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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 周泰立(Tai-Li Chou) | |
dc.contributor.author | Ting Chen | en |
dc.contributor.author | 陳庭 | zh_TW |
dc.date.accessioned | 2021-06-17T07:17:01Z | - |
dc.date.available | 2021-10-09 | |
dc.date.copyright | 2019-10-09 | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019-07-12 | |
dc.identifier.citation | Abell, F., Happe, F., & Frith, U. (2000). Do triangles play tricks? Attribution of mental states to animated shapes in normal and abnormal development. Cognitive Development, 15, 1-16.
Apperly, I. A., Samson, D., Chiavarino, C., & Humphreys, G. W. (2004). Frontal and temporo-parietal lobe contributions to theory of mind: Neuropsychological evidence from a false-belief task with reduced language and executive demands. Journal of Cognitive Neuroscience, 16, 1773-1784. Association, A. P. (2013). Diagnostic and statistical manual of mental disorders (DSM-5®). Arlington, VA: American Psychiatric Publishing. Baron-Cohen, S., Leslie, A. M., & Frith, U. (1985). Does the autistic child have a “theory of mind”? Cognition, 21, 37-46. Baron‐Cohen, S., Jolliffe, T., Mortimore, C., & Robertson, M. (1997). Another advanced test of theory of mind: Evidence from very high functioning adults with autism or Asperger syndrome. Journal of Child Psychology and Psychiatry, 38, 813-822. Baron‐Cohen, S., Ring, H. A., Wheelwright, S., Bullmore, E. T., Brammer, M. J., Simmons, A., & Williams, S. C. (1999). Social intelligence in the normal and autistic brain: An fMRI study. European Journal of Neuroscience, 11, 1891-1898. Barrett, H. C., Todd, P. M., Miller, G. F., & Blythe, P. W. (2005). Accurate judgments of intention from motion cues alone: A cross-cultural study. Evolution and Human Behavior, 26, 313-331. Bigler, E. D., Mortensen, S., Neeley, E. S., Ozonoff, S., Krasny, L., Johnson, M., . . . Lainhart, J. E. (2007). Superior temporal gyrus, language function, and autism. Developmental Neuropsychology, 31, 217-238. doi:10.1080/87565640701190841 Blakemore, S. J., Boyer, P., Pachot-Clouard, M., Meltzoff, A., Segebarth, C., & Decety, J. (2003). The detection of contingency and animacy from simple animations in the human brain. Cerebral Cortex, 13, 837-844. Blakemore, S. J., Rees, G., & Frith, C. D. (1998). How do we predict the consequences of our actions? A functional imaging study. Neuropsychologia, 36, 521-529. Bonda, E., Petrides, M., Ostry, D., & Evans, A. (1996). Specific involvement of human parietal systems and the amygdala in the perception of biological motion. Journal of Neuroscience, 16, 3737-3744. Brunet, E., Sarfati, Y., Hardy-Baylé, M.-C., & Decety, J. (2000). A PET investigation of the attribution of intentions with a nonverbal task. NeuroImage, 11, 157-166. Castelli, F., Happé, F., Frith, U., & Frith, C. (2000). Movement and mind: A functional imaging study of perception and interpretation of complex intentional movement patterns. NeuroImage, 12, 314-325. Castelli, F., Frith, C., Happé, F., & Frith, U. (2002). Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain, 125, 1839-1849. Cavanna, A. E., & Trimble, M. R. (2006). The precuneus: A review of its functional anatomy and behavioural correlates. Brain, 129, 564-583. doi:10.1093/brain/awl004 Craik, F. I., Moroz, T. M., Moscovitch, M., Stuss, D. T., Winocur, G., Tulving, E., & Kapur, S. (1999). In search of the self: A positron emission tomography study. Psychological Science, 10, 26-34. Frith, C. D., & Frith, U. (2006). The neural basis of mentalizing. Neuron, 50, 531-534. Frith, U., & Happé, F. (1994). Autism: Beyond “theory of mind”. Cognition, 50, 115-132. Gallagher, H. L., Happe, F., Brunswick, N., Fletcher, P. C., Frith, U., & Frith, C. D. (2000). Reading the mind in cartoons and stories: An fMRI study of 'theory of mind' in verbal and nonverbal tasks. Neuropsychologia, 38, 11-21. Gallagher, H. L., & Frith, C. D. (2003). Functional imaging of 'theory of mind'. Trends Cogn Sci, 7, 77-83. Gau, S. S.-F., Liu, L.-T., Wu, Y.-Y., Chiu, Y.-N., & Tsai, W.-C. (2013). Psychometric properties of the Chinese version of the social responsiveness scale. Research in Autism Spectrum Disorders, 7, 349-360. Gobbini, M. I., Koralek, A. C., Bryan, R. E., Montgomery, K. J., & Haxby, J. V. (2007). Two takes on the social brain: A comparison of theory of mind tasks. Journal of Cognitive Neuroscience, 19, 1803-1814. doi:10.1162/jocn.2007.19.11.1803 Gusnard, D. A., Akbudak, E., Shulman, G. L., & Raichle, M. E. (2001). Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America, 98, 4259-4264. doi:10.1073/pnas.071043098 Happé, F. G. (1994). An advanced test of theory of mind: Understanding of story characters' thoughts and feelings by able autistic, mentally handicapped, and normal children and adults. Journal of Autism Developmental Disorder, 24, 129-154. Heider, F., & Simmel, M. (1944). An experimental study of apparent behavior. The American Journal of Psychology, 57, 243-259. Kana, R. K., Keller, T. A., Cherkassky, V. L., Minshew, N. J., & Just, M. A. (2009). Atypical frontal-posterior synchronization of Theory of Mind regions in autism during mental state attribution. Social Neuroscience, 4, 135-152. Kana, R. K., Maximo, J. O., Williams, D. L., Keller, T. A., Schipul, S. E., Cherkassky, V. L., . . . Just, M. A. (2015). Aberrant functioning of the theory-of-mind network in children and adolescents with autism. Molecular Autism, 6, 59. Koelkebeck, K., Hirao, K., Kawada, R., Miyata, J., Saze, T., Ubukata, S., . . . Murai, T. (2011). Transcultural differences in brain activation patterns during theory of mind (ToM) task performance in Japanese and Caucasian participants. Social Neuroscience, 6, 615-626. doi:10.1080/17470919.2011.620763 Koshino, H., Kana, R. K., Keller, T. A., Cherkassky, V. L., Minshew, N. J., & Just, M. A. (2008). fMRI investigation of working memory for faces in autism: Visual coding and underconnectivity with frontal areas. Cerebral Cortex, 18, 289-300. Doi:10.1093/cercor/bhm054 Leslie, A. M., Friedman, O., & German, T. P. (2004). Core mechanisms in “theory of mind.” Trends in Cognitive Sciences, 8, 528-533. Libero, L. E. (2012). The Role of the Mirror Neuron System in Mental State Attribution in Autism: An FMRI Study (Unpublished doctoral dissertation or master’s thesis). University of Alabama at Birmingham, Graduate School. Ma, N., Vandekerckhove, M., Van Overwalle, F., Seurinck, R., & Fias, W. (2011). Spontaneous and intentional trait inferences recruit a common mentalizing network to a different degree: Spontaneous inferences activate only its core areas. Social Neuroscience, 6, 123-138. Maras, K. L., Wimmer, M. C., Robinson, E. J., and Bowler, D. M. (2014). Mental imagery scanning in autism spectrum disorder. Research in Autism Spectrum Disorder, 8, 1416–1423. doi: 10.1016/j.rasd.2014.07.003 Martin, A., & Weisberg, J. (2003). Neural foundations for understanding social and mechanical concepts. Cognitive Neuropsychology, 20, 575-587. doi:10.1080/02643290342000005 Mitchell, P., Currie, G., & Ziegler, F. (2009). Is there an alternative to simulation and theory in understanding the mind? British Journal of Developmental Psychology, 27, 561-567. Misra, V. (2014). The social brain network and autism. Annals of Neuroscience, 21, 69-73. doi:10.5214/ans.0972.7531.210208 Nijhof, A. D., Bardi, L., Brass, M., & Wiersema, J. R. (2018). Brain activity for spontaneous and explicit mentalizing in adults with autism spectrum disorder: An fMRI study. NeuroImage: Clinical, 18, 475-484. Ozonoff, S., Pennington, B. F., & Rogers, S. J. (1991). Executive function deficits in high‐functioning autistic individuals: Relationship to theory of mind. Journal of Child Psychology and Psychiatry, 32, 1081-1105. Perkins, T. J., Bittar, R. G., McGillivray, J. A., Cox, I. I., & Stokes, M. A. (2015). Increased premotor cortex activation in high functioning autism during action observation. Journal of Clinical Neuroscience, 22, 664-669. Perner, J., & Leekam, S. (2008). The curious incident of the photo that was accused of being false: Issues of domain specificity in development, autism, and brain imaging. The Quarterly Journal of Experimental Psychology, 61, 76-89. Premack, D., & Woodruff, G. (1978). Does the chimpanzee have a theory of mind? Behavioral and Brain Sciences, 1, 515-526. Puce, A., & Perrett, D. (2003). Electrophysiology and brain imaging of biological motion. Philosophical Transactions of the Royal Society of London. Series B, Biological Science, 358, 435-445. doi:10.1098/rstb.2002.1221 Rizzolatti, G., & Craighero, L. (2004). The mirror-neuron system. Annual Review of Neuroscience, 27, 169-192. doi:10.1146/annurev.neuro.27.070203.144230 Rizzolatti, G., & Fabbri-Destro, M. (2010). Mirror neurons: from discovery to autism. Experimental Brain Research, 200, 223-237. doi:10.1007/s00221-009-2002-3 Ross, L. A., & Olson, I. R. (2010). Social cognition and the anterior temporal lobes. NeuroImage, 49, 3452-3462. doi:10.1016/j.neuroimage.2009.11.012 Samson, D., Apperly, I. A., Chiavarino, C., & Humphreys, G. W. (2004). Left temporoparietal junction is necessary for representing someone else's belief. Nature Neuroscience, 7, 499. Santos, N. S., David, N., Bente, G., & Vogeley, K. (2008). Parametric induction of animacy experience. Consciousness and Cognition, 17, 425-437. Santos, N. S., Kuzmanovic, B., David, N., Rotarska-Jagiela, A., Eickhoff, S. B., Shah, J. N., . . . Vogeley, K. (2010). Animated brain: A functional neuroimaging study on animacy experience. NeuroImage, 53, 291-302. doi:10.1016/j.neuroimage.2010.05.080 Saxe, R. (2006). Uniquely human social cognition. Current Opinion in Neurobiology, 16, 235-239. doi:10.1016/j.conb.2006.03.001 Saxe, R., & Kanwisher, N. (2003). People thinking about thinking people. The role of the temporo-parietal junction in 'theory of mind'. NeuroImage, 19, 1835-1842. Saxe, R., Schulz, L. E., & Jiang, Y. V. (2006). Reading minds versus following rules: Dissociating theory of mind and executive control in the brain. Social Neuroscience, 1, 284-298. doi:10.1080/17470910601000446 Scheeren, A. M., de Rosnay, M., Koot, H. M., & Begeer, S. (2013). Rethinking theory of mind in high‐functioning autism spectrum disorder. Journal of Child Psychology and Psychiatry, 54, 628-635. Schulte-Rüther, M., Greimel, E., Markowitsch, H. J., Kamp-Becker, I., Remschmidt, H., Fink, G. R., & Piefke, M. (2011). Dysfunctions in brain networks supporting empathy: An fMRI study in adults with autism spectrum disorders. Social Neuroscience, 6, 1-21. Schultz, J., Imamizu, H., Kawato, M., & Frith, C. D. (2004). Activation of the human superior temporal gyrus during observation of goal attribution by intentional objects. Journal of Cognitive Neuroscience, 16, 1695-1705. doi:10.1162/0898929042947874 Schultz, R. T. (2005). Developmental deficits in social perception in autism: The role of the amygdala and fusiform face area. International Journal of Developmental Neuroscience, 23, 125-141. doi:10.1016/j.ijdevneu.2004.12.012 Schurz, M., Radua, J., Aichhorn, M., Richlan, F., & Perner, J. (2014). Fractionating theory of mind: A meta-analysis of functional brain imaging studies. Neuroscience & Biobehavioral Reviews, 42, 9-34. Spek, A. A., Scholte, E. M., & Van Berckelaer-Onnes, I. A. (2010). Theory of mind in adults with HFA and Asperger syndrome. Journal of Autism and Developmental Disorders, 40, 280-289. Travers, B. G., Bigler, E. D., Tromp do, P. M., Adluru, N., Froehlich, A. L., Ennis, C., . . . Lainhart, J. E. (2014). Longitudinal processing speed impairments in males with autism and the effects of white matter microstructure. Neuropsychologia, 53, 137-145. doi:10.1016/j.neuropsychologia.2013.11.008 Tavares, P., Lawrence, A. D., & Barnard, P. J. (2008). Paying attention to social meaning: An FMRI study. Cerebral Cortex, 18, 1876-1885. doi:10.1093/cercor/bhm212 Tremoulet, P. D., & Feldman, J. (2006). The influence of spatial context and the role of intentionality in the interpretation of animacy from motion. Perception & Psychophysics, 68, 1047-1058. Vogeley, K., May, M., Ritzl, A., Falkai, P., Zilles, K., & Fink, G. R. (2004). Neural correlates of first-person perspective as one constituent of human self-consciousness. Journal of Cognitive Neuroscience, 16, 817-827. doi:10.1162/089892904970799 Wang, A. T., Lee, S. S., Sigman, M., & Dapretto, M. (2006). Neural basis of irony comprehension in children with autism: The role of prosody and context. Brain, 129, 932-943. doi:10.1093/brain/awl032 Weisberg, J., Milleville, S. C., Kenworthy, L., Wallace, G. L., Gotts, S. J., Beauchamp, M. S., & Martin, A. (2012). Social perception in autism spectrum disorders: Impaired category selectivity for dynamic but not static images in ventral temporal cortex. Cerebral Cortex, 24(1), 37-48. Wechsler, D. (2002). Wechsler adult intelligence scale-Third Edition (WAIS-III). San Antonio, TX: NCS Pearson. Wellman, H. M., Cross, D., & Watson, J. (2001). Meta‐analysis of theory‐of‐mind development: The truth about false belief. Child Development, 72, 655-684. Wimmer, H., & Perner, J. (1983). Beliefs about beliefs: Representation and constraining function of wrong beliefs in young children's understanding of deception. Cognition, 13, 103-128. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/73089 | - |
dc.description.abstract | 心智理論(Theory of Mind, ToM)為推論他人心智狀態的能力,例如:想法、信念、慾望和意圖等,也是所有社會互動的基礎。過往研究發現自閉症患者在心智理論的能力上有所缺損,且可能為腦神經機制的異常所導致。然而,過往此類心智理論相關腦造影研究多聚焦於兒童及青少年自閉症患者,較缺乏納入自閉症成人患者作為樣本研究,樣本數較少,且目前所發現之結果也尚無定論。因此,本研究欲藉功能性磁振造影,探討健康成人與自閉症成人之心智理論神經機制。本研究共有健康組與自閉症組成人各24位,使其於掃描時進行心智理論作業-社會動畫作業。作業中會出現兩個三角形,受試者需判斷兩者是否正進行互動,抑或隨機移動。結果發現,自閉症組較健康組於左側楔前葉腦區(precuneus)、右上側顳腦迴(superior temporal gyrus, STG)、及右中側額葉迴(middle frontal gyrus, MFG)有較高活化量,而健康組較自閉症組於左側中央前迴(precentral gyrus)、及右側腦島區(insula)有較低活化量。結果亦顯示自閉症組較高的右上側顳腦迴活化,與其日常社會溝通行為上的缺損有顯著關聯。綜上所述,本研究認為自閉症成人與正常健康發展成人之心智理論神經機制有所不同,且自閉症成人患者於心智理論神經機制上的缺損,亦干擾其日常社交互動之功能。 | zh_TW |
dc.description.abstract | Theory of Mind (ToM), defined as the ability to infer another person's mental states, such as beliefs, desires, and intentions, is a fundamental process of social interaction. The deficit of ToM is one of the core features of autism spectrum disorder (ASD). The present study aimed to explore the differential neural substrates of ToM using the social animation task (Castelli et al., 2000) between ASD adults and healthy controls. We assessed 24 healthy controls (mean age: 20.99±2.03) and 24 adults with ASD (mean age: 22.10±1.93) with the social animation task of ToM, which featured two triangles moving on a framed background with ToM and control animations. Participants were asked to decide if a social interaction was presented for each animation in functional MRI. The imaging analyses were conducted to explore the process of ToM. Correlation analysis were conducted to explore the relationship between neural activations associated with ToM and social interaction abilities measure by the Social responsiveness scale (SRS) and the Chinese version of Autism Diagnostic Interview, Revised (ADI-R). In within-group contrast, the [ToM-Random] exhibited common activation in the bilateral superior temporal gyri (STG), right middle temporal gyri (MTG), and left inferior frontal gyrus (IFG) across two groups. In between-groups contrast, the [ToM-Random] displayed greater activation in the left precuneus, right superior temporal gyrus (STG), right middle frontal gyrus (MFG) in ASD than the controls. Reversed comparisons showed that the controls displayed additional activation in left precentral gyrus and right insula relative to the ASD group. For correlation analysis, greater right superior temporal gyrus(STG) activation was positively correlated with the ADIR Qualitative Communication Abnormalities in the ASD group. Aberrant neural activities of ToM in ASD suggest that adults with ASD might spend a great deal of effort on ToM processing. The correlation finding implied that adults with ASD might spend excessive effort on the identification processing, thereby influencing the performance of social communication skills. In summary, the results indicated that the neural deficits of ToM in ASD might be associated with their daily social interaction difficulties. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T07:17:01Z (GMT). No. of bitstreams: 1 ntu-108-R04227210-1.pdf: 822887 bytes, checksum: 455f699d381bbf3c2cad6f8dd67ffbcf (MD5) Previous issue date: 2019 | en |
dc.description.tableofcontents | 1. Introduction 1
2. Methods 7 2.1. Participants 7 2.2. Experimental Paradigm 8 2.3. MRI Data Acquisition 9 2.4. Image Data Analysis 10 2.5. Correlation Analysis 11 3. Results 12 3.1. Behavioral Performance 12 3.2. Within-Group Brain Activations for the Typically Developing(TD) group 12 3.3. Within-Group Brain Activations for the ASD group 13 3.4. Between-Group Activation Differences for the ASD and TD Groups 13 3.5. Correlation Analysis between ADI-R/SRS and Brain Activation in ASD 16 4. Discussion 17 5. References 23 Table1. Demographic Information of Participants 7 Table2. Descriptive Statistics and Two-way Mixed-effects Repeated-measure Analysis Results for Group (TD & ASD) by Condition (ToM & RD) 12 Table3. Summary of Within-Group Activations for the ToM Compared with Random Condition (contrast [ToM>RD]) 14 Table4. Summary of Between-Group Activations for the ToM Compared with Random Condition (contrast [ToM>RD]) 15 Figure1. Between-Group Brain Activations 15 Figure2. Scatter Plot of Correlation Analysis Results 16 | |
dc.language.iso | en | |
dc.title | 自閉症成人之心智理論神經機制:社會動畫作業之功能性核磁造影研究 | zh_TW |
dc.title | Neural Substrates of Theory of Mind for Adults with Autism Spectrum Disorder: An fMRI Study of the Social Animation Task | en |
dc.type | Thesis | |
dc.date.schoolyear | 107-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 張玉玲(Yu-Ling Chang) | |
dc.contributor.oralexamcommittee | 陳修元(Shiou-Yuan Chen),李姝慧(Shu-Hui Lee) | |
dc.subject.keyword | 心智理論,自閉症,功能性磁振造影,社會動畫作業, | zh_TW |
dc.subject.keyword | theory of mind,autism spectrum disorder,fMRI,social animation, | en |
dc.relation.page | 30 | |
dc.identifier.doi | 10.6342/NTU201901439 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2019-07-12 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 心理學研究所 | zh_TW |
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