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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 鄭如忠 | |
dc.contributor.author | Wen-Hao Chuang | en |
dc.contributor.author | 莊文豪 | zh_TW |
dc.date.accessioned | 2021-06-17T05:02:29Z | - |
dc.date.available | 2023-07-26 | |
dc.date.copyright | 2018-07-26 | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018-07-24 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/71278 | - |
dc.description.abstract | 本研究成功開發具有刺激應答型的表面增強拉曼散射基板(surface-enhanced Raman scat-tering substrates, SERS substrates),因分子結構具有溫度敏感性的性質,可藉由溫度的調控來改變分子的親疏水性,進而影響微胞的表面型態,同時使得還原於微胞上的銀奈銀粒子彼此間的距離變小,產生了增強的熱點效應(hot-spots resonance effects),將可有效的提升拉曼訊號之偵測靈敏度,應用於快速檢測多種化合物。
實驗先利用具有反應選擇性的雙官能基單體 IDD,和結構單元交替反應,以收斂法先製備出一系列以長烷鏈段為末端基團的poly(urethane/malonamide)規則樹枝狀分子,並導入具有溫度敏感性的嵌段共聚物進行修飾,使不同代數之規則樹枝狀分子具有溫度敏感性的性質。由於雙親性的特性,分子會自組裝形成以疏水之C18長碳鏈為核,親水鏈段為殼的微胞結構。之後,以高分子鏈上之醚基與羰基作為成核點,利用還原反應生成奈米銀粒子而製備出具有溫敏性的SERS微胞基板。 探討以不同代數之數樹枝狀高分子製備出的微胞基板於高低溫下對SERS效應的影響,藉由拉曼光譜的分析並輔以TEM圖像的說明,推論高代數的微胞基板能還原較多的奈米銀粒子,故有較好的拉曼訊號放大能力;在高溫時,由於熱能造成的相轉換,誘發更強的熱點效應,使SERS效應比室溫下來的顯著。此外,利用該SERS基板對不同待測物進行最低檢測濃度(Limitation of detection, LOD)檢測,輔以微胞基板及不同待測物之表面張力分析,說明熱刺激誘發熱點效應對表面增強拉曼散射具有重要的影響。證實了本系統之SERS基板在高溫下,除了能放大微量待測物的拉曼訊號以利檢測,亦可應用於多種化合物分子之快速偵測及分析。 | zh_TW |
dc.description.abstract | A series of thermo-sensitive dendritic-polymer micelles have been developed for sur-face-enhanced Raman scattering (SERS) substrates featuring with silver nanoparticles (AgNPs) of tunable spatial distribution which could effectively improve sensitivity of SERS signals with rapid de-tection of small molecules. Different generations of amphiphilic poly(urea/malonamide) dendrons with thermo-sensitive property were synthesized by post-modified diblock copolymers through the addition reactions. In aqueous solution, amphiphilic dendrons self-assembled into core-corona micelles with the alkyl chains as core and the poly(oxyethylene) block as corona. AgNPs were subsequently immo-bilized on dendritic-like micelle templates through in-situ reduction reaction of AgNO3 in aqueous dispersion to form thermo-sensitive SERS substrates. We explore the influence of different generation and temperature to the SERS effect. Results show that the higher generation of the micellar substrates the much stronger Raman signals will be detected owning to the more nucleation places for the silver nanoparticles on the micelles through observation of the Raman spectrums and TEM images. Fur-thermore, at high temperature, the even more pronounced hot spots effects will be induced which causing the enhanced amplication of signals than ones at room temperature. We assume that ther-mo-enhanced hot spot resonance effects will affect SERS behaviors much effectively, which can overcome the affinity effect between substrates and analytes as verified through analysis of limitation of detection (LOD) and surface tension for differenr analytes. Such substrates possess great potential to apply in the rapid and label-free SERS detection. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T05:02:29Z (GMT). No. of bitstreams: 1 ntu-107-R05549007-1.pdf: 6966389 bytes, checksum: d14417481516c6892cee8141eb6538ce (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 中文摘要 i
Abstract v 目錄 vi 圖目錄 ix 表目錄 xi 第一章、 緒論 1 第二章、 文獻回顧 2 2.1. 刺激應答型材料 2 2.1.1 刺激應答型材料之簡介 2 2.1.2 溫度應答型材料之簡介 3 2.2. 表面增強拉曼散射 5 2.2.1 拉曼光譜之簡介及原理 5 2.2.2. 表面增強拉曼散射之簡介及原理 7 2.2.3. 表面增強拉曼散射之應用 9 2.3. 規則樹枝狀高分子 10 2.3.1. Dendrimer合成路徑 11 2.3.2. 反應選擇性單體 IDD 製備規則樹枝狀高分子 13 2.4. 雙親性共聚物與高分子自組裝行為 16 2.4.1. 雙親性嵌段共聚物 16 2.4.2. 高分子自組裝行為 16 2.5. 研究動機 19 第三章、實驗內容 20 3.1 藥品及溶劑 20 3.2 實驗儀器 22 3.3 實驗流程圖 24 3.4 實驗步驟 25 3.4.1 Isocyanato-4’(3,3-dimethyl-2,4-dioxo-azetidino) diphenylmethane (IDD) 之合成 25 3.4.2 C18系列polyurea/malonamide dendrons 之合成 26 3.4.3 溫度敏感性樹枝狀高分子(共聚物)之合成 29 3.4.4 具溫敏性樹枝狀高分子微胞之製備 30 3.4.5 具奈米銀粒子之溫敏性樹枝狀高分子微胞之製備 31 3.4.6 SERS基板之製備 32 3.4.7 表面增強拉曼散射之檢測方式 32 第四章、結果討論 33 4.1 IDD之合成及結構鑑定 33 4.2 C18系列polyurea/malonamide dendrons 之合成與結構鑑定 36 4.2.1. DG-0.5之合成與結構鑑定 36 4.2.2. DG-1.0之合成與結構鑑定 38 4.2.3. DG-1.5之合成與結構鑑定 40 4.2.4. DG-2.0之合成與結構鑑定 42 4.2.5. DG-2.5之合成與結構鑑定 45 4.3 溫度敏感性樹枝狀高分子(共聚物)之合成 47 4.3.1. TD-G-0.5之合成與結構鑑定 47 4.3.2. TD-G-1.5之合成與結構鑑定 49 4.3.3. TD-G-2.5之合成與結構鑑定 51 4.4 粒徑分析與高分子微胞型態之觀察 53 4.5 高分子微胞之溫度敏感性測定 55 4.6 具奈米銀粒子之溫敏性高分子微胞於SERS基板之分析 56 4.6.1. 不同代數之溫敏性樹枝狀高分子及溫度對SERS效應之影響 56 4.6.2. SERS基板之極限偵測濃度分析 59 4.6.3. SERS基板應用於不同待測物之分析 62 4.6.4. 親疏水性及熱點效應對SERS效應之影響探討 65 第五章、結論 67 第六章、參考文獻 69 | |
dc.language.iso | zh-TW | |
dc.title | 含奈米銀粒子之溫敏性樹枝狀高分子微胞調控表面增強拉曼效應 | zh_TW |
dc.title | Silver Nanoparticles Immobilized on Thermosensitive Dendritic-Polymer Micelles for Tunable SERS Sensitivity | en |
dc.type | Thesis | |
dc.date.schoolyear | 106-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 劉定宇 | |
dc.contributor.oralexamcommittee | 邱文英,童世煌,曾文祺 | |
dc.subject.keyword | 表面增強拉曼散,溫度敏感性,樹枝狀分子,奈米銀粒子,熱點效應, | zh_TW |
dc.subject.keyword | surface-enhanced Raman scattering (SERS),thermo-sensitive,dendritic-like molecule,silver nanopar-ticles,hot-spots resonance effects, | en |
dc.relation.page | 74 | |
dc.identifier.doi | 10.6342/NTU201801736 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2018-07-25 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
顯示於系所單位: | 高分子科學與工程學研究所 |
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ntu-107-1.pdf 目前未授權公開取用 | 6.8 MB | Adobe PDF |
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