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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/71513完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳賢燁(Hsien-Yeh Chen) | |
| dc.contributor.author | Zhen-Yu Guan | en |
| dc.contributor.author | 官振禹 | zh_TW |
| dc.date.accessioned | 2021-06-17T06:02:13Z | - |
| dc.date.available | 2022-02-12 | |
| dc.date.copyright | 2019-02-12 | |
| dc.date.issued | 2019 | |
| dc.date.submitted | 2019-01-30 | |
| dc.identifier.citation | 1. Castner, D. G., Surface science: View from the edge. Nature 2003, 422, 129-130.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/71513 | - |
| dc.description.abstract | 隨著生醫材料領域的發展，表面修飾技術不僅滿足於被動固定生物分子而沒有任何控制能力。從材料科學角度來看，控制生物界面分子修飾可利用許多物理或化學機制來實現。在本論文中，我們將基於不同功能性聚對二甲苯高分子化學氣相沉積鍍膜提出四種機制來控制表面修飾的生物分子進而達到材料生物界面之操控，包括：(一) 利用操控溶液相中的蛋白質混合物比例控制功能性蛋白質在表面的多重和競爭吸附。(二) 利用側鏈尾端反應性炔基進行雙反向點擊反應形成多功能連續反向生物分子梯度。(三) 利用帶有雙硫鍵官能基進行氧化還原硫醇-二硫化物交換反應置換表面功能性生物分子達到可切換與可編程生物界面。(四) 利用反應性末端基團和光化學斷鍵基團鄰硝基芐基達成可點擊反應和光化學分離的生物界面。藉由這四種可控制機制，精確的在時間和空間上操控了生物界面性質的表現如：表面親疏水性、細胞粘附、細胞增殖和幹細胞誘導分化等。
基於上述最先進的生物分子修飾技術，具操控性的仿生生物界面已經實現於聚對二甲苯高分子塗層上。 | zh_TW |
| dc.description.abstract | Surface modification does not satisfy with passively immobilizing biomolecules without any controllable ability. Controllable biomolecules modification on biointerface can be realized by several physical or chemical mechanisms. In this work presented herein, four types of controllable mechanisms were realized as followed: (i) Multiple and competing adsorption of functional proteins based on the composition of proteins mixture in the solution phase. (ii) Multifunctional and continuous gradients based on dual reverse click reactions. (iii) Switchable and programmable biointerface based on thiol-disulfide interchange reaction. (iv) Clickable and photo-cleavable biointerface based on ortho-nitrobenzyl photo-chemistry. This four strategies were proposed to control biomolecules modified on the surface based on different functionalized poly-para-xylylene coatings synthesized via chemical vapor deposition (CVD) polymerization. Based on the controllable biomolecules modification described above, the biointerface properties, including wettability, cell adhesion, proliferation, differentiation and etc., were manipulated over temporal and spatial dimensions, and the new advanced and biomimic biointerface has been available on poly‑p‑xylylene coatings. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T06:02:13Z (GMT). No. of bitstreams: 1 ntu-108-F03549004-1.pdf: 8467610 bytes, checksum: 9a41486139a8f251c989d6e49be537ff (MD5) Previous issue date: 2019 | en |
| dc.description.tableofcontents | 致謝 I
摘要 II Abstract III Table of Content X List of Figures XIV List of Tables XXVII Chapter 1 Introduction 1 1.1 Surface Modification of Biointerfaces 1 1.2 Functionalized Poly-para-xylylene via CVD Polymerization Process 2 1.3 Specific Aims: Controllable Biomolecules Modification 3 Chapter 2 Controlling Multi-function of Biomaterials Interfaces Based on Multiple and Competing Adsorption of Functional Proteins 5 2.1 Introduction 5 2.2 Methods 8 2.2.1 Surface Modification of Parylene-C Coating 8 2.2.2 Protein Adsorption 8 2.2.3 Characterizations 9 2.2.4 Cell Proliferation 11 2.2.5 Osteogenic Activities 12 2.3 Results and Discussion 14 2.3.1 Sole Adsorption of Functional Protein on Parylene-C Surface 15 2.3.2 Combined and Competing Adsorption of Functional Proteins 21 2.3.2 Topography and Nanomechanical Properties 24 2.3.3 Multifaceted and Synergistic Biological Activities 27 2.4 Conclusions 32 Chapter 3 Multifunctional and Continuous Gradients of Biointerfaces Based on Dual Reverse Click Reactions 33 3.1 Introduction 33 3.2 Methods 35 3.2.1 CVD Polymerization 35 3.2.2 Click Reactions and Immobilizations 36 3.2.3 Surface Characterizations 38 3.2.4 Cell Culture 39 3.3 Results and Discussion 41 3.3.1 Dual Reversed Gradient Based on Two Steps Click Reactions 42 3.3.2 Cell Attachment on Dual Reversed Gradient Surface 46 3.3.3 Divergent Biological Properties on Dual Reversed Gradient Surface 50 3.4 Conclusions 56 Chapter 4 Switchable and Programmable Biointerface Based on Displaceable Poly‑p‑xylylene Coatings 57 4.1 Introduction 57 4.2 Methods 60 4.2.1 CVD Polymerization 60 4.2.2 Surface Characterizations 61 4.2.3 Thiol-Redox and Disulfide Interchange Reaction 63 4.2.4 Wettability 65 4.2.5 Cell Adhesion 66 4.2.6 Growth Factor Immobilization and Displacement 68 4.2.7 Cell Proliferation and Osteogenesis 69 4.3 Results and Discussion 72 4.3.1 Characterizations of Parylene S-S Coating 74 4.3.2 Displacing Ability of Parylene S-S Coating 78 4.3.3 Switching Ability of Parylene S-S Coating 84 4.3.4 Switching of Surface Wettability 86 4.3.5 Switching of Cell Adhesion Property 88 4.3.6 Stepwise and Programmable Growth Factor Displacement 91 4.3.7 Activation and Deactivation of Biological Function 96 4.3.8 Programmable Controlled Stem Cells Differentiation Pathways 104 4.4 Conclusions 108 Chapter 5 Clickable and Photo-cleavable Biointerface Based on Ortho-nitrobenzyl Substituted Poly‑p‑xylylene Coatings 109 5.1 Introduction 109 5.2 Methods 111 5.2.1 CVD Polymerization 111 5.2.2 Characterizations 112 5.2.3 Immobilization and Localized Photo-Displacement 113 5.2.4 Wettability 115 5.2.5 Cell adhesion 116 5.3 Results and Discussion 118 5.3.1 Characterizations of Clickable/Cleavable Parylene Coating 122 5.3.2 Localized Photo-Cleavage/Re-Installation 129 5.3.3 Cell Pattern Based on Localized Photo-Cleavage/Re-Installation 134 5.4 Conclusions 137 Chapter 6 Conclusions 138 6.1 Summary of Controllable Biomolecules Modification 138 6.2 Future Directions 139 References 141 | |
| dc.language.iso | en | |
| dc.subject | 可控制生物分子修飾 | zh_TW |
| dc.subject | 聚對二甲苯鍍膜 | zh_TW |
| dc.subject | 多蛋白吸附 | zh_TW |
| dc.subject | 雙反向梯度 | zh_TW |
| dc.subject | 可切換表面 | zh_TW |
| dc.subject | 光化學分離表面 | zh_TW |
| dc.subject | photo-cleavable surface | en |
| dc.subject | poly-para-xylylene | en |
| dc.subject | multiprotein adsorption | en |
| dc.subject | controllable biomolecules modification | en |
| dc.subject | dual reverse gradient | en |
| dc.subject | switchable surface | en |
| dc.title | 利用氣相多功能高分子鍍膜於生物分子工程及材料生物界面現象之操控 | zh_TW |
| dc.title | Vapor-Phased Multifunctional Polymer Coatings for Biomolecular and Biointerface Engineering | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 107-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 康敦彥(Dun-Yen Kang),游佳欣(Jiashing Yu),黃聲東(Sheng-Tung Huang),陳柏均(Po-Chun Chen) | |
| dc.subject.keyword | 可控制生物分子修飾,聚對二甲苯鍍膜,多蛋白吸附,雙反向梯度,可切換表面,光化學分離表面, | zh_TW |
| dc.subject.keyword | controllable biomolecules modification,poly-para-xylylene,multiprotein adsorption,dual reverse gradient,switchable surface,photo-cleavable surface, | en |
| dc.relation.page | 152 | |
| dc.identifier.doi | 10.6342/NTU201900329 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2019-01-30 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 化學工程學研究所 | zh_TW |
| 顯示於系所單位： | 化學工程學系 | |
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