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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 嚴震東(Chen-Tung Yen) | |
dc.contributor.author | Han-Hsiung Chi | en |
dc.contributor.author | 紀瀚雄 | zh_TW |
dc.date.accessioned | 2021-06-17T06:59:14Z | - |
dc.date.available | 2021-04-07 | |
dc.date.copyright | 2021-04-07 | |
dc.date.issued | 2021 | |
dc.date.submitted | 2021-03-02 | |
dc.identifier.citation | 1. Thakor, D.K.; Lin, A.; Matsuka, Y.; Meyer, E.M.; Ruangsri, S.; Nishimura, I.; Spigelman, I. Increased peripheral nerve excitability and local NaV1. 8 mRNA up-regulation in painful neuropathy. Molecular Pain 2009, 5, 14. 2. Omori, S.; Isose, S.; Misawa, S.; Watanabe, K.; Sekiguchi, Y.; Shibuya, K.; Beppu, M.; Amino, H.; Kuwabara, S. Pain-related evoked potentials after intraepidermal electrical stimulation to Aδ and C fibers in patients with neuropathic pain. Neuroscience Research 2017, 121, 43-48. 3. Hovaguimian, A.; Gibbons, C.H. Diagnosis and treatment of pain in small-fiber neuropathy. Current pain and headache reports 2011, 15, 193-200. 4. McCarthy, B.; Hsieh, S.-T.; Stocks, A.; Hauer, P.; Macko, C.; Cornblath, D.; Griffin, J.; McArthur, J.C. Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy. Neurology 1995, 45, 1848-1855. 5. Lauria, G.; Bakkers, M.; Schmitz, C.; Lombardi, R.; Penza, P.; Devigili, G.; Smith, A.G.; Hsieh, S.T.; Mellgren, S.I.; Umapathi, T. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. Journal of the Peripheral Nervous System 2010, 15, 202-207. 6. Chien, H.-F.; Tseng, T.-J.; Lin, W.-M.; Yang, C.-C.; Chang, Y.-C.; Chen, R.-C.; Hsieh, S.-T. Quantitative pathology of cutaneous nerve terminal degeneration in the human skin. Acta neuropathologica 2001, 102, 455-461. 7. Shun, C.T.; Chang, Y.C.; Wu, H.P.; Hsieh, S.C.; Lin, W.M.; Lin, Y.H.; Tai, T.Y.; Hsieh, S.T. Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments. Brain 2004, 127, 1593-1605. 8. Hsieh, S.-T.; Chiang, H.-Y.; Lin, W.-M. Pathology of nerve terminal degeneration in the skin. Journal of Neuropathology Experimental Neurology 2000, 59, 297-307. 9. Chiang, M.-C.; Lin, Y.-H.; Pan, C.-L.; Tseng, T.-J.; Lin, W.-M.; Hsieh, S.-T. Cutaneous innervation in chronic inflammatory demyelinating polyneuropathy. Neurology 2002, 59, 1094-1098. 10. Chiang, H.; Chang, K.C.; Kan, H.W.; Wu, S.W.; Tseng, M.T.; Hsueh, H.W.; Lin, Y.H.; Chao, C.C.; Hsieh, S.T. Physiological and pathological characterization of capsaicin‐induced reversible nerve degeneration and hyperalgesia. European Journal of Pain 2018, 22, 1043-1056. 11. Lin, Y.-W.; Tseng, T.-J.; Lin, W.-M.; Hsieh, S.-T. Cutaneous nerve terminal degeneration in painful mononeuropathy. Experimental neurology 2001, 170, 290-296. 12. Tseng, T.-J.; Chen, C.-C.; Hsieh, Y.-L.; Hsieh, S.-T. Effects of decompression on neuropathic pain behaviors and skin reinnervation in chronic constriction injury. Experimental neurology 2007, 204, 574-582. 13. Hsieh, Y.-L.; Kan, H.-W.; Chiang, H.; Lee, Y.-C.; Hsieh, S.-T. Distinct TrkA and Ret modulated negative and positive neuropathic behaviors in a mouse model of resiniferatoxin-induced small fiber neuropathy. Experimental neurology 2018, 300, 87-99. 14. Rajan, B.; Polydefkis, M.; Hauer, P.; Griffin, J.W.; McArthur, J.C. Epidermal reinnervation after intracutaneous axotomy in man. Journal of Comparative Neurology 2003, 457, 24-36. 15. Liu, Y.; Sebastian, B.; Liu, B.; Zhang, Y.; Fissel, J.A.; Pan, B.; Polydefkis, M.; Farah, M.H. Sensory and autonomic function and structure in footpads of a diabetic mouse model. Scientific reports 2017, 7, 1-9. 16. Polydefkis, M.; Yiannoutsos, C.; Cohen, B.; Hollander, H.; Schifitto, G.; Clifford, D.; Simpson, D.; Katzenstein, D.; Shriver, S.; Hauer, P. Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy. Neurology 2002, 58, 115-119. 17. Zhou, L.; Kitch, D.; Evans, S.; Hauer, P.; Raman, S.; Ebenezer, G.; Gerschenson, M.; Marra, C.; Valcour, V.; Diaz-Arrastia, R. Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathy. Neurology 2007, 68, 2113-2119. 18. Herrmann, D.; McDermott, M.; Sowden, J.; Henderson, D.; Messing, S.; Cruttenden, K.; Schifitto, G. Is skin biopsy a predictor of transition to symptomatic HIV neuropathy?: A longitudinal study. Neurology 2006, 66, 857-861. 19. Sorensen, L.; Molyneaux, L.; Yue, D.K. The relationship among pain, sensory loss, and small nerve fibers in diabetes. Diabetes care 2006, 29, 883-887. 20. Devigili, G.; Tugnoli, V.; Penza, P.; Camozzi, F.; Lombardi, R.; Melli, G.; Broglio, L.; Granieri, E.; Lauria, G. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain 2008, 131, 1912-1925. 21. Yoon, Y.W.; Na, H.S.; Chung, J.M. Contributions of injured and intact afferents to neuropathic pain in an experimental rat model. Pain 1996, 64, 27-36. 22. Li, Y.; Dorsi, M.J.; Meyer, R.A.; Belzberg, A.J. Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers. Pain 2000, 85, 493-502. 23. Berta, T.; Poirot, O.; Pertin, M.; Ji, R.-R.; Kellenberger, S.; Decosterd, I. Transcriptional and functional profiles of voltage-gated Na+ channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain. Molecular and Cellular Neuroscience 2008, 37, 196-208. 24. Berta, T.; Perrin, F.E.; Pertin, M.; Tonello, R.; Liu, Y.-C.; Chamessian, A.; Kato, A.C.; Ji, R.-R.; Decosterd, I. Gene expression profiling of cutaneous injured and non-injured nociceptors in SNI animal model of neuropathic pain. Scientific reports 2017, 7, 1-11. 25. Reinhold, A.; Batti, L.; Bilbao, D.; Buness, A.; Rittner, H.; Heppenstall, P. Differential transcriptional profiling of damaged and intact adjacent dorsal root ganglia neurons in neuropathic pain. PloS one 2015, 10, e0123342. 26. Helmchen, F.; Denk, W. Deep tissue two-photon microscopy. Nature methods 2005, 2, 932. 27. Yuryev, M.; Molotkov, D. In vivo two-photon microscopy of single nerve endings in skin. JoVE (Journal of Visualized Experiments) 2014, e51045. 28. Li, J.L.; Goh, C.C.; Keeble, J.L.; Qin, J.S.; Roediger, B.; Jain, R.; Wang, Y.; Chew, W.K.; Weninger, W.; Ng, L.G. Intravital multiphoton imaging of immune responses in the mouse ear skin. Nature protocols 2012, 7, 221. 29. Barreiro, O.; Cibrian, D.; Clemente, C.; Alvarez, D.; Moreno, V.; Valiente, I.; Bernad, A.; Vestweber, D.; Arroyo, A.G.; Martín, P. Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair. Elife 2016, 5, e15251. 30. Yuryev, M.; Khiroug, L. Dynamic longitudinal investigation of individual nerve endings in the skin of anesthetized mice using in vivo two-photon microscopy. Journal of biomedical optics 2012, 17, 046007. 31. Wang, S.; Bian, C.; Yang, J.; Arora, V.; Gao, Y.; Wei, F.; Chung, M.-K. Ablation of TRPV1+ afferent terminals by capsaicin mediates long-lasting analgesia for trigeminal neuropathic pain. Eneuro 2020, 7. 32. Kim, S.H.; Chung, J.M. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992, 50, 355-363. 33. Bennett, G.J.; Xie, Y.-K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33, 87-107. 34. Decosterd, I.; Woolf, C.J. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 2000, 87, 149-158. 35. Yeh, T.-Y.; Luo, I.-W.; Hsieh, Y.-L.; Tseng, T.-J.; Chiang, H.; Hsieh, S.-T. Peripheral Neuropathic Pain: From Experimental Models to Potential Therapeutic Targets in Dorsal Root Ganglion Neurons. Cells 2020, 9, 2725. 36. Guo, S.-H.; Lin, J.-P.; Huang, L.-E.; Yang, Y.; Chen, C.-Q.; Li, N.-N.; Su, M.-Y.; Zhao, X.; Zhu, S.-M.; Yao, Y.-X. Silencing of spinal Trpv1 attenuates neuropathic pain in rats by inhibiting CAMKII expression and ERK2 phosphorylation. Scientific reports 2019, 9, 2769. 37. Rivat, C.; Sar, C.; Mechaly, I.; Leyris, J.-P.; Diouloufet, L.; Sonrier, C.; Philipson, Y.; Lucas, O.; Mallié, S.; Jouvenel, A. Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice. Nature communications 2018, 9, 1042. 38. Tseng, T.-J.; Hsieh, Y.-L.; Ko, M.-H.; Hsieh, S.-T. Redistribution of voltage-gated sodium channels after nerve decompression contributes to relieve neuropathic pain in chronic constriction injury. Brain research 2014, 1589, 15-25. 39. Challa, S.R. Surgical animal models of neuropathic pain: Pros and Cons. International Journal of Neuroscience 2015, 125, 170-174. 40. Kumar, A.; Kaur, H.; Singh, A. Neuropathic pain models caused by damage to central or peripheral nervous system. Pharmacological Reports 2018, 70, 206-216. 41. Shields, S.D.; Ahn, H.-S.; Yang, Y.; Han, C.; Seal, R.P.; Wood, J.N.; Waxman, S.G.; Dib-Hajj, S.D. Nav1. 8 expression is not restricted to nociceptors in mouse peripheral nervous system. PAIN® 2012, 153, 2017-2030. 42. Lakomá, J.; Rimondini, R.; Donadio, V.; Liguori, R.; Caprini, M. Pain related channels are differentially expressed in neuronal and non-neuronal cells of glabrous skin of fabry knockout male mice. PLoS One 2014, 9, e108641. 43. Persson, A.-K.; Black, J.A.; Gasser, A.; Cheng, X.; Fischer, T.Z.; Waxman, S.G. Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals. Molecular pain 2010, 6, 84. 44. Persson, A.-K.; Kim, I.; Zhao, P.; Estacion, M.; Black, J.A.; Waxman, S.G. Sodium channels contribute to degeneration of dorsal root ganglion neurites induced by mitochondrial dysfunction in an in vitro model of axonal injury. Journal of Neuroscience 2013, 33, 19250-19261. 45. Daou, I.; Beaudry, H.; Ase, A.R.; Wieskopf, J.S.; Ribeiro-da-Silva, A.; Mogil, J.S.; Séguéla, P. Optogenetic silencing of Nav1. 8-positive afferents alleviates inflammatory and neuropathic pain. eNeuro 2016, 3. 46. Dong, X.-W.; Goregoaker, S.; Engler, H.; Zhou, X.; Mark, L.; Crona, J.; Terry, R.; Hunter, J.; Priestley, T. Small interfering RNA-mediated selective knockdown of NaV1. 8 tetrodotoxin-resistant sodium channel reverses mechanical allodynia in neuropathic rats. Neuroscience 2007, 146, 812-821. 47. Ito, A.; Takeda, M.; Yoshimura, T.; Komatsu, T.; Ohno, T.; Kuriyama, H.; Matsuda, A.; Yoshimura, M. Anti-hyperalgesic effects of calcitonin on neuropathic pain interacting with its peripheral receptors. Molecular pain 2012, 8, 42. 48. Wilson-Gerwing, T.D.; Stucky, C.L.; McComb, G.W.; Verge, V.M. Neurotrophin-3 significantly reduces sodium channel expression linked to neuropathic pain states. Experimental neurology 2008, 213, 303-314. 49. Urru, M.; Muzzi, M.; Coppi, E.; Ranieri, G.; Buonvicino, D.; Camaioni, E.; Coppini, R.; Pugliese, A.M.; Tanaka, B.; Estacion, M. Dexpramipexole blocks Nav1. 8 sodium channels and provides analgesia in multiple nociceptive and neuropathic pain models. Pain 2020, 161, 831-841. 50. Dworetzky, S.I.; Hebrank, G.T.; Archibald, D.G.; Reynolds, I.J.; Farwell, W.; Bozik, M.E. The targeted eosinophil-lowering effects of dexpramipexole in clinical studies. Blood Cells, Molecules, and Diseases 2017, 63, 62-65. 51. Cudkowicz, M.E.; van den Berg, L.H.; Shefner, J.M.; Mitsumoto, H.; Mora, J.S.; Ludolph, A.; Hardiman, O.; Bozik, M.E.; Ingersoll, E.W.; Archibald, D. Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial. The Lancet Neurology 2013, 12, 1059-1067. 52. Hai, T.; Wolfgang, C.D.; Marsee, D.K.; Allen, A.E.; Sivaprasad, U. ATF3 and stress responses. Gene Expression, The Journal of Liver Research 1999, 7, 321-335. 53. Obata, K.; Yamanaka, H.; Fukuoka, T.; Yi, D.; Tokunaga, A.; Hashimoto, N.; Yoshikawa, H.; Noguchi, K. Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats. Pain 2003, 101, 65-77. 54. Grace, P.M.; Fabisiak, T.J.; Green-Fulgham, S.M.; Anderson, N.D.; Strand, K.A.; Kwilasz, A.J.; Galer, E.L.; Walker, F.R.; Greenwood, B.N.; Maier, S.F. Prior voluntary wheel running attenuates neuropathic pain. Pain 2016, 157, 2012. 55. Stirling, L.C.; Forlani, G.; Baker, M.D.; Wood, J.N.; Matthews, E.A.; Dickenson, A.H.; Nassar, M.A. Nociceptor-specific gene deletion using heterozygous NaV1. 8-Cre recombinase mice. Pain 2005, 113, 27-36. 56. Chuang, Y.-C.; Lee, C.-H.; Sun, W.-H.; Chen, C.-C. Involvement of advillin in somatosensory neuron subtype-specific axon regeneration and neuropathic pain. Proceedings of the National Academy of Sciences 2018, 115, E8557-E8566. 57. Chaplan, S.R.; Bach, F.W.; Pogrel, J.W.; Chung, J.M.; Yaksh, T.L. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994, 53, 55-63. 58. Hargreaves, K.; Dubner, R.; Brown, F.; Flores, C.; Joris, J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988, 32, 77-88. 59. Schindelin, J.; Arganda-Carreras, I.; Frise, E.; Kaynig, V.; Longair, M.; Pietzsch, T.; Preibisch, S.; Rueden, C.; Saalfeld, S.; Schmid, B. Fiji: an open-source platform for biological-image analysis. Nature methods 2012, 9, 676. 60. Faul, F.; Erdfelder, E.; Buchner, A.; Lang, A.-G. Statistical power analyses using G* Power 3.1: Tests for correlation and regression analyses. Behavior research methods 2009, 41, 1149-1160. 61. Kennedy, W.R. Opportunities afforded by the study of unmyelinated nerves in skin and other organs. Muscle Nerve: Official Journal of the American Association of Electrodiagnostic Medicine 2004, 29, 756-767. 62. Peleshok, J.C.; Ribeiro‐da‐Silva, A. Delayed reinnervation by nonpeptidergic nociceptive afferents of the glabrous skin of the rat hindpaw in a neuropathic pain model. Journal of Comparative Neurology 2011, 519, 49-63. 63. Yen, L.D.; Bennett, G.J.; Ribeiro‐da‐Silva, A. Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injury. Journal of Comparative Neurology 2006, 495, 679-690. 64. Casals-Díaz, L.; Vivó, M.; Navarro, X. Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat. Experimental neurology 2009, 217, 84-95. 65. Braz, J.M.; Nassar, M.A.; Wood, J.N.; Basbaum, A.I. Parallel “pain” pathways arise from subpopulations of primary afferent nociceptor. Neuron 2005, 47, 787-793. 66. Lawson, S.; Waddell, P. Soma neurofilament immunoreactivity is related to cell size and fibre conduction velocity in rat primary sensory neurons. The Journal of physiology 1991, 435, 41-63. 67. Scherrer, G.; Imamachi, N.; Cao, Y.-Q.; Contet, C.; Mennicken, F.; O'Donnell, D.; Kieffer, B.L.; Basbaum, A.I. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell 2009, 137, 1148-1159. 68. Zylka, M.J.; Rice, F.L.; Anderson, D.J. Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron 2005, 45, 17-25. 69. Akopian, A.N.; Sivilotti, L.; Wood, J.N. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 1996, 379, 257. 70. Rush, A.; Bräu, M.; Elliott, A.; Elliott, J. Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia. The Journal of Physiology 1998, 511, 771-789. 71. Blair, N.T.; Bean, B.P. Role of tetrodotoxin-resistant Na+ current slow inactivation in adaptation of action potential firing in small-diameter dorsal root ganglion neurons. Journal of Neuroscience 2003, 23, 10338-10350. 72. Joshi, S.; Honore, P.; Hernandez, G.; Schmidt, R.; Gomtsyan, A.; Scanio, M.; Kort, M.; Jarvis, M.F. Additive antinociceptive effects of the selective Nav1. 8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models. The Journal of Pain 2009, 10, 306-315. 73. Joshi, S.; Mikusa, J.P.; Hernandez, G.; Baker, S.; Shieh, C.-C.; Neelands, T.; Zhang, X.-F.; Niforatos, W.; Kage, K.; Han, P. Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states. Pain 2006, 123, 75-82. 74. Porreca, F.; Lai, J.; Bian, D.; Wegert, S.; Ossipov, M.H.; Eglen, R.M.; Kassotakis, L.; Novakovic, S.; Rabert, D.K.; Sangameswaran, L. A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain. Proceedings of the National Academy of Sciences 1999, 96, 7640-7644. 75. Ko, M.-H.; Hsieh, Y.-L.; Hsieh, S.-T.; Tseng, T.-J. Nerve demyelination increases metabotropic glutamate receptor subtype 5 expression in peripheral painful mononeuropathy. International Journal of Molecular Sciences 2015, 16, 4642-4665. 76. Yonehara, N.; Yoshimura, M. Influence of painful chronic neuropathy on neurogenic inflammation. Pain 2001, 92, 259-265. 77. La Rana, G.; Russo, R.; D'Agostino, G.; Sasso, O.; Raso, G.M.; Iacono, A.; Meli, R.; Piomelli, D.; Calignano, A. AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors. Neuropharmacology 2008, 54, 521-529. 78. Shimada, N.; Sakata, A.; Igarashi, T.; Takeuchi, M.; Nishimura, S. M1 macrophage infiltration exacerbate muscle/bone atrophy after peripheral nerve injury. BMC musculoskeletal disorders 2020, 21, 1-10. 79. Clatworthy, A.; Illich, P.; Castro, G.; Walters, E. Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain. Neuroscience letters 1995, 184, 5-8. 80. Okamoto, K.; Martin, D.P.; Schmelzer, J.D.; Mitsui, Y.; Low, P.A. Pro-and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain. Experimental neurology 2001, 169, 386-391. 81. Malek, N.; Pajak, A.; Kolosowska, N.; Kucharczyk, M.; Starowicz, K. The importance of TRPV1-sensitisation factors for the development of neuropathic pain. Molecular and Cellular Neuroscience 2015, 65, 1-10. 82. Kung, C.-C.; Huang, Y.-C.; Hung, T.-Y.; Teng, C.-Y.; Lee, T.-Y.; Sun, W.-H. Deletion of Acid-Sensing Ion Channel 3 Relieves the Late Phase of Neuropathic Pain by Preventing Neuron Degeneration and Promoting Neuron Repair. Cells 2020, 9, 2355. 83. Kabashima, K.; Egawa, G. Intravital multiphoton imaging of cutaneous immune responses. J Invest Dermatol 2014, 134, 2680-2684. 84. Goh, C.C.; Li, J.L.; Becker, D.; Weninger, W.; Angeli, V.; Ng, L.G. Inducing ischemia-reperfusion injury in the mouse ear skin for intravital multiphoton imaging of immune responses. JoVE (Journal of Visualized Experiments) 2016, e54956. 85. Kolter, J.; Feuerstein, R.; Zeis, P.; Hagemeyer, N.; Paterson, N.; d’Errico, P.; Baasch, S.; Amann, L.; Masuda, T.; Lösslein, A. A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves. Immunity 2019. 86. Lauria, G.; Cornblath, D.; Johansson, O.; McArthur, J.C.; Mellgren, S.; Nolano, M.; Rosenberg, N.; Sommer, C. EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. European journal of neurology 2005, 12, 747-758. 87. Lauria, G.; Morbin, M.; Lombardi, R.; Capobianco, R.; Camozzi, F.; Pareyson, D.; Manconi, M.; Geppetti, P. Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies. Journal of the Peripheral Nervous System 2006, 11, 262-271. 88. Mosconi, T.; Kruger, L. Fixed-diameter polyethylene cuffs applied to the rat sciatic nerve induce a painful neuropathy: ultrastructural morphometric analysis of axonal alterations. Pain 1996, 64, 37-57. 89. Tsujino, H.; Kondo, E.; Fukuoka, T.; Dai, Y.; Tokunaga, A.; Miki, K.; Yonenobu, K.; Ochi, T.; Noguchi, K. Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: a novel neuronal marker of nerve injury. Molecular and Cellular Neuroscience 2000, 15, 170-182. 90. Tsuzuki, K.; Kondo, E.; Fukuoka, T.; Yi, D.; Tsujino, H.; Sakagami, M.; Noguchi, K. Differential regulation of P2X3 mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia. Pain 2001, 91, 351-360. 91. Shortland, P.J.; Baytug, B.; Krzyzanowska, A.; McMahon, S.B.; Priestley, J.V.; Averill, S. ATF3 expression in L4 dorsal root ganglion neurons after L5 spinal nerve transection. European Journal of Neuroscience 2006, 23, 365-373. 92. Ivanavicius, S.P.; Ball, A.D.; Heapy, C.G.; Westwood, F.R.; Murray, F.; Read, S.J. Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation. Pain 2007, 128, 272-282. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/72438 | - |
dc.description.abstract | 已知許多周邊神經在神經壓迫性損傷之後會有退化的現象,然而神經損傷所造成的變化與疼痛的嚴重程度,兩者之間的相關性仍是未知的。在本研究中,我們發明了透過雙光子螢光顯微鏡的中幅與微幅的活體影像評估方式,來長期觀察慢性壓迫性損傷(chronic constriction injury, CCI)後,電壓門控鈉離子通道1.8基因轉殖螢光小鼠(Nav1.8-Cre-tdTomato mice)後腳掌皮下的神經纖維變化。我們比較三種不同的分析方式來對應全腳掌神經評分與局部活體包含了神經叢長度與神經末梢變化的評分,來尋找一個與機械力過敏感現象最相關的新型生物性標誌物。結果顯示CCI造成不同程度的皮下神經叢和表皮神經纖維受損。我們也發現Nav1.8神經纖維損失的時間點和機械力過敏感化發展相關。此外,使用非線性回歸模型分析全腳掌神經評分和局部活體神經分數,或使用多元線性回歸模型結合第五趾趾尖的局部活體內神經叢長度和末端數目變化,兩者均與機械性縮足閾值顯著相關並具有機械力過敏感化的預測效果。這些結果顯示出誘發的神經性神經痛既需要存活的神經且需要受損的神經。此外,這兩種評估方法均具有預測作用,可用作神經性疼痛的診斷和預後生物標誌物。 | zh_TW |
dc.description.abstract | Multiple peripheral nerves are known to degenerate after nerve compression injury, but the correlation between the extent of nerve alteration and pain severity remains unclear. Here, we developed meso- and micro- intravital imaging assessments via the two-photon fluorescence microscopy to longitudinally observe changes in cutaneous fibers in the hind paw of Nav1.8-tdTomato mice after chronic constriction injury (CCI). We compared three different analysis approaches for the whole-paw nerve score and the local intravital scores, including plexus length and terminal number changes, to search for a novel biomarker best correlated with the mechanical hypersensitivity. Results showed that CCI led to variable loss of the skin nerve plexus and intraepidermal nerve fibers. The timing of Nav1.8 nerve fiber loss correlated with the development of mechanical hypersensitivity. Moreover, using the non-linear regression model analyzed the whole-paw nerve score and the local intravital nerve scores, or using the multiple linear regression model combined the local intravital plexus length and terminal number changes in the fifth toe tip, both these two methods significantly correlated with the mechanical withdrawal threshold and had the predictive power for the mechanical hypersensitivity. In summary, these findings imply that both surviving and injured nerves are necessary for evoked neuropathic pain. In addition, both of these assessments have the predictive effect to be used as a diagnostic and prognostic biomarker for neuropathic pain. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T06:59:14Z (GMT). No. of bitstreams: 1 U0001-0103202111535400.pdf: 5817961 bytes, checksum: 14ddd375f8e4b1d2cceb6ce6f24c02d0 (MD5) Previous issue date: 2021 | en |
dc.description.tableofcontents | 口試委員會審定書 i 致謝 ii 中文摘要 iii Abstract iv Content v Lists of Tables vii Lists of Figures viii Abbreviation table xi Chapter 1 Introduction 1 Chapter 2 Materials and Methods 6 2.1 Animals 6 2.2 Experimental design 6 2.3 Chronic constriction injury 7 2.4 Nociceptive tests for pain threshold measurement 7 2.5 Immunohistochemistry 8 2.6 Intravital microscopy 9 2.7 3D intravital image processing and analysis 11 2.8 Statistical analysis 11 Chapter 3 Results 13 3.1 CCI-induced neuropathic pain behavior 13 3.2 Whole-paw nerve scoring method 14 3.3 Local intravital scoring method 18 3.4 Multiple variable analysis 31 Chapter 4 Discussion 35 Chapter 5 Conclusion 41 Chapter 6 Tables 42 Chapter 7 Figures 48 Chapter 8 References 77 | |
dc.language.iso | en | |
dc.title | 慢性神經壓迫損傷誘發小鼠神經性疼痛的中幅與微幅之活體影像評估方式 | zh_TW |
dc.title | Meso- and Micro- Intravital Imaging Assessments for Chronic Constriction Injury-Induced Neuropathic Pain in Mice | en |
dc.type | Thesis | |
dc.date.schoolyear | 109-2 | |
dc.description.degree | 博士 | |
dc.contributor.author-orcid | 0000-0002-7884-7696 | |
dc.contributor.oralexamcommittee | 閔明源(Ming-Yuan Min),孫維仁(Wei-Zen Sun),謝松蒼(Sung-Tsang Hsieh),陳志成(Chih-Cheng Chen) | |
dc.subject.keyword | 慢性壓迫性損傷,皮下神經纖維,活體雙光子螢光顯微鏡,電壓門控鈉離子通道1.8 亞型,神經性神經痛, | zh_TW |
dc.subject.keyword | Chronic constriction injury,Cutaneous nerve fiber,Intravital two-photon fluorescence microscopy,Nav1.8,Neuropathic pain, | en |
dc.relation.page | 88 | |
dc.identifier.doi | 10.6342/NTU202100764 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2021-03-03 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 生命科學系 | zh_TW |
顯示於系所單位: | 生命科學系 |
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