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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 姜昱至(Yu-Chih Chiang) | |
dc.contributor.author | Pei-Ying Lu | en |
dc.contributor.author | 呂佩穎 | zh_TW |
dc.date.accessioned | 2021-06-17T08:27:52Z | - |
dc.date.available | 2024-08-27 | |
dc.date.copyright | 2019-08-27 | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019-08-12 | |
dc.identifier.citation | 1. Advances in calcium phosphate biomaterials. 2014. Berlin, Heidelberg: Springer Berlin Heidelberg.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/74283 | - |
dc.description.abstract | 目前關於牙本質黏著劑用於齲損牙本質上之黏著強度測試中的體外牙本質模型為兩大類:使用不同pH值的去礦化與再礦化循環溶液,或在生物反應器下創造之齲齒環境所製造之人工齲損(硬化)牙本質。然而,臨床上被齲齒、磨損、咬耗、磨耗或酸蝕等影響之牙本質病灶區,常可見到透明化之深棕色或黃褐色的硬化牙本質層,於顯微結構下可觀察到其牙本質小管內充滿Mg-β-tricalcium phosphate結晶。但是目前為止,尚沒有體外人工牙本質模型能製造具有類似自然牙齒牙本質小管內硬化結晶之結構成分與形態,且能廣泛用於模擬以上各種真實臨床狀況。
因此本研究目的為: 建立標準化模擬硬化牙本質層之體外模型,且能應用於牙本質黏著測試。 本研究總共分為三大部分:第一部份為觀察及分析因齒頸部磨損產生的自然硬化牙本質之顯微結構與組成成分;第二部分主要是建立標準化的人工硬化牙本質實驗模型,以不同配方之sclerotic dentin simulation solutions令牙本質小管內產生結晶,並分析其生長長度、化學組成及結晶性,調整出最佳配方後,利用奈米級電腦斷層掃描,與自然硬化牙本質及正常健康牙本質進行孔隙度及礦化程度分析;第三部份則是利用建立出的人工硬化牙本質進行牙本質黏著劑之微伸拉黏著強度測試。 結果顯示自然硬化牙本質內結晶生成與的膠原蛋白絲有關,小管內充滿由含有Mg的tricalcium phosphate所構成的菱形狀結晶,且愈接近外界處牙本質小管管壁上結晶層愈厚。本實驗建立之人工硬化牙本質模型能令牙本質小管內形成深度至少500 μm之結晶,主要成分應為OCP (octacalcium phosphate)。另外實驗中牙本質小管內晶體由管壁往管中央方向逐漸生成結晶,且初期於管壁上形成的晶體粒徑較小;後期於管中央形成的晶體粒徑較大。奈米級電腦斷層掃描分析結果顯示本研究中所建立的人工硬化牙本質模型與自然牙齒頸部磨損所產生的硬化牙本質於病灶表面往下至50 μm深之範圍內有相似的孔隙率,礦物質密度略高於自然硬化牙本質,其微拉伸黏著強度(25.8±8.1 MPa)低於健康牙本質(30.9±7.6 MPa),但無統計學上顯著差異(p>0.05),且較自然硬化牙本質(18.6±5.1 MPa)高。由目前結果我們得到以下三點結論:(1).自然硬化牙本質應是從生物礦化與生物去礦化的過程中形成。(2).本研究所建立的硬化牙本質模型與自然硬化牙質有相似的顯微結構及組成。(3).目前建立之人工硬化牙本質模型在微拉伸黏著強度低於健康牙本質,高於自然硬化牙本質。 | zh_TW |
dc.description.abstract | The common artificial dentin models used for in vitro adhesive studies can be classified into two categories: the chemical-pH cycling model and the biofilm model. The chemical-pH cycling model executes different pH values to simulate the demineralization and remineralization of caries initiation process. However, it’s a tough work to mimic the real progress of caries, cervical abrasion, abfraction, attrition or erosion. When restoring teeth with these lesions, we always have to face the challenge of sclerotic dentin which was filled with Mg-β-tricalcium phosphate crystals in dentinal tubules microscopically. Up to now, there is no artificial dentin model can mimic these crystals in the dentinal tubules. Thus, we aimed to simulation the artificial sclerotic dentin model and test with in vitro bond strength test.
This study was carried out in three parts, Part I: To investigate the microstructure and compositions of natural sclerotic dentin. Part ΙΙ: To establish an artificial sclerotic dentin model with the simulation of natural sclerotic dentin, growing the crystal inside dentinal tubules. We proposed an appropriate formulation and explore the crystal length, compositions and mechanisms in of the intratubular crystals. The porosity and mineral density were also evaluated by non-destructive nano-CT for comparing with natural sclerotic dentin and sound dentin. Part ΙIΙ: To perform the micro-tensile bonding strength (μ-TBS) of the dental adhesive with artificial sclerotic dentin, natural sclerotic dentin and sound dentin. The results revealed that the rhombus intratubular Mg-tricalcium phosphate crystals in natural sclerotic dentin were formed to tight correlation with collagen fibrils inside the dentinal tubules. In the artificial sclerotic dentin model, crystals in dentinal tubules were detected as OCP (octacalcium phosphate)-like crystals. The growth depth was more than 500 μm and direction of crystal growth was from the surface of peritubular dentinal wall inward the center of dentinal tubule. The initial crystallization was in contact with the peritubular dentin with smaller crystal size. The dentinal tubules were completely occluded by accumulating crystals later on. Porosity evaluation with nano-CT showed similar results of artificial and natural sclerotic dentin around the 50 μm superficial region. The mineral density in artificial sclerotic dentin was slightly higher than the natural sclerotic dentin, and also demonstrated lower μ-TBS than sound dentin (25.8±8.1 MPa vs. 30.9±7.6 MPa, p>0.05). Based the limited results, we concluded that: (1) Natural sclerotic dentin was formed via a “bio-de and -re-mineralization” process. (2) The simulated artificial sclerotic dentin model in our study showed similar micro-/ ultra-structure and compositions. (3) The μ-TBS of artificial sclerotic dentin was lower than the sound dentin which can be applied for further adhesive investigation of standardized model. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T08:27:52Z (GMT). No. of bitstreams: 1 ntu-108-R05422016-1.pdf: 6224542 bytes, checksum: 74109332e6fb56bbb877345d73ab258e (MD5) Previous issue date: 2019 | en |
dc.description.tableofcontents | 中文摘要 i
ABSTRACT iii 目錄 v 圖目錄 viii 表目錄 ix 第一章 緒論 1 1.1 自然之硬化牙本質 1 1.1.1 牙齒結構 1 1.1.2 牙齒礦物質成分的性質 1 1.1.3 自然硬化牙本質之發生 2 1.1.4 硬化牙本質之生成機制理論 4 1.2 牙本質黏著劑 5 1.2.1 牙本質黏著劑之作用機制 6 1.2.2 硬化牙本質對牙本質黏著劑之影響 6 1.2.3 目前人工齲齒模型及其應用於牙本質黏著強度測試之限制 8 1.3 牙本小管之填充 9 1.3.1 充填牙本質小管之文獻回顧 9 1.3.2 磷酸鈣結晶之生成機制 12 1.3.3 牙本質小管內仿生結晶生成機制 14 第二章 實驗動機與目的 15 第三章 實驗材料與方法 16 3.1 實驗架構 16 3.2 自然硬化牙本質之顯微結構 16 3.2.1 牙齒蒐集及樣本製備 16 3.2.2 掃瞄式電子顯微觀察(Scanning Electron Microscope, SEM)與能量色散X射線(Energy-dispersive X-ray spectroscopy, EDS)分析 17 3.3 人工硬化牙本質模型 17 3.3.1 標準化人工硬化牙本質模型之建立 17 3.3.2 人工硬化牙本質模型之性質分析 20 3.3.2.1 掃描式電子顯微鏡(SEM)與能量色散X射線(EDS) 20 3.3.2.2 X 射線繞射 (X-Ray Diffractometer, XRD) 20 3.3.2.3 穿透式電子顯微鏡(Transmission electron microscope, TEM)及選區電子繞射(Selected area electron diffraction, SAED) 20 3.3.2.4 奈米X光電腦斷層掃描(nano-CT) 21 3.4 人工硬化牙本質之微拉伸黏著鍵結強度測試 24 3.4.1 牙本質樣品分組及製備 24 3.4.2 微伸拉黏著強度測試 26 3.4.3 統計方法 27 第四章 實驗結果 28 4.1 自然硬化牙本質模型之顯微結構分析 28 4.2 人工硬化牙本質模型之性質分析 29 4.2.1 標準化人工硬化牙本質模型之建立 29 4.2.2 X 射線繞射分析 30 4.2.3 掃描式電子顯微鏡觀察及能量色散X射線 30 4.2.4 穿透式電子顯微鏡觀察及選區電子繞射分析 31 4.2.5 奈米級X光電腦斷層掃描分析 32 4.2.5.1 Total porosity 32 4.2.5.2 vBMD 33 4.3 人工硬化牙本質之微拉伸黏著鍵結強度測試 33 第五章 討論 34 5.1 自然硬化牙本質之生成機制探討 34 5.2 人工硬化牙本質模型探討 38 5.2.1 人工硬化牙本質小管內之結晶機制 39 5.2.1.1 成核(nucleation) 39 5.2.1.2 晶體生長(crystal growth) 41 5.2.1.3 鎂離子之作用機制 41 5.2.1.4 結晶之轉換(Crystal transformation) 42 5.2.2 Nano-CT 43 5.2.3 人工硬化牙本質vs.自然硬化牙本質 44 5.3 微拉伸測著鍵結強度測試 45 第六章 結論 48 第七章 未來研究方向 49 參考資料 51 | |
dc.language.iso | zh-TW | |
dc.title | 建立人工硬化牙本質模型用於體外微伸拉黏著強度測試 | zh_TW |
dc.title | Simulation of Artificial Sclerotic Dentin Model for in vitro Micro-tensile Bond Strength Test | en |
dc.type | Thesis | |
dc.date.schoolyear | 107-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 李伯訓,林弘萍 | |
dc.subject.keyword | 硬化牙本質,牙本質小管,奈米級X光電腦斷層掃描,牙本質黏著劑,微拉伸黏著強度, | zh_TW |
dc.subject.keyword | sclerotic dentin,dentinal tubule,nano-CT,dental adhesive,micro-tensile bond strength, | en |
dc.relation.page | 77 | |
dc.identifier.doi | 10.6342/NTU201903273 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2019-08-13 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
顯示於系所單位: | 臨床牙醫學研究所 |
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