請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75082完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.author | Bor－Long Huang | en |
| dc.contributor.author | 黃博隆 | zh_TW |
| dc.date.accessioned | 2021-07-01T08:11:45Z | - |
| dc.date.available | 2021-07-01T08:11:45Z | - |
| dc.date.issued | 1999 | |
| dc.identifier.citation | Abbas, A.K., Lichliman, A.H., and Pober, J.S. (1997) Cellular and Molecular Immunology 3rd, W.B.Saunders.Co, U.S.A
AlonsoDeVelasco, E., Verheul, A.F., Verhoef, J., and Snippe, H. (1995) Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccines. Microbiol. Rev. 59(4): 59 1-603 Arai, K.I., Lee, F., Miyajima, A., Miyatake, S., Arai, N., and Yokota, T. (1990) cytokines: coordinators of immune and inflammatory responses. Annu. Rev. Biochem. 59:783-836 Auboeuf, D. and Vidal, H. (1997) The use of the reverse transcription-competitive polymerase chain reaction to investigate the in vivo regulation of gene expression in small tissue samples. Anal. Biochem. 245(2): 141-148 Balk, S.P., Bleicher, P.A., and Terhorst, C. (1991) Isolation and expression of cDNA encoding the murine homologues of CD1.J. Immunol. 146(2):768-774 Bebr, T., Fischer, W., Peter-Katalinic, J., and Egge, H. (1992) The structure of pneumococcal lipoteichoic acid. Improved preparation, chemical and mass spectrometric studies. Eur. J Biochem. 207(3): 1063-1075 Benham, A., Tulp, A., and Neefjes, J. (1995) Synthesis and assembly of MHC-peptide complexes. Immunol. Today 16(7):359-362 Benoist, C.O., Mathis, D.J., Kanter, M.R., and Williams, V.E 2d, and McDevitt, H.O.(1983) Regions of allelic hypervariability in the murine A alpha immune response gene.Cell 34(1):169-177 Blumberg, R.S., Gerdes, D., Chott, A., Porcelli, S.A., and Balk, S.P. (1995) Structure and function of the CD1 family of MHC-like cell surface proteins. Immunol. Rev. 147:5-29 Braud, V.M., Allan, D.S., and McMichael, A.J. (1999) Functions of nonclassical MHC and non-MHC-encoded class I molecules. Curr. Opin. Immunol. 11(1):100-108 Bradbury, A., Belt, K.T., Neri, T.M., Milstein, C. and Calabi, F. (1988) Mouse CD1 is distinct from and co-exists with TL in the same thymus. EMBO. J. 7(10):3081-3086 Busch, R., and Mellins, E.D. (1996) Developing and shedding inhibitions: how MHC class II molecules reach maturity. Curr. Opin. Immunol. 8(1):5 1-58 Carter, L.L. and Swain, S.L. Single cell analyses of cytokine production. Curr. Opin. Immunol. (1997) 9(2):177-182 Chalvardjian, A. and Rudnicki, E. (1970) Determination of lipid phosphorus in the nanomolar range. Anal. Biochem. 36(l):225-226 Chapman, H.A. (1998) Endosomal proteolysis and MHC class II function. Curr. Opin. Immunol. 10(1):93-102 Fernander, N. and Butcher, G. (1998) MHC: a practical approach, p15-18, Oxford. New York. Fischer, W., Behr, T., Hartmann, R., Peter-Katalinic, J., and Egge, H. (1993) Teichoic acid and lipoteichoic acid of Streptococcus pneumoniae possess identical chain structures. A reinvestigation of teichoid acid (C polysaccharide). Eur. J Biochem. 21 5(3):85 1-857 Fischer, W. (1997) Pneumococcal lipoteichoic and teichoic acid. Microb. Drug. Resist. 3(4): 309-325 Germain, R.N. (1994) MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76(2):287-299 Gotschlich, E.C. and Liu, T.Y. (1967) Structural and immunological studies on the pneumococcal C polysaccharide.J Biol Chem 242(3):463-70 Jackman, R.M., Moody, D.B., and Porcelli, S.A. (1999) Mechanisms of lipid antigen presentation by CD 1. Crit. Rev. Immunol. 19(1): 49-63 Johnston, R.B.Jr. (1991) Pathogenesis of pneumococcal pneumonia. Rev. Infect. Dis. 13 Suppl 6:S509-517. Koopmann, J.O., Hammerling, G.J., and Momburg, F. (1997) Generation, intracellular transport and loading of peptides associated with MHC class I molecules. Curr. Opin. Immunol. 9(1):80-88 Kovacsovics-Bankowski, M., and Rock, K.L. (1994) Presentation of exogenous antigens by macrophages: analysis of major histocompatibility complex class I and II presentation and regulation by cytokines. Eur. J. Immunol. 24(l0):2421-2428 Kuby, J. (1997) Immunology 3rd. p313-333, Freeman Lehner, P.J., and Cresswell, P. (1996) Processing and delivery of peptides presented by MHC class I molecules. Curr. Opin. Immunol. 8(1): 59-67 Liles, W.C. and Van Voorhis, W.C. (1995) Review: nomenclature and biologic significance of cytokines involved in inflammation and the host immune response. J. Infect. Dis. 172(6):1573-1580 Liu, T.Y. and Gotschlich, E.C. (1963) The chemical composition of pneumococcal C polysaccharide. J Biol Chem 238(6): 1928-1934 Maffei, A., and Harris, P.E. (1998) Peptides bound to major histocompatibility complex molecules. Peptides. 19(1): 179-198. Mizel, S.B. (1989) The interleukins. FASEB. J. 3(12):2379-2388 Porcelli, S.A. and Brenner, M.B. (1997) Antigen presentation: mixing oil and water. Curr. Biol. 7(8):R508-511 Porcelli, S.A., Segelke, B.W., Sugita, M., Wilson, I.A., and Brenner, (1998) M.B.The CD1 family of lipid antigen-presenting molecules. Immunol. Today 19(8): 362-368 Rammensee, H.-G., Friede, T., and Stevanoviic, S. (1995) MHC ligands and peptide motifs: first listing. Immunogenetics 41(4): 178-228 Robertson, M. (1998) Antigen presentation. Curr. Biol. l9;8(23):R829-831 Robinson, P.J., Bevec, D., and Mellor, A.L., and Weiss, E.H. (1988) Sequence of the mouse Q4 class I gene and characterization of the gene product. Immunogenetics 27(2):79-86 Scott, P. (1993) IL-12: initistion cytokine for cell-mediated immunity. Science. 260:496- 497 Simpson, A.E., Tomkins, P.T., and Cooper, K.L. (1997) An investigation of the temporal induction of cytokine mRNAs in LPS-challenged thioglycollate-elicited murine peritoneal macrophages using the reverse transcription polymerase chain reaction. Inflamm. Res.46(2): 65-71 Trinchieri, G. and Gerosa, F. (1996) Immunoregulation by interleukin- 12. J. Leukoc. Biol. 59(4):505-511 Trinchieri, G. (1997) Cytokines acting on or secreted by macrophages during intracellular infection (IL-10 , IL-12, IFN-gamma). Curr. Opin. Immunol. 9(1): 17-23 Vidal, H., Auboeuf, D., Beylot, M., and Riou, J.P. (1995) Regulation of insulin receptor mRNA splicing in rat tissues. Effect of fasting, aging, and diabetes. Diabetes 44(10): 1196-1201 Yother, J., Leopold, K., White, J., and Fischer, W. (1998) Generation and properties of a Streptococcus pneumoniae mutant which does not require choline or analogs for growth. J. Bacteriol. 180(8):2093-2101 Zeng, Z., Castano, A.R., Segelke, B.W., Stura, E.A., Peterson P.A., and Wilson l.A. (1997) Crystal structure of mouse CD1: an MHC-like fold with a large hydrophoic binding Groove. Science. 277(5324): 339-345. Zirk, N.M., Hashmi, S.F., and Ziegler, H.K. (1999) The polysaccharide portion of lipopolysaccharide regulates antigen-specific T-cell activation via effects on macrophagemediated antigen processing. Infect. Immun. 67(1): 319-326. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/75082 | - |
| dc.description.abstract | 數百萬年來，脊椎動物生活在各種入侵者的環境之中；這些入侵者包含了病毒，細菌及各種寄生蟲。免疫系統演化的首要目的是為了對抗外來的致命入侵者。免疫反應在對抗外來抗原之基本特徵為；針對特定抗原有其專一性。其中，第一類、第二類 MHC 及 CDI 分子是包含在 T 細胞反應中的三種主要抗原呈現分子，同時他們和細胞激素的釋放有關聯。
肺炎雙球菌是一種革蘭氏陽性細菌。肺炎雙球菌的細胞壁主要是由?聚醣所組成：其中的聚醣鏈是由 N－乙醯葡萄糖胺及 N－乙醯胞壁酸的殘基交錯所組成，糖鏈間的交互聯結是藉由勝?鍵及乙醱胞壁酸結合完成。細胞壁的多醣是一種包含了磷脂膽鹼殘基的台口酸，而且也是藉由磷酸二脂鍵結到 N－乙醯胞壁酸和?聚糖相連結。另一種重要的結構是脂台口酸（或稱為福氏抗原『Forssman antigen』）是一種台口酸相似於細胞壁中的多醣且具有額外的共價鍵連結到脂質的部份。 在一篇研究中，我使用了化學性質已明的肺炎雙球菌細胞壁成份去刺激取自腹腔的巨噬細胞。我發現了下列的現象： l ）當用萃取出來的細胞壁刺激時，第一類 MHC 分子 mRNA 的表現會提升； 2 ）當台口酸刺激巨噬細胞時，CDI 的 mRNA 表現增加， ; 3 )當受到萃取出來的細胞壁刺激時，間白素－Iα mRNA 的增加，是； 4 ）用萃取出來的細胞壁及?聚糖刺激時，則會促進間白素－6 的 mRNA 的表現； 5 ）間白素－12 mRNA 的表現則會受到肺炎雙球菌細胞壁所有成份的影響； 6 ）相對地，間白素－l β , 2 , 4 及幹擾素－γ的 mRNA 則不會受到細胞壁成份的刺激而發生重大改變。 | zh_TW |
| dc.description.abstract | Vertebrates, over the course of millions of years, have been continuously exposed to invasion by viruses, bacteria, and other parasites. The immune system has evolved primarily to deal with these potentially lethal invaders. The most basic feature of the immune response to a foreign antigen is its specificity for that particular antigen. Three antigen-presenting molecules, MHC class I, MHC class II, and CD1, are implicated in T cell responses and together they are associated with the release of cytokines.
Streptococcus pneumoniae is one type of gram-positive bacteria. Pneumococcal cell wall is composed mainly of peptidoglycan: glycan chains of alternating N-acetylglucosamine and N-acetylmuramic acid residues, cross-linked to each other through peptide side-chains via N-acetylmuramic acid. The cell wall polysaccharide, a complex teichoic acid containing phosphocholine residues, is also attached to peptidoglycan via phosphodieaster bond to Nacetylmuramic acid. Another important structure is lipoteichoic acid or Forssman antigen, a polysaccharide similar to teichoic acid with additional covalently attached lipid moiety. In this study, I used chemically well-defined components from pneumococcal cell wall to stimulate the peritoneal macrophages. I found that: 1) The expression of the MHC class I mRNA was elevated by the cell wall materials. 2) CD1 mRNA expression was stimulated by lipoteichoic acid. 3) The IL-lα mRNA increased when macrophages were stimulated by cell wall materials. 4) The expression of IL-6 mRNA was elevated by using cell wall materials and peptidoglycan. 5) The expression of IL- 12 mRNA is influenced by all components from streptococcal cell wall. and 6) The mRNA expressions of IL-1β, 1L2, 1L4, and IFN- γ did not change significantly by all of the cell wall components. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-01T08:11:45Z (GMT). No. of bitstreams: 0 Previous issue date: 1999 | en |
| dc.description.tableofcontents | 中文摘要 2 ABSTRACT 4 ABBREVIATION 6 INTRODUCTION 8 MATERIAS AND METHODS 20 RSULTS 29 DISCUTION 34 EIGURES 40 TABLE 60 REFFERENCES 61 | |
| dc.language.iso | zh-TW | |
| dc.title | 肺炎雙球菌的細胞壁成份對巨噬細胞內抗原呈現分子及細胞激素之信使核糖核酸的影嚮 | zh_TW |
| dc.title | Expressions of mRNAs of antigen-presenting molecules and cytokines in macrophages when stimulated by the Cell Wall Components of Streptococcus pneumoniae | en |
| dc.date.schoolyear | 87-2 | |
| dc.description.degree | 碩士 | |
| dc.relation.page | 68 | |
| dc.rights.note | 未授權 | |
| dc.contributor.author-dept | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科學研究所 | zh_TW |
| 顯示於系所單位： | 生化科學研究所 | |
文件中的檔案：
沒有與此文件相關的檔案。
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。