請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/74894
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 鄧麗珍(Lee-Jene Teng) | |
dc.contributor.author | Jia-Chuan Hsu | en |
dc.contributor.author | 許家銓 | zh_TW |
dc.date.accessioned | 2021-06-17T09:09:44Z | - |
dc.date.available | 2021-02-23 | |
dc.date.copyright | 2021-02-23 | |
dc.date.issued | 2021 | |
dc.date.submitted | 2021-02-02 | |
dc.identifier.citation | 1.Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998 Aug 20;339(8):520-32. 2.Thammavongsa V, Kim HK, Missiakas D, Schneewind O. Staphylococcal manipulation of host immune responses. Nat Rev Microbiol. 2015 Sep;13(9):529-43. 3.Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol. 2000 Mar;38(3):1008-15. 4.Holt DC, Holden MT, Tong SY, Castillo-Ramirez S, Clarke L, Quail MA, Currie BJ, Parkhill J, Bentley SD, Feil EJ, Giffard PM. A very early-branching Staphylococcus aureus lineage lacking the carotenoid pigment staphyloxanthin. Genome Biol Evol. 2011;3:881-95. 5.McDonald M, Dougall A, Holt D, Huygens F, Oppedisano F, Giffard PM, Inman-Bamber J, Stephens AJ, Towers R, Carapetis JR, Currie BJ. Use of a single-nucleotide polymorphism genotyping system to demonstrate the unique epidemiology of methicillin-resistant Staphylococcus aureus in remote aboriginal communities. J Clin Microbiol. 2006 Oct;44(10):3720-7. 6.Okuma K, Iwakawa K, Turnidge JD, Grubb WB, Bell JM, O'Brien FG, Coombs GW, Pearman JW, Tenover FC, Kapi M, Tiensasitorn C, Ito T, Hiramatsu K. Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J Clin Microbiol. 2002 Nov;40(11):4289-94. 7.O'Brien FG, Lim TT, Chong FN, Coombs GW, Enright MC, Robinson DA, Monk A, Saïd-Salim B, Kreiswirth BN, Grubb WB. Diversity among community isolates of methicillin-resistant Staphylococcus aureus in Australia. J Clin Microbiol. 2004 Jul;42(7):3185-90. 8.Ng JW, Holt DC, Lilliebridge RA, Stephens AJ, Huygens F, Tong SY, Currie BJ, Giffard PM. Phylogenetically distinct Staphylococcus aureus lineage prevalent among indigenous communities in northern Australia. J Clin Microbiol. 2009 Jul;47(7):2295-300. 9.Ruimy R, Armand-Lefevre L, Barbier F, Ruppé E, Cocojaru R, Mesli Y, Maiga A, Benkalfat M, Benchouk S, Hassaine H, Dufourcq JB, Nareth C, Sarthou JL, Andremont A, Feil EJ. Comparisons between geographically diverse samples of carried Staphylococcus aureus. J Bacteriol. 2009 Sep;191(18):5577-83. 10.Tong SYC, Schaumburg F, Ellington MJ, Corander J, Pichon B, Leendertz F, Bentley SD, Parkhill J, Holt DC, Peters G, Giffard PM. Novel staphylococcal species that form part of a Staphylococcus aureus-related complex: the non-pigmented Staphylococcus argenteus sp. nov. and the non-human primate-associated Staphylococcus schweitzeri sp. nov. Int J Syst Evol Microbiol. 2015 Jan;65(Pt 1):15-22. 11.Brakstad OG, Aasbakk K, Maeland JA. Detection of Staphylococcus aureus by polymerase chain reaction amplification of the nuc gene. J Clin Microbiol. 1992 Jul;30(7):1654-60. 12.Kwok AYC, Chow AW. Phylogenetic study of Staphylococcus and Macrococcus species based on partial hsp60 gene sequences. Int J Syst Evol Microbiol. 2003 Jan;53(Pt 1):87-92. 13.Shah MM, Iihara H, Noda M, Song SX, Nhung PH, Ohkusu K, Kawamura Y, Ezaki T. dnaJ gene sequence-based assay for species identification and phylogenetic grouping in the genus Staphylococcus. Int J Syst Evol Microbiol. 2007 Jan;57(Pt 1):25-30. 14.Sasaki T, Tsubakishita S, Tanaka Y, Sakusabe A, Ohtsuka M, Hirotaki S, Kawakami T, Fukata T, Hiramatsu K. Multiplex-PCR method for species identification of coagulase-positive Staphylococci. J Clin Microbiol. 2010 Mar;48(3):765-9. 15.Hirotaki S, Sasaki T, Kuwahara-Arai K, Hiramatsu K. Rapid and accurate identification of human-associated Staphylococci by use of multiplex PCR. J Clin Microbiol. 2011 Oct;49(10):3627-31. 16.Fey PD, Endres JL, Yajjala VK, Widhelm TJ, Boissy RJ, Bose JL, Bayles KW. A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes. mBio. 2013 Feb 12;4(1):e00537-12. 17.Argudín MA, Dodémont M, Vandendriessche S, Rottiers S, Tribes C, Roisin S, de Mendonça R, Nonhoff C, Deplano A, Denis O. Low occurrence of the new species Staphylococcus argenteus in a Staphylococcus aureus collection of human isolates from Belgium. Eur J Clin Microbiol Infect Dis. 2016 Jun;35(6):1017-22. 18.Thaipadungpanit J, Amornchai P, Nickerson EK, Wongsuvan G, Wuthiekanun V, Limmathurotsakul D, Peacock SJ. Clinical and molecular epidemiology of Staphylococcus argenteus infections in Thailand. J Clin Microbiol. 2015 Mar;53(3):1005-8. 19.Chantratita N, Wikraiphat C, Tandhavanant S, Wongsuvan G, Ariyaprasert P, Suntornsut P, Thaipadungpanit J, Teerawattanasook N, Jutrakul Y, Srisurat N, Chaimanee P, Anukunananchai J, Phiphitaporn S, Srisamang P, Chetchotisakd P, West TE, Peacock SJ. Comparison of community-onset Staphylococcus argenteus and Staphylococcus aureus sepsis in Thailand: a prospective multicentre observational study. Clin Microbiol Infect. 2016 May;22(5):458.e11-9. 20.Zhang DF, Xu X, Song Q, Bai Y, Zhang Y, Song M, Shi C, Shi X. Identification of Staphylococcus argenteus in Eastern China based on a nonribosomal peptide synthetase (NRPS) gene. Future Microbiol. 2016 Sep;11:1113-21. 21.Chen SY, Lee H, Teng SH, Wang XM, Lee TF, Huang YC, Liao CH, Teng LJ, Hsueh PR. Accurate differentiation of novel Staphylococcus argenteus from Staphylococcus aureus using MALDI-TOF MS. Future Microbiol. 2018 Jul;13:997-1006. 22.Hauschild T, Stepanovic S. Identification of Staphylococcus spp. by PCR-restriction fragment length polymorphism analysis of dnaJ gene. J Clin Microbiol. 2008 Dec;46(12):3875-9. 23.Hao Lee. Characterization of Unusual Staphylococcus aureus Lineage Revealed by Atypical dnaJ PCR-RFLP Pattern. 2014. Master Thesis. 24.Xiao-Mei Wang. Characterization of Non-pigmented Staphylococcus aureus in Northern Taiwan. 2016. Master Thesis. 25.Ruimy R, Angebault C, Djossou F, Dupont C, Epelboin L, Jarraud S, Lefevre LA, Bes M, Lixandru BE, Bertine M, El Miniai A, Renard M, Bettinger RM, Lescat M, Clermont O, Peroz G, Lina G, Tavakol M, Vandenesch F, van Belkum A, Rousset F, Andremont A. Are host genetics the predominant determinant of persistent nasal Staphylococcus aureus carriage in humans? J Infect Dis. 2010 Sep 15;202(6):924-34. 26.Monecke S, Stieber B, Roberts R, Akpaka PE, Slickers P, Ehricht R. Population structure of Staphylococcus aureus from Trinidad Tobago. PLoS One. 2014 Feb 19;9(2):e89120. 27.Jenney A, Holt D, Ritika R, Southwell P, Pravin S, Buadromo E, Carapetis J, Tong S, Steer A. The clinical and molecular epidemiology of Staphylococcus aureus infections in Fiji. BMC Infect Dis. 2014 Mar 24;14:160. 28.Dupieux C, Blondé R, Bouchiat C, Meugnier H, Bes M, Laurent S, Vandenesch F, Laurent F, Tristan A. Community-acquired infections due to Staphylococcus argenteus lineage isolates harbouring the Panton-Valentine leucocidin, France, 2014. Euro Surveill. 2015 Jun 11;20(23):21154. 29.Suzuki Y, Kubota H, Ono HK, Kobayashi M, Murauchi K, Kato R, Hirai A, Sadamasu K. Food poisoning outbreak in Tokyo, Japan caused by Staphylococcus argenteus. Int J Food Microbiol. 2017 Dec 4;262:31-37. 30.Wakabayashi Y, Umeda K, Yonogi S, Nakamura H, Yamamoto K, Kumeda Y, Kawatsu K. Staphylococcal food poisoning caused by Staphylococcus argenteus harboring staphylococcal enterotoxin genes. Int J Food Microbiol. 2018 Jan 16;265:23-29. 31.Ohnishi T, Shinjoh M, Ohara H, Kawai T, Kamimaki I, Mizushima R, Kamada K, Itakura Y, Iguchi S, Uzawa Y, Yoshida A, Kikuchi K. Purulent lymphadenitis caused by Staphylococcus argenteus, representing the first Japanese case of Staphylococcus argenteus (multilocus sequence type 2250) infection in a 12-year-old boy. J Infect Chemother. 2018 Nov;24(11):925-927. 32.Chen SY, Lee H, Wang XM, Lee TF, Liao CH, Teng LJ, Hsueh PR. High mortality impact of Staphylococcus argenteus on patients with community-onset staphylococcal bacteraemia. Int J Antimicrob Agents. 2018 Dec;52(6):747-753. 33.Chu C, Wong MY, Tseng YH, Lin CL, Tung CW, Kao CC, Huang YK. Vascular access infection by Staphylococcus aureus from removed dialysis accesses. Microbiologyopen. 2019 Aug;8(8):e00800. 34.Zhang DF, Zhi XY, Zhang J, Paoli GC, Cui Y, Shi C, Shi X. Preliminary comparative genomics revealed pathogenic potential and international spread of Staphylococcus argenteus. BMC Genomics. 2017 Oct 23;18(1):808. 35.Hansen TA, Bartels MD, Høgh SV, Dons LE, Pedersen M, Jensen TG, Kemp M, Skov MN, Gumpert H, Worning P, Westh H. Whole Genome Sequencing of Danish Staphylococcus argenteus Reveals a Genetically Diverse Collection with Clear Separation from Staphylococcus aureus. Front Microbiol. 2017 Aug 9;8:1512. 36.Moradigaravand D, Jamrozy D, Mostowy R, Anderson A, Nickerson EK, Thaipadungpanit J, Wuthiekanun V, Limmathurotsakul D, Tandhavanant S, Wikraiphat C, Wongsuvan G, Teerawattanasook N, Jutrakul Y, Srisurat N, Chaimanee P, Eoin West T, Blane B, Parkhill J, Chantratita N, Peacock SJ. Evolution of the Staphylococcus argenteus ST2250 Clone in Northeastern Thailand Is Linked with the Acquisition of Livestock-Associated Staphylococcal Genes. mBio. 2017 Jul 5;8(4):e00802-17. 37.Giske CG, Dyrkell F, Arnellos D, Vestberg N, Hermansson Panna S, Fröding I, Ullberg M, Fang H. Transmission events and antimicrobial susceptibilities of methicillin-resistant Staphylococcus argenteus in Stockholm. Clin Microbiol Infect. 2019 Oct;25(10):1289.e5-1289.e8. 38.Aung MS, Urushibara N, Kawaguchiya M, Sumi A, Takahashi S, Ike M, Ito M, Habadera S, Kobayashi N. Molecular Epidemiological Characterization of Staphylococcus argenteus Clinical Isolates in Japan: Identification of Three Clones (ST1223, ST2198, and ST2550) and a Novel Staphylocoagulase Genotype XV. Microorganisms. 2019 Sep 24;7(10):389. 39.Aung MS, San T, Aye MM, Mya S, Maw WW, Zan KN, Htut WHW, Kawaguchiya M, Urushibara N, Kobayashi N. Prevalence and Genetic Characteristics of Staphylococcus aureus and Staphylococcus argenteus Isolates Harboring Panton-Valentine Leukocidin, Enterotoxins, and TSST-1 Genes from Food Handlers in Myanmar. Toxins (Basel). 2017 Aug 4;9(8):241. 40.Liu GY, Essex A, Buchanan JT, Datta V, Hoffman HM, Bastian JF, Fierer J, Nizet V. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med. 2005 Jul 18;202(2):209-15. 41.Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008 Mar 7;319(5868):1391-4. 42.Xiong YQ, Yang SJ, Tong SY, Alvarez DN, Mishra NN. The role of Staphylococcal carotenogenesis in resistance to host defense peptides and in vivo virulence in experimental endocarditis model. Pathog Dis. 2015 Oct;73(7):ftv056. 43.Peacock SJ, Moore CE, Justice A, Kantzanou M, Story L, Mackie K, O'Neill G, Day NP. Virulent combinations of adhesin and toxin genes in natural populations of Staphylococcus aureus. Infect Immun. 2002 Sep;70(9):4987-96. 44.Jarraud S, Mougel C, Thioulouse J, Lina G, Meugnier H, Forey F, Nesme X, Etienne J, Vandenesch F. Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease. Infect Immun. 2002 Feb;70(2):631-41. 45.Tristan A, Ying L, Bes M, Etienne J, Vandenesch F, Lina G. Use of multiplex PCR to identify Staphylococcus aureus adhesins involved in human hematogenous infections. J Clin Microbiol. 2003 Sep;41(9):4465-7. 46.Tong SY, Sharma-Kuinkel BK, Thaden JT, Whitney AR, Yang SJ, Mishra NN, Rude T, Lilliebridge RA, Selim MA, Ahn SH, Holt DC, Giffard PM, Bayer AS, Deleo FR, Fowler VG Jr. Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin. J Infect Dis. 2013 Aug 1;208(3):520-7. 47.Aung MS, San T, San N, Oo WM, Ko PM, Thet KT, Urushibara N, Kawaguchiya M, Sumi A, Kobayashi N. Molecular characterization of Staphylococcus argenteus in Myanmar: identification of novel genotypes/clusters in staphylocoagulase, protein A, alpha-haemolysin and other virulence factors. J Med Microbiol. 2019 Jan;68(1):95-104. 48.Hao Lee, Shey-Ying Chen, Li-Ching Yen, Shin-Hei Du, Lee-Jene Teng, and Po-Ren Hsueh. 2019. Increasing Incidence of Bacteremia Caused by Staphylococcus argenteus at a Medical Center in Northern Taiwan from 2007 to 2016. The 23rd Annual Meeting of the Taiwan Society of Microbiology. Nov. 24. Taipei, Taiwan. 49.Koreen L, Ramaswamy SV, Graviss EA, Naidich S, Musser JM, Kreiswirth BN. spa typing method for discriminating among Staphylococcus aureus isolates: implications for use of a single marker to detect genetic micro- and macrovariation. J Clin Microbiol. 2004 Feb;42(2):792-9. 50.Harmsen D, Claus H, Witte W, Rothgänger J, Claus H, Turnwald D, Vogel U. Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management. J Clin Microbiol. 2003 Dec;41(12):5442-8. 51.Strommenger B, Cuny C, Werner G, Witte W. Obvious lack of association between dynamics of epidemic methicillin-resistant Staphylococcus aureus in central Europe and agr specificity groups. Eur J Clin Microbiol Infect Dis. 2004 Jan;23(1):15-9. 52.Kinoshita M, Kobayashi N, Nagashima S, Ishino M, Otokozawa S, Mise K, Sumi A, Tsutsumi H, Uehara N, Watanabe N, Endo M. Diversity of staphylocoagulase and identification of novel variants of staphylocoagulase gene in Staphylococcus aureus. Microbiol Immunol. 2008 Jul;52(7):334-48. 53.van Wamel WJ, Rooijakkers SH, Ruyken M, van Kessel KP, van Strijp JA. The innate immune modulators staphylococcal complement inhibitor and chemotaxis inhibitory protein of Staphylococcus aureus are located on beta-hemolysin-converting bacteriophages. J Bacteriol. 2006 Feb;188(4):1310-5. 54.Sifri CD, Begun J, Ausubel FM, Calderwood SB. Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Infect Immun. 2003 Apr;71(4):2208-17. 55.Thompson TA, Brown PD. Association between the agr locus and the presence of virulence genes and pathogenesis in Staphylococcus aureus using a Caenorhabditis elegans model. Int J Infect Dis. 2017 Jan;54:72-76. 56.Aziz RK, Bartels D, Best AA, DeJongh M, Disz T, Edwards RA, Formsma K, Gerdes S, Glass EM, Kubal M, Meyer F, Olsen GJ, Olson R, Osterman AL, Overbeek RA, McNeil LK, Paarmann D, Paczian T, Parrello B, Pusch GD, Reich C, Stevens R, Vassieva O, Vonstein V, Wilke A, Zagnitko O. The RAST Server: rapid annotations using subsystems technology. BMC Genomics. 2008 Feb 8;9:75. 57.Bortolaia V, Kaas RS, Ruppe E, Roberts MC, Schwarz S, Cattoir V, Philippon A, Allesoe RL, Rebelo AR, Florensa AF, Fagelhauer L, Chakraborty T, Neumann B, Werner G, Bender JK, Stingl K, Nguyen M, Coppens J, Xavier BB, Malhotra-Kumar S, Westh H, Pinholt M, Anjum MF, Duggett NA, Kempf I, Nykäsenoja S, Olkkola S, Wieczorek K, Amaro A, Clemente L, Mossong J, Losch S, Ragimbeau C, Lund O, Aarestrup FM. ResFinder 4.0 for predictions of phenotypes from genotypes. J Antimicrob Chemother. 2020 Dec;75(12): 2491-3500. 58.Carattoli A, Hasman H. PlasmidFinder and In Silico pMLST: Identification and Typing of Plasmid Replicons in Whole-Genome Sequencing (WGS). Methods Mol Biol. 2020;2075:285-294. 59.Joensen KG, Scheutz F, Lund O, Hasman H, Kaas RS, Nielsen EM, Aarestrup FM. Real-time whole-genome sequencing for routine typing, surveillance, and outbreak detection of verotoxigenic Escherichia coli. J Clin Microbiol. 2014 May;52(5):1501-10. 60.Tamura K, Dudley J, Nei M, Kumar S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol. 2007 Aug;24(8):1596-9. 61.Becker K, Schaumburg F, Kearns A, Larsen AR, Lindsay JA, Skov RL, Westh H. Implications of identifying the recently defined members of the Staphylococcus aureus complex S. argenteus and S. schweitzeri: a position paper of members of the ESCMID Study Group for Staphylococci and Staphylococcal Diseases (ESGS). Clin Microbiol Infect. 2019 Sep;25(9):1064-1070. 62.Shinya Watanabe, Teruyo Ito, Takashi Sasaki, Shanshuang Li, Ikuo Uchiyama, Kozue Kishii, Ken Kikuchi, Robert Leo Skov, Keiichi Hiramatsu. Genetic Diversity of Staphylocoagulase Genes (coa): Insight into the Evolution of Variable Chromosomal Virulence Factors in Staphylococcus aureus. PLoS One 2009. 4(5):e5714. 63.Hirose M, Kobayashi N, Ghosh S, Paul SK, Shen T, Urushibara N, Kawaguchiya M, Shinagawa M, Watanabe N. Identification of staphylocoagulase genotypes I-X and discrimination of type IV and V subtypes by multiplex PCR assay for clinical isolates of Staphylococcus aureus. Jpn J Infect Dis. 2010. 63(4):257-63. 64.Matthew Thoendel, Jeffrey S. Kavanaugh, Caralyn E. Flack, and Alexander R. Horswill. Peptide Signaling in the Staphylococci. Chem. Rev. 2011. 111:117-151. 65.Kimberley L. Painter, Aishwarya Krishna, Sivaramesh Wigneshweraraj, and Andrew M. Edwards. What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia? Trends Microbiol. 2014. 22(12):676-685. 66.Foster TJ, Höök M. Surface protein adhesins of Staphylococcus aureus. Trends Microbiol. 1998 Dec;6(12):484-8. 67.Horvath P, Barrangou R. CRISPR/Cas, the immune system of bacteria and archaea. Science. 2010 Jan 8;327(5962):167-70. 68.Gill SR, Fouts DE, Archer GL, Mongodin EF, Deboy RT, Ravel J, Paulsen IT, Kolonay JF, Brinkac L, Beanan M, Dodson RJ, Daugherty SC, Madupu R, Angiuoli SV, Durkin AS, Haft DH, Vamathevan J, Khouri H, Utterback T, Lee C, Dimitrov G, Jiang L, Qin H, Weidman J, Tran K, Kang K, Hance IR, Nelson KE, Fraser CM. Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. J Bacteriol. 2005 Apr;187(7):2426-38. 69.Golding GR, Bryden L, Levett PN, McDonald RR, Wong A, Wylie J, Graham MR, Tyler S, Van Domselaar G, Simor AE, Gravel D, Mulvey MR. Livestock-associated methicillin-resistant Staphylococcus aureus sequence type 398 in humans, Canada. Emerg Infect Dis. 2010 Apr;16(4):587-94. 70.Kinnevey PM, Shore AC, Brennan GI, Sullivan DJ, Ehricht R, Monecke S, Slickers P, Coleman DC. Emergence of sequence type 779 methicillin-resistant Staphylococcus aureus harboring a novel pseudo staphylococcal cassette chromosome mec (SCCmec)-SCC-SCCCRISPR composite element in Irish hospitals. Antimicrob Agents Chemother. 2013 Jan;57(1):524-31. 71.Lindsay JA. Staphylococcus aureus genomics and the impact of horizontal gene transfer. Int J Med Microbiol. 2014 Mar;304(2):103-9. 72.Cao L, Gao CH, Zhu J, Zhao L, Wu Q, Li M, Sun B. Identification and functional study of type III-A CRISPR-Cas systems in clinical isolates of Staphylococcus aureus. Int J Med Microbiol. 2016 Dec;306(8):686-696. 73.Wu K, Conly J, McClure JA, Elsayed S, Louie T, Zhang K. Caenorhabditis elegans as a host model for community-associated methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect. 2010 Mar;16(3):245-54. 74.Figueiredo AMS, Ferreira FA, Beltrame CO, Côrtes MF. The role of biofilms in persistent infections and factors involved in ica-independent biofilm development and gene regulation in Staphylococcus aureus. Crit Rev Microbiol. 2017 Sep;43(5):602-620. 75.Moormeier DE, Bayles KW. Staphylococcus aureus biofilm: a complex developmental organism. Mol Microbiol. 2017 May;104(3):365-376. 76.Fluit AC, Jansen MD, Bosch T, Jansen WT, Schouls L, Jonker MJ, Boel CH. rRNA Operon Copy Number Can Explain the Distinct Epidemiology of Hospital-Associated Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7313-7320. 77.Cheung GY, Yeh AJ, Kretschmer D, Duong AC, Tuffuor K, Fu CL, Joo HS, Diep BA, Li M, Nakamura Y, Nunez G, Peschel A, Otto M. Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S. Sci Rep. 2015 Dec 10;5:18023. 78.Malachowa N, DeLeo FR. Mobile genetic elements of Staphylococcus aureus. Cell Mol Life Sci. 2010 Sep;67(18):3057-71. 79.Argudín MÁ, Mendoza MC, Rodicio MR. Food poisoning and Staphylococcus aureus enterotoxins. Toxins (Basel). 2010 Jul;2(7):1751-73. 80.Schuster D, Rickmeyer J, Gajdiss M, Thye T, Lorenzen S, Reif M, Josten M, Szekat C, Melo LDR, Schmithausen RM, Liégeois F, Sahl HG, Gonzalez JJ, Nagel M, Bierbaum G. Differentiation of Staphylococcus argenteus (formerly: Staphylococcus aureus clonal complex 75) by mass spectrometry from S. aureus using the first strain isolated from a wild African great ape. Int J Med Microbiol. 2017 Jan;307(1):57-63. 81.Neyaz L, Karki AB, Fakhr MK. The Whole-Genome Sequence of Plasmid-Bearing Staphylococcus argenteus Strain B3-25B from Retail Beef Liver Encodes the Type VII Secretion System and Several Virulence Factors. Microbiol Resour Announc. 2019 Nov 7;8(45):e00962-19. 82.Cao, Z., Casabona, M. G., Kneuper, H., Chalmers, J. D. Palmer, T. The type VII secretion system of Staphylococcus aureus secretes a nuclease toxin that targets competitor bacteria. Nat. Microbiol. 2, 16183. 83.Kane, T., Carothers, K. E., Bao, Y., Yeo, W. S., Bae, T., Park, C., Francisco R. Fields, Henry M. Vu, Daniel E. Hammers, Jessica N. Ross, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee. (2019). Discovery of genes encoding a Streptolysin S-like toxin biosynthetic cluster in a select highly pathogenic methicillin resistant Staphylococcus aureus JKD6159 strain. bioRxiv, 752204. 84.Tong SY, Lilliebridge RA, Bishop EJ, Cheng AC, Holt DC, McDonald MI, Giffard PM, Currie BJ, Boutlis CS. Clinical correlates of Panton-Valentine leukocidin (PVL), PVL isoforms, and clonal complex in the Staphylococcus aureus population of Northern Australia. J Infect Dis. 2010 Sep 1;202(5):760-9. 85.Monecke S, Kanig H, Rudolph W, Müller E, Coombs G, Hotzel H, Slickers P, Ehricht R. Characterisation of Australian MRSA strains ST75- and ST883-MRSA-IV and analysis of their accessory gene regulator locus. PLoS One. 2010 Nov 17;5(11):e14025. 86.Jiang B, You B, Tan L, Yu S, Li H, Bai G, Li S, Rao X, Xie Z, Shi X, Peng Y, Hu X. Clinical Staphylococcus argenteus Develops to Small Colony Variants to Promote Persistent Infection. Front Microbiol. 2018 Jun 27;9:1347. 87.Rigaill J, Grattard F, Grange S, Forest F, Haddad E, Carricajo A, Tristan A, Laurent F, Botelho-Nevers E, Verhoeven PO. Community-Acquired Staphylococcus argenteus Sequence Type 2250 Bone and Joint Infection, France, 2017. Emerg Infect Dis. 2018 Oct;24(10):1958-1961. 88.Söderquist B, Wildeman P, Stenmark B, Stegger M. Staphylococcus argenteus as an etiological agent of prosthetic hip joint infection: a case presentation. J Bone Jt Infect. 2020 May 25;5(4):172-175. 89.Diot A, Dyon-Tafani V, Bergot M, Tasse J, Martins-Simões P, Josse J, Valour F, Laurent F. Investigation of a Staphylococcus argenteus Strain Involved in a Chronic Prosthetic-Joint Infection. Int J Mol Sci. 2020 Aug 28;21(17):6245. 90.Indrawattana N, Pumipuntu N, Suriyakhun N, Jangsangthong A, Kulpeanprasit S, Chantratita N, Sookrung N, Chaicumpa W, Buranasinsup S. Staphylococcus argenteus from rabbits in Thailand. Microbiologyopen. 2019 Apr;8(4):e00665. 91.Pumipuntu N, Tunyong W, Chantratita N, Diraphat P, Pumirat P, Sookrung N, Chaicumpa W, Indrawattana N.2019. Staphylococcus spp. associated with subclinical bovine mastitis in central and northeast provinces of Thailand. PeerJ 7:e6587. 92.Pumipuntu N. Staphylococcus argenteus: An emerging subclinical bovine mastitis pathogen in Thailand. Vet World. 2019 Dec;12(12):1940-1944. 93.Li, Q., Li, Y., Tang, Y., Meng, C., Ingmer, H., Jiao, X. (2019). Prevalence and characterization of Staphylococcus aureus and Staphylococcus argenteus in chicken from retail markets in China. Food control, 96, 158-164. 94.Wu S, Huang J, Zhang F, Dai J, Pang R, Zhang J, Zeng H, Gu Q, Zhang S, Zhang Y, Xue L, Wang J, Ding Y, Wu Q. Staphylococcus argenteus isolated from retail foods in China: Incidence, antibiotic resistance, biofilm formation and toxin gene profile. Food Microbiol. 2020 Oct;91:103531. 95.Senok A, Nassar R, Kaklamanos EG, Belhoul K, Abu Fanas S, Nassar M, Azar AJ, Müller E, Reissig A, Gawlik D, Monecke S, Ehricht R. Molecular Characterization of Staphylococcus aureus Isolates Associated with Nasal Colonization and Environmental Contamination in Academic Dental Clinics. Microb Drug Resist. 2020 Jun;26(6):661-669. 96.Hao S, Abdelghany M, Lyden A, Sit R, Tan M, Tato CM, DeRisi JL, Miller S, Doernberg SB, Langelier C. Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis. Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00961-20. 97.Tång Hallbäck E, Karami N, Adlerberth I, Cardew S, Ohlén M, Engström Jakobsson H, Svensson Stadler L. Methicillin-resistant Staphylococcus argenteus misidentified as methicillin-resistant Staphylococcus aureus emerging in western Sweden. J Med Microbiol. 2018 Jul;67(7):968-971. 98.Zhang DF, Yang XY, Zhang J, Qin X, Huang X, Cui Y, Zhou M, Shi C, French NP, Shi X. Identification and characterization of two novel superantigens among Staphylococcus aureus complex. Int J Med Microbiol. 2018 Jun;308(4):438-446. 99.Alhussein F, Fürstenberg J, Gaupp R, Eisenbeis J, Last K, Becker SL, Papan C. Human infections caused by Staphylococcus argenteus in Germany: genetic characterisation and clinical implications of novel species designation. Eur J Clin Microbiol Infect Dis. 2020 Jun 23. 100.Long SW, Beres SB, Olsen RJ, Musser JM. Absence of patient-to-patient intrahospital transmission of Staphylococcus aureus as determined by whole-genome sequencing. mBio. 2014 Oct 7;5(5):e01692-14. 101.Mao T, Long J, Duan G, Yang H. Commentary: Study the Features of 57 Confirmed CRISPR Loci in 38 Strains of Staphylococcus aureus. Front Microbiol. 2019 Feb 1;10:59. 102.Zhao X, Yu Z, Xu Z. Study the Features of 57 Confirmed CRISPR Loci in 38 Strains of Staphylococcus aureus. Front Microbiol. 2018 Jul 26;9:1591. 103.Zhang J, Suo Y, Zhang D, Jin F, Zhao H, Shi C. Genetic and virulent difference between pigmented and non-pigmented Staphylococcus aureus. Front Microbiol. 2018;9:598. 104.Johansson C, Rautelin H, Kaden R. Staphylococcus argenteus and Staphylococcus schweitzeri are cytotoxic to human cells in vitro due to high expression of alpha-hemolysin Hla. Virulence. 2019 Dec;10(1):502-510. 105.Miyoshi-Akiyama T, Ohnishi T, Shinjoh M, Ohara H, Kawai T, Kamimaki I, Mizushima R, Kamada K, Itakura Y, Iguchi S, Uzawa Y, Yoshida A, Kikuchi K, Takemoto N. Complete Genome Sequences of Staphylococcus argenteus TWCC 58113, Which Bears Two Plasmids. Microbiol Resour Announc. 2019 Apr 25;8(17):e01582-18. 106.Jolley KA, Bray JE, Maiden MCJ. Open-access bacterial population genomics: BIGSdb software, the PubMLST.org website and their applications. Wellcome Open Res. 2018 Sep 24;3:124. 107.Ritchie SR, Thomas MG, Rainey PB. The genetic structure of Staphylococcus aureus populations from the Southwest Pacific. PLoS One. 2014 Jul 8;9(7):e100300. 108.Yeap AD, Woods K, Dance DAB, Pichon B, Rattanavong S, Davong V, Phetsouvanh R, Newton PN, Shetty N, Kearns AM. Molecular Epidemiology of Staphylococcus aureus Skin and Soft Tissue Infections in the Lao People's Democratic Republic. Am J Trop Med Hyg. 2017 Aug;97(2):423-428. 109.Bogestam K, Vondracek M, Karlsson M, Fang H, Giske CG. Introduction of a hydrolysis probe PCR assay for high-throughput screening of methicillin-resistant Staphylococcus aureus with the ability to include or exclude detection of Staphylococcus argenteus. PLoS One. 2018 Feb 9;13(2):e0192782. 110.Olatimehin A, Shittu AO, Onwugamba FC, Mellmann A, Becker K, Schaumburg F. Staphylococcus aureus Complex in the Straw-Colored Fruit Bat (Eidolon helvum) in Nigeria. Front Microbiol. 2018 Feb 13;9:162. 111.Kaden R, Engstrand L, Rautelin H, Johansson C. Which methods are appropriate for the detection of Staphylococcus argenteus and is it worthwhile to distinguish S. argenteus from S. aureus? Infect Drug Resist. 2018 Nov 21;11:2335-2344. 112.Tunsjø HS, Kalyanasundaram S, Charnock C, Leegaard TM, Moen AEF. Challenges in the identification of methicillin-resistant Staphylococcus argenteus by routine diagnostics. APMIS. 2018 Jun;126(6):533-537. 113.Bruins, M. J., van Coppenraet, L. E. B., Wolfhagen, M. J. (2019). Methicillin-Resistant Staphylococcus argenteus in The Netherlands—a Case Report. Clinical Microbiology Newsletter. 114.Kitagawa H, Ohge H, Hisatsune J, Masuda K, Aziz F, Hara T, Kuroo Y, Sugai M. Low incidence of Staphylococcus argenteus bacteremia in Hiroshima, Japan. J Infect Chemother. 2020 Jan;26(1):140-143. 115.Kukla R, Neradová K, Petráš P, Kekláková J, Ryšková L, Žemličková H. The first confirmed detection of Staphylococcus argenteus in the Czech Republic. Epidemiol Mikrobiol Imunol. 2020 Winter;69(1):48-52. 116.Mitsutake K, Watanabe N, Karaushi H, Tarumoto N, Koyama S, Ebihara Y, Yoshitake A, Nakajima H. Thoracic aortic mycotic aneurysm due to Staphylococcus argenteus: A case report. J Infect Chemother. 2020 Nov;26(11):1213-1215. 117.Yamada K, Sasaki M, Imai W, Kato M, Maehara C, Yasui K, Fukuzawa S, Murakami H, Kakisu K, Hori Y, Nagasawa T, Aoki K, Yamaguchi T, Ishii Y, Tateda K. Bacterial keratoconjunctivitis caused by Staphylococcus argenteus belonging to sequence type 1223 isolated in Japan. J Infect Chemother. 2020 Sep;26(9):1002-1004. 118.Shi X, Zhang DF. Staphylococcus argenteus: an emerging foodborne pathogen? Curr Opin Food Sci. 2018;20:76–81. 119.Banaszkiewicz S, Calland JK, Mourkas E, Sheppard SK, Pascoe B, Bania J. Genetic Diversity of Composite Enterotoxigenic Staphylococcus epidermidis Pathogenicity Islands. Genome Biol Evol. 2019 Dec 1;11(12):3498-3509. 120.Chieffi D, Fanelli F, Cho GS, Schubert J, Blaiotta G, Franz CMAP, Bania J, Fusco V. Novel insights into the enterotoxigenic potential and genomic background of Staphylococcus aureus isolated from raw milk. Food Microbiol. 2020 Sep;90:103482. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/74894 | - |
dc.description.abstract | 銀色葡萄球菌(Staphylococcus argenteus),原是來自無色素之金黃色葡萄球菌(Staphylococcus aureus),其特點為無色素基因(crtOPQMN)而呈現白色菌落,2015年被重新正式命名。由於近年S. argenteus臨床分離菌株明顯增加,但大家對此菌的特性仍不是很了解,因此本研究進行北台灣某醫學中心自臨床血液檢體分離出之S. argenteus 菌株之分子分型及表現型分析,並選取20株進行全基因定序,以探討菌株特性及適應力可能機制。 依MLST分型,有ST2250 (72株)、ST2793 (12株)、ST1223 (10株)及ST2198 (2株)四型。葡萄球菌蛋白A基因(spa)則以ST2250的t5078 (55株)佔最大宗,亦發現多達11種新spa型別,其中8株ST2793帶有新型t19483。輔助基因調節基因(agr)分別為第I型(ST2250)、第III型(ST1223與ST2793)及第IV型(ST2198)。進行PFGE、dnaJ及groEL基因序列分析,演化圖顯示相同ST菌株之基因型也較接近。凝固酶基因(coa)分屬4種基因型。 在分子異質性部分,CRISPR/Cas基因僅發現於72株ST2250,其重複序列(direct repeat, DR)及間隔序列(spacer)具有多樣性,較特別的是所有12株ST2793均帶有膠原蛋白結合基因(cna),其他ST則全無此基因,僅有的2株ST2198則帶有骨橋蛋白基因(bone sialoprotein-binding protein, bbp)基因。8株ST2793帶有腸毒素C基因(sec),未有文獻發表。所有10株ST1223帶有腸毒素基因群(enterotoxin gene cluster, egc),亦發現4株(3株ST1223與1株ST2198)帶有腸毒素B基因(seb)。MSCRAMMs (Microbial surface components recognizing adhesive matrix molecules)各種吸附因子基因的分析結果顯示,S. argenteus具生物膜生成及吸附相關的大多數基因(如eno、ebpS、fnbA、fnbB、fib、clfA及clfB)。 表現型分析顯示所有96株S. argenteus均為methicillin-susceptible (MS),且僅對非常少數之抗生素具抗藥性,大多數菌株具青黴素(benzylpenicillin)及部分菌株具四環素(tetracycline)抗藥性。生化分析結果發現N-acetyl-D-glucosamine (NAG)、urea及D-ribose等試驗或部分脂肪酸之比例似可輔助傳統生化鑑定。另進行線蟲試驗、H2O2氧化壓力測試、全血殺菌能力測試及生物膜(biofilm)生成能力測試等,結果顯示S. argenteus具生物膜生成能力且部分菌株生長速度稍慢,恐與最近多篇文獻報導之慢行感染相關。 選取20菌株(ST2250 4株、ST2793全部12株、ST1223 2株及ST2198全部2株)進行全基因定序(whole genome sequencing, WGS),以比較不同ST之差異或特殊基因標誌,另一方面可確認前述各種PCR分子檢驗結果之正確性,發現可能有少部分之基因特異性引子須重新設計。亦確認ST2793帶有之sec位於vSa基因島上,ST1223帶有之egc位於vSa基因島,seb位於致病島(SaPI)。在其他基因的分析比對上,發現所有20株帶有完整或部份第VII型分泌系統,各種ST型別在vSa基因島上帶有數量不一之脂蛋白基因(lpl)及超抗原蛋白基因(ssl),亦發現各種毒力因子散佈於各型,例如:selw僅發現於ST1223、selx發現於所有型別、sely則僅在ST2250;vSa基因於ST2250帶有sel26(seq)、sel27(sec-bovine)、bsaG(bacitracin相關基因)及lukDE,而在ST2793帶有hyaluronate lyase、bsaG及lukDE。ST1223之跳耀基因(transposon, Tn)帶有sagB(streptolysin S相關基因)亦未有文獻報告於S. argenteus,18株(90%)有嗜菌體Sa3嵌入並帶有scn、chp或sak基因。17株(85%)帶有質體,大致分成6種樣態,分別帶有不同rep、blaZ、tet(L)、aph、czcD或cadD等基因。 本研究發現北台灣96株S. argenteus 之四種ST各有其獨特的基因型,部分型別帶有之特殊毒力基因亦尚未有文獻報告。但基因型與表現型關聯仍不清楚,有待未來進一步深入研究及探討。 | zh_TW |
dc.description.abstract | Staphylococcus argenteus, a newly species renamed from a branching and divergent lineage of S. aureus displaying white colonies due to lacking crtOPQMN gene for the production of staphyloxanthin. The increasing worldwide occurrence of S. argenteus is a considerable concern. However, knowledge about its genomic characteristics or virulence is limited. In the present study, we investigate genotyping and phenotyping for 96 S. argenteus isolated from northern Taiwan. Whole genome sequencing from 20 selected isolates was also performed. Multilocus sequence typing (MLST) identified four sequence types (ST2250, ST2793, ST1223, and ST2198 with 72, 12, 10, and 2 isolates, respectively). The majority of spa (staphylococcal protein A gene) type was t5078 in ST2250. A total of 11 novel spa types were found. All 12 ST2793 isolates harboured newly spa types, in which eight belonged to t19483. The ST2250, ST2793, ST1223 and ST2198 belonged to agr type I, III, III, and IV, respectively, and displayed four staphylocoagulase (coa) types. The CRISPR/Cas gene was solely found in ST2250. Collagen binding protein gene (cna) was exclusively detected in all ST2793, and eight of them carried enterotoxin type C gene (sec) which was located in vSa genomic island. Two ST2198 carried bbp gene. All of ten ST1223 uniquely harboured enterotoxin gene cluster (egc) located in vSa genomic island. The enterotoxin type B gene (seb) in SaPI was found in three ST1223 isolates and one ST2198 isolate. Detection of MSCRAMMs (Microbial surface components recognizing adhesive matrix molecules) by PCR displayed common carriage of adhesion and biofilm-related genes, which may be linked to chronic infections. Phenotypic characteristics indicated all S. argenteus are methicillin-susceptible (MS). Most isolates were positive for N-acetyl-D-glucosamine (NAG), urea, or D-ribose tests. A slight difference in cellular fatty acid composition among four STs was observed. In addition, we performed C. elegans pathogenicity assay, H2O2 oxidative stress study, whole blood bactericidal activities assay, and biofilm formation test for selected isolates. WGS from 20 selected S. argenteus isolates including ST2250 (n = 4), ST2793 (n = 12), ST1223 (n = 2), and ST2198 (n = 2) was performed. All isolates harboured a complete or partial type VII secretion system and staphylococcal enterotoxin-like X gene (selx). The lipoprotein genes (lpl) and super-antigen-like protein genes (ssl) were located in vSa genomic islands. Each ST or isolate may display its native specialty or acquired genes by phage integration. For example, selw or sely was exclusively detected in ST1223 or ST2250. The vSa genomic island of ST2250 harboured sel26 (seq), sel27 (sec-bovine), bsaG (bacitracin related genes), and lukDE while that of ST2793 possessed hyaluronate lyase, bsaG and lukDE. The sagB (streptolysin S related genes) located in transposon (Tn) in the ST1223 lineage was first found in S. argenteus. The 18 isolates (90%) harboured Sa3 which was mainly consisted of scn, chp, or sak genes. Most isolates (85%, 17 out of 20) born one plasmid, which can be classified into six patterns. In conclusion, each ST of S. argenteus isolates in northern Taiwan carried specific genetic markers, in which some have not been previously reported. Our study unveils the molecular heterogeneity of S. argenteus. However, the correlation of genotypes and phenotypes is not clear, which needs further studies. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T09:09:44Z (GMT). No. of bitstreams: 1 U0001-3101202122453600.pdf: 4691153 bytes, checksum: 396605207f49aafe20f167282dac4cc0 (MD5) Previous issue date: 2021 | en |
dc.description.tableofcontents | 中文摘要 I Abstract III Content V List of Figures VII List of Tables VIII Chapter 1 Introduction 1 1.1 CC75 and CC75-like Staphylococcus aureus 1 1.2 Strain S. aureus MSHR1132 WGS (whole genome sequencing) 1 1.3 A novel species-Staphylococcus argenteus 2 1.4 Species identification and dnaJ PCR-RFLP 3 1.5 S. argenteus prevalence and clinical manifestation 4 1.6 The phenotype, antibiotic resistance and virulence factors of S. argenteus 4 1.7 Specific aims 8 Chapter 2 Materials and Methods 10 2.1 Bacterial strains 10 2.2 Primer lists 10 2.3 Chromosomal DNA extraction 12 2.4 Pulsed-field gel electrophoresis (PFGE), MLST, spa, coa, and agrD typing 13 2.5 The dnaJ PCR-RFLP, groESL PCR and sequencing 14 2.6 Detection of virulence factors and enterotoxin A~E 16 2.7 MSCRAMMs PCR and sequencing 16 2.8 Biochemical activity-N-acetyl-D-glucosamine and urease 17 2.9 Fatty acid composition 17 2.10 Bacterial growth curves 17 2.11 Caenorhabditis elegans pathogenicity assay (Nematode-killing assay) 18 2.12 H2O2 oxidative stress study 19 2.13 Whole blood bactericidal activity assay 20 2.14 Biofilm formation test 20 2.15 Whole genome sequencing (WGS) 21 2.16 Statistical and phylogenetic analysis 22 2.17 Nucleotide sequence accession numbers 22 Chapter 3 Results 24 3.1 Genotypic characterization for S. argenteus 24 3.1.1 Pulsed-field gel electrophoresis (PFGE), MLST, and spa 24 3.1.2 The dnaJ and groESL sequencing 25 3.1.3 Staphylocoagulase (coa) and agr type 26 3.1.4 Virulence factors and MSCRAMMs 27 3.1.5 Polymorphism of CRISPR/Cas system in ST2250 isolates 29 3.2 Phenotypic characterization for S. argenteus 30 3.2.1 Biochemical activity 30 3.2.2 Fatty acid composition 31 3.2.3 Bacterial growth curves 31 3.2.4 C. elegans pathogenicity assay 31 3.2.5 H2O2 oxidative stress study 32 3.2.6 Whole blood bactericidal activity assay 32 3.2.7 Biofilm formation ability 33 3.3. Whole genome sequencing (WGS) 34 3.3.1 The 20 selected S. argenteus isolates 34 3.3.2 Virulence genes 35 3.3.3 Mobile genetic elements (MGEs) 36 3.3.4 Special gene clusters 38 Chapter 4 Discussion 40 4.1 Clinical relevance for S. argenteus 40 4.2 Identification for S. argenteus 41 4.3 Epidemiology of S. argenteus in Taiwan and in the world 42 4.4 Genotyping for S. argenteus 44 4.5 Phenotypes and characterization of S. argenteus 47 4.6 Comparative analysis of WGS 49 4.7 Heterogeneity among S. argenteus STs 51 4.8 Conclusion 52 References 106 Appendix 122 | |
dc.language.iso | en | |
dc.title | 北台灣銀色葡萄球菌臨床菌株之分子異質性 | zh_TW |
dc.title | Molecular Heterogeneity of Staphylococcus argenteus Clinical Isolates in Northern Taiwan | en |
dc.type | Thesis | |
dc.date.schoolyear | 109-1 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 廖淑貞(Shwu-Jen Liaw),鍾筱菁(Chiau-Jing Jung),洪薇鈞(Wei-Chun Hung),林瑜姿(Yu-Tzu Lin) | |
dc.subject.keyword | 銀色葡萄球菌,基因分型,表現型分型,全基因定序, | zh_TW |
dc.subject.keyword | Staphylococcus argenteus,genotyping,phenotyping,whole genome sequencing, | en |
dc.relation.page | 122 | |
dc.identifier.doi | 10.6342/NTU202100303 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2021-02-03 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 醫學檢驗暨生物技術學研究所 | zh_TW |
顯示於系所單位: | 醫學檢驗暨生物技術學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
U0001-3101202122453600.pdf 目前未授權公開取用 | 4.58 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。