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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張玉玲(Yu-Ling Chang) | |
| dc.contributor.author | Yi-Yuan Zhuo | en |
| dc.contributor.author | 卓邑垣 | zh_TW |
| dc.date.accessioned | 2021-06-17T06:23:13Z | - |
| dc.date.available | 2023-08-21 | |
| dc.date.copyright | 2018-08-21 | |
| dc.date.issued | 2018 | |
| dc.date.submitted | 2018-08-17 | |
| dc.identifier.citation | Alvarez, J. A., & Emory, E. (2006). Executive function and the frontal lobes: A meta-analytic review. Neuropsychology Review, 16, 17-42. doi:10.1007/s11065-006-9002-x
Arenaza-Urquijo, E. M., Gonneaud, J., Fouquet, M., Perrotin, A., Mezenge, F., Landeau, B., . . . Chetelat, G. (2015). Interaction between years of education and APOE epsilon4 status on frontal and temporal metabolism. Neurology, 85, 1392-1399. doi:10.1212/WNL.0000000000002034 Belanger, S., & Belleville, S. (2009). Semantic inhibition impairment in mild cognitive impairment: A distinctive feature of upcoming cognitive decline? Neuropsychology, 23, 592-606. doi:10.1037/a0016152 Bender, A. R., & Raz, N. (2012). Age-related differences in memory and executive functions in healthy APOE epsilon4 carriers: The contribution of individual differences in prefrontal volumes and systolic blood pressure. Neuropsychologia, 50, 704-714. doi:10.1016/j.neuropsychologia.2011.12.025 Borenstein, M., Hedges, L. V., Higgins, J. P., & Rothstein, H. R. (2009). Introduction to meta-analysis. Chichester, England: Wiley. Burgess, P. W., & Shallice, T. (1997). The Hayling and Brixton Tests. Bury St. Edmunds, England: Thames Valley Test Company. Byrd, A. L., & Manuck, S. B. (2014). MAOA, childhood maltreatment, and antisocial behavior: Meta-analysis of a gene-environment interaction. Biological Psychiatry, 75, 9-17. doi:10.1016/j.biopsych.2013.05.004 Chen, H. Y., & Chen, R. H. (2002). Wechsler Adult Intelligence Scale-Third Edition (WAIS-III) Manual for Taiwan. Taipei, Taiwan: The Chinese Behavioral Science Corporation. Clouston, S. A., Glymour, M., & Terrera, G. M. (2015). Educational inequalities in aging-related declines in fluid cognition and the onset of cognitive pathology. Alzheimer's and Dementia, 1, 303-310. doi:10.1016/j.dadm.2015.06.001 Cook, C. J., & Fletcher, J. M. (2015). Can education rescue genetic liability for cognitive decline? Social Science and Medicine, 127, 159-170. doi:10.1016/j.socscimed.2014.06.049 D'Elia, L., Satz, P., Uchiyama, C., & White, T. (1996). Color Trails Test: Professional manual. Odessa, FL: Psychological Assessment Resources. Delis, D. C., Kaplan, E., & Kramer, J. H. (2001). Delis-Kaplan executive function system (D-KEFS): Examiner’s manual. San Antonio, TX: Psychological Corporation. Diamond, A. (2013). Executive functions. Annual Review of Psychology, 64, 135-168. doi:10.1146/annurev-psych-113011-143750 Emi, M., Wu, L. L., Robertson, M. A., Myers, R. L., Hegele, R. A., Williams, R. R., . . . Lalouel, J.-M. (1988). Genotyping and sequence analysis of apolipoprotein E isoforms. Genomics, 3, 373-379. doi:10.1016/0888-7543(88)90130-9 Espeseth, T., Westlye, L. T., Fjell, A. M., Walhovd, K. B., Rootwelt, H., & Reinvang, I. (2008). Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E epsilon 4. Neurobiology of Aging, 29, 329-340. doi:10.1016/j.neurobiolaging.2006.10.030 Fjell, A. M., McEvoy, L., Holland, D., Dale, A. M., Walhovd, K. B., & Alzheimer's Disease Neuroimaging, I. (2014). What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus. Progress in Neurobiology, 117, 20-40. doi:10.1016/j.pneurobio.2014.02.004 Friedman, N. P., & Miyake, A. (2017). Unity and diversity of executive functions: Individual differences as a window on cognitive structure. Cortex, 86, 186-204. doi:10.1016/j.cortex.2016.04.023 Friedman, N. P., Miyake, A., Young, S. E., Defries, J. C., Corley, R. P., & Hewitt, J. K. (2008). Individual differences in executive functions are almost entirely genetic in origin. Journal of Experimental Psychology: General, 137, 201-225. doi:10.1037/0096-3445.137.2.201 Giogkaraki, E., Michaelides, M. P., & Constantinidou, F. (2013). The role of cognitive reserve in cognitive aging: Results from the neurocognitive study on aging. Journal of Clinical and Experimental Neuropsychology, 35, 1024-1035. doi:10.1080/13803395.2013.847906 Hixson, J. E., & Vernier, D. T. (1990). Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. Journal of Lipid Research, 31, 545-548. Houston, W. S., Delis, D. C., Lansing, A., Jacobson, M. W., Cobell, K. R., Salmon, D. P., & Bondi, M. W. (2005). Executive function asymmetry in older adults genetically at-risk for Alzheimer's disease: Verbal versus design fluency. Journal of the International Neuropsychological Society, 11, 863-870. Kray, J., & Feher, B. (2017). Age differences in the transfer and maintenance of practice-induced improvements in task switching: The impact of working-memory and inhibition demands. Frontiers in Psychology, 8, 410. doi:10.3389/fpsyg.2017.00410 Lenehan, M. E., Summers, M. J., Saunders, N. L., Summers, J. J., Ward, D. D., Ritchie, K., & Vickers, J. C. (2016). Sending your grandparents to university increases cognitive reserve: The Tasmanian Healthy Brain Project. Neuropsychology, 30, 525-531. doi:10.1037/neu0000249 Levitt, H. (1971). Transformed up‐down methods in psychoacoustics. Journal of the Acoustical Society of America, 49, 467-477. doi:10.1121/1.1912375 Lewandowsky, S., Oberauer, K., Yang, L. X., & Ecker, U. K. (2010). A working memory test battery for MATLAB. Behavior Research Methods, 42, 571-585. doi:10.3758/BRM.42.2.571 Li, C.-s. R., Huang, C., Yan, P., Paliwal, P., Constable, R. T., & Sinha, R. (2008). Neural correlates of post-error slowing during a stop signal task: A functional magnetic resonance imaging study. Journal of Cognitive Neuroscience, 20, 1021-1029. Lin, C. H., Lin, E., & Lane, H. Y. (2017). Genetic biomarkers on age-related cognitive decline. Frontiers in Psychiatry, 8, 247. doi:10.3389/fpsyt.2017.00247 Miyake, A., Friedman, N. P., Emerson, M. J., Witzki, A. H., Howerter, A., & Wager, T. D. (2000). The unity and diversity of executive functions and their contributions to complex “Frontal Lobe” tasks: A latent variable analysis. Cognitive Psychology, 41, 49-100. doi:10.1006/cogp.1999.0734 Morris, J. C. (1993). The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology, 43, 2412-2412-a. doi:10.1212/WNL.43.11.2412-a Mui, A. C. (1996). Geriatric Depression Scale as a community screening instrument for elderly Chinese immigrants. International Psychogeriatrics, 8, 445-458. Nee, D. E., Brown, J. W., Askren, M. K., Berman, M. G., Demiralp, E., Krawitz, A., & Jonides, J. (2013). A meta-analysis of executive components of working memory. Cerebral Cortex, 23, 264-282. doi:10.1093/cercor/bhs007 Nelson, H. E. (1976). A modified card sorting test sensitive to frontal lobe defects. Cortex, 12, 313-324. Nucci, M., Mapelli, D., & Mondini, S. (2012). Cognitive Reserve Index questionnaire (CRIq): A new instrument for measuring cognitive reserve. Aging Clinical and Experimental Research, 24, 218-226. doi:10.3275/7800 Nyberg, L., Lovden, M., Riklund, K., Lindenberger, U., & Backman, L. (2012). Memory aging and brain maintenance. Trends in Cognitive Sciences, 16, 292-305. doi:10.1016/j.tics.2012.04.005 O'Donoghue, M. C., Murphy, S. E., Zamboni, G., Nobre, A. C., & Mackay, C. E. (2018). APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review. Cortex, 104, 103-123. doi:10.1016/j.cortex.2018.03.025 Reuter-Lorenz, P. A., & Park, D. C. (2014). How does it STAC up? Revisiting the scaffolding theory of aging and cognition. Neuropsychology Review, 24, 355-370. doi:10.1007/s11065-014-9270-9 Robertson, I. H. (2013). A noradrenergic theory of cognitive reserve: Implications for Alzheimer's disease. Neurobiology of Aging, 34, 298-308. doi:10.1016/j.neurobiolaging.2012.05.019 Robertson, I. H. (2014). Right hemisphere role in cognitive reserve. Neurobiology of Aging, 35, 1375-1385. doi:10.1016/j.neurobiolaging.2013.11.028 Rocha, T. B., Hutz, M. H., Salatino-Oliveira, A., Genro, J. P., Polanczyk, G. V., Sato, J. R., . . . Kieling, C. (2015). Gene-environment interaction in youth depression: Replication of the 5-HTTLPR moderation in a diverse setting. American Journal of Psychiatry, 172, 978-985. doi:10.1176/appi.ajp.2015.14070896 Roldan-Tapia, L., Garcia, J., Canovas, R., & Leon, I. (2012). Cognitive reserve, age, and their relation to attentional and executive functions. Applied Neuropsychology: Adult, 19, 2-8. doi:10.1080/09084282.2011.595458 Rosen, V. M., Bergeson, J. L., Putnam, K., Harwell, A., & Sunderland, T. (2002). Working memory and apolipoprotein E: What's the connection? Neuropsychologia, 40, 2226-2233. Schiepers, O. J., Harris, S. E., Gow, A. J., Pattie, A., Brett, C. E., Starr, J. M., & Deary, I. J. (2012). APOE E4 status predicts age-related cognitive decline in the ninth decade: Longitudinal follow-up of the Lothian Birth Cohort 1921. Molecular Psychiatry, 17, 315-324. doi:10.1038/mp.2010.137 Sebastian, A., Pohl, M. F., Kloppel, S., Feige, B., Lange, T., Stahl, C., . . . Tuscher, O. (2013). Disentangling common and specific neural subprocesses of response inhibition. Neuroimage, 64, 601-615. doi:10.1016/j.neuroimage.2012.09.020 Singh-Manoux, A., Marmot, M. G., Glymour, M., Sabia, S., Kivimäki, M., & Dugravot, A. (2011). Does cognitive reserve shape cognitive decline? Annals of Neurology, 70, 296-304. doi:10.1002/ana.22391 Small, B. J., Rosnick, C. B., Fratiglioni, L., & Backman, L. (2004). Apolipoprotein E and cognitive performance: A meta-analysis. Psychology and Aging, 19, 592-600. doi:10.1037/0882-7974.19.4.592 Stern, Y. (2002). What is cognitive reserve? Theory and research application of the reserve concept. Journal of the International Neuropsychological Society, 8, 448-460. Stern, Y. (2012). Cognitive reserve in ageing and Alzheimer's disease. The Lancet Neurology, 11, 1006-1012. doi:10.1016/s1474-4422(12)70191-6 Summers, M. J., Saunders, N. L., Valenzuela, M. J., Summers, J. J., Ritchie, K., Robinson, A., & Vickers, J. C. (2013). The Tasmanian Healthy Brain Project (THBP): A prospective longitudinal examination of the effect of university-level education in older adults in preventing age-related cognitive decline and reducing the risk of dementia. International Psychogeriatrics, 25, 1145-1155. doi:10.1017/S1041610213000380 Swan, G. E., Lessov-Schlaggar, C. N., Carmelli, D., Schellenberg, G. D., & La Rue, A. (2005). Apolipoprotein E epsilon4 and change in cognitive functioning in community-dwelling older adults. Journal of Geriatric Psychiatry and Neurology, 18, 196-201. doi:10.1177/0891988705281864 Thow, M. E., Summers, M. J., Saunders, N. L., Summers, J. J., Ritchie, K., & Vickers, J. C. (2018). Further education improves cognitive reserve and triggers improvement in selective cognitive functions in older adults: The Tasmanian Healthy Brain Project. Alzheimer's and Dementia, 10, 22-30. doi:10.1016/j.dadm.2017.08.004 Velichkovsky, B. B., Roschina, I. F., & Selezneva, N. D. (2015). Cognitive control and memory in healthy ApoE-E4 carriers with a family history of Alzheimer's disease. Psychology in Russia: State of the Art, 8, 4. Watson, C. E., & Chatterjee, A. (2012). A bilateral frontoparietal network underlies visuospatial analogical reasoning. Neuroimage, 59, 2831-2838. doi:10.1016/j.neuroimage.2011.09.030 West, R. L. (1996). An application of prefrontal cortex function theory to cognitive aging. Psychological Bulletin, 120, 272. Wetter, S. R., Delis, D. C., Houston, W. S., Jacobson, M. W., Lansing, A., Cobell, K., . . . Bondi, M. W. (2005). Deficits in inhibition and flexibility are associated with the APOE-E4 allele in nondemented older adults. Journal of Clinical and Experimental Neuropsychology, 27, 943-952. doi:10.1080/13803390490919001 Wilson, R. S., Beckett, L. A., Barnes, L. L., Schneider, J. A., Bach, J., Evans, D. A., & Bennett, D. A. (2002). Individual differences in rates of change in cognitive abilities of older persons. Psychology and Aging, 17, 179-193. doi:10.1037/0882-7974.17.2.179 Winnock, M., Letenneur, L., Jacqmin-Gadda, H., Dallongeville, J., Amouyel, P., & Dartigues, J. F. (2002). Longitudinal analysis of the effect of apolipoprotein E epsilon4 and education on cognitive performance in elderly subjects: The PAQUID study. Journal of Neurology, Neurosurgery, and Psychiatry, 72, 794-797. Wisdom, N. M., Callahan, J. L., & Hawkins, K. A. (2011). The effects of apolipoprotein E on non-impaired cognitive functioning: A meta-analysis. Neurobiology of Aging, 32, 63-74. doi:10.1016/j.neurobiolaging.2009.02.003 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/72097 | - |
| dc.description.abstract | 載脂蛋白基因（Apolipoprotein E, ApoE）的ε4基因型是影響認知老化的重要因素。過去研究發現攜帶ε4基因型的認知正常老年人在執行功能上的表現較非攜帶者差，然而有些研究並無觀察到此差異。研究結果的不一致可能來自於測量執行功能的方法差異，且此差異使得比較不同執行功能成分有困難。另一方面，認知存量被認為會降低個體受大腦病理變化之影響，亦可能降低ApoE ε4造成的認知老化效果。本研究藉由完整的執行功能評估探討ε4基因型在反應抑制、轉換、工作記憶以及抽象推理四個執行功能成分表現上之負面影響。並藉由教育程度作為評量認知存量的指標，探究認知存量高低是否影響ε4基因型在認知老化的負面影響。本研究收集51位認知正常老年人的ApoE基因型、受教育年數、執行功能測驗表現。受試者依照ε4基因型分組，再做認知存量高低的次分組，並比較不同組別在四個執行功能成分的表現是否有差異。結果並無觀察到ε4基因型在執行功能表現上的主要效果。然而在ε4基因型及認知存量的分組上，ε4陽性低認知存量組在反應抑制成分的表現顯著低於ε4陰性高認知存量以及低認知存量組，反之ε4陽性高認知存量組的表現與兩ε4陰性組相當。此外，認知存量在抽象推理表現上有主要效果。研究結果顯示，相較於轉換、工作記憶以及抽象推理成分，反應抑制在探究先天因素及後天教育影響時扮演重要的角色。 | zh_TW |
| dc.description.abstract | Apolipoprotein E epsilon 4 (ApoE-ε4) has been associated with individual difference in cognitive aging. Previous studies have reported that possessing the ApoE ε4 allele adversely influenced the performances of executive functions (EFs) in late adulthood; however, results were inconsistent. Methodological differences may account for the inconsistency. Furthermore, cognitive reserve (CR), which explained the individual differences in susceptibility to brain changes, may also modulate the negative ε4 effect. The present study aimed to examine the potential negative effects of ApoE ε4 allele on four components of EFs, namely switching, working memory, inhibition, and abstract reasoning. We further investigated whether a higher education attainment, a common proxy measure for CR, could alleviate the adverse effect of ApoE ε4 allele on EFs. In present study we recruited 51 cognitively intact older adults. Participants were divided into groups by possessing ε4 allele (ε4+) or not (ε4-) and subgroups by high CR (HCR) or low CR (LCR). Results showed that although no main effect of ApoE genotype was observed across the four EF components, the potentially adverse ε4 effect on inhibition component was alleviated by higher education attainment. Specifically, the ε4+ LCR group had a significantly lower performance on the inhibition domain than ε4- HCR and LCR groups, whereas the performance of ε4+ HCR group was comparable to the two ε4- groups. A main effect of CR on abstract reasoning component was also observed. In this study, we heighten the distinctive role of response inhibition in the gene-environment interaction. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T06:23:13Z (GMT). No. of bitstreams: 1 ntu-107-R01227205-1.pdf: 1018488 bytes, checksum: cf8e83817d4129a1b29c4af87789fb3d (MD5) Previous issue date: 2018 | en |
| dc.description.tableofcontents | 致謝 i
摘要 ii abstract iii Table of Contents v Introduction 1 Methods 4 Participants 4 ApoE Genotype Acquisition 5 Measurements 6 Statistical Analyses 9 Results 11 Demographic and Clinical Characteristics 11 Executive Function Components and Other Neuropsychological Functions 11 Discussion 14 References 21 Tables 31 Figures 34 Supplement 36 | |
| dc.language.iso | en | |
| dc.subject | 教育程度 | zh_TW |
| dc.subject | 執行功能 | zh_TW |
| dc.subject | 反應抑制 | zh_TW |
| dc.subject | 認知正常老年人 | zh_TW |
| dc.subject | 載脂蛋白基因型 | zh_TW |
| dc.subject | 認知存量 | zh_TW |
| dc.subject | cognitively intact older adults | en |
| dc.subject | Apolipoprotein E | en |
| dc.subject | response inhibition | en |
| dc.subject | executive functions | en |
| dc.subject | cognitive reserve | en |
| dc.subject | education | en |
| dc.title | 認知正常老年人之教育程度減輕失智症高風險基因於反應抑制之負面效果 | zh_TW |
| dc.title | Education Alleviates the Negative Effect of ApoE-epsilon 4 on Response Inhibition in Cognitively Intact Older Adults | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 106-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 葉怡玉(Yei-Yu Yeh,),阮啟弘(Chi-Hung Juan) | |
| dc.subject.keyword | 載脂蛋白基因型,教育程度,認知存量,執行功能,反應抑制,認知正常老年人, | zh_TW |
| dc.subject.keyword | Apolipoprotein E,education,cognitive reserve,executive functions,response inhibition,cognitively intact older adults, | en |
| dc.relation.page | 42 | |
| dc.identifier.doi | 10.6342/NTU201803844 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2018-08-18 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 心理學研究所 | zh_TW |
| 顯示於系所單位： | 心理學系 | |
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