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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 楊雅倩(Ya-Chien Yang) | |
dc.contributor.author | Wan-Syuan Lin | en |
dc.contributor.author | 林琬璇 | zh_TW |
dc.date.accessioned | 2021-06-17T08:41:53Z | - |
dc.date.available | 2024-08-27 | |
dc.date.copyright | 2019-08-27 | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019-08-07 | |
dc.identifier.citation | 1 Mundade, R., Imperiale, T. F., Prabhu, L., Loehrer, P. J. & Lu, T. Genetic pathways, prevention, and treatment of sporadic colorectal cancer. Oncoscience 1, 400 (2014).
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/74545 | - |
dc.description.abstract | 大腸直腸癌於臺灣已攀升為每年發生率最高之癌症。本實驗室先前的研究,於人類第四號染色體 4q26區域鑑定 N-deacetylase/N-sulfotransferase 4 (NDST4) 為大腸直腸癌相關之抑癌基因。目前已知NDST4參與Heparan sulfate proteoglycans (HSPGs) 生合成之過程,而HSPGs於人體之發育、生長、發炎反應、抵抗微生物侵襲、癌症發生等不同生理及病理機制皆扮演重要角色。本論文將探討NDST4於大腸直腸癌細胞對未摺疊蛋白質反應 (Unfolded protein response, UPR) 和巨噬細胞分化之調控。第一部份利用doxycycline誘導方式使大腸直腸癌細胞株HCT116表現NDST4,並檢測UPR相關基因表現量,結果顯示NDST4於HCT116細胞未明顯影響UPR相關基因之表現;進一步利用內質網壓力 (ER stress) 促進劑tunicamycin提高HCT116細胞之UPR相關分子表現,NDST4對於UPR相關分子之調控仍是無顯著變化。另外,檢測52對臨床大腸直腸癌檢體UPR相關基因表現,並依其NDST4表現量分為表現降低組以及正常組,結果亦發現UPR基因表現於此兩群組間無顯著差異,利用大腸直腸癌資料庫之分析亦支持NDST4與UPR相關分子之表現無顯著相關。第二部份關於巨噬細胞分化調控之研究,乃利用 THP-1細胞株以及人類周邊血液單核細胞建立巨噬細胞分化模型,藉由細胞激素刺激使其分化為M1或M2亞型,以細胞形態、M1和M2亞型特異性基因及表面抗原表現確認分化模型之建立,並作為實驗之陽性控制組,實驗組則以大腸直腸癌細胞之條件培養液取代細胞激素之誘導分化作用,結果顯示:表現NDST4之大腸直腸癌細胞的條件培養液可促進巨噬細胞分化成M1亞型。另外,利用免疫組織化學染色檢測azoxymethane/dextran sodium sulfate (AOM/DSS) 小鼠模型之大腸腫瘤組織切片,分析其巨噬細胞的數量和分型,結果顯示Ndst4基因缺失會減少腫瘤及其相鄰正常組織之巨噬細胞浸潤,特別是M1亞型顯著降低;然而於NDST4異體移植腫瘤模型則發現不論大腸直腸癌細胞是否表現NDST4,僅少數巨噬細胞浸潤於腫瘤部位。 | zh_TW |
dc.description.abstract | Colorectal cancer (CRC) is the cancer with the highest annual incidence in Taiwan. In our previous study, we identified N-deacetylase/N-sulfotransferase 4 (NDST4) as a novel tumor suppressor gene located at chromosome 4q26. NDST4 is one of the pivotal enzymes responsible for heparan sulfate biosynthesis on a core protein to form heparan sulfate proteoglycans (HSPGs), which play important roles in development, inflammation and tumorigenesis. In the study, we further aimed to investigate NDST4-mediated modulation of unfolded protein response (UPR) and macrophage polarization in CRC. In the first part, using doxycycline to induce various levels of NDST4 expression in CRC HCT116 cells showed that NDST4 had no effect on expression of UPR-related genes. The consistant results were observed when tunicamycin, an ER stress inducer, was used to upregulate UPR-related gene expression. In addition, there were no significant correlations between the expression of NDST4 and UPR-related genes in 52 primary tumors collected and TCGA CRC datasets. In the second part for modulation of macrophage polarization, macrophage differentiation models were established by THP-1 and monocyte-derived macrophages (MDM) which obtained from human peripheral blood mononuclear cells, and determined by morphological change, subtype-specific gene expression and surface markers. The conditioned media harvested from NDST4- expressing HCT116 cells could promote the polarization of M0 cells toward M1 macrophages. In addition, previously established azoxymethane/dextran sodium sulfate (AOM/DSS) murine model of colitis-associated cancer were used to measure the macrophage phenotypes. The results revealed that Ndst4 deficiency significantly decreased macrophage infiltration and M1 polarization in both of tumors and adjacent normal tissues. Whereas, in a murine xenograft tumor model using HCT116 cells, only few macrophages were observed in tumor tissue sections. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T08:41:53Z (GMT). No. of bitstreams: 1 ntu-108-R06424025-1.pdf: 4135217 bytes, checksum: 98328f5e8c31fbc9f687e4d4c88bdb30 (MD5) Previous issue date: 2019 | en |
dc.description.tableofcontents | 致謝 i
中文摘要 ii 英文摘要 iv 縮寫對照表 vi 圖目錄 xii 表目錄 xiv 一、 緒論 1 1. 大腸直腸癌 1 1.1 大腸直腸癌簡介 1 1.2 大腸直腸癌之生成機制 2 1.3 大腸直腸癌分子特徵之分類系統 3 2. N-deacetylase/N-sulfotransferase 4 (NDST4) 5 2.1 NDST4 與 Heparan sulfate proteoglycan簡介 5 2.2 NDST 家族相關研究 7 2.3 Heparan sulfate proteoglycan 與癌症發生及轉移 8 3. 未摺疊蛋白質反應 (Unfolded protein response, UPR) 10 3.1 UPR簡介 10 3.2 UPR 相關訊息傳遞路徑 10 3.3 UPR 與大腸直腸癌之相關研究 11 4. 腫瘤相關巨噬細胞 (Tumor associated macrophages, TAMs) 12 4.1 TAMs簡介 12 4.2 TAMs 相關訊息傳遞路徑 13 4.3 TAMs 與大腸直腸癌之相關研究 14 5. 實驗室先前研究結果 15 5.1 第四號染色體之失異合性檢測 15 5.2 NDST4表現對腫瘤微環境造成之影響 16 二、研究目標 17 三、材料與方法 18 1. 細胞培養 18 1.1 大腸直腸癌細胞株 18 1.2 單核球細胞株 18 2. 人類周邊血液單核細胞之分離 18 3. 巨噬細胞分化 19 3.1 THP-1細胞分化模型 19 3.2 單核球衍生巨噬細胞分化模型 19 4. NDST4條件培養液製備和保存 20 5. RNA萃取 20 6. 反轉錄合成互補DNA 21 7. 即時聚合酶連鎖反應 21 8. 蛋白質抽取及定量 22 9. 西方墨點法 22 10. 流式細胞分析技術 23 11. 腫瘤組織切片 23 12. 免疫組織化學染色 24 13. TCGA大腸直腸癌公共資料庫臨床數據分析 25 14. 統計分析 25 四、研究結果 26 1. 探討NDST4表現於大腸直腸癌細胞對其UPR路徑相關分子之影響 26 2. 探討以Tunicamycin處理大腸直腸癌細胞後NDST4表現對其UPR路 徑相關分子之影響 26 3. 利用臨床大腸直腸癌檢體及大腸直腸癌資料庫分析NDST4 與UPR 相關分子之基因表現的相關性 27 4. 利用THP-1細胞建立巨噬細胞分化之細胞模型 28 5. 表現NDST4之大腸直腸癌細胞的條件培養液對於THP-1衍生之巨噬 細胞的分化影響 29 6. 利用人類周邊血液之單核球建立巨噬細胞分化模型 31 7. 表現NDST4之大腸直腸癌細胞的條件培養液對於單核球衍生之巨噬 細胞之分化影響 32 8. 探討以AOM/DSS誘發腸炎相關大腸腫瘤之小鼠模型的巨噬細胞分型 33 9. 探討NDST4異體移植腫瘤之小鼠模型的巨噬細胞分型 33 五、討論 35 圖 41 表 66 參考文獻 70 附錄 83 | |
dc.language.iso | zh-TW | |
dc.title | 探討N-deacetylase/N-sulfotransferase 4於大腸直腸癌對未摺疊蛋白質反應和巨噬細胞分化之調節 | zh_TW |
dc.title | Study of N-deacetylase/N-sulfotransferase 4-mediated modulation of unfolded protein response and macrophage differentiation in colorectal cancer | en |
dc.type | Thesis | |
dc.date.schoolyear | 107-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 莊雅惠(Ya-Hui Chuang),蘇剛毅(Kang-Yi Su),郭靜穎(Ching-Ying Kuo),饒梓明(Tzu-Ming Jao) | |
dc.subject.keyword | 大腸直腸癌,NDST4,內質網壓力,未摺疊蛋白質反應,巨噬細胞分化, | zh_TW |
dc.subject.keyword | Colorectal cancer,NDST4,Endoplasmic reticulum stress,Unfolded protein response,macrophage differentiation, | en |
dc.relation.page | 92 | |
dc.identifier.doi | 10.6342/NTU201902717 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2019-08-07 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 醫學檢驗暨生物技術學研究所 | zh_TW |
顯示於系所單位: | 醫學檢驗暨生物技術學系 |
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