請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/73559完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 江建文(Kien Voon Kong) | |
| dc.contributor.author | Yi-Cheng Lin | en |
| dc.contributor.author | 林毅橙 | zh_TW |
| dc.date.accessioned | 2021-06-17T08:06:04Z | - |
| dc.date.available | 2019-09-02 | |
| dc.date.copyright | 2019-09-02 | |
| dc.date.issued | 2019 | |
| dc.date.submitted | 2019-08-20 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/73559 | - |
| dc.description.abstract | 這份論文主要會分為四個章節：第一章會概要介紹表面增強拉曼散射 (Surfaced-Enhanced Raman Scattering, SERS)和尖端增強拉曼散射 (Tip-Enhanced Raman Scattering, TERS)。我們將簡要回顧SERS和TERS的發展和應用的相關文獻。在研究中使用的所有化學藥品和實驗流程會在第二章中描述。
在第三章的第一部份，我們會探討發展以SERS為基礎，針對醣類的靈敏度以低樣品體積分析方法之可能性。這是和中正大學化生系游景晴老師合作的計畫，由游老師提供不同類型的寡聚醣作為我們的研究材料。我們發現SERS是一項靈敏的技術，能夠分辨由酵素合成的不同寡聚醣結構關係。這開啟了理解醣類合成機制新的研究方式。 在第三章的第二部份，我們記述結合有機金屬分子的TERS探針之製備，也展示了有機金屬化學領域與TERS技術的完美結合可應用於雙重分子的訊號偵測。由有機金屬分子所產生的獨特拉曼訊號可以避開來自血液中生化分子的干擾，因而讓對兩個重要指標分子(葡萄糖和硫醇)在極低樣品需求量 (50 nL)下進行快速分析變得可行。這建立起在血液中葡萄糖和硫醇的含量對糖尿病患者與否的關聯性研究潛力。 在第三章的第三部份，我們描述一個新方法能夠直接量測Ferrocifen (Fe-Tam；一種以二茂鐵為基底的藥物)在細胞中的反應中間體。解明其抗增殖行為具有重大意義，能夠幫助合理設計有更有效機制的新穎化療藥物，以及開發化學方法以避免特定抗藥性機轉。在實驗中，可以觀察到明確的振動特徵訊號代表二茂鐵基醌甲基化物 (Fe-Tam-QM)於細胞內的生成以及其進一步和細胞中親核試劑之反應。由我們的合作者中研院化學所江明錫老師與朱愷悌博士協助密度泛函理論計算 (density functional theory, DFT)，證明了振動模式的改變來自於不同二茂鐵基相關之結構。以上結果啟發了對二茂鐵基藥物的完整了解和開發更多金屬基底之治療藥物的可能性。 在第四章，我們列出這份研究工作中的主要結論。此外，我們也討論這份工作遇到的限制和失敗，強調這領域中未來的研究方向。 | zh_TW |
| dc.description.abstract | The thesis is divided into four chapters. Chapter 1 gives a brief introduction to surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS). Literature reports on development and applications of SERS and TERS are discussed in brief. All the experimental and chemicals used in this projects are listed in chapter 2.
In first part of chapter 3, we discuss our exploration of the possibility of development of SERS-based sensitive technique with ultra-low volume for carbohydrates. This is a collaboration project with Prof. Ching-Ching Yu in National Chung Cheng University (Department of Chemistry and Biochemistry). Prof. Yu provided different types of oligosaccharides in our study. Our findings show that SERS is a sensitive technique that is able to characterize the structure-property relationship of oligosaccharides synthesized by enzymes which opens a new way to realize mechanisms of carbohydrates synthesis. In second part of chapter 3, we report the preparation of an organometallic-conjugated TERS tip. We demonstrate that organometallic chemistry can be perfectly coupled with TERS for dual-molecule sensing. The unique Raman signals generated by the organometallic compound circumvent signal interference from the biomolecules in blood, allowing the rapid analysis of two important molecules (glucose and thiol) in ultralow volume (50 nL) samples. This enabled a correlation between the thiol and glucose levels in the blood of nondiabetic and diabetic patients to be drawn. The third part of chapter 3 describes a method that can directly detect intermediates of ferrocifen (Fe-Tam; a ferrocene-based drug) in cells which is of paramount importance to unravel their anti-proliferative action that rationally design new chemotherapy drugs with a more effective mechanism of action and develop chemical strategies to circumvent specific drug resistance mechanism. In the experiment, distinct vibrational features are observed for the formation of ferrocenyl quinone methide (Fe-Tam-QM) in cellular and toward reacts with cellular nucleophiles. DFT calculations from our collaborators (Prof Ming-Hsi Chiang and Dr Kai-Ti Chu) in Institute of Chemistry of academic sinica show the observed vibrational mode changes is resulted in the different configuration of ferrocenyl-related modes. These results shed light on the full understanding of the ferrocenyl-based medicine and developing more advanced metal-based therapy agents. In chapter 4, we list out the major conclusions arrived at in this work. In addition, we discuss the limitations and major failures of this work and highlight the scope for future research in this area. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T08:06:04Z (GMT). No. of bitstreams: 1 ntu-108-R06223167-1.pdf: 3167401 bytes, checksum: 149fbdc6f528dd020b2a3da05f56eb60 (MD5) Previous issue date: 2019 | en |
| dc.description.tableofcontents | 誌謝 I
摘要 II ABSTRACT III 目錄 IV 圖目錄 VIII 第一章 緒論 1 1.1 拉曼光譜 (Raman spectroscopy)的發展與特性 1 1.2 表面增強拉曼散射 (Surfaced-Enhanced Raman Scattering, SERS) 3 1.2.1 發展 3 1.2.2 電磁增強效應 (Electromagnetic Field Enhancement) 3 1.2.3 熱點效應 (Hot Spots) 4 1.2.4 化學增強效應 (Chemical Enhancement) 4 1.3 尖端增強拉曼散射 (Tip-Enhanced Raman Scattering, TERS) 6 1.3.1 發展 6 1.3.2 原子力顯微術為底之尖端增強拉曼散射 (Atomic Force Microscopy Based Tip Enhanced Raman Spectrum, AFM-TERS) 6 1.3.3 掃瞄穿隧顯微術為底之尖端增強拉曼散射 (Scanning Tunneling Microscopy Based Tip Enhanced Raman Spectrum, STM-TERS) 7 1.3.4 剪力顯微術為底之尖端增強拉曼散射 (Shear Force Microscopy Based Tip Enhanced Raman Spectrum, SFM-TERS) 7 1.4 常見醣類分析技術與拉曼光譜學之比較 8 1.4.1 遠紅外光譜學 (Infrared Spectroscopy, IR) 8 1.4.2 質譜法 (Mass Spectrometry, MS) 8 研究動機 9 第二章 實驗方法 11 2.1 化學藥品 11 2.2 實驗儀器 11 2.2.1 拉曼光譜儀 (Raman Microscope) 11 2.2.2 場發射掃瞄式電子顯微鏡 (Field Emission Scanning Electron Microscope, FE-SEM) 12 2.2.3 原子力顯微鏡系統 (Atomic Force Microscopy, AFM) 12 2.3 實驗步驟 12 2.3.1 SERS之醣類鑑定 12 2.3.1.1 寡聚醣分子SERS訊號量測 12 2.3.1.2 寡聚醣酵素合成SERS訊號量測 13 2.3.2 TERS之雙重化合物量測實驗 14 2.3.2.1 TERS探針修飾有機金屬分子 14 2.3.2.2 有機金屬探針和H_2 O_2濃度關係量測 15 2.3.2.3 有機金屬探針對葡萄糖和硫醇訊號的同步量測 15 2.3.3 TERS 之Fe-Tam氧化與細胞內量測實驗 15 2.3.3.1 TERS探針修飾金奈米粒子 15 2.3.3.2 Fe-Tam氧化反應TERS訊號量測 16 2.3.3.3 單一活體細胞內TERS訊號量測 17 第三章 結果與討論 18 3.1 SERS醣類分析 18 3.1.1 FJL-B2、Gal和Glc三者的拉曼光譜比較 18 3.1.2 GlcNAc、FJL-B2和TWT-B3三者的拉曼光譜比較 20 3.1.3 Gal、TWT-B3和TWT-B4三者的拉曼光譜比較 21 3.1.4 單醣數量與拉曼訊號強度之關係 23 3.1.5 醣類合成反應隨時間之拉曼訊號變化 24 3.1.6 結果整理 25 3.2 有機金屬修飾TERS探針對雙重化合物之偵測分析 26 3.2.1 TERS探針之有機金屬修飾結果 26 3.2.2 TERS強度與樣品濃度關係分析 29 3.2.3 TERS特徵峰值偏移現象探討 30 3.2.4 對葡萄糖和硫醇TERS訊號的同步量測 34 3.2.5 結果整理 35 3.3 TERS在單細胞中對二茂鐵抗癌藥物反應中間物直接觀測之應用 35 3.3.1 Fe-Tam的氧化反應觀測 35 3.3.2 DFT理論計算與實驗結果比較 36 3.3.3 Fe-Tam-QM和cysteine反應觀測 40 3.3.4 細胞內TERS訊號量測結果分析 41 3.3.5 結果整理 43 第四章 結論 45 第五章 參考文獻 47 | |
| dc.language.iso | zh-TW | |
| dc.subject | 乳癌治療 | zh_TW |
| dc.subject | 拉曼光譜 | zh_TW |
| dc.subject | 表面增幅拉曼散射 | zh_TW |
| dc.subject | 針尖增幅拉曼散射 | zh_TW |
| dc.subject | 醣類分析 | zh_TW |
| dc.subject | 有機金屬化學 | zh_TW |
| dc.subject | 糖尿病 | zh_TW |
| dc.subject | 二茂鐵基底藥物 | zh_TW |
| dc.subject | tip-enhanced Raman scattering | en |
| dc.subject | ferrocene-based drug | en |
| dc.subject | diabetes | en |
| dc.subject | organometallic chemistry | en |
| dc.subject | carbohydrates identification | en |
| dc.subject | Raman spectroscopy | en |
| dc.subject | surfaced-enhanced Raman scattering | en |
| dc.subject | breast cancer therapy | en |
| dc.title | TERS和SERS於醣類分子與二茂鐵基底藥物分析之應用 | zh_TW |
| dc.title | Application of TERS and SERS to Carbohydrates and Ferrocene-based Drugs Characterization | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 107-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳振中(Chun Chung Chan),游景晴(Ching-Ching Yu) | |
| dc.subject.keyword | 拉曼光譜,表面增幅拉曼散射,針尖增幅拉曼散射,醣類分析,有機金屬化學,糖尿病,二茂鐵基底藥物,乳癌治療, | zh_TW |
| dc.subject.keyword | Raman spectroscopy,surfaced-enhanced Raman scattering,tip-enhanced Raman scattering,carbohydrates identification,organometallic chemistry,diabetes,ferrocene-based drug,breast cancer therapy, | en |
| dc.relation.page | 55 | |
| dc.identifier.doi | 10.6342/NTU201904062 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2019-08-20 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 化學研究所 | zh_TW |
| 顯示於系所單位： | 化學系 | |
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