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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 廖秀娟 | |
dc.contributor.author | Tzu-Ting Chang | en |
dc.contributor.author | 張慈庭 | zh_TW |
dc.date.accessioned | 2021-06-17T08:22:59Z | - |
dc.date.available | 2024-08-27 | |
dc.date.copyright | 2019-08-27 | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019-08-14 | |
dc.identifier.citation | Aballay, A., and Ausubel, F.M. (2002). Caenorhabditis elegans as a host for the study of host-pathogen interactions. Curr Opin Microbiol 5, 97-101.
Alegado, R.A., Campbell, M.C., Chen, W.C., Slutz, S.S., and Tan, M.W. (2003). Characterization of mediators of microbial virulence and innate immunity using the Caenorhabditis elegans host-pathogen model. Cell Microbiol 5, 435-444. Amaike, S., and Keller, N.P. (2011). Aspergillus flavus. Annu Rev Phytopathol 49, 107-133. Anderson, O.A., Finkelstein, A., and Shima, D.T. (2013). A2E induces IL-1β production in retinal pigment epithelial cells via the NLRP3 inflammasome. PLoS One 8, e67263. Anukul, N., Vangnai, K., and Mahakarnchanakul, W. (2013). Significance of regulation limits in mycotoxin contamination in Asia and risk management programs at the national level. J Food Drug Anal 21, 227-241. Bansal, A., Kwon, E.S., Conte, D., Jr., Liu, H., Gilchrist, M.J., MacNeil, L.T., and Tissenbaum, H.A. (2014). Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan. Longev Healthspan 3, 5. Bansal, A., Zhu, L.J., Yen, K., and Tissenbaum, H.A. (2015). Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci U S A 112, E277-286. Barbieri, M., Bonafe, M., Franceschi, C., and Paolisso, G. (2003). Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab 285, E1064-1071. Bennett, J.W., Kale, S., and Yu, J. (2007). Aflatoxins: background, toxicology, and molecular biology. Foodborne Diseases, S. Simjee, ed. (Totowa, NJ: Humana Press), pp. 355-373. Bishop, N.A., and Guarente, L. (2007). Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447, 545. Blackwell, T.K., Steinbaugh, M.J., Hourihan, J.M., Ewald, C.Y., and Isik, M. (2015). SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans. Free Radic Biol Med 88, 290-301. Blount, W. (1961). Turkey “X” disease. Turkeys 9, 55-58. Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. Chang, C.H., Ho, C.T., and Liao, V.H. (2017). N-γ-(L-Glutamyl)-L-selenomethionine enhances stress resistance and ameliorates aging indicators via the selenoprotein TRXR-1 in Caenorhabditis elegans. Mol Nutr Food Res 61(8), 1600954. Chen, M.-T., Hsu, Y.-H., Wang, T.-S., and Chien, S.-W. (2016). Mycotoxin monitoring for commercial foodstuffs in Taiwan. J Food Drug Anal 24, 147-156. Collins, J.J., Huang, C., Hughes, S., and Kornfeld, K. (2008). The measurement and analysis of age-related changes in Caenorhabditis elegans. WormBook : the online review of C elegans biology, 1-21. Comber, S.D., Conrad, A.U., Hoss, S., Webb, S., and Marshall, S. (2006). Chronic toxicity of sediment-associated linear alkylbenzene sulphonates (LAS) to freshwater benthic organisms. Environ Pollut 144, 661-668. Dues, D.J., Andrews, E.K., Schaar, C.E., Bergsma, A.L., Senchuk, M.M., and Van Raamsdonk, J.M. (2016). Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways. Aging (Albany NY) 8, 777-795. EFSA (2006). Commission regulation (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Official Journal L364, 5-24. El-Sayed, Y.S., and Khalil, R.H. (2009). Toxicity, biochemical effects and residue of aflatoxin B1 in marine water-reared sea bass (Dicentrarchus labrax L.). Food Chem Toxicol 47, 1606-1609. Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E., and Mello, C.C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811. Garigan, D., Hsu, A.L., Fraser, A.G., Kamath, R.S., Ahringer, J., and Kenyon, C. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161, 1101-1112. Gomez, F., Monsalve, G.C., Tse, V., Saiki, R., Weng, E., Lee, L., Srinivasan, C., Frand, A.R., and Clarke, C.F. (2012). Delayed accumulation of intestinal coliform bacteria enhances life span and stress resistance in Caenorhabditis elegans fed respiratory deficient E. coli. BMC Microbiol 12, 300. Gong, Y.Y., Cardwell, K., Hounsa, A., Egal, S., Turner, P.C., Hall, A.J., and Wild, C.P. (2002). Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: cross sectional study. BMJ 325, 20. Gruber, J., Chen, C.B., Fong, S., Ng, L.F., Teo, E., and Halliwell, B. (2015). Caenorhabditis elegans: What we can and cannot learn from aging worms. Antioxid Redox Signal 23, 256-279. Guengerich, F.P., Johnson, W.W., Shimada, T., Ueng, Y.F., Yamazaki, H., and Langouet, S. (1998). Activation and detoxication of aflatoxin B1. Mutat Res 402, 121-128. Hahm, J.H., Kim, S., and Paik, Y.K. (2011). GPA-9 is a novel regulator of innate immunity against Escherichia coli foods in adult Caenorhabditis elegans. Aging Cell 10, 208-219. Harman, D. (2003). The free radical theory of aging. Antioxid Redox Signal 5, 557-561. Henderson, S.T., and Johnson, T.E. (2001). Daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 11, 1975-1980. Hendrickse, R.G. (1997). Of sick turkeys, kwashiorkor, malaria, perinatal mortality, heroin addicts and food poisoning: research on the influence of aflatoxins on child health in the tropics. Ann Trop Med Parasitol 91, 787-793. Herndon, L.A., Schmeissner, P.J., Dudaronek, J.M., Brown, P.A., Listner, K.M., Sakano, Y., Paupard, M.C., Hall, D.H., and Driscoll, M. (2002). Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808-814. Hodgkin, J., and Barnes, T.M. (1991). More is not better: brood size and population growth in a self-fertilizing nematode. Proc Biol Sci 246, 19-24. Holliday, R. (1989). Food, reproduction and longevity: Is the extended lifespan of calorie-restricted animals an evolutionary adaptation? BioEssays 10, 125-127. Hoogewijs, D., Houthoofd, K., Matthijssens, F., Vandesompele, J., and Vanfleteren, J.R. (2008). Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans. BMC Mol Biol 9, 9. Hosono, R., Nishimoto, S., and Kuno, S. (1989). Alterations of life span in the nematode Caenorhabditis elegans under monoxenic culture conditions. Exp Gerontol 24, 251-264. How, C.M., Li, S.W., and Liao, V.H. (2018). Chronic exposure to triadimenol at environmentally relevant concentration adversely affects aging biomarkers in Caenorhabditis elegans associated with insulin/IGF-1 signaling pathway. Sci Total Environ 640-641, 485-492. How, C.M., Yen, P.L., Wei, C.C., Li, S.W., and Liao, V.H. (2019). Early life exposure to di (2-ethylhexyl) phthalate causes age-related declines associated with insulin/IGF-1-like signaling pathway and SKN-1 in Caenorhabditis elegans. Environ Pollut 251, 871-878. Huang, C., Xiong, C., and Kornfeld, K. (2004). Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proc Natl Acad Sci U S A 101, 8084-8089. Inoue, H., Hisamoto, N., An, J.H., Oliveira, R.P., Nishida, E., Blackwell, T.K., and Matsumoto, K. (2005). The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev 19, 2278-2283. Irazoqui, J.E., Troemel, E.R., Feinbaum, R.L., Luhachack, L.G., Cezairliyan, B.O., and Ausubel, F.M. (2010). Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathog 6, e1000982. Jaimez, J., Fente, C.A., Vazquez, B.I., Franco, C.M., Cepeda, A., Mahuzier, G., and Prognon, P. (2000). Application of the assay of aflatoxins by liquid chromatography with fluorescence detection in food analysis. J Chromatogr A 882, 1-10. Jenkins, N.L., McColl, G., and Lithgow, G.J. (2004). Fitness cost of extended lifespan in Caenorhabditis elegans. Proc Biol Sci 271, 2523-2526. Jiang, Y., Jolly, P.E., Ellis, W.O., Wang, J.S., Phillips, T.D., and Williams, J.H. (2005). Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians. Int Immunol 17, 807-814. Jiang, Y., Jolly, P.E., Preko, P., Wang, J.S., Ellis, W.O., Phillips, T.D., and Williams, J.H. (2008). Aflatoxin-related immune dysfunction in health and in human immunodeficiency virus disease. Clin Dev Immunol 2008, 790309. Kealy, R.D., Lawler, D.F., Ballam, J.M., Mantz, S.L., Biery, D.N., Greeley, E.H., Lust, G., Segre, M., Smith, G.K., and Stowe, H.D. (2002). Effects of diet restriction on life span and age-related changes in dogs. J Am Vet Med Assoc 220, 1315-1320. Kelly, J.D., Eaton, D.L., Guengerich, F.P., and Coulombe, R.A., Jr. (1997). Aflatoxin B1 activation in human lung. Toxicol Appl Pharmacol 144, 88-95. Kensler, T.W., Roebuck, B.D., Wogan, G.N., and Groopman, J.D. (2011). Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicol Sci 120 Suppl 1, S28-48. Kenyon, C. (2005). The plasticity of aging: insights from long-lived mutants. Cell 120, 449-460. Kenyon, C., Chang, J., Gensch, E., Rudner, A., and Tabtiang, R. (1993). A C. elegans mutant that lives twice as long as wild type. Nature 366, 461-464. Kim, D.H. (2013). Bacteria and the aging and longevity of Caenorhabditis elegans. Annu Rev Genet 47, 233-246. Kim, D.H., and Ewbank, J.J. (2018). Signaling in the innate immune response. WormBook : the online review of C. elegans biology 2018, 1-35. Kim, D.H., Feinbaum, R., Alloing, G., Emerson, F.E., Garsin, D.A., Inoue, H., Tanaka- Hino, M., Hisamoto, N., Matsumoto, K., Tan, M.W., Ausubel, F.M., 2002. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297, 623-626. Klass, M.R. (1977). Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech Ageing Dev 6, 413-429. Knipstein, B., Huang, J., Barr, E., Sossenheimer, P., Dietzen, D., Egner, P.A., Groopman, J.D., and Rudnick, D.A. (2015). Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance. Pediatr Res 78, 120-127. Kujawa, M. (1994). Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC monographs on the evaluation of carcinogenic risks to humans. Mol Nutr Food Res 38, 351-351. Kumar, S., Egan, B.M., Kocsisova, Z., Schneider, D.L., Murphy, J.T., Diwan, A., and Kornfeld, K. (2019). Lifespan extension in C. elegans caused by bacterial colonization of the intestine and subsequent activation of an innate immune response. Dev Cell 49, 100-117. Kurz, C.L., and Tan, M.W. (2004). Regulation of aging and innate immunity in C. elegans. Aging Cell 3, 185-193. Li, L., Chen, Y., Chenzhao, C., Fu, S., Xu, Q., and Zhao, J. (2018a). Glucose negatively affects Nrf2/SKN-1-mediated innate immunity in C. elegans. Aging (Albany NY) 10, 3089-3103. Li, S.W., How, C.M., and Liao, V.H. (2018b). Prolonged exposure of di (2-ethylhexyl) phthalate induces multigenerational toxic effects in Caenorhabditis elegans. Sci Total Environ 634, 260-266. Li, W.H., Chang, C.H., Huang, C.W., Wei, C.C., and Liao, V.H. (2014a). Selenite enhances immune response against Pseudomonas aeruginosa PA14 via SKN-1 in Caenorhabditis elegans. PLoS One 9, e105810. Li, W.H., Ju, Y.R., Liao, C.M., and Liao, V.H. (2014b). Assessment of selenium toxicity on the life cycle of Caenorhabditis elegans. Ecotoxicology 23, 1245-1253. Liao, V.H. (2018). Use of Caenorhabditis elegans to study the potential bioactivity of natural compounds. J Agric Food Chem 66, 1737-1742. Lien, K.W., Wang, X., Pan, M.H., and Ling, M.P. (2019). Assessing aflatoxin rxposure risk from peanuts and peanut products imported to Taiwan. Toxins (Basel) 11(2), 80. Manton, K.G., and Vaupel, J.W. (1995). Survival after the age of 80 in the United States, Sweden, France, England, and Japan. N Engl J Med 333, 1232-1235. Masoro, E.J., and Austad, S.N. (1996). The evolution of the antiaging action of dietary restriction: a hypothesis. J Gerontol A Biol Sci Med Sci 51(6), B387-B391. McCallum, K.C., and Garsin, D.A. (2016). The role of reactive oxygen species in modulating the Caenorhabditis elegans immune response. PLoS Pathog 12, e1005923. McCallum, K.C., Liu, B., Fierro-Gonzalez, J.C., Swoboda, P., Arur, S., Miranda-Vizuete, A., and Garsin, D.A. (2016). TRX-1 regulates SKN-1 nuclear localization cell non-autonomously in Caenorhabditis elegans. Genetics 203, 387-402. Mehrzad, J., Devriendt, B., Baert, K., and Cox, E. (2014). Aflatoxin B(1) interferes with the antigen-presenting capacity of porcine dendritic cells. Toxicol In Vitro 28, 531-537. Methenitou, G., Maravelias, C., Athanaselis, S., Dona, A., and Koutselinis, A. (2001). Immunomodulative effects of aflatoxins and selenium on human natural killer cells. Vet Hum Toxicol 43, 232-234. Minciullo, P.L., Catalano, A., Mandraffino, G., Casciaro, M., Crucitti, A., Maltese, G., Morabito, N., Lasco, A., Gangemi, S., and Basile, G. (2016). Inflammaging and anti-inflammaging: the role of cytokines in extreme longevity. Arch Immunol Ther Exp (Warsz) 64, 111-126. Mitchell, N.J., Bowers, E., Hurburgh, C., and Wu, F. (2016). Potential economic losses to the US corn industry from aflatoxin contamination. Food Addit Contam Part A-Chem 33, 540-550. Moore, B.T., Jordan, J.M., and Baugh, L.R. (2013). WormSizer: high-throughput analysis of nematode size and shape. PLoS One 8, e57142. Morley, J.F., and Morimoto, R.I. (2004). Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Bio Cell 15, 657-664. Murphy, C.T., McCarroll, S.A., Bargmann, C.I., Fraser, A., Kamath, R.S., Ahringer, J., Li, H., and Kenyon, C. (2003). Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-283. Murshid, A., Eguchi, T., and Calderwood, S.K. (2013). Stress proteins in aging and life span. Int J Hyperthermia 29, 442-447. Mykkanen, H., Zhu, H., Salminen, E., Juvonen, R.O., Ling, W., Ma, J., Polychronaki, N., Kemilainen, H., Mykkanen, O., Salminen, S., El-Nezami, H. (2005). Fecal and urinary excretion of aflatoxin B1 metabolites (AFQ1, AFM1 and AFB-N7-guanine) in young Chinese males. Int J Cancer 115, 879-884. Nunes, E.M.C.G., Pereira, M.M.G., Costa, A.P.R., Araripe, M.N.B.A., Calvet, R.M., Pereyra, C.M., Azevedo, M.L.X., Pinheiro, R.E.E., Alves, V.C., Conde Júnior, A.M., Ramos, L.S.N., Lopes, J.B., Marinho, C.G., Muratori, M.C.S. (2019). Effects of aflatoxin B1 on performance and health of tambaqui fingerlings (Colossoma macropomum). Int Aquat Res 11, 73-83. Papp, D., Csermely, P., and Sőti, C. (2012). A role for SKN-1/Nrf in pathogen resistance and immunosenescence in Caenorhabditis elegans. PLoS Pathog 8, e1002673. Partridge, L., Green, A., and Fowler, K. (1987). Effects of egg-production and of exposure to males on female survival in Drosophila melanogaster. J Insect Physiol 33, 745-749. Pincus, Z., and Slack, F.J. (2010). Developmental biomarkers of aging in Caenorhabditis elegans. Dev Dyn 239, 1306-1314. Porta-de-la-Riva, M., Fontrodona, L., Villanueva, A., and Cerón, J. (2012). Basic Caenorhabditis elegans methods: synchronization and observation. J Vis Exp, e4019. Pukkila-Worley, R., and Ausubel, F.M. (2012). Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium. Curr Opin Immunol 24, 3-9. Qian, G., Tang, L., Guo, X., Wang, F., Massey, M.E., Su, J., Guo, T.L., Williams, J.H., Phillips, T.D., and Wang, J.S. (2014). Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats. J Appl Toxicol 34, 241-249. Raju, M.V., and Devegowda, G. (2000). Influence of esterified-glucomannan on performance and organ morphology, serum biochemistry and haematology in broilers exposed to individual and combined mycotoxicosis (aflatoxin, ochratoxin and T-2 toxin). Br Poult Sci 41, 640-650. Roze, L.V., Hong, S.Y., and Linz, J.E. (2013). Aflatoxin biosynthesis: current frontiers. Annu Rev Food Sci Technol 4, 293-311. Rushing, B.R., and Selim, M.I. (2019). Aflatoxin B1: a review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods. Food Chem Toxicol 124, 81-100. Saul, N., Baberschke, N., Chakrabarti, S., Sturzenbaum, S.R., Lieke, T., Menzel, R., Jonas, A., and Steinberg, C.E. (2014). Two organobromines trigger lifespan, growth, reproductive and transcriptional changes in Caenorhabditis elegans. Environ Sci Pollut Res Int 21, 10419-10431. Schaible, R., Sussman, M., and Kramer, B.H. (2014). Aging and potential for self-renewal: hydra living in the age of aging - a mini-review. Gerontology 60, 548-556. Shuaib, F.M., Jolly, P.E., Ehiri, J.E., Yatich, N., Jiang, Y., Funkhouser, E., Person, S.D., Wilson, C., Ellis, W.O., Wang, J.S., Williams, J.H. (2010). Association between birth outcomes and aflatoxin B1 biomarker blood levels in pregnant women in Kumasi, Ghana. Trop Med Int Health 15, 160-167. Solana, R., Tarazona, R., Gayoso, I., Lesur, O., Dupuis, G., and Fulop, T. (2012). Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin Immunol 24, 331-341. Storvik, M., Huuskonen, P., Kyllonen, T., Lehtonen, S., El-Nezami, H., Auriola, S., and Pasanen, M. (2011). Aflatoxin B1--a potential endocrine disruptor--up-regulates CYP19A1 in JEG-3 cells. Toxicol Lett 202, 161-167. Streit, E., Schatzmayr, G., Tassis, P., Tzika, E., Marin, D., Taranu, I., Tabuc, C., Nicolau, A., Aprodu, I., Puel, O., Oswald, I.P. (2012). Current situation of mycotoxin contamination and co-occurrence in animal feed--focus on Europe. Toxins 4, 788-809. Sun, X., Chen, W.D., and Wang, Y.D. (2017). DAF-16/FOXO transcription factor in aging and longevity. Front Pharmacol 8, 548. Supriya, C., Akhila, B., Pratap Reddy, K., Girish, B.P., and Sreenivasula Reddy, P. (2016). Effects of maternal exposure to aflatoxin B1 during pregnancy on fertility output of dams and developmental, behavioral and reproductive consequences in female offspring using a rat model. Toxicol Mech Methods 26, 202-210. Supriya, C., Girish, B.P., and Reddy, P.S. (2014). Aflatoxin B1-induced reproductive toxicity in male rats: possible mechanism of action. Int J Toxicol 33, 155-161. Supriya, C., and Reddy, P.S. (2015). Prenatal exposure to aflatoxin B1: developmental, behavioral, and reproductive alterations in male rats. Sci Nat 102, 26. Tan, L., Wang, S., Wang, Y., He, M., and Liu, D. (2015). Bisphenol A exposure accelerated the aging process in the nematode Caenorhabditis elegans. Toxicol Lett 235, 75-83. Tan, M.-W., Mahajan-Miklos, S., and Ausubel, F.M.J.P.o.t.N.A.o.S. (1999). Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis. Proc Natl Acad Sci U S A 96, 715-720. Tosato, M., Zamboni, V., Ferrini, A., and Cesari, M. (2007). The aging process and potential interventions to extend life expectancy. Clin Interv Aging 2, 401-412. Tseng, I.L., Yang, Y.F., Yu, C.W., Li, W.H., and Liao, V.H. (2013). Phthalates induce neurotoxicity affecting locomotor and thermotactic behaviors and AFD neurons through oxidative stress in Caenorhabditis elegans. PLoS One 8, e82657. Tuan, N.A., Grizzle, J.M., Lovell, R.T., Manning, B.B., and Rottinghaus, G.E. (2002). Growth and hepatic lesions of Nile tilapia (Oreochromis niloticus) fed diets containing aflatoxin B1. Aquaculture 212, 311-319. Tullet, J.M.A., Hertweck, M., An, J.H., Baker, J., Hwang, J.Y., Liu, S., Oliveira, R.P., Baumeister, R., and Blackwell, T.K. (2008). Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132, 1025-1038. Vanduyn, N., Settivari, R., Wong, G., and Nass, R. (2010). SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity. Toxicol Sci 118, 613-624. Vida, C., de Toda, I.M., Cruces, J., Garrido, A., Gonzalez-Sanchez, M., and De la Fuente, M. (2017). Role of macrophages in age-related oxidative stress and lipofuscin accumulation in mice. Redox Biol 12, 423-437. Voss, P., and Siems, W. (2006). Clinical oxidation parameters of aging. Free Radic Res 40, 1339-1349. Wannop, C.C. (1963). Groundnut toxicity in Poultry:: Turkey X Disease*. Br Vet J 119, 174-177. Wilkinson, D.S., Taylor, R.C., and Dillin, A. (2012). Chapter 12 - Analysis of aging in Caenorhabditis elegans. In Methods Cell Biol, J.H. Rothman, and A. Singson, eds. (Academic Press), pp. 353-381. Wu, F., and Guclu, H. (2012). Aflatoxin regulations in a network of global maize trade. PLoS One 7, e45151. Wu, H.C., Wang, Q., Yang, H.I., Ahsan, H., Tsai, W.Y., Wang, L.Y., Chen, S.Y., Chen, C.J., and Santella, R.M. (2009). Aflatoxin B1 exposure, hepatitis B virus infection, and hepatocellular carcinoma in Taiwan. Cancer Epidemiol Biomarkers Prev 18, 846-853. Wu, Q., Zhao, Y., Fang, J., and Wang, D. (2014). Immune response is required for the control of in vivo translocation and chronic toxicity of graphene oxide. Nanoscale 6, 5894-5906. Yen, K., Narasimhan, S.D., and Tissenbaum, H.A. (2011). DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road. Antioxid Redox Signal 14, 623-634. Yin, D. (1996). Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores. Free Radic Biol Med 21, 871-888. Yin, J., Liu, R., Jian, Z., Yang, D., Pu, Y., Yin, L., and Wang, D. (2018). Di (2-ethylhexyl) phthalate-induced reproductive toxicity involved in dna damage-dependent oocyte apoptosis and oxidative stress in Caenorhabditis elegans. Ecotoxicol Environ Saf 163, 298-306. Yin, Y.N., Yan, L.Y., Jiang, J.H., and Ma, Z.H. (2008). Biological control of aflatoxin contamination of crops. J Zhejiang Univ Sci B 9, 787-792. Yu, C.W., How, C.M., and Liao, V.H. (2016). Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16/FOXO in Caenorhabditis elegans. Chemosphere 150, 632-638. Yu, C.W., and Liao, V.H. (2016). Transgenerational reproductive effects of arsenite are associated with H3K4 dimethylation and SPR-5 downregulation in Caenorhabditis elegans. Environ Sci Technol 50, 10673-10681. Yunus, A.W., Razzazi-Fazeli, E., and Bohm, J. (2011). Aflatoxin B(1) in affecting broiler's performance, immunity, and gastrointestinal tract: a review of history and contemporary issues. Toxins 3, 566-590. 食藥署 (2018). 食品中污染物質及毒素衛生標準, 衛福部食藥署, ed. (臺灣). | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/74175 | - |
dc.description.abstract | 黃麴毒素B1 (aflatoxin B1) 是已知的人類一級致癌物,也是麴菌毒素中毒性最強的毒素。Aflatoxin B1常存在於保存不良的農作物產品,尤其常在米、花生和玉米中發現。Aflatoxin B1會造成肝臟毒性及和免疫毒性等不量反應,然而,鮮少研究探討長期暴露aflatoxin B1如何影響老化及先天免疫。本研究利用秀麗隱桿線蟲Caenorhabditis elegans以及綠膿桿菌 (Pseudomonas aeruginosa PA14) 之host-pathogen模式,探討長期暴露aflatoxin B1所造成之老化及先天免疫能力的影響;並利用C. elegans食物Escherichia coli OP50的活性和暴露aflatoxin B1對C. elegans老化相關指標的影響,探討aflatoxin B1對免疫老化的調節和其分子機制。研究結果指出C. elegans從幼蟲 (L1) 暴露5與10 µM aflatoxin B1到成蟲第0天會延遲C. elegans的成長,並在2.5與5 µM的暴露下會顯著降低C. elegans的繁殖能力;而在較高濃度 (2.5及5 µM) 暴露的情況下也會縮短C. elegans的壽命長度。在先天免疫方面,長期暴露2.5 μM aflatoxin B1後會顯著降低C. elegans在遭受P. aeruginosa PA14感染後的存活。結果亦顯示,長期曝露aflatoxin B1 2.5 µM至成蟲第4天及第6天,野生種N2 C. elegans腸道體內累積的live E. coli OP50顯著多於未暴露aflatoxin B1的野生種N2 C. elegans;然而並未在餵食以經UV去活性dead E. coli OP50 觀察到此現象。暴露aflatoxin B1並以live E. coli OP50餵養之C. elegans的老化指標 (body bends, head thrashes, defecation cycle, lipofuscin) 都受到影響,但以dead E. coli OP50餵養的C. elegans則沒有統計上顯著差異。進一步利用two-way AVONA進行統計分析,顯示E. coli OP50的活性和aflatoxin B1在C. elegans有交互作用。利用基因轉殖C. elegans LD1發現,暴露於aflatoxin B1 2.5 μM會抑制SKN-1轉移入細胞核的現象,而在skn-1突變種的實驗中,有無暴露aflatoxin B1和以live及dead E. coli OP50餵養之C. elegans之間皆無顯著差異,推論aflatoxin B1抑制先天免疫和老化與抑制SKN-1及其下游基因表達相關。最後,在基因表達量的結果顯示,aflatoxin B1會抑制gst-4、gcs-1、hsp-16.1、hsp-16.49及hsp-70的mRNA表達量。綜合本研究之實驗結果顯示,長期暴露2.5 µM aflatoxin B1會加速老化和抑制先天免疫能力,並和其食物E. coli OP50的病源性有交互作用。 | zh_TW |
dc.description.abstract | Aflatoxin B1, a human carcinogen, is the most toxic secondary metabolite in aflatoxins. It is usually found in poor storage of agricultural products, especially in rice, peanut, and maize. Aflatoxin B1 exposure causes several adverse effects such as hepatotoxicity and immunotoxicity. However, studies regarding effects of aging and innate immunity by aflatoxin B1 are limited. This study used Caenorhabditis elegans and Pseudomonas aeruginosa PA14 as a host-pathogen model to study how aflatoxin B1 affects aging and innate immunity. Moreover, live Escherichia coli OP50 and UV-treated dead E. coli OP50 were used to test aging-related indicators by chronic aflatoxin B1 exposure in C. elegans and the underlying molecular mechanisms were investigated. The results showed that prolonged exposure to aflatoxin B1 from L1 larvae delayed the growth stage (5, 10 μM), decreased reproduction, and reduced longevity (2.5, 5 μM) of C. elegans. Moreover, exposure to 2.5 µM aflatoxin B1 also significantly reduced the survival of C. elegans against the infection of P. aeruginosa PA14. Furthermore, after chronic aflatoxin B1 exposure (2.5 µM), there was a significantly increased accumulation of E. coli OP50 in the intestine of wild-type N2 C. elegans in day-4 adulthood compared with the untreated ones while feeding with live E. coli OP50. In contrast, the phenomena was absent while feeding with dead E. coli OP50. In addition, an increased body bends and head thrashes as well as a decreased defecation cycle and lipofuscin were observed in wild-type N2 C. elegans fed with dead E. coli OP50 in day-4 and day-6 adulthood in the presence of aflatoxin B1. Moreover, two-way ANOVA analysis revealed that aflatoxin B1 and the pathogenic activity of E. coli OP50 interact together affecting aging indicators in C. elegans. By using the transgenic strain LD1, 2.5 µM aflatoxin B1 inhibited the nuclear translocation of SKN-1. In skn-1 mutant, chronic exposure to 2.5 µM aflatoxin B1 didn’t affect lipofuscin at day-4 adulthood fed with either live or dead E. coli OP50. This suggests that aflatoxin B1 suppresses innate immunity as well as adversely affect aging indicators mediated by SKN-1. Finally, chronic exposure to 2.5 µM aflatoxin B1 suppressed the mRNA levels of gst-4, gcs-1, hsp-16.1, hsp-16.49 and hsp-70. Taken togethetr, results from this study demonstrate that chronic aflatoxin B1 exposure enhances aging decline and suppresses innate immunity and has an interaction with the pathogenic activity of E. coli OP50. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T08:22:59Z (GMT). No. of bitstreams: 1 ntu-108-R06851005-1.pdf: 9636100 bytes, checksum: a9601c97a181bb6f3f619d31dc497135 (MD5) Previous issue date: 2019 | en |
dc.description.tableofcontents | 碩士學位論文口試委員會審定書 i
誌謝 ii 摘要 iii Abstract v Graphic Abstract vii Highlights viii 目錄 ix 圖次 xii 表次 xiii 縮寫表 xiv 1. 研究動機 1 2. 文獻回顧及研究目的 2 2.1 黃麴毒素 (aflatoxins) 2 2.2 黃麴毒素B1 (aflatoxin B1)之毒性性質 3 2.2.1 Aflatoxin B1之吸收、分佈、代謝與排除 3 2.2.2 Aflatoxin B1之生長毒性 4 2.2.3 Aflatoxin B1之生殖毒性 4 2.2.4 Aflatoxin B1之免疫毒性 4 2.3 以秀麗隱桿線蟲 (Caenorhabditis elegans) 探討aflatoxin B1之長期毒性 5 2.3.1 秀麗隱桿線蟲 5 2.3.2 以C. elegans探討老化機制 6 2.3.3 以C. elegans探討先天免疫機制 7 2.3.4 以C. elegans研究免疫老化 (immunosenescence) 7 2.4 研究目的 8 2.4.1 研究假說 8 3. 材料與方法 10 3.1 實驗架構流程圖 10 3.2 實驗藥品 11 3.3 C. elegans之培養條件 11 3.4 Aflatoxin B1對C. elegans生長毒性測試 11 3.5 Aflatoxin B1對C. elegans繁殖毒性測試 12 3.6 Aflatoxin B1對C. elegans壽命之毒性測試 12 3.7 Slow killing assay 12 3.8 低濃度E. coli OP50培養條件 13 3.9 Aflatoxin B1對C. elegans老化相關行為之毒性測試 13 3.10 Aflatoxin B1對C. elegans體內累積脂褐素 (lipofuscin) 之測試 14 3.11 Aflatoxin B1對C. elegans pharyngeal pumping rate之測試 14 3.12 Aflatoxin B1對C. elegans SKN-1入核現象實驗 14 3.13 利用即時定量反轉錄聚合酶鏈鎖反應 (qRT-PCR) 分析aflatoxin B1對基因表達量之影響 15 3.14 統計分析 15 4. 結果與討論 16 4.1 Aflatoxin B1對C. elegans生長與繁殖能力之影響 16 4.2 Aflatoxin B1對C. elegans壽命之影響 19 4.3 長期暴露aflatoxin B1對C. elegans 抵抗P. aeruginosa PA14 感染之影響 22 4.4 Aflatoxin B1對C. elegans免疫老化之毒性測試 25 4.4.1 長期暴露aflatoxin B1對C. elegans老化相關行為之改變 25 4.4.2 長期暴露aflatoxin B1對C. elegans脂褐素的累積影響 37 4.5 長期暴露aflatoxin B1對C. elegans攝食之影響 42 4.6 長期暴露aflatoxin B1對SKN-1的影響 47 4.7 長期暴露aflatoxin B1對C. elegans免疫以及老化相關基因表達之影響 52 5. 結論 55 6. 參考文獻 56 7. 附錄 70 附錄1、Summary of worldwide aflatoxins regulation 70 附錄2、引子序列 71 附錄3、C. elegans暴露於aflatoxin B1 72小時至成蟲後之體長示意圖 72 附錄4、Summary of two-way ANOVA 74 附錄5、SKN-1入核判斷示意圖 75 | |
dc.language.iso | zh-TW | |
dc.title | 長期暴露黃麴毒素B1影響秀麗隱桿線蟲的老化及先天免疫 | zh_TW |
dc.title | Chronic exposure to aflatoxin B1 adversely affects aging and innate immunity in Caenorhabditis elegans | en |
dc.type | Thesis | |
dc.date.schoolyear | 107-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 劉貞佑 | |
dc.contributor.oralexamcommittee | 潘敏雄,魏嘉徵 | |
dc.subject.keyword | 黃麴毒素B1,長期暴露,秀麗隱桿線蟲,先天免疫,SKN-1,老化, | zh_TW |
dc.subject.keyword | Aflatoxin B1,chronic exposure,Caenorhabditis elegans,innate immunity,SKN-1,aging, | en |
dc.relation.page | 75 | |
dc.identifier.doi | 10.6342/NTU201903362 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2019-08-14 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 食品安全與健康研究所 | zh_TW |
顯示於系所單位: | 食品安全與健康研究所 |
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