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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 李繼忠 | |
dc.contributor.author | Ching-Mei Tsai | en |
dc.contributor.author | 蔡晶玫 | zh_TW |
dc.date.accessioned | 2021-06-17T07:07:10Z | - |
dc.date.available | 2019-08-05 | |
dc.date.copyright | 2019-08-05 | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019-07-24 | |
dc.identifier.citation | 1. Warland, J. and J. Dobson, Breed predispositions in canine mast cell tumour: a single centre experience in the United Kingdom. Vet J, 2013. 197(2): p. 496-8.
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Bavcar, S., et al., Combination toceranib and lomustine shows frequent high grade toxicities when used for treatment of non-resectable or recurrent mast cell tumours in dogs: A European multicentre study. Vet J, 2017. 224: p. 1-6. 39. Hahn, K.A., et al., Masitinib is safe and effective for the treatment of canine mast cell tumors. J Vet Intern Med, 2008. 22(6): p. 1301-9. 40. Hahn, K.A., et al., Evaluation of 12- and 24-month survival rates after treatment with masitinib in dogs with nonresectable mast cell tumors. Am J Vet Res, 2010. 71(11): p. 1354-61. 41. Grant, J., S. North, and D. Lanore, Clinical response of masitinib mesylate in the treatment of canine macroscopic mast cell tumours. J Small Anim Pract, 2016. 57(6): p. 283-90. 42. Isotani, M., et al., Effect of tyrosine kinase inhibition by imatinib mesylate on mast cell tumors in dogs. J Vet Intern Med, 2008. 22(4): p. 985-8. 43. Bostock, D.E., The prognosis following surgical removal of mastocytomas in dogs. J Small Anim Pract, 1973. 14(1): p. 27-41. 44. Murphy, S., et al., Relationships between the histological grade of cutaneous mast cell tumours in dogs, their survival and the efficacy of surgical resection. Veterinary Record, 2004. 154(24): p. 743-746. 45. Simoes, J.P., P. Schoning, and M. Butine, Prognosis of canine mast cell tumors: a comparison of three methods. Vet Pathol, 1994. 31(6): p. 637-47. 46. Sabattini, S., et al., Histologic grading of canine mast cell tumor: is 2 better than 3? Vet Pathol, 2015. 52(1): p. 70-3. 47. Stefanello, D., et al., Comparison of 2- and 3-category histologic grading systems for predicting the presence of metastasis at the time of initial evaluation in dogs with cutaneous mast cell tumors: 386 cases (2009-2014). J Am Vet Med Assoc, 2015. 246(7): p. 765-9. 48. Takeuchi, Y., et al., Validation of the prognostic value of histopathological grading or c-kit mutation in canine cutaneous mast cell tumours: A retrospective cohort study. The Veterinary Journal, 2013. 196(3): p. 492-498. 49. Bostock, D.E., Neoplasms of the skin and subcutaneous tissues in dogs and cats. Br Vet J, 1986. 142(1): p. 1-19. 50. McNiel, E.A., A.L. Prink, and T.D. O'Brien, Evaluation of risk and clinical outcome of mast cell tumours in pug dogs. Vet Comp Oncol, 2006. 4(1): p. 2-8. 51. Mullins, M.N., et al., Evaluation of prognostic factors associated with outcome in dogs with multiple cutaneous mast cell tumors treated with surgery with and without adjuvant treatment: 54 cases (1998-2004). J Am Vet Med Assoc, 2006. 228(1): p. 91-5. 52. Pierini, A., et al., Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy. Vet Sci, 2019. 6(2). 53. Smiech, A., et al., Occurrence and Distribution of Canine Cutaneous Mast Cell Tumour Characteristics Among Predisposed Breeds. J Vet Res, 2019. 63(1): p. 141-148. 54. Mochizuki, H., et al., Association of breed and histopathological grade in canine mast cell tumours. Veterinary and Comparative Oncology, 2017. 15(3): p. 829-839. 55. Michels, G.M., et al., Prognosis following surgical excision of canine cutaneous mast cell tumors with histopathologically tumor-free versus nontumor-free margins: a retrospective study of 31 cases. J Am Anim Hosp Assoc, 2002. 38(5): p. 458-66. 56. Pizzoni, S., et al., Features and prognostic impact of distant metastases in 45 dogs with de novo stage IV cutaneous mast cell tumours: A prospective study. Vet Comp Oncol, 2018. 16(1): p. 28-36. 57. Gerritsen, R.J., et al., Multi-agent chemotherapy for mast cell tumours in the dog. Vet Q, 1998. 20(1): p. 28-31. 58. Khoo, A., A. Lane, and K. Wyatt, Intranasal mast cell tumor in the dog: A case series. Can Vet J, 2017. 58(8): p. 851-854. 59. Baginski, H., G. Davis, and R.P. Bastian, The prognostic value of lymph node metastasis with grade 2 MCTs in dogs: 55 cases (2001-2010). J Am Anim Hosp Assoc, 2014. 50(2): p. 89-95. 60. Sfiligoi, G., et al., Outcome of dogs with mast cell tumors in the inguinal or perineal region versus other cutaneous locations: 124 cases (1990-2001). J Am Vet Med Assoc, 2005. 226(8): p. 1368-74. 61. Cahalane, A.K., et al., Prognostic factors for survival of dogs with inguinal and perineal mast cell tumors treated surgically with or without adjunctive treatment: 68 cases (1994-2002). J Am Vet Med Assoc, 2004. 225(3): p. 401-8. 62. Moirano, S.J., et al., Association of prognostic features and treatment on survival time of dogs with systemic mastocytosis: A retrospective analysis of 40 dogs. Vet Comp Oncol, 2018. 16(1): p. E194-e201. 63. Horta, R.S., et al., Assessment of Canine Mast Cell Tumor Mortality Risk Based on Clinical, Histologic, Immunohistochemical, and Molecular Features. Vet Pathol, 2018. 55(2): p. 212-223. 64. O’Keefe, D.A., Canine Mast Cell Tumors. Veterinary Clinics of North America: Small Animal Practice, 1990. 20(4): p. 1105-1115. 65. Govier, S.M., Principles of treatment for mast cell tumors. Clin Tech Small Anim Pract, 2003. 18(2): p. 103-6. 66. Vozdova, M., et al., Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours. Vet J, 2019. 247: p. 71-74. 67. Webster, J.D., et al., The role of c-KIT in tumorigenesis: evaluation in canine cutaneous mast cell tumors. Neoplasia (New York, N.Y.), 2006. 8(2): p. 104-111. 68. Letard, S., et al., Gain-of-Function Mutations in the Extracellular Domain of KIT Are Common in Canine Mast Cell Tumors. Molecular Cancer Research, 2008. 6(7): p. 1137-1145. 69. Gil da Costa, R.M., C-kit as a prognostic and therapeutic marker in canine cutaneous mast cell tumours: From laboratory to clinic. Vet J, 2015. 205(1): p. 5-10. 70. Scase, T.J., et al., Canine mast cell tumors: correlation of apoptosis and proliferation markers with prognosis. J Vet Intern Med, 2006. 20(1): p. 151-8. 71. van Lelyveld, S., et al., Comparison between Ki-67 index and mitotic index for predicting outcome in canine mast cell tumours. J Small Anim Pract, 2015. 56(5): p. 312-9. 72. Thompson, J.J., et al., Canine subcutaneous mast cell tumor: characterization and prognostic indices. Vet Pathol, 2011. 48(1): p. 156-68. 73. Miller, R.L., et al., A retrospective review of treatment and response of high-risk mast cell tumours in dogs. Vet Comp Oncol, 2016. 14(4): p. 361-370. 74. Hume, C.T., et al., Outcomes of dogs with grade 3 mast cell tumors: 43 cases (1997-2007). J Am Anim Hosp Assoc, 2011. 47(1): p. 37-44. 75. Chaffin, K. and D.E. Thrall, Results of radiation therapy in 19 dogs with cutaneous mast cell tumor and regional lymph node metastasis. Vet Radiol Ultrasound, 2002. 43(4): p. 392-5. 76. Frimberger, A.E., et al., Radiotherapy of incompletely resected, moderately differentiated mast cell tumors in the dog: 37 cases (1989-1993). J Am Anim Hosp Assoc, 1997. 33(4): p. 320-4. 77. Rassnick, K.M., et al., Efficacy of vinblastine for treatment of canine mast cell tumors. J Vet Intern Med, 2008. 22(6): p. 1390-6. 78. Fowler, J.F., 21 years of biologically effective dose. The British Journal of Radiology, 2010. 83(991): p. 554-68. 79. Nguyen, S., et al., Response evaluation criteria for solid tumours in dogs (v1.0): A Veterinary Cooperative Oncology Group (VCOG) consensus document. Vol. 12032. 2013. 80. Veterinary cooperative oncology group - common terminology criteria for adverse events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.1. Vet Comp Oncol, 2016. 14(4): p. 417-446. 81. LaDue, T. and M.K. Klein, Toxicity criteria of the veterinary radiation therapy oncology group. Veterinary Radiology & Ultrasound, 2001. 42(5): p. 475-476. 82. Stefanello, D., et al., Ultrasound-guided cytology of spleen and liver: a prognostic tool in canine cutaneous mast cell tumor. 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J Am Vet Med Assoc, 2010. 237(8): p. 936-42. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/72821 | - |
dc.description.abstract | 肥大細胞瘤(Mast cell tumor, MCT)為犬體表最常見腫瘤,占所有犬體表腫瘤之16-21%。肥大細胞瘤之臨床表現受到許多因子影響,其中組織病理分級為最重要的因子之一。根據Patnaik組織分級系統,第二級以及第三級的肥大細胞瘤,由於單純手術切除後有較高局部復發以及遠端轉移機率,因此治療建議為手術切除加上合併輔助治療。
此研究收集國立台灣大學生物資源暨農學院附設動物醫院動物腫瘤治療中心從西元2009年至西元2019年診斷為第二級以及第三級肥大細胞瘤的病例,進行回溯性方法分析與研究。共有42例犬隻符合收案條件而納入,並進一步就合併低分次放射線治療在此類病患中的治療效力進行分析。依據是否有接受手術後放射線治療進行分組,10隻犬隻進行外科手術、低分次放射線治療及內科治療而歸類為放療組,另外32隻進行外科手術及內科治療而歸類為非放療組。 結果顯示放療組相較於非放療組有較長的無疾病進展時間(Progression-free interval, PFI)、總體存活時間(Overall survival time, OST)以及較低的局部腫瘤復發率。兩組的中位無疾病進展時間為230 以及119 天(P = 0.029),總體存活時間為533 以及224 天(P = 0.021), 以及局部復發率為40% 以及75 % (P = 0.012)。 在多變數分析不同因子分別與無疾病進展時間以及總體存活時間的關係時,接受放射線治療對於無疾病進展時間有顯著差異 (P = 0.041, 危害比 2.876),以及對於總體存活時間也有顯著差異 (P = 0.021, 危害比 2.549)。腫瘤組織分級對於無疾病進展時間 (P = 0.035, hazard ratio 3.169)以及總體存活時間 (P = 0.016,危害比 2.803)有顯著影響。臨床分期對於總體存活時間有顯著影響(P = 0.025, 危害比2.643)但是對於無疾病進展時間並無顯著影響(P = 0.064)。 此篇研究之結果顯示,罹患臨床表現較惡性之肥大細胞瘤之犬隻,接受積極局部控制包括手術以及手術後低分次放射線治療,加上合併內科治療,相較於進行手術以及單純內科治療有較好之預後。 | zh_TW |
dc.description.abstract | Mast cell tumor (MCT) is the most common skin tumor in dogs, representing for 16% to 21% of all canine cutaneous neoplasms. The clinical behavior of the MCT is highly variable due to many factors, with the histologic grade being the most important one. For grade II and grade III (according to the Patnaik classification) MCTs, adjuvant therapy is generally recommended because of the high incidence of local recurrence and distant metastasis after surgical excision alone.
The medical records of the dogs diagnosed with intermediate to high grade mast cell tumor from 2009 to 2019 at National Taiwan University Veterinary Hospital were reviewed and analyzed retrospectively. Forty-two client-owned dogs met the inclusion criteria, receiving surgery and post-operative systemic treatment with or without hypofractionated radiation therapy (RT) were analyzed in the study, 10 cases were receiving adjuvant RT treatment and designated as RT group and 32 cases were not. The efficacy of aggressive local tumor control by adjuvant radiation therapy and the prognostic factors of these patients were evaluated in this study. The result revealed the dogs treated with adjuvant hypofractionated RT had the clinical benefit on progression-free interval (PFI), overall survival time (OST) and local recurrence rate compared to the non-RT group. The median PFI was 230 and 119 days (P = 0.029), the median OST was 533 and 224 days (P = 0.021), the local recurrence rate was 40% and 75% (P = 0.012). In the multivariate analysis of the association of several factors with PFI and OST, the dogs that received adjuvant radiation therapy had statistically significant influence on PFI (P = 0.041, hazard ratio 2.876) and OST (P = 0.021, hazard ratio 2.549). Tumor grade also had statistically significant influence on PFI (P = 0.035, hazard ratio 3.169) and OST (P = 0.016, hazard ratio 2.803). The clinical stage had statistically significant influence on OST (P = 0.025, hazard ratio 2.643) but not for PFI (P = 0.064). The result from the present study indicates that the aggressive local control including surgery excision and hypofractionated radiation therapy combined with systemic treatment can improve the outcome for the dogs with histologic grade II to grade III MCT compared to surgical excision and systemic treatment alone. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T07:07:10Z (GMT). No. of bitstreams: 1 ntu-108-R05643009-1.pdf: 1125418 bytes, checksum: d7f1f7cdbb7bb721cb7ec9df720e592c (MD5) Previous issue date: 2019 | en |
dc.description.tableofcontents | 口試委員審定書 i
誌謝 ii List of abbreviations iii 中文摘要 iv ABSTRACT vi CONTENTS viii LIST OF TABLES xi LIST OF FIGURES xii Chapter 1 Literature review 14 1.1 Canine mast cell tumor 14 1.2 Local control 15 1.3 Systemic treatment 18 1.3.1 Corticosteroid 18 1.3.2 Chemotherapy 19 1.3.3 Target therapy 19 1.4 Prognostic factors 20 Chapter 2 Introduction 23 Chapter 3 Material and methods 24 3.1 Patient selection 24 3.2 Data collection 24 3.3 Clinical stage 25 3.4 Tumor grade 26 3.5 Surgery 26 3.6 Systemic treatment 26 3.6.1 Medication 26 3.6.2 Monitor 27 3.7 Radiation therapy 27 3.8 Treatment response 28 3.9 Treatment toxicity 29 3.10 Statistical analysis 29 Chapter 4 Results 32 4.1 Demographic 32 4.2 Adjuvant hypofractionated radiation therapy group 33 4.2.1 Radiation therapy 35 4.2.2 Medical treatment and outcome 36 4.2.3 Outcome 38 4.3 Non-radiation therapy group 39 4.3.1 Post-operative first-line medical treatment and outcome 41 4.3.2 Outcome 45 4.4 Statistical analysis 46 4.4.1 Compare two study groups 46 4.4.2 Kaplan-Meier curve of PFI in RT and non-RT group 46 4.4.3 Kaplan-Meier curve of ST in RT and non-RT group 47 4.4.4 Prognostic factors of the RT group 47 4.4.5 Prognostic factors analysis for the progression-free interval (PFI) 48 4.4.6 Prognostic factors analysis for overall survival time (OST) 49 Chapter 5 Discussion 51 5.1 Demographic 51 5.2 Treatment efficacy 52 5.3 Influential factors evaluation 55 5.4 Limitations of this study 60 Chapter 6 Conclusion 61 Appendix 62 Appendix 1. Treatment timeline of the RT and non-RT group 62 Appendix 2. Diagnostic and treatment algorithms for MCT 63 Tables 65 Figures 83 REFERENCE 105 | |
dc.language.iso | en | |
dc.title | 合併放射線治療在犬中至高分級惡性肥大細胞瘤之療效 | zh_TW |
dc.title | The Efficacy of Adjuvant Radiation Therapy in Treating Canine Intermediate to High Grade Mast Cell Tumor | en |
dc.type | Thesis | |
dc.date.schoolyear | 107-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 李雅珍,林辰栖,廖泰慶,王尚麟 | |
dc.subject.keyword | 犬肥大細胞瘤,低分次放射線治療, | zh_TW |
dc.subject.keyword | Canine mast cell tumor,Hypofractionated radiation therapy, | en |
dc.relation.page | 113 | |
dc.identifier.doi | 10.6342/NTU201901771 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2019-07-24 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
顯示於系所單位: | 臨床動物醫學研究所 |
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