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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 王興國(Hsing-Kuo Wang) | |
dc.contributor.author | Chia-Yu Kuo | en |
dc.contributor.author | 郭家瑜 | zh_TW |
dc.date.accessioned | 2021-06-17T04:40:39Z | - |
dc.date.available | 2018-09-06 | |
dc.date.copyright | 2018-09-06 | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018-08-06 | |
dc.identifier.citation | 1. Abate M, Schiavone C, Salini V, Andia I. Occurrence of tendon pathologies in metabolic disorders. Rheumatology. 2013.
2. Zakaria MH, Davis WA, Davis TM. Incidence and predictors of hospitalization for tendon rupture in type 2 diabetes: the Fremantle diabetes study. Diabet Med. 2014;31:425-30. 3. Grant WP, Sullivan R, Sonenshine DE, Adam M, Slusser JH, Carson KA, et al. Electron microscopic investigation of the effects of diabetes mellitus on the Achilles tendon. The Journal of Foot and Ankle Surgery. 1997;36:272-78. 4. Abate M, Schiavone C, Salini S. Neoangiogenesis is reduced in chronic tendinopathies of type 2 diabetic patients. Int J Immunopathol Pharmacol. 2012;25:757-61. 5. Trujillo-Santos AJ. Diabetic Muscle Infarction. Diabetes Care. 2003;26:211. 6. Trovato MF, Imbesi R, Conway N, Castrogiovanni P. Morphological and Functional Aspects of Human Skeletal Muscle. Journal of Functional Morphology and Kinesiology. 2016;1. 7. Kannus P. Structure of the tendon connective tissue. Scand J Med Sci Sports. 2000;10:312-20. 8. Magnusson SP, Hansen P, Kjaer M. Tendon properties in relation to muscular activity and physical training. Scand J Med Sci Sports. 2003;13:211-23. 9. Tortora GJ, Derrickson B. Principles of anatomy and physiology. Hoboken, N.J.: Wiley; 2011. 10. Frontera WR, Ochala J. Skeletal muscle: a brief review of structure and function. Calcif Tissue Int. 2015;96:183-95. 11. Kirkendall DT, Garrett WE. Function and biomechanics of tendons. Scand J Med Sci Sports. 1997;7:62-6. 12. Screen HR, Berk DE, Kadler KE, Ramirez F, Young MF. Tendon functional extracellular matrix. J Orthop Res. 2015;33:793-9. 13. Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev. 2004;84:649-98. 14. Ricard-Blum S. The collagen family. Cold Spring Harb Perspect Biol. 2011;3:a004978. 15. Thorpe CT, Birch HL, Clegg PD, Screen HRC. Chapter 1 - Tendon Physiology and Mechanical Behavior: Structure–Function Relationships. Tendon Regeneration. Boston: Academic Press; 2015:3-39. 16. Kastelic J, Galeski A, Baer E. The multicomposite structure of tendon. Connect Tissue Res. 1978;6:11-23. 17. Franchi M, Trire A, Quaranta M, Orsini E, Ottani V. Collagen structure of tendon relates to function. ScientificWorldJournal. 2007;7:404-20. 18. Kashiwagi K, Mochizuki Y, Yasunaga Y, Ishida O, Deie M, Ochi M. Effects of transforming growth factor-beta 1 on the early stages of healing of the Achilles tendon in a rat model. Scand J Plast Reconstr Surg Hand Surg. 2004;38:193-7. 19. Chan KM, Fu SC, Wong YP, Hui WC, Cheuk YC, Wong MW. Expression of transforming growth factor beta isoforms and their roles in tendon healing. Wound Repair Regen. 2008;16:399-407. 20. James R, Kesturu G, Balian G, Chhabra AB. Tendon: biology, biomechanics, repair, growth factors, and evolving treatment options. J Hand Surg Am. 2008;33:102-12. 21. Domanski M, Mitchell G, Pfeffer M, Neaton JD, Norman J, Svendsen K, et al. Pulse pressure and cardiovascular disease-related mortality: follow-up study of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA. 2002;287:2677-83. 22. Zhang F, Liu H, Stile F, Lei MP, Pang Y, Oswald TM, et al. Effect of vascular endothelial growth factor on rat Achilles tendon healing. Plast Reconstr Surg. 2003;112:1613-9. 23. Laitinen O. The metabolism of collagen and its hormonal control in the rat with special emphasis on the interactions of collagen and calcium in the bones. Acta Endocrinol (Copenh). 1967;56:Suppl 120:1-86. 24. Vailas AC, Tipton CM, Laughlin HL, Tcheng TK, Matthes RD. Physical activity and hypophysectomy on the aerobic capacity of ligaments and tendons. J Appl Physiol Respir Environ Exerc Physiol. 1978;44:542-6. 25. Hudlicka O. Microcirculation in skeletal muscle. Muscles, Ligaments and Tendons Journal. 2011;1:3-11. 26. Clifford PS. Local control of blood flow. Adv Physiol Educ. 2011;35:5-15. 27. Scapinelli R. BLOOD SUPPLY OF THE HUMAN PATELLA. Journal of Bone & Joint Surgery, British Volume. 1967;49-B:563. 28. Carr AJ, Norris SH. The blood supply of the calcaneal tendon. J Bone Joint Surg Br. 1989;71:100-1. 29. Ahmed IM, Lagopoulos M, McConnell P, Soames RW, Sefton GK. Blood supply of the Achilles tendon. J Orthop Res. 1998;16:591-6. 30. Arai T, Ikuta Y, Ikeda A. A study of the arterial supply in the human rectus femoris muscle. Plast Reconstr Surg. 1993;92:43-8. 31. Wong CH, Ong YS, Wei FC. Revisiting vascular supply of the rectus femoris and its relevance in the harvest of the anterolateral thigh flap. Ann Plast Surg. 2013;71:586-90. 32. Barrett EJ, Rattigan S. Muscle perfusion: its measurement and role in metabolic regulation. Diabetes. 2012;61:2661-8. 33. Brockis JG. The blood supply of the flexor and extensor tendons of the fingers in man. J Bone Joint Surg Br. 1953;35-B:131-8. 34. Clark MG, Rattigan S, Clerk LH, Vincent MA, Clark AD, Youd JM, et al. Nutritive and non-nutritive blood flow: rest and exercise. Acta Physiol Scand. 2000;168:519-30. 35. Boushel R, Langberg H, Green S, Skovgaard D, Bulow J, Kjaer M. Blood flow and oxygenation in peritendinous tissue and calf muscle during dynamic exercise in humans. J Physiol. 2000;524 Pt 1:305-13. 36. Larsson SE, Cai H, Zhang Q, Larsson R, Oberg PA. Measurement by laser-Doppler flowmetry of microcirculation in lower leg muscle at different blood fluxes in relation to electromyographically determined contraction and accumulated fatigue. Eur J Appl Physiol Occup Physiol. 1995;70:288-93. 37. Kubo K, Ishigaki T, Ikebukuro T. Measurement of blood flow in the human Achilles tendon <i>in vivo</i>. The Journal of Physical Fitness and Sports Medicine. 2017;6:251-56. 38. Langberg H, Bulow J, Kjaer M. Blood flow in the peritendinous space of the human Achilles tendon during exercise. Acta Physiol Scand. 1998;163:149-53. 39. Langberg H, Bulow J, Kjaer M. Standardized intermittent static exercise increases peritendinous blood flow in human leg. Clin Physiol. 1999;19:89-93. 40. Langberg H, Skovgaard D, Bulow J, Kjaer M. Negative interstitial pressure in the peritendinous region during exercise. J Appl Physiol (1985). 1999;87:999-1002. 41. Boushel R, Piantadosi CA. Near-infrared spectroscopy for monitoring muscle oxygenation. Acta Physiol Scand. 2000;168:615-22. 42. Boushel R, Langberg H, Olesen J, Nowak M, Simonsen L, Bulow J, et al. Regional blood flow during exercise in humans measured by near-infrared spectroscopy and indocyanine green. J Appl Physiol (1985). 2000;89:1868-78. 43. Laughlin MH, Schrage WG. Effects of muscle contraction on skeletal muscle blood flow: when is there a muscle pump? Med Sci Sports Exerc. 1999;31:1027-35. 44. Kagaya A, Ogita F. Blood flow during muscle contraction and relaxation in rhythmic exercise at different intensities. Ann Physiol Anthropol. 1992;11:251-6. 45. Kubo K, Ikebukuro T, Tsunoda N, Kanehisa H. Changes in oxygen consumption of human muscle and tendon following repeat muscle contractions. Eur J Appl Physiol. 2008;104:859-66. 46. Poole D, Behnke B, Musch T. Capillary hemodynamics and oxygen pressures in the aging microcirculation. Microcirculation. 2006;13:289-99. 47. Astrom M, Westlin N. Blood flow in the human Achilles tendon assessed by laser Doppler flowmetry. J Orthop Res. 1994;12:246-52. 48. Knobloch K, Kraemer R, Lichtenberg A, Jagodzinski M, Gossling T, Richter M, et al. Achilles tendon and paratendon microcirculation in midportion and insertional tendinopathy in athletes. Am J Sports Med. 2006;34:92-7. 49. Ohberg L, Lorentzon R, Alfredson H. Neovascularisation in Achilles tendons with painful tendinosis but not in normal tendons: an ultrasonographic investigation. Knee Surg Sports Traumatol Arthrosc. 2001;9:233-8. 50. Divani K, Chan O, Padhiar N, Twycross-Lewis R, Maffulli N, Crisp T, et al. Site of maximum neovascularisation correlates with the site of pain in recalcitrant mid-tendon Achilles tendinopathy. Man Ther. 2010;15:463-8. 51. Knobloch K. The role of tendon microcirculation in Achilles and patellar tendinopathy. J Orthop Surg Res. 2008;3:18. 52. Kubo K, Yajima H, Takayama M, Ikebukuro T, Mizoguchi H, Takakura N. Changes in blood circulation of the contralateral Achilles tendon during and after acupuncture and heating. Int J Sports Med. 2011;32:807-13. 53. Gennisson JL, Deffieux T, Fink M, Tanter M. Ultrasound elastography: principles and techniques. Diagn Interv Imaging. 2013;94:487-95. 54. Ryu J, Jeong WK. Current status of musculoskeletal application of shear wave elastography. Ultrasonography. 2017;36:185-97. 55. Doherty JR, Trahey GE, Nightingale KR, Palmeri ML. Acoustic radiation force elasticity imaging in diagnostic ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control. 2013;60:685-701. 56. Urban MW, Nenadic IZ, Chen S, Greenleaf JF. Discrepancies in reporting tissue material properties. J Ultrasound Med. 2013;32:886-8. 57. Maganaris CN. Tensile properties of in vivo human tendinous tissue. J Biomech. 2002;35:1019-27. 58. Foure A, Nordez A, McNair P, Cornu C. Effects of plyometric training on both active and passive parts of the plantarflexors series elastic component stiffness of muscle-tendon complex. Eur J Appl Physiol. 2011;111:539-48. 59. Shinohara M, Sabra K, Gennisson JL, Fink M, Tanter M. Real-time visualization of muscle stiffness distribution with ultrasound shear wave imaging during muscle contraction. Muscle Nerve. 2010;42:438-41. 60. Eby SF, Song P, Chen S, Chen Q, Greenleaf JF, An KN. Validation of shear wave elastography in skeletal muscle. J Biomech. 2013;46:2381-7. 61. Akagi R, Yamashita Y, Ueyasu Y. Age-Related Differences in Muscle Shear Moduli in the Lower Extremity. Ultrasound Med Biol. 2015;41:2906-12. 62. Zhang ZJ, Fu SN. Shear Elastic Modulus on Patellar Tendon Captured from Supersonic Shear Imaging: Correlation with Tangent Traction Modulus Computed from Material Testing System and Test-Retest Reliability. PLoS One. 2013;8:e68216. 63. Arda K, Ciledag N, Aktas E, Aribas BK, Kose K. Quantitative assessment of normal soft-tissue elasticity using shear-wave ultrasound elastography. AJR Am J Roentgenol. 2011;197:532-6. 64. Chiu TC, Ngo HC, Lau LW, Leung KW, Lo MH, Yu HF, et al. An Investigation of the Immediate Effect of Static Stretching on the Morphology and Stiffness of Achilles Tendon in Dominant and Non-Dominant Legs. PLoS One. 2016;11:e0154443. 65. Siu WL, Chan CH, Lam CH, Lee CM, Ying M. Sonographic evaluation of the effect of long-term exercise on Achilles tendon stiffness using shear wave elastography. J Sci Med Sport. 2016;19:883-87. 66. Hsiao MY, Chen YC, Lin CY, Chen WS, Wang TG. Reduced Patellar Tendon Elasticity with Aging: In Vivo Assessment by Shear Wave Elastography. Ultrasound Med Biol. 2015;41:2899-905. 67. Kot BC, Zhang ZJ, Lee AW, Leung VY, Fu SN. Elastic modulus of muscle and tendon with shear wave ultrasound elastography: variations with different technical settings. PLoS One. 2012;7:e44348. 68. Chino K, Takahashi H. Measurement of gastrocnemius muscle elasticity by shear wave elastography: association with passive ankle joint stiffness and sex differences. Eur J Appl Physiol. 2016;116:823-30. 69. Maisetti O, Hug F, Bouillard K, Nordez A. Characterization of passive elastic properties of the human medial gastrocnemius muscle belly using supersonic shear imaging. J Biomech. 2012;45:978-84. 70. Chimenti RL, Flemister AS, Tome J, McMahon JM, Flannery MA, Xue Y, et al. Altered tendon characteristics and mechanical properties associated with insertional achilles tendinopathy. J Orthop Sports Phys Ther. 2014;44:680-9. 71. Kubo K, Kanehisa H, Fukunaga T. Gender differences in the viscoelastic properties of tendon structures. Eur J Appl Physiol. 2003;88:520-6. 72. Muraoka T, Muramatsu T, Fukunaga T, Kanehisa H. Elastic properties of human Achilles tendon are correlated to muscle strength. J Appl Physiol (1985). 2005;99:665-9. 73. Kubo K, Morimoto M, Komuro T, Tsunoda N, Kanehisa H, Fukunaga T. Influences of tendon stiffness, joint stiffness, and electromyographic activity on jump performances using single joint. Eur J Appl Physiol. 2007;99:235-43. 74. McHugh MP, Connolly DA, Eston RG, Kremenic IJ, Nicholas SJ, Gleim GW. The role of passive muscle stiffness in symptoms of exercise-induced muscle damage. Am J Sports Med. 1999;27:594-9. 75. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature. 1994;371:130-6. 76. Keenan HA, Sun JK, Levine J, Doria A, Aiello LP, Eisenbarth G, et al. Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes. 2010;59:2846-53. 77. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539-53. 78. Forbes JM, Cooper ME. Mechanisms of diabetic complications. Physiol Rev. 2013;93:137-88. 79. Muntoni S, Muntoni S. Insulin resistance: pathophysiology and rationale for treatment. Ann Nutr Metab. 2011;58:25-36. 80. Russell ND, Cooper ME. 50 years forward: mechanisms of hyperglycaemia-driven diabetic complications. Diabetologia. 2015;58:1708-14. 81. Skyler JS. Effects of Glycemic Control on Diabetes Complications and on the Prevention of Diabetes. Clinical Diabetes. 2004;22:162. 82. Gregg EW, Williams DE, Geiss L. Changes in diabetes-related complications in the United States. N Engl J Med. 2014;371:286-7. 83. Zoungas S, Chalmers J, Ninomiya T, Li Q, Cooper ME, Colagiuri S, et al. Association of HbA1c levels with vascular complications and death in patients with type 2 diabetes: evidence of glycaemic thresholds. Diabetologia. 2012;55:636-43. 84. Battisti WP, Palmisano J, Keane WE. Dyslipidemia in patients with type 2 diabetes. relationships between lipids, kidney disease and cardiovascular disease. Clin Chem Lab Med. 2003;41:1174-81. 85. Mooradian AD. Dyslipidemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab. 2009;5:150-9. 86. Setter SM, Campbell RK, Cahoon CJ. Biochemical pathways for microvascular complications of diabetes mellitus. Ann Pharmacother. 2003;37:1858-66. 87. Obrosova IG, Minchenko AG, Vasupuram R, White L, Abatan OI, Kumagai AK, et al. Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats. Diabetes. 2003;52:864-71. 88. Dagher Z, Park YS, Asnaghi V, Hoehn T, Gerhardinger C, Lorenzi M. Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy. Diabetes. 2004;53:2404-11. 89. Cotter MA, Cameron NE, Robertson S, Ewing I. Polyol pathway-related skeletal muscle contractile and morphological abnormalities in diabetic rats. Exp Physiol. 1993;78:139-55. 90. Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation. 2006;114:597-605. 91. Stirban A, Gawlowski T, Roden M. Vascular effects of advanced glycation endproducts: Clinical effects and molecular mechanisms. Mol Metab. 2014;3:94-108. 92. Chiu CY, Yang RS, Sheu ML, Chan DC, Yang TH, Tsai KS, et al. Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway. J Pathol. 2016;238:470-82. 93. Singh VP, Bali A, Singh N, Jaggi AS. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol. 2014;18:1-14. 94. Buse MG, Robinson KA, Gettys TW, McMahon EG, Gulve EA. Increased activity of the hexosamine synthesis pathway in muscles of insulin-resistant ob/ob mice. Am J Physiol. 1997;272:E1080-8. 95. Goldberg H, Whiteside C, Fantus IG. O-linked beta-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells. Am J Physiol Endocrinol Metab. 2011;301:E713-26. 96. Calle MC, Fernandez ML. Inflammation and type 2 diabetes. Diabetes Metab. 2012;38:183-91. 97. Kengne AP, Batty GD, Hamer M, Stamatakis E, Czernichow S. Association of C-reactive protein with cardiovascular disease mortality according to diabetes status: pooled analyses of 25,979 participants from four U.K. prospective cohort studies. Diabetes Care. 2012;35:396-403. 98. Schaap LA, Pluijm SM, Deeg DJ, Visser M. Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med. 2006;119:526 e9-17. 99. Mavros Y, Kay S, Simpson KA, Baker MK, Wang Y, Zhao RR, et al. Reductions in C-reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training. J Cachexia Sarcopenia Muscle. 2014;5:111-20. 100. Ceddia RB, Somwar R, Maida A, Fang X, Bikopoulos G, Sweeney G. Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia. 2005;48:132-9. 101. Rothan HA, Suhaeb AM, Kamarul T. Recombinant human adiponectin as a potential protein for treating diabetic tendinopathy promotes tenocyte progenitor cells proliferation and tenogenic differentiation in vitro. Int J Med Sci. 2013;10:1899-906. 102. Pingel J, Petersen MC, Fredberg U, Kjaer SG, Quistorff B, Langberg H, et al. Inflammatory and Metabolic Alterations of Kager's Fat Pad in Chronic Achilles Tendinopathy. PLoS One. 2015;10:e0127811. 103. Gaida J, Alfredson H, Forsgren S, Cook J. DECREASED TUMOUR NECROSIS FACTOR ALPHA (TNF-Α) IN SERUM OF PATIENTS WITH ACHILLES TENDINOPATHY: FURTHER EVIDENCE AGAINST THE ROLE OF INFLAMMATION IN THE CHRONIC STAGE. British Journal of Sports Medicine. 2014;48:597. 104. Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998;339:229-34. 105. King KD, Jones JD, Warthen J. Microvascular and Macrovascular Complications of Diabetes Mellitus. American Journal of Pharmaceutical Education. 2005;69:87. 106. Lin T, Chou P, Tsai ST, Lee YC, Tai TY. Predicting factors associated with costs of diabetic patients in Taiwan. Diabetes Res Clin Pract. 2004;63:119-25. 107. Abbott CA, Malik RA, van Ross ER, Kulkarni J, Boulton AJ. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K. Diabetes Care. 2011;34:2220-4. 108. Obrosova IG. Diabetic painful and insensate neuropathy: pathogenesis and potential treatments. Neurotherapeutics. 2009;6:638-47. 109. Koitka A, Abraham P, Bouhanick B, Sigaudo-Roussel D, Demiot C, Saumet JL. Impaired pressure-induced vasodilation at the foot in young adults with type 1 diabetes. Diabetes. 2004;53:721-5. 110. Huang YY, Lin KD, Jiang YD, Chang CH, Chung CH, Chuang LM, et al. Diabetes-related kidney, eye, and foot disease in Taiwan: an analysis of the nationwide data for 2000-2009. J Formos Med Assoc. 2012;111:637-44. 111. Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, et al. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005;28:956-62. 112. Severinsen K, Obel A, Jakobsen J, Andersen H. Atrophy of Foot Muscles in Diabetic Patients Can Be Detected With Ultrasonography. Diabetes Care. 2007;30:3053. 113. Andersen H, Gadeberg PC, Brock B, Jakobsen J. Muscular atrophy in diabetic neuropathy: a stereological magnetic resonance imaging study. Diabetologia. 1997;40:1062-9. 114. Meijer JW, Lange F, Links TP, van der Hoeven JH. Muscle fiber conduction abnormalities in early diabetic polyneuropathy. Clin Neurophysiol. 2008;119:1379-84. 115. Sawacha Z, Spolaor F, Guarneri G, Contessa P, Carraro E, Venturin A, et al. Abnormal muscle activation during gait in diabetes patients with and without neuropathy. Gait Posture. 2012;35:101-5. 116. Abbott CA, Carrington AL, Ashe H, Bath S, Every LC, Griffiths J, et al. The North-West Diabetes Foot Care Study: incidence of, and risk factors for, new diabetic foot ulceration in a community-based patient cohort. Diabet Med. 2002;19:377-84. 117. Potier L, Abi Khalil C, Mohammedi K, Roussel R. Use and utility of ankle brachial index in patients with diabetes. Eur J Vasc Endovasc Surg. 2011;41:110-6. 118. Kramer H. Screening for kidney disease in adults with diabetes and prediabetes. Curr Opin Nephrol Hypertens. 2005;14:249-52. 119. O'Bryan GT, Hostetter TH. The renal hemodynamic basis of diabetic nephropathy. Semin Nephrol. 1997;17:93-100. 120. Mauer SM, Steffes MW, Ellis EN, Sutherland DE, Brown DM, Goetz FC. Structural-functional relationships in diabetic nephropathy. J Clin Invest. 1984;74:1143-55. 121. DeFronzo RA, Tripathy D. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care. 2009;32 Suppl 2:S157-63. 122. Ranger TA, Wong AM, Cook JL, Gaida JE. Is there an association between tendinopathy and diabetes mellitus? A systematic review with meta-analysis. Br J Sports Med. 2016;50:982-9. 123. Abate M, Schiavone C, Di Carlo L, Salini V. Prevalence of and risk factors for asymptomatic rotator cuff tears in postmenopausal women. Menopause. 2014;21:275-80. 124. Burner T, Gohr C, Mitton-Fitzgerald E, Rosenthal AK. Hyperglycemia Reduces Proteoglycan Levels in Tendons. Connective Tissue Research. 2012;53:535-41. 125. Li Y, Fessel G, Georgiadis M, Snedeker JG. Advanced glycation end-products diminish tendon collagen fiber sliding. Matrix Biol. 2013;32:169-77. 126. Trayhurn P, Wang B, Wood IS. Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr. 2008;100:227-35. 127. Tanaka S, Tanaka T, Nangaku M. Hypoxia and Dysregulated Angiogenesis in Kidney Disease. Kidney Dis (Basel). 2015;1:80-9. 128. Abate M, Di Carlo L, Salini V, Schiavone C. Metabolic syndrome associated to non-inflammatory Achilles enthesopathy. Clin Rheumatol. 2014;33:1517-22. 129. Guney A, Vatansever F, Karaman I, Kafadar IH, Oner M, Turk CY. Biomechanical properties of Achilles tendon in diabetic vs. non-diabetic patients. Exp Clin Endocrinol Diabetes. 2015;123:428-32. 130. Batista F, Nery C, Pinzur M, Monteiro AC, de Souza EF, Felippe FH, et al. Achilles tendinopathy in diabetes mellitus. Foot Ankle Int. 2008;29:498-501. 131. Ling SC, Chen CF, Wan RX. A study on the vascular supply of the supraspinatus tendon. Surg Radiol Anat. 1990;12:161-5. 132. Lui PPY. Tendinopathy in diabetes mellitus patients-Epidemiology, pathogenesis, and management. Scand J Med Sci Sports. 2017;27:776-87. 133. Nell EM, van der Merwe L, Cook J, Handley CJ, Collins M, September AV. The apoptosis pathway and the genetic predisposition to Achilles tendinopathy. J Orthop Res. 2012;30:1719-24. 134. Mobasheri A, Shakibaei M. Is tendinitis an inflammatory disease initiated and driven by pro-inflammatory cytokines such as interleukin 1beta? Histol Histopathol. 2013;28:955-64. 135. Yamagishi S, Amano S, Inagaki Y, Okamoto T, Koga K, Sasaki N, et al. Advanced glycation end products-induced apoptosis and overexpression of vascular endothelial growth factor in bovine retinal pericytes. Biochem Biophys Res Commun. 2002;290:973-8. 136. Andreassen CS, Jakobsen J, Ringgaard S, Ejskjaer N, Andersen H. Accelerated atrophy of lower leg and foot muscles--a follow-up study of long-term diabetic polyneuropathy using magnetic resonance imaging (MRI). Diabetologia. 2009;52:1182-91. 137. Benedict KF, Coffin GS, Barrett EJ, Skalak TC. Hemodynamic systems analysis of capillary network remodeling during the progression of type 2 diabetes. Microcirculation. 2011;18:63-73. 138. Padilla DJ, McDonough P, Behnke BJ, Kano Y, Hageman KS, Musch TI, et al. Effects of Type II diabetes on capillary hemodynamics in skeletal muscle. Am J Physiol Heart Circ Physiol. 2006;291:H2439-44. 139. Song Y, Li Y, Wang PJ, Gao Y. Contrast-enhanced ultrasonography of skeletal muscles for type 2 diabetes mellitus patients with microvascular complications. Int J Clin Exp Med. 2014;7:573-9. 140. Zheng J, Hasting MK, Zhang X, Coggan A, An H, Snozek D, et al. A pilot study of regional perfusion and oxygenation in calf muscles of individuals with diabetes with a noninvasive measure. J Vasc Surg. 2014;59:419-26. 141. Moalla W, Merzouk A, Costes F, Tabka Z, Ahmaidi S. Muscle oxygenation and EMG activity during isometric exercise in children. J Sports Sci. 2006;24:1195-201. 142. Russell RD, Hu D, Greenaway T, Blackwood SJ, Dwyer RM, Sharman JE, et al. Skeletal Muscle Microvascular-Linked Improvements in Glycemic Control From Resistance Training in Individuals With Type 2 Diabetes. Diabetes Care. 2017;40:1256-63. 143. Kubo K, Ikebukuro T, Tsunoda N, Kanehisa H. Noninvasive measures of blood volume and oxygen saturation of human Achilles tendon by red laser lights. Acta Physiol (Oxf). 2008;193:257-64. 144. Kashima S. Spectroscopic measurement of blood volume and its oxygenation in a small volume of tissue using red laser lights and differential calculation between two point detections. Optics & Laser Technology. 2003;35:485-89. 145. Hamaoka T, Iwane H, Shimomitsu T, Katsumura T, Murase N, Nishio S, et al. Noninvasive measures of oxidative metabolism on working human muscles by near-infrared spectroscopy. J Appl Physiol (1985). 1996;81:1410-7. 146. Brum J, Bernal M, Gennisson JL, Tanter M. In vivo evaluation of the elastic anisotropy of the human Achilles tendon using shear wave dispersion analysis. Phys Med Biol. 2014;59:505-23. 147. Alfuraih AM, O'Connor P, Hensor E, Tan AL, Emery P, Wakefield RJ. The effect of unit, depth, and probe load on the reliability of muscle shear wave elastography: Variables affecting reliability of SWE. J Clin Ultrasound. 2017. 148. Ewertsen C, Carlsen JF, Christiansen IR, Jensen JA, Nielsen MB. Evaluation of healthy muscle tissue by strain and shear wave elastography - Dependency on depth and ROI position in relation to underlying bone. Ultrasonics. 2016;71:127-33. 149. Miyamoto N, Hirata K, Kanehisa H, Yoshitake Y. Validity of measurement of shear modulus by ultrasound shear wave elastography in human pennate muscle. PLoS One. 2015;10:e0124311. 150. Aubry S, Risson JR, Kastler A, Barbier-Brion B, Siliman G, Runge M, et al. Biomechanical properties of the calcaneal tendon in vivo assessed by transient shear wave elastography. Skeletal Radiol. 2013;42:1143-50. 151. Dirrichs T, Quack V, Gatz M, Tingart M, Kuhl CK, Schrading S. Shear Wave Elastography (SWE) for the Evaluation of Patients with Tendinopathies. Acad Radiol. 2016;23:1204-13. 152. Portney LG, Watkins MP. Foundations of Clinical Research: Pearson New International Edition: Applications to Practice. Pearson Education Limited; 2013. 153. Sherwani SI, Khan HA, Ekhzaimy A, Masood A, Sakharkar MK. Significance of HbA1c Test in Diagnosis and Prognosis of Diabetic Patients. Biomark Insights. 2016;11:95-104. 154. Paffett ML, Walker BR. Vascular adaptations to hypoxia: molecular and cellular mechanisms regulating vascular tone. Essays Biochem. 2007;43:105-19. 155. Gustafsson P, Crenshaw AG, Edmundsson D, Toolanen G, Crnalic S. Muscle oxygenation in Type 1 diabetic and non-diabetic patients with and without chronic compartment syndrome. PLoS One. 2017;12:e0186790. 156. Samaja M, Melotti D, Carenini A, Pozza G. Glycosylated haemoglobins and the oxygen affinity of whole blood. Diabetologia. 1982;23:399-402. 157. Segal SS. Regulation of blood flow in the microcirculation. Microcirculation. 2005;12:33-45. 158. Joyner MJ, Casey DP. Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs. Physiol Rev. 2015;95:549-601. 159. Kubo K, Yajima H, Takayama M, Ikebukuro T, Mizoguchi H, Takakura N. Effects of acupuncture and heating on blood volume and oxygen saturation of human Achilles tendon in vivo. Eur J Appl Physiol. 2010;109:545-50. 160. Mason McClatchey P, Bauer TA, Regensteiner JG, Schauer IE, Huebschmann AG, Reusch JEB. Dissociation of local and global skeletal muscle oxygen transport metrics in type 2 diabetes. J Diabetes Complications. 2017;31:1311-17. 161. Spires J, Lai N, Zhou H, Saidel GM. Hemoglobin and myoglobin contributions to skeletal muscle oxygenation in response to exercise. Adv Exp Med Biol. 2011;701:347-52. 162. Garg S, Gupta S, Mobeen MS, Madhu SV. Effect of obesity and glycated hemoglobin on oxygen saturation in ambulatory type 2 diabetic individuals: A pilot study. Diabetes Metab Syndr. 2016;10:157-60. 163. Ohberg L, Alfredson H. Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment. Br J Sports Med. 2002;36:173-5; discussion 76-7. 164. De Marchi A, Pozza S, Cenna E, Cavallo F, Gays G, Simbula L, et al. In Achilles tendinopathy, the neovascularization, detected by contrast-enhanced ultrasound (CEUS), is abundant but not related to symptoms. Knee Surg Sports Traumatol Arthrosc. 2017. 165. Alfredson H, Ohberg L. Neovascularisation in chronic painful patellar tendinosis--promising results after sclerosing neovessels outside the tendon challenge the need for surgery. Knee Surg Sports Traumatol Arthrosc. 2005;13:74-80. 166. Alfredson H, Ohberg L. Increased intratendinous vascularity in the early period after sclerosing injection treatment in Achilles tendinosis : a healing response? Knee Surg Sports Traumatol Arthrosc. 2006;14:399-401. 167. Tempfer H, Traweger A. Tendon Vasculature in Health and Disease. Front Physiol. 2015;6:330. 168. Vasta S, Di Martino A, Zampogna B, Torre G, Papalia R, Denaro V. Role of VEGF, Nitric Oxide, and Sympathetic Neurotransmitters in the Pathogenesis of Tendinopathy: A Review of the Current Evidences. Front Aging Neurosci. 2016;8:186. 169. Pufe T, Petersen WJ, Mentlein R, Tillmann BN. The role of vasculature and angiogenesis for the pathogenesis of degenerative tendons disease. Scand J Med Sci Sports. 2005;15:211-22. 170. Tsai W-C, Liang F-C, Cheng J-W, Lin L-P, Chang S-C, Chen H-H, et al. High glucose concentration up-regulates the expression of matrix metalloproteinase-9 and -13 in tendon cells. BMC Musculoskeletal Disorders. 2013;14:255-55. 171. Richardson RS, Knight DR, Poole DC, Kurdak SS, Hogan MC, Grassi B, et al. Determinants of maximal exercise VO2 during single leg knee-extensor exercise in humans. Am J Physiol. 1995;268:H1453-61. 172. McNeil CJ, Allen MD, Olympico E, Shoemaker JK, Rice CL. Blood flow and muscle oxygenation during low, moderate, and maximal sustained isometric contractions. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2015;309:R475-R81. 173. Caliandro P, Mirabella M, Padua L, Simbolotti C, Fino CD, Iacovelli C, et al. Idiopathic inflammatory myopathies evaluated by near-infrared spectroscopy. Muscle Nerve. 2015;51:830-7. 174. Thamer C, Stumvoll M, Niess A, Tschritter O, Haap M, Becker R, et al. Reduced Skeletal Muscle Oxygen Uptake and Reduced β-Cell Function. Diabetes Care. 2003;26:2126. 175. Tagougui S, Leclair E, Fontaine P, Matran R, Marais G, Aucouturier J, et al. Muscle oxygen supply impairment during exercise in poorly controlled type 1 diabetes. Med Sci Sports Exerc. 2015;47:231-9. 176. Mohler ER, 3rd, Lech G, Supple GE, Wang H, Chance B. Impaired exercise-induced blood volume in type 2 diabetes with or without peripheral arterial disease measured by continuous-wave near-infrared spectroscopy. Diabetes Care. 2006;29:1856-9. 177. Nyberg M, Gliemann L, Hellsten Y. Vascular function in health, hypertension, and diabetes: effect of physical activity on skeletal muscle | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/70843 | - |
dc.description.abstract | 研究背景:糖尿病為全球盛行之代謝性疾病,且易導致併發症包括血管系統病變等,近年來研究發現糖尿病併發症也出現在骨骼肌肉系統,且過去文獻提出可能的機制為微循環變異導致組織的缺氧所致。但就糖尿病之骨骼肌肉系統於運動過程中是否會有微循環的改變,卻缺乏完整的了解,因此無法了解糖尿病造成患者的肌肉與肌腱功能缺失之機制並給予適當的建議。研究目的:本研究目的在於收集糖尿病患者與非糖尿病受試者,其下肢肌肉與肌腱微循環特徵與機械特性,並與糖尿病臨床檢查如血糖控制,進行相關性分析。設計:本研究為橫斷式研究。實驗對象:本研究共90位患有糖尿病之受試者與31位非糖尿病控制組,其平均年齡分別為61.8歲與58.6歲,並排除會影響微循環之相關疾病。方法:本研究所量測之微循環特徵包含氧氣飽和度與總血紅素含量,使用近場遠紅外線光譜與紅光雷射檢測受試者於靜態之下肢肌肉(包含股直肌與內側腓腸肌)與肌腱(髕骨肌腱與阿基里斯腱)微循環特徵,以及肌肉等長收縮過程中之肌肉與肌腱微循環變化,並使用超音波剪力波彈性成像儀檢測肌肉與肌腱剛性。統計分析:本研究使用Mann-Whitney U test進行統計分析,比較糖尿病患者與非糖尿病受試者之(1)靜態下肌肉與肌腱之微循環、剛性、(2)肌肉等長收縮過程中微循環變化量、變化速度、(3)肌力與肌耐力是否有顯著差異。第二部分則使用斯皮爾曼等級相關係數(Spearman correlation coefficient)分析肌肉與肌腱之微循環、糖尿病受試者之年紀與疾病史、運動表現及糖尿病患者臨床檢查之相關性。結果:髕骨肌腱與阿基里氏腱靜態下的微循環數值皆高於控制組,其中髕骨肌腱與阿基里氏肌腱氧氣飽和度之p值為0.002與0.003,總血紅素含量則為0.001與0.01。股直肌與內側腓腸肌靜態下微循環基準值則發現糖尿病組之氧氣飽和度皆低於控制組(p值皆小於0.001)。在肌肉等長收縮過程中,股直肌與內側腓腸肌之氧氣飽和度最低值皆是糖尿病組顯著低於控制組(p=0.001與p<0.001),內側腓腸肌氧氣飽和度的變化總量與變化速率糖尿病組則顯著高於控制組(p=0.001與p<0.001)。股四頭肌腱之機械特性為糖尿病組顯著高於控制組(p=0.041),而內側腓腸肌機械特性則是控制組高於糖尿病組(p=0.033)。相關性分析大多數的結果為無顯著相關性,僅部分結果得到低強度相關性。結論:糖尿病患者之肌肉於靜態之氧氣飽和度低於控制組,指出其肌肉之氧氣供應較不足,因此在運動過程中氧氣的供應不平衡而導致肌肉縮收時容易缺氧,且此現象在靠近下肢末端的內側腓腸肌較顯著。糖尿病患者之下肢肌腱微循環特徵與肌腱病變之血管新生特徵相似,因此可能暗示糖尿病患者之肌腱處於肌腱病變之前期,或是有肌腱病變的高風險。根據本研究之結果,糖尿病患者之下肢肌肉與肌腱微循環受到糖尿病的影響,可能影響其運動表現,因此期望未來有相關研究探討此現象是否能透過特定運動介入進行改善。 | zh_TW |
dc.description.abstract | Background: Diabetes mellitus (DM) is recognized as a global epidemic and often causes numerous complications, some of which have been found, in recent years, to affect the musculoskeletal system. One of the possible mechanisms is hypoxia due to microvascular impairment. However, a clear understanding of microcirculation in the musculoskeletal system at rest and during isometric muscle contraction is still lacking. Purpose: The purpose of this study was (1) to investigate the variation in microcirculatory properties during resting phases and isometric muscle contraction and the mechanical properties of muscles and tendons in patients with DM and (2) to investigate the correlation between the variation in microcirculatory properties, mechanical properties, and clinical tests in patients with DM. Design: This study was a cross-sectional study. Participants: Ninety subjects were recruited for the DM group and 31 were recruited for the control group, with the average age of 61.8 years old and 58.6 years old, respectively. Conditions that may affect microcirculation were excluded. Methods: The microcirculation included total hemoglobin (THb) and oxygen saturation (StO2), which were measured using near-field infrared spectroscopy and red laser light for the muscles and tendons, respectively. Each subject was assessed for microcirculation in the rectus femoris (RF) and the patellar tendon (PT) during maximal isometric contraction of knee extension, as well as for microcirculation in the medial gastrocnemius (MG) and Achilles tendon (AT) during a one-leg heel raise. The mechanical properties of the muscles and tendons were assessed by shear wave elastography. The results of measurements were compared with routine clinical tests, such as blood glucose measurements. Statistical analysis: The Mann-Whitney U test was used to compare the differences in microcirculatory properties, mechanical properties and muscle performances between the DM and control groups. A Spearman correlation coefficient was used to analyze the correlation between variables. Results: The microcirculatory properties of tendons in a resting state were higher in the DM group, with p-values of 0.002 and 0.003 for the SaO2 of the PT and AT, respectively. The THb of the PT and AT were higher in the DM group as well, with p-values of 0.001 and 0.01, respectively. The baseline of SaO2 in the muscles was lower in the DM group, with p-values of <0.001 for the SaO2 of both muscles. During isometric muscle contraction, the lowest values of SaO2 in the RF and MG were lower in the DM group, with p-values of 0.001 and <0.001, respectively. The amount and rate of change of SaO2 in the MG were significantly higher in the DM group, with p-values of 0.001 and <0.001, respectively. The mechanical property of the quadriceps tendon in the resting state was significantly higher in the DM group (p = 0.041), and the mechanical property of the MG was lower in the DM group (p = 0.033). The relationship between microcirculatory properties, age and clinical test results presented little to fair strengths of correlation. Conclusion: According to the findings of this study, the microcirculation of muscles was lower in muscles at rest, indicating the oxygen supply for these muscles was impaired. Furthermore, the oxygen supply for muscles during exercise was impaired in the distal muscle, which may lead to the hypoxia of the muscle during contraction. This may indicate that the local regulation of microcirculation is impaired by DM, affecting the delivery of oxygen. The higher microcirculatory properties of tendons in patients with DM indicate the presence of tendinopathy or high risks of tendinopathy. Therefore, based on the findings of our study, further investigation of exercise intervention for these patients may be valuable, and more evidence is needed of the reversibility of microcirculatory properties in muscles and tendons in future studies. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T04:40:39Z (GMT). No. of bitstreams: 1 ntu-107-R05428012-1.pdf: 15740317 bytes, checksum: 2bc5f7e92867245edeb480a1c8281efa (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 口試委員會審定書 i
誌謝 ii 中文摘要 iii Abstract v 第一章 前言 1 第一節 研究背景 1 第二節 研究目的 3 第二章 文獻回顧 4 第一節 肌肉與肌腱 4 一、 肌肉與肌腱之解剖與生理 4 二、 肌肉與肌腱之微循環 7 三、 肌肉與肌腱之超音波剪力波彈性成像儀 14 第二節 糖尿病的介紹與肌肉肌腱病變 17 一、 糖尿病之介紹 17 二、 糖尿病之血管病變 19 三、 糖尿病之神經病變 23 四、 糖尿病之腎臟病變 25 五、 糖尿病之肌肉與肌腱病變 26 第三節 應用於本研究之非侵入式研究設備 30 一、 近場遠紅外線光譜儀與紅光雷射 30 二、 超音波剪力波彈性成像儀 31 第四節 總結 34 第三章 研究方法 35 第一節 理論架構 35 第二節 假說 37 第三節 參數與操作型定義 43 第四節 研究對象 48 第五節 研究方法 49 第六節 統計分析 53 第四章 結果 54 第五章 討論 59 第六章 結論 72 參考文獻 73 附錄一 本研究結果圖表 91 附錄二 臨床試驗/研究受試者說明書 110 附錄三 研究倫理委員會臨床/試驗研究許可書 117 | |
dc.language.iso | zh-TW | |
dc.title | 糖尿病患者下肢肌肉肌腱微循環及機械特性之變異與血糖控制之相關性 | zh_TW |
dc.title | Variation of Microcirculatory and Mechanical Properties in Muscles and Tendons of Lower Extremity in Subjects with Diabetes Mellitus | en |
dc.type | Thesis | |
dc.date.schoolyear | 106-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 莊立民(Lee-Ming Chuang),趙遠宏(Yuan-Hung Chao) | |
dc.subject.keyword | 糖尿病,肌肉骨骼系統併發症,微循環,肌肉肌腱機械特性,血糖控制, | zh_TW |
dc.subject.keyword | diabetes mellitus,diabetic musculoskeletal complications,microcirculation,muscle and tendon stiffness,glycemic control, | en |
dc.relation.page | 117 | |
dc.identifier.doi | 10.6342/NTU201802483 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2018-08-06 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 物理治療學研究所 | zh_TW |
顯示於系所單位: | 物理治療學系所 |
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