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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 季瑋珠(Wei-Chu Chie) | |
dc.contributor.author | Hao-Wei Chen | en |
dc.contributor.author | 陳浩維 | zh_TW |
dc.date.accessioned | 2021-06-17T08:07:03Z | - |
dc.date.available | 2021-08-27 | |
dc.date.copyright | 2019-08-27 | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019-08-19 | |
dc.identifier.citation | 參考文獻
Blome, C., & Augustin, M. (2015). Measuring change in quality of life: bias in prospective and retrospective evaluation. Value Health, 18(1), 110-115. doi:10.1016/j.jval.2014.10.007 Braun, D. P., Gupta, D., & Staren, E. D. (2011). Quality of life assessment as a predictor of survival in non-small cell lung cancer. BMC Cancer, 11, 353. doi:10.1186/1471-2407-11-353 Cortinovis, D., Abbate, M., Bidoli, P., Capici, S., & Canova, S. (2016). Targeted therapies and immunotherapy in non-small-cell lung cancer. Ecancermedicalscience, 10, 648. doi:10.3332/ecancer.2016.648 de Groot, P. M., Wu, C. C., Carter, B. W., & Munden, R. F. (2018). The epidemiology of lung cancer. Transl Lung Cancer Res, 7(3), 220-233. doi:10.21037/tlcr.2018.05.06 Freire, M. E. M., Sawada, N. O., de Franca, I. S. X., da Costa, S. F. G., & Oliveira, C. D. B. (2014). Health-related quality of life among patients with advanced cancer: an integrative review. Revista Da Escola De Enfermagem Da Usp, 48(2), 351-361. doi:10.1590/S0080-6234201400002000022 John, L. D. (2001). Quality of life in patients receiving radiation therapy for nonsmall cell lung cancer. Oncol Nurs Forum, 28(5), 807-813. Karczmarek-Borowska, B., Pelc, M., Rabiej, E., & Gradalska-Lampart, M. (2014). The quality of life of non-small cell lung cancer patients treated with chemotherapy. Pneumonol Alergol Pol, 82(4), 349-357. doi:10.5603/PiAP.2014.0044 Kuyken, W., Orley, J., Power, M., Herrman, H., Schofield, H., Murphy, B., . . . Vandam, F. (1995). The World-Health-Organization Quality-of-Life Assessment (Whoqol) - Position Paper from the World-Health-Organization. Social Science & Medicine, 41(10), 1403-1409. Langendijk, J. A., ten Velde, G. P., Aaronson, N. K., de Jong, J. M., Muller, M. J., & Wouters, E. F. (2000). Quality of life after palliative radiotherapy in non-small cell lung cancer: a prospective study. Int J Radiat Oncol Biol Phys, 47(1), 149155. Mañas, J. I. A. U. M. M. A. A. M. B. E. S. P. E. M. L. R. V. G. J. J. I. (2005). Quality of life assessment in Spanish lung cancer patients by the EORTC questionnaires. Oncología (Barc.), 28. Milosevic, B., Pejic, D., Momcicevic, D., Kovacevic, P., Stanetic, M., & Dragic, S. (2016). Quality of life in lung cancer patients due to treatment. Signa Vitae, 11, 47-50. doi:Doi 10.22514/Sv112.062016.10 27 Montazeri, A., Gillis, C. R., & McEwen, J. (1998). Quality of life in patients with lung cancer: a review of literature from 1970 to 1995. Chest, 113(2), 467-481. doi:10.1378/chest.113.2.467 Polanski, J., Jankowska-Polanska, B., Rosinczuk, J., Chabowski, M., & SzymanskaChabowska, A. (2016). Quality of life of patients with lung cancer. Onco Targets Ther, 9, 1023-1028. doi:10.2147/OTT.S100685 Ramirez, R. A., Lu, J., & Thomas, K. E. H. (2018). Quality of life for non-small cell lung cancer patients in the age of immunotherapy. Transl Lung Cancer Res, 7(Suppl 2), S149-S152. doi:10.21037/tlcr.2018.03.10 Rosenberg, J. E., Hoffman-Censits, J., Powles, T., van der Heijden, M. S., Balar, A. V., Necchi, A., . . . Dreicer, R. (2016). Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet, 387(10031), 1909-1920. doi:10.1016/S0140-6736(16)00561-4 Shu-Fen Lo, W.-Y. H. (2008). The Critical Review of Health-Related Quality of Life (HRQL) Concept and Measure Instrument for Cancer Patients. doi:10.6537/TJHPC.2008.13(1).4 Xuan, L. Z., Chern, J., Chang, S., & Wen-Tsung, H. (2017). Longitudinal Studies of Quality of Life in Advanced Non-Small Cell Lung Cancer Patients Undergoing First-Line Target Therapy. Journal of Thoracic Oncology, 12(11), S1923-S1923. Zappa, C., & Mousa, S. A. (2016). Non-small cell lung cancer: current treatment and future advances. Transl Lung Cancer Res, 5(3), 288-300. doi:10.21037/tlcr.2016.06.07 Zimmermann, C., Burman, D., Swami, N., Krzyzanowska, M. K., Leighl, N., Moore, M., . . . Tannock, I. (2011). Determinants of quality of life in patients with advanced cancer. Support Care Cancer, 19(5), 621-629. doi:10.1007/s00520010-0866-1 柯獻欽, 鄭. (2018). 晚期非小細胞肺癌之化學治療與標靶治療. 內科學誌 . doi:10.6314/JIMT.201806_29(3).04 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/73629 | - |
dc.description.abstract | 緒論
癌症是目前全球第二大死因,其中又肺癌的死亡率與發生率皆為癌症死因的首位。肺癌病人中約有 85%為非小細胞肺癌病人,非小細胞肺癌相較於小細胞肺癌的病程發展較為緩慢,預後較佳且存活率較高,由於肺癌早期症狀不明顯,加上篩檢診斷較為困難,較容易被忽略,多數病人被診斷時都已經是晚期的階段,五年的存活率只有 6~18%,考量病患多數為年老伴隨共病與晚期肺癌無法痊癒的因素,因此治療的目標不僅止有集中在控制疾病上,更應該針對與顧及病患生活品質的維護甚至提升。 方法 此研究為縱貫型研究,使用便利取樣的抽樣方式,研究對象為從台大醫院腫瘤醫學部門診收取 20 歲以上的 130 名受訪者,研究收案期間為 2017 年 12 月至 2019 年 4 月,並且將病患根據治療方式分成三組分別比較不同治療方式前後的生活品質差異。 結果 本研究中總共收集到 104 位受訪者,依照治療方式將病人分為三個組別,可以發現在整體病患的總體生活品質與功能及症狀構面都有變好的趨勢,但只有免疫治療的整體生活品質治療前後的改變相對於化學與放射治療提高 7.23 分且達到統計上顯著,標靶治療則是在噁心與嘔吐上相較於化學與放射治療改變程度較差,但在腹瀉改變程度則是相對較好。 結論 鑒於生活品質對於晚期肺癌的重要性,我們更該在減少疾病症狀與提高存活率還有優化生活品質之間找到一個最佳的平衡點,幫助病人得到更適當的醫療照護並且減少不必要的不良反應。 | zh_TW |
dc.description.abstract | Background
In more recent years, lung cancer is the major cause of oncologic-related death worldwide. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer (85%). Because of delayed diagnosis, most NSCLC patients are diagnosed at an advanced-stage and predominantly receive palliative treatment. Treatment includes chemotherapy, radiotherapy, targeted therapy and immunotherapy. In view of incurable nature of advanced NSCLC, the goals of therapy should not only focus on attempts at controlling the disease, but it should also be directed at optimizing the patient’s quality of life (QoL). In the light of these various therapeutic options, it is clear that old version questionnaire cannot cover many important QoL issues or potential side-effects, so the objective of research is to evaluate the QoL of advanced-stage NSCLC patients receiving palliative anti-cancer modalities by using the latest questionnaire. Method This research design was a longitudinal design and utilizing convenience sampling. The participants for this study were recruited from the patients with advanced NSCLC and receiving anti-cancer treatment at National Taiwan University Hospital. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and EORTC QLQ-LC29 were used to investigate changes in QoL. The data was analyzed by SAS 9.4. The continuous data were analyzed by t-test and the categorical data were analyzed by Chi-squared test. ANCOVA and Multiple regression was applied to analytic statistics., P<0.05 was defined as statistically significant. Result One hundred and four participants were included in the study. The median age of the participants was 63.6 years, and 55.8% were male. Compared three therapy mean difference after 4 to 6 weeks anti-cancer treatment. For the Global health status using immunotherapy improvement of quality of life, and for the Symptoms scales using targeted therapy improvement of diarrhea, but worsening of nausea and vomiting were observed (P <0.05). Conclusion Longitudinal QoL assessments are important in advanced lung cancer patients because the data they provide could, for example, evaluate the benefit and risk on QoL under different anti-cancer modalities for doctor to do decision making. During the treatment period, not only is it necessary trying to improve the quality of life for the functional scales and symptomatic scales, but also should pay attention to the adverse effect of the target therapy on physical functioning. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T08:07:03Z (GMT). No. of bitstreams: 1 ntu-108-R06849039-1.pdf: 1914350 bytes, checksum: 51dd11dcb2527c442fd4e7f3e9614ec9 (MD5) Previous issue date: 2019 | en |
dc.description.tableofcontents | 目 錄
致謝 ...................................................... ii 中文摘要 ................................................. iii 英文摘要 .................................................. iv 專有名詞中英對照表 ....................................... vi 目錄 ...................................................... 1 圖目錄 .................................................... 4 表目錄 .................................................... 5 附錄目錄 .................................................. 6 第一章 緒論 ............................................ 7 第一節 研究背景 ...................................... 7 第二節 生活品質 ...................................... 8 第三節 文獻回顧 ...................................... 9 第四節 研究目的 ..................................... 11 第二章 方法 ........................................... 13 第一節 研究設計與研究族群 ........................... 13 第二節 研究流程 ..................................... 13 第三節 生活品質評估工具 ........................... 14 第四節 新版問卷 QLQ-LC29 與舊版 QLQ-LC13 差異 ..... 15 第五節 問卷分數轉換與計算 ......................... 16 第六節 樣本數估計 ................................ 17 第七節 統計分析 .................................. 17 第三章 結果 ...................................... 18 第一節 描述性統計與研究族群基本人口學特徵 ........... 18 第二節 不同治療方式治療前後的生活品質 ............... 18 第三節 不同治療方式與生活品質的關係 ................. 19 第四章 討論 ........................................ 20 第一節 研究主要發現 ................................ 20 第二節 與過去文獻比較 ............................. 20 第三節 研究優勢及貢獻 ............................... 21 第四節 研究限制 ..................................... 22 第五章 結論 ........................................... 25 參考文獻 .................................................26 附錄 ..................................................... 38 | |
dc.language.iso | zh-TW | |
dc.title | 使用不同癌症治療方式的晚期非小細胞肺癌病
人與生活品質的關聯性 | zh_TW |
dc.title | Association of Quality of Life in Patients with advanced Non-small Cell
Lung Cancer and Anti-cancer Treatment Modalities: A longitudinal Study | en |
dc.type | Thesis | |
dc.date.schoolyear | 107-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 李永凌(Yung-Ling Lee),陳苓諭(Ling-Yu Chen) | |
dc.subject.keyword | 生活品質,非小細胞肺癌,晚期肺癌, | zh_TW |
dc.subject.keyword | Quality of life,non-small cell lung cancer,advanced lung cancer, | en |
dc.relation.page | 56 | |
dc.identifier.doi | 10.6342/NTU201903990 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2019-08-19 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 流行病學與預防醫學研究所 | zh_TW |
顯示於系所單位: | 流行病學與預防醫學研究所 |
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