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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 楊偉勛(Wei-Shiung Yang) | |
dc.contributor.author | Po-Ju Hung | en |
dc.contributor.author | 洪泊儒 | zh_TW |
dc.date.accessioned | 2021-06-17T06:24:07Z | - |
dc.date.available | 2018-08-30 | |
dc.date.copyright | 2018-08-30 | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018-08-17 | |
dc.identifier.citation | REFERENCES
Albaugh, V. L. and N. N. Abumrad (2018). 'Surgical treatment of obesity.' F1000Res 7. Anderson, G. W., Q. Zhu, J. Metkowski, M. J. Stack, S. Gopinath and C. N. Mariash (2009). 'The Thrsp null mouse (Thrsp(tm1cnm)) and diet-induced obesity.' Mol Cell Endocrinol 302(1): 99-107. Chang, H. C., H. C. Yang, H. Y. Chang, C. J. Yeh, H. H. Chen, K. C. Huang and W. H. Pan (2017). 'Morbid obesity in Taiwan: Prevalence, trends, associated social demographics, and lifestyle factors.' PLoS One 12(2): e0169577. Chen, Y. T., F. Y. Tseng, P. L. Chen, Y. C. Chi, D. S. Han and W. S. Yang (2016). 'Serum Spot 14 concentration is negatively associated with thyroid-stimulating hormone level.' Medicine (Baltimore) 95(40). Corcelles, R., C. R. Daigle and P. R. Schauer (2016). 'MANAGEMENT OF ENDOCRINE DISEASE: Metabolic effects of bariatric surgery.' European Journal of Endocrinology 174(1): R19-R28. Engin, A. B. (2017). Adipocyte-Macrophage Cross-Talk in Obesity. Obesity and Lipotoxicity. A. B. Engin and A. Engin. Cham, Springer International Publishing: 327-343. Erol, V., T. H. Yilmaz, B. Tuncali, B. Arslan and H. Gulay (2017). 'Changes in serum lipid levels after laparoscopic sleeve gastrectomy in morbidly obese dyslipidemic and normolipidemic patients.' Acta Chir Belg: 1-6. Jump, D. B. and J. H. Oppenheimer (1985). 'High basal expression and 3,5,3'-triiodothyronine regulation of messenger ribonucleic acid S14 in lipogenic tissues.' Endocrinology 117(6): 2259-2266. Kinlaw, W. B., J. L. Church, J. Harmon and C. N. Mariash (1995). 'Direct evidence for a role of the 'spot 14' protein in the regulation of lipid synthesis.' J Biol Chem 270(28): 16615-16618. Kirschner, L. S. and C. N. Mariash (1999). 'Adipose S14 mRNA is abnormally regulated in obese subjects.' Thyroid 9(2): 143-148. LaFave, L. T., L. B. Augustin and C. N. Mariash (2006). 'S14: insights from knockout mice.' Endocrinology 147(9): 4044-4047. Li, L., X. Wang, L. Bai, H. Yu, Z. Huang, A. Huang, Y. Luo and J. Wang (2018). 'The Effects of Sleeve Gastrectomy on Glucose Metabolism and Glucagon-Like Peptide 1 in Goto-Kakizaki Rats.' J Diabetes Res 2018: 1082561. Liu, F., J. Di, H. Yu, J. Han, Y. Bao and W. Jia (2017). 'Effect of Roux-en-Y gastric bypass on thyroid function in euthyroid patients with obesity and type 2 diabetes.' Surg Obes Relat Dis 13(10): 1701-1707. MacCuish, A., S. Razvi and A. A. Syed (2012). 'Effect of weight loss after gastric bypass surgery on thyroid function in euthyroid people with morbid obesity.' Clin Obes 2(1-2): 25-28. Neeland, I. J., P. Poirier and J. P. Despres (2018). 'Cardiovascular and Metabolic Heterogeneity of Obesity: Clinical Challenges and Implications for Management.' Circulation 137(13): 1391-1406. Ortega, F. J., A. Vazquez-Martin, J. M. Moreno-Navarrete, J. Bassols, J. Rodriguez-Hermosa, J. Girones, W. Ricart, B. Peral, F. J. Tinahones, G. Fruhbeck, J. A. Menendez and J. M. Fernandez-Real (2010). 'Thyroid hormone responsive Spot 14 increases during differentiation of human adipocytes and its expression is down-regulated in obese subjects.' Int J Obes (Lond) 34(3): 487-499. Ozsoy, Z. and F. Kutluturk (2018). 'Effect of Laparoscopic Sleeve Gastrectomy on Thyroid Hormones in Euthyroid Obese Patients.' Endocr Metab Immune Disord Drug Targets 18(4): 407-411. Pirola, L. and J. C. Ferraz (2017). 'Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity.' World J Biol Chem 8(2): 120-128. Qi, L., Y. Guo, C. Q. Liu, Z. P. Huang, Y. Sheng and D. J. Zou (2017). 'Effects of bariatric surgery on glycemic and lipid metabolism, surgical complication and quality of life in adolescents with obesity: a systematic review and meta-analysis.' Surg Obes Relat Dis 13(12): 2037-2055. Reilly, S. M. and A. R. Saltiel (2017). 'Adapting to obesity with adipose tissue inflammation.' Nat Rev Endocrinol 13(11): 633-643. Seelig, S., C. Liaw, H. C. Towle and J. H. Oppenheimer (1981). 'Thyroid hormone attenuates and augments hepatic gene expression at a pretranslational level.' Proc Natl Acad Sci U S A 78(8): 4733-4737. Serrano, M., M. Moreno, J. Bassols, J. M. Moreno-Navarrete, F. Ortega, W. Ricart and J. M. Fernandez-Real (2015). 'Coxsackie and adenovirus receptor is increased in adipose tissue of obese subjects: a role for adenovirus infection?' J Clin Endocrinol Metab 100(3): 1156-1163. Tremmel, M., U. G. Gerdtham, P. M. Nilsson and S. Saha (2017). 'Economic Burden of Obesity: A Systematic Literature Review.' Int J Environ Res Public Health 14(4). Yang, W. S., W. J. Lee, T. Funahashi, S. Tanaka, Y. Matsuzawa, C. L. Chao, C. L. Chen, T. Y. Tai and L. M. Chuang (2001). 'Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin.' J Clin Endocrinol Metab 86(8): 3815-3819. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/72115 | - |
dc.description.abstract | 簡介
肥胖症是全世界的課題,根據統計,全球超過五億人口有肥胖的問題。肥胖是一種身體堆積了過量脂肪,以至於對健康產生負面影響的狀態。過多的脂肪組織,以及堆積在身體各處的異位性脂肪,往往造成身體正常組織或器官的功能受損。研究顯示,肥胖的特徵是免疫系統的慢性低度活化,其中巨噬細胞引起的發炎反應、脂肪細胞和巨噬細胞的交互作用,扮演關鍵角色。介白質1β是在肥胖時聚集的促發炎細胞因子之一。經過介白質1β刺激的小鼠3T3-L1細胞株,在和控制組對照後,基因表現生物晶片顯示thyroid hormone responsive (THRSP)是唯一被顯著抑制的基因。THRSP的蛋白質產物Spot 14 (S14),是一種在接受甲狀腺荷爾蒙、碳水化合物或胰島素刺激之後,會由肝臟和脂肪細胞分泌的蛋白質。S14被發現能強力促進實驗鼠身上的脂質新生,但在人體的作用卻仍未明。研究發現,肥胖病人的S14有調控異常的情形。此次研究設計將探討重度肥胖患者接受減重手術前後,身上S14的血清濃度變化。 目的 透過回溯性觀察研究,探討重度肥胖患者接受減重手術前後,身上S14的血清濃度變化。 方法 本研究收錄自2013年五月至2017年九月之間,於台大減重暨代謝手術中心接受腹腔鏡胃袖狀切除手術的病人,記錄所有病人之基本資訊、生化檢驗、醫療史和藥物史。這些病人在手術前及術後六個月接受抽血採樣分析。本實驗採用競爭抑制型enzyme-linked immunoassay (ELISA)來檢測血清S14的濃度。 結果 此次研究最後共收錄87位接受腹腔鏡胃袖狀切除手術的病人,平均年齡為38 ± 10.7歲,其中39位是男性,47位是女性。大多數受試者有脂肪肝 (N = 80, 91.9%),有高血脂 (N = 50, 57.5%) 及高血壓 (N = 44,50.6%)的情形都超過半數,只有約三分之一(N = 31, 35.6%)的受試者有糖尿病。術後在體重、身體質量指數、腰圍、臀圍、收縮壓及舒張壓改善的數據分別為28.5 kg (±8.0), 10.30 kg/m2 (±2.8), 21.3 cm (±7.3), 16.9 cm (±6.9), 12.7 mmHg (±15.9) and 9.2 mmHg (±13.4),皆達統計顯著差異(p < 0.0001)。我們同時觀察到空腹血糖、糖化血紅素、胰島素、三酸甘油脂、高密度脂蛋白膽固醇、尿酸和C反應蛋白在術後都有顯著的差異(p < 0.0001)。然而,總膽固醇(p = 0.2729)和低密度脂蛋白膽固醇(p = 0.6779)未達顯著差異,低密度脂蛋白膽固醇甚至在術後有上升的趨勢。至於血清S14的濃度(術前432.9 ng/dL (±313.1);術後368.1 ng/dL (±216.6)),手術前後並沒有顯著的變化(p = 0.6956)。 討論 這是首個探討減重和血清S14濃度的研究。我們並未觀察到很可能有脂質新生調節功能的血清S14濃度在肥胖病患接受減重手術前後有顯著的變化。橫斷分析也未發現術前血清S14濃度和數前體重的關聯。將來值得探討較大規模的橫斷世代研究來探討肥胖病患和正常控制組的血清S14濃度是否有差異。 結論 在此研究中,肥胖病患接受腹腔鏡胃袖狀切除手術後六個月血清S14濃度並無顯著差異。 | zh_TW |
dc.description.abstract | ABSTRACT
Introduction Obesity is a worldwide issue, more than half a billion adults were obese. It is a condition in which excess fat has accumulated in the body, such that it can have an adverse effect on health. Excessive fat accumulation in adipose tissue and ectopic fat accumulation in non-adipose tissue may lead to dysfunction of different tissues or organs. Studies had revealed that obesity is characterized by the chronic low-grade activation of the innate immune system. Macrophage-elicited inflammation and adipocyte-macrophage interaction might play a pivotal role. Interleukin-1β (IL-1β) is one of those accumulated pro-inflammatory cytokines. Using IL-1β treated mouse 3T3-L1 cells with control, gene expression chip showed that thyroid hormone responsive (THRSP) was the only one significantly down-regulated gene. The protein product Spot 14 (S14) is a liver and adipose tissue-secreted protein which is stimulated by thyroid hormone, carbohydrate and insulin. It is a potent stimulator of de novo lipogenesis in mice. However, little is known about the role of S14 in humans. In obese human subjects, the expression of S14 is abnormally-regulated. We conducted this study to further investigate the role of S14 in obese human subjects receiving bariatric surgery. Methods and Materials Patients who met the criteria and received bariatric surgery at National Taiwan University Hospital Center for Obesity, Life Style and Metabolic Surgery since May, 2013 were evaluated in this study. A total of 87 patients were included. The information of their anthropometric measurements, biochemical data, medical history and medication usage were documented. The serum samples of those patients who received follow-up at 6 months after the surgery were analyzed. A competitive enzyme-linked immunoassay (ELISA) was used to measure fasting serum levels of S14. Results There were 87 patients received laparoscopic sleeve gastrectomy (LSG). The mean age is 38 ± 10.7 years old. Among these subjects, 39 of them are males and 47 are females. Most of the subjects had fatty liver disease (N = 80, 91.9%). More than half of these subjects had hyperlipidemia (N = 50, 57.5%) and hypertension (N = 44, 50.6%). Only about one-third had diabetes (N = 31, 35.6%). The reductions in body weight (BW), body mass index (BMI), waist circumference (WC), hip circumference (HC), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 28.5 ±8.0 kg, 10.3 ±2.8 kg/m2, 21.3 ±7.3 cm, 16.9 ±6.9 cm, 12.7 ±15.9 mmHg and 9.2 ±13.4 mmHg, respectively. The differences between the means of these variables before and after surgery were highly significant (all p <0.0001). We also observed a significant improvement in fasting plasma glucose (FPG), glycated hemoglobulin (HbA1c), insulin, triglyceride (TG), high density lipoprotein cholesterol (HDL-C), uric acid and C-reactive protein (CRP) after surgery (all p < 0.0001). However, there was no significant changes in total cholesterol (TC) (p = 0.2729) and low density lipoprotein cholesterol (LDL-C) (p = 0.6779). The level of LDL-C even increased after surgery. There was no significant change of S14 level before (432.9 ng/dL (±313.1)) and after (368.1 ng/dL (±216.6)) the surgery (p = 0.6956). Discussion Our study is the first to investigate whether weight reduction is associated with the change in serum S14. In this study, we observed no changes in serum S14, a measure of possible regulator of lipogenesis, in obese subjects receiving bariatric surgery. Cross-sectional analysis in our results did not reveal correlation between baseline serum S14 level and pre-operation body weight. Cross-sectional study in a larger scale comparing obese subjects with control groups deserve further investigation. Conclusion In our study, showed that the change of serum levels of S14 in obese patients receiving LSG were not significant after 6 months. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T06:24:07Z (GMT). No. of bitstreams: 1 ntu-107-P05421017-1.pdf: 796211 bytes, checksum: dcd698ce0d2b7536b57e88bfc4719d35 (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 口試委員會審定書……………………………………………………………… i
誌謝……………………………………………………………….………………. ii 中文摘要……………………………………………………………….………… iii 英文摘要………………………………………………………………………….. v Introduction……………………………………………………………………….. 1 Methods and Materials……………………..……………………………………... 4 Result…………………………………………………………………………….... 8 Discussion………………………………………………………………………….. 10 Conclusion and Perspective..………………………………………………….….. 13 References…………………………………………………………………….…... 14 Table 1……………………………………………………………………….……. 18 Table 2…………………………………………………………………….………. 19 Table 3…………………………………………………………………………….. 20 Table 4…………………………………………………………………………….. 21 Figure 1…………………………………………………………………….……… 22 Figure 2……………………………………………………………………………. 23 Figure 3……………………………………………………………………………. 24 | |
dc.language.iso | en | |
dc.title | 重度肥胖病患接受減重手術前後血清S14濃度之變化 | zh_TW |
dc.title | The Change of Serum S14 Level in Severely Obese Patients Undergoing Bariatric Surgery | en |
dc.type | Thesis | |
dc.date.schoolyear | 106-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 王治元(Chih-Yuan Wang) | |
dc.contributor.oralexamcommittee | 施翔蓉(Shyang-Rong Shih) | |
dc.subject.keyword | 血清中Spot 14,重度肥胖,腹腔鏡胃袖狀切除手術, | zh_TW |
dc.subject.keyword | Serum Spot 14,Obesity,Laparoscopic sleeve gastrectomy, | en |
dc.relation.page | 24 | |
dc.identifier.doi | 10.6342/NTU201803872 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2018-08-17 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 臨床醫學研究所 | zh_TW |
顯示於系所單位: | 臨床醫學研究所 |
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