J., Klemm, M., Jaenisch, R., and Wahl, G. M. (1998). ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol 8, 145-55. Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G., Thornberry, N. A., Wong, W. W., and Yuan, J. (1996). Human ICE/CED-3 protease nomenclature. Cell 87, 171. Antonsson, B. (2001). Bax and other pro-apoptotic Bcl-2 family “killer-proteins’ and their victim the mitochondrion. Cell Tissue Res 306, 347-61. Ashkenazi, A., and Dixit, V. M. (1998). Death receptors: signaling and modulation. Science 281, 1305-8. Borner, C., Olivier, R., Martinou, I., Mattmann, C., Tschopp, J., and Martinou, J. C. (1994). Dissection of functional domains in Bcl-2 alpha by site-directed mutagenesis. Biochem Cell Biol 72, 463-9. Bouillet, P., Cory, S., Zhang, L. C., Strasser,A., and Adams, J. M. (2001). Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. Dev Cell 1, 645-53. Bouillet, P., Metcalf, D., Huang, D. C., Tarlinton, D. M., Kay, T. W., Kontgen, F., Adams, J. M., and Strasser, A. (1999). Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286, 1735-8. Bouillet, P., Purton, J. F., Godfrey, D. I., Zhang, L. C., Coultas, L., Puthalakath, H.,Pellegrini, M., Cory, S., Adams, J. M., and Strasser, A. (2002). BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415, 922-6. Budihardjo, I., Oliver, H., Lutter, M., Luo, X., and Wang, X. (1999). Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15,269-90. Chao, D. T., and Korsmeyer, S. J. (1998). BCL-2 family: regulators of cell death. Annu Rev Immunol 16, 395-419. Chen, M. C., Gong, H. Y, Cheng, C. Y., Wang, J. P., Hong, J. R., and Wu, J. L. (2000). Cloning and characterization of a novel nuclear Bcl-2 family protein, zfMcl-1a, in zebrafish embryo. Biochem Biophys Res Commun 279, 725-31. Chen, M. C., Gong, H. Y., Cheng, C. Y., Wang, J. P., Hong, J. R., and Wu, J. L. (2001). Cloning and characterization of zfBLP1, a Bcl-XL homologue from the zebrafish, Danio rerio. Biochim Biophys Acta 1519, 127-33. Cheng, E. H., Wei, M. C., Weiler, S., Flavell, R. A., Mak, T. W., Lindsten, T., and Korsmeyer, S. J. (2001). BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 8, 705-11. Chittenden, T, Flemington, C., Houghton, A. B., Ebb, R. G., Gallo, G. J., Elangovan, B., Chinnadurai, G., and Lutz, R. J. (1995). A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. Embo J14, 5589-96. Desagher, S., and Martinou, J. C. (2000). Mitochondria as the central control point of apoptosis. Trends Cell Biol 10, 369-77. Eamshaw, W. C., Martins, L. M., and Kaufmann, S. H. (1999). Mammalian caspases:structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68, 383-424. - Gong, Z., Ju, B., and Wan, H. (2001). Green fluorescent protein (GFP) transgenic fish and their applications. Genetica 111, 213-25. Green, D. R., and Reed, J. C. (1998). Mitochondria and apoptosis. Science 281, 1309-12. Hengartner, M.O., and Horvitz, H. R. (1994). C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell76, 665-76. Her, G. M., Chiang, C. C., Chen, W. Y., and Wu, J. L. (2003a). In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio). FEBS Lett 538, 125-33. Her, G. M., Yeh, Y. H., and Wu, J. L. (2003b). 435-bp liver regulatory sequence in the liver fatty acid binding protein (L-FABP) gene is sufficient to modulate liver regional expression in transgenic zebrafish. Dev Dyn 227, 347-56. Hong, Y. S., Ham, Y. A., Choi, J. H., and Kim, J. (2000). Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines. Exp Mol Med 32, 127-34. Hsieh, Y. C., Chang, M. S., Chen, J. Y., Yen, J. J., Lu, I. C., Chou, C. M., and Huang, C. J. (2003). Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos. Biochem Biophys Res Commun 304, 667-75. Huang, D. C., and Strasser, A. (2000). BH3-Only proteins-essential initiators of apoptotic cell death. Cell 103, 839-42. Iber, T., and Rintala, R. (1999). Intrapulmonary ectopic liver. JPediatr Surg 34, 1425-6. Ikegami, R., Hunter, P., and Yager, T. D. (1999). Developmental activation of the capability to undergo checkpoint-induced apoptosis in the early zebrafish embryo. Dev Biol 209, 409-33. Inohara, N., and Nunez, G. (2000). Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell Death Differ 7, 509-10. Jacobson, M.D., Weil, M., and Raff, M. C. (1997). Programmed cell death in animal development. Cell 88, 347-54. Jurisicova, A., Varmuza, S., and Casper, R. F. (1996). Programmed cell death and human embryo fragmentation. Mol Hum Reprod 2, 93-8. Kamada, S., Shimono, A., Shinto, Y., Tsujimura, T., Takahashi, T., Noda, T., Kitamura, Y., Kondoh, H., and Tsujimoto, Y. (1995). bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res 55, 354-9. Kamarajan, P., Sun, N. K., Sun, C. L., and Chao, C. C. (2001). Apaf-1 overexpression partially overcomes apoptotic resistance in a cisplatin-selected HeLa cell line. FEBS Lett 505, 206-12. Kerr, J. F., Wyllie, A. H., and Currie, A. R. (1972). Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26,239-57. Kim, H., Lee, H., and Yun, Y. (1998). X-gene product of hepatitis B virus induces apoptosis in liver cells. J Biol Chem 273, 38 1-5. Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., and Schilling, T. F. (1995). Stages of embryonic development of the zebrafish. Dev Dyn 203, 253-310. Lane, D. (2001). How cells choose to die. Nature 414, 25, 27. Long, Q., Meng, A., Wang, H., Jessen, J. R., Farrell, M. J., and Lin, S. (1997). GATA-l expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development 124, 4105-11. Nakayama, K., Negishi, I., Kuida, K., Sawa, H., and Loh, D. Y. (1994). Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci USA 91, 3700-4. Ober, E. A., Field, H. A., and Stainier, D. Y (2003). From endoderm formation to liver and pancreas development in zebrafish. Mech Dev 120, 5-18. Pack, M., Solnica-Krezel, L., Malicki, J., Neuhauss, S. C., Schier, A. F., Stemple, D. L., Driever, W., and Fishman, M. C. (1996). Mutations affecting development of zebrafish digestive organs. Development 123, 321-8. Park, W. H., Choi, S. O., Lee, S. S., and Randolph, J. G. (1991). Ectopic umbilical liver in conjunction with biliary atresia: uncommon association. J Pediatr Surg26, 219-22. Puthalakath, H., Huang, D. C., O’Reilly, L.A., King, S. M., and Strasser, A. (1999). The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 3, 287-96. Raff, M. C. (1992). Social controls on cell survival and cell death. Nature 356,397-400. Ranganath, R. M., and Nagashree, N. R. (2001). Role of programmed cell death in development. Int Rev Cytol 202, 159-242. Reimold, A. M., Etkin, A., Clauss, I., Perkins, A., Friend, D. S., Zhang, J., Horton, H.F., Scott, A., Orkin, S. H., Byrne, M. C., Grusby, M. J., and Glimcher, L. H.(2000). An essential role in liver development for transcription factor XBP-1.Genes Dev 14, 152-7. Ruiz-Vela, A., Albar, J. P., and Martinez, C. A. (2001). Apaf-f localization is modulated indirectly by Bcl-2 expression. FEBS Lett 501, 79-83. Sakarya, A., Erhan, Y., Aydede, H., Kara, E., Ilkgul, O., and Ciftdogan, C,. (2002). Ectopic liver (choristoma) associated with the gallbladder encountered during laparoscopic cholecystectomy: a case report. Surg Endosc 16, 1106. Sentman, C. L., Shutter, J. R., Hockenbery, D., Kanagawa, O., and Korsmeyer, S. J. (1991). bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67, 879-88. Shimizu, S., Ide, T., Yanagida, T., and Tsujimoto, Y. (2000a). Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J Biol Chem 275, 12321-5. Shimizu, S., Konishi, A., Kodama, T., and Tsujimoto, Y. (2000b). BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci USA 97, 3 100-5. Shimizu, S., and Tsujimoto, Y. (2000). Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. Proc Natl Acad Sci USA 97, 577-82. Shuda, M., Kondoh, N., Imazeki, N., Tanaka, K., Okada, T., Mori, K., Hada, A., Arai, M., Wakatsuki, T., Matsubara, O, Yamamoto, N., and Yamamoto, M. (2003). Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J Hepatol 38, 605-14. Sible, J. C., Anderson, J. A., Leweilyn, A. L., and Mailer, J. L. (1997). Zygotic transcription is required to block a maternal program of apoptosis in Xenopus embryos. Dev Biol 189, 335-46. Strasser, A., Harris, A. W., and Cory, S. (1991a). bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67, 889-99. Strasser, A., Whittingham, S., Vaux, D. L., Bath, M. L., Adams, J. M., Cory, S., and Harris, A. W. (1991b). Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA 88, 8661-5. Suzuki, M., Youle, R. J., and Tjandra, N. (2000). Structure of Bax: coregulation of dimer formation and intracellular localization. Cell 103, 645-54. Terradillos, O., de La Coste, A., Pollicino, T., Neuveut, C., Sitterlin, D., Lecoeur, H., Gougeon, M. L., Kahn, A., and Buendia, M. A. (2002). The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver. Oncogene 21, 377-86. Thornberry, N. A., and Lazebnik, Y. (1998). Caspases: enemies within. Science 281,1312-6. Udvadia, A. J., Koster, R. W., and Skene, J. H. (2001). GAP-43 promoter elements in transgenic zebrafish reveal a difference in signals for axon growth during CNS development and regeneration. Development 128, 1175-82. Vaux, D. L., Cory, S., and Adams, J. M. (1988). Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature335, 440-2. Veerkamp, J. H., and Maatman, R. G. (1995). Cytoplasmic fatty acid-binding proteins: their structure and genes. Prog Lipid Res 34, 17-52. Wells, J. M., and Melton, D. A. (1999). Vertebrate endoderm development. Annu Rev Cell Dev Biol 15, 393-410. Yang, E., Zha, J., Jockel, J., Boise, L. H., Thompson, C. B., and Korsmeyer, S. J. (1995). Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80, 285-91. Yasuda, M., and Chinnadurai, G. (2000). Functional identification of the apoptosis effector BH3 domain in cellular protein BNIP1. Oncogene 19, 2363-7. Yin, X. M., Wang, K., Gross, A., Zhao, Y., Zinkel, S., Klocke, B., Roth, K. A., and Korsmeyer, S. J. (1999). Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400, 886-91. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75432 | - |
dc.description.abstract | 斑馬魚在研究發展上有許多實驗上的優點,雖然在傳統上已經用他們來闡明早期胚發育的機制,但是他們也能夠被善加地利用在較後期的發育上,例如在器官發生的發展方面調查問題。 Bcl - 2 基因群為調控細胞凋亡(apoptosis)進行之基因,而細胞凋亡是脊椎動物早期發育的一個十分重要部分,它涉及在雕塑器官的形狀上,所以當肝臟形成時,促細胞凋亡和抗細胞凋亡之間的平衡被打破將可能導致肝臟過度增殖或者發育不全。而為瞭解肝臟形成的發育過程,利用斑馬魚作為一個模式系統,並使用實驗室中已有的表現綠螢光肝臟之基因轉殖魚,來瞭解過量表現 BLP1 和 Mcl-1a 基因時會對肝臟的器官發生產生如何的影響。從基因轉殖魚分析的結果,發現到過量表現BLP1 和Mcl-1a 基因於斑馬魚幼魚發育期間會導致肝臟的過度生長,並且發現到許多調節生長的基因受到改變,如XBP -1和 C /EBP? 等基因都會增加表現。 | zh_TW |
dc.description.abstract | Zebrafish embryos have several experimental advantages for studying development. Although they have traditionally been used to elucidate mechanisms of early development, they can also be exploited to investigate issues later in development such as organogenesis. Previous studies have identified genes of the Bcl-2 family as a group of evolutionarily conserved genes that regulate cellular apoptosis. Since apoptosis is an essential part of normal embryonic development in vertebrates, it is involved in sculpturing organs. For instance, interruption of the balance between apoptosis and anti-apoptosis in liver formation may cause liver hyperplasia or hypoplasia. To understand the apoptosis regulated liver formation, we have used the zebrafish as a model to understand the liver organogenesis by overexpressing BLP1 and Mcl-la genes in the liver of transgenic zebrafish, LF2.8-TG1, whose liver could express GFP. Results from the transient transgenic analysis suggest that the zebrafish BLP1 and Mcl-la genes might interrupt the liver formation during zebrafish embryogenesis. Results from our findings in the enlarged liver indicate that overexpression of Bcl-2 family proteins in zebrafish leads to liver overgrowth, and several transcription factors, such as XBP-1 and C/EBP? are up regulated. | en |
dc.description.provenance | Made available in DSpace on 2021-07-01T08:13:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2003 | en |
dc.description.tableofcontents | 英文摘要---------------------------------------------------2 中文摘要---------------------------------------------------3 壹、前言---------------------------------------------------4 貳、研究架構---------------------------------------------------16 參、實驗材料---------------------------------------------------17 一、儀器及器材---------------------------------------------------l7 二、反應試劑---------------------------------------------------l8 肆、實驗方法---------------------------------------------------27 伍、實驗結果---------------------------------------------------33 陸、討論---------------------------------------------------37 染、參考文獻---------------------------------------------------42 捌、圖表---------------------------------------------------47 | |
dc.language.iso | zh-TW | |
dc.title | Bcl - 2 細胞凋亡家族基 因轉殖對斑馬魚肝臟器官發育之調控 | zh_TW |
dc.title | Apoptotic Bcl-2 family genes regulate the zebrafish liver organogenesis through transgenesis | en |
dc.date.schoolyear | 91-2 | |
dc.description.degree | 碩士 | |
dc.relation.page | 61 | |
dc.rights.note | 未授權 | |
dc.contributor.author-dept | 生命科學院 | zh_TW |
dc.contributor.author-dept | 漁業科學研究所 | zh_TW |
顯示於系所單位: | 漁業科學研究所 |
文件中的檔案:
沒有與此文件相關的檔案。
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。