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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳明汝 | |
dc.contributor.author | Chun-Cheng Chu | en |
dc.contributor.author | 朱峻成 | zh_TW |
dc.date.accessioned | 2021-06-17T04:26:53Z | - |
dc.date.available | 2028-08-13 | |
dc.date.copyright | 2018-08-16 | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018-08-14 | |
dc.identifier.citation | 湯芯瑜。2016。Lactobacillus kefiranofaciens M1 對不同壓力之反應及其於噴霧乾燥和冷凍乾燥後存活之探討。國立台灣大學動物科學與技術學系。碩士論文。
謝馨慧。2011。糖液克弗爾粒於不同發酵基質中之菌相分布與其分離菌株抗腸炎機能性之研究。國立台灣大學動物科學與技術學系。碩士論文。 Abee, T. and J. A.Wouters. 1999. Microbial stress response in minimal processing. Int. J. Food Microbiol. 50: 65-91. Altermann, E., W. M. Russell, M. A. Azcarate-Peril, R. Barrangou, B. L. Buck, O. McAuliffe, N. Souther, A. Dobson, T. Duong, M. Callanan, S. Lick, A. Hamrick, R. Cano and T. R. Klaenhammer. 2005. Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM. Proc. Natl. Acad. Sci. U.S.A. 102: 3906-3912. Anonymous. 1992. Yoghurt and probiotics. Choice. 11: 32-35. Augusteyn, R. C. 2004. alpha-crystallin: a review of its structure and function. Clin. Exp. Optom. 87: 356-366. Azcarate-Peril, M. A., O. McAuliffe, E. Altermann, S. Lick, W. M. Russell and T. R. Klaenhammer. 2005. Microarray analysis of a two-component regulatory system involved in acid resistance and proteolytic activity in Lactobacillus acidophilus. Appl. Environ. Microbiol. 71: 5794-5804. Bâati, L., C. Fabre-Gea, D. Auriol and P. J. Blanc. 2000. Study of the cryotolerance of Lactobacillus acidophilus: effect of culture and freezing conditions on the viability and cellular protein levels. Int. J. Food Microbiol. 59: 241-247. Bae, W., B. Xia, M. Inouye and K. Severinov. 2000. Escherichia coli CspA-family RNA chaperones are transcription antiterminators. Proc. Natl. Acad. Sci. U.S.A. 97: 7784-7789. Baillon, M. L., Z. V. Marshall-Jones and R. F. Butterwick. 2004. Effects of probiotic Lactobacillus acidophilus strain DSM13241 in healthy adult dogs. Am. J. Vet. Res. 65: 338-343. Ballesteros, S. A., J. Chirife and J. P. Bozzini. 1992. Antibacterial Effects and Cell Morphological Changes in Staphylococcus aureus Subjected to Low Ethanol Concentrations. J. Food Sci. 58: 435-438. Bearson, S., B. Bearson and J. W. Foster. 1997. Acid stress responses in enterobacteria. FEMS Microbiol. Lett. 147: 173-180. Beauchamp, D. L. and M. Khajehpour. 2012. Studying salt effects on protein stability using ribonuclease t1 as a model system. Biophys. Chem. 161: 29-38. Begley, M., C. G. Gahan and C. Hill. 2005. The interaction between bacteria and bile. FEMS Microbiol. Rev. 73: 915-921. Bernstein, C., H. Bernstein, C. M. Payne, S. E. Beard and J. Schneider. 1999. Bile salt activation of stress response promoters in Escherichia coli. Curr. Microbiol. 39: 68-72. Bernstein, H., C. M. Payne, C. Bernstein, J. Schneider, S. E. Beard and C. L. Crowley. 1999. Activation of the promoters of genes associated with DNA damage, oxidative stress, ER stress and protein malfolding by the bile salt, deoxycholate. Toxicol. Lett. 108: 37-46. Bintsis, T., E. Litopoulou-Tzanetaki and R. K. Robinson. 2000. Existing and potential applications of ultraviolet light in the food industry - a critical review. J. Sci. Food Agric. 80: 637-645. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254. Broadbent, J. R., R. L. Larsen, V. Deibel and J. L. Steele. 2010. Physiological and Transcriptional Response of Lactobacillus casei ATCC 334 to Acid Stress. J. Bacteriol. 192: 2445-2458. Burns, P., B. Sánchez, G. Vinderola, P. Ruas-Madiedo, L. Ruiz, A. Margolles, J. Reinheimer and C. G. de los Reyes-Gavilán. 2010. Inside the adaptation process of Lactobacillus delbrueckii subsp. lactis to bile. Int. J. Food Microbiol. 142: 132-141. Burns, P., J. Reinheimer and G. Vinderola. 2011. Impact of bile salt adaptation of Lactobacillus delbrueckii subsp. lactis 200 on its interaction capacity with the gut. Res. Microbiol. 162: 782-790. Burnsa, P., G. Vinderolaa, A. Binettia, A. Quiberonia, C. G. de los Reyes-Gavila’nb and J. Reinheimera. 2008. Bile-resistant derivatives obtained from non-intestinal dairy lactobacilli. Int. Dairy J. 18: 377-385. Carpita, N. C. 1985. Tensile strength of cell walls of living cells. Plant Physiol. 79: 485-488. Carr, J. G. and P. A. Davies. 1970. Homofermentative Lactobacilli of ciders including Lactobacillus mali nov. spec. J. Appl. Bacteriol. 33: 768-774. Cartwright, C. P., J. R. juroszek, M. J. Beavan, F. M. S. Ruby, S. M. F. De Morais and A. H. Rose. 1986. Ethanol Dissipates the Proton-motive Force across the Plasma Membrane of Saccharomyces cerevisiae. J. Gen. Microbiol. 132: 369–377. Chen, M. J., H. Y. Tang and M. L. Chiang. 2017. Effects of heat, cold, acid and bile salt adaptations on the stress tolerance and protein expression of kefir-isolated probiotic Lactobacillus kefiranofaciens M1. Food Microbiol. 66: 20-27. Cody, W. L., J. W. Wilson, D. R. Hendrixson, K. S. McIver, K. E. Hagman, C.M. Ott, C. A. Nickerson and M. J. Schurr. 2008. Skim Milk Enhances the Preservation of Thawed -80°C Bacterial Stocks. J. Microbiol. Methods. 75: 135-138. Coleman, R., P. J. Lowe and D. Billington. 1980. Membrane lipid composition and susceptibility to bile salt damage. Biochim. Biophys. Acta, Biomembr. 599: 294-300. Condon, S. 1987. Responses of lactic acid bacteria to oxygen. FEMS Microbiol. Rev. 46: 269–280. Cotter, P. D. and C. Hill. 2003. Surviving the Acid Test: Responses of Gram-Positive Bacteria to Low pH. Microbiol. Mol. Biol. Rev. 67: 429-453. Csonka, L. N. 1989. Physiological and genetic responses of bacteria to osmotic stress. Microbiol. Rev. 53: 121-147. De Angelis, M. and M. Gobbetti. 2004. Environmental stress responses in Lactobacillus: a review. Proteomics. 4: 106-122. De Angelis, M., L. Bini, V. Pallini, P. S. Cocconcelli and M. Gobbetti. 2001. The acid-stress response in Lactobacillus sanfranciscensis CB1. Microbiology. 147: 1863-1873. De Angelis, M., R. Di Cagno, C. Huet, C. Crecchio, P. F. Fox and M. Gobbetti. 2004. Heat shock response in Lactobacillus plantarum. Appl. Environ. Microbiol. 70: 1336-1346. De Boever, P., R. Wouters, L. Verschaeve, P. Berckmans, G. Schoeters and W. Verstraete. 2000. Protective effect of the bile salt hydrolase-active Lactobacillus reuteri against bile salt cytotoxicity. Appl. Microbiol. Biotechnol. 53: 709-714. De Smet, I., L. Van Hoorde, M. Vande Woestyne, H. Christiaens and W. Verstraete. 1995. Significance of bile salt hydrolytic activities of lactobacilli. J. Appl. Bacteriol. 79: 292-301. Derzelle, S., B. Hallet, T. Ferain, J. Delcour and P. Hols. 2003. Improved Adaptation to Cold-Shock, Stationary-Phase, and Freezing Stresses in Lactobacillus plantarum Overproducing Cold-Shock Proteins. Appl. Environ. Microbiol. 69: 4285-4290. Desmond, C., C. Stantona, G. F. Fitzgerald, K. Collins and R. P. Rossa. 2011. Environmental adaptation of probiotic lactobacilli towards improvement of performance during spray drying. Int. Dairy J. 11: 801-808. Dong, Z., J. Zhang, B. Lee, H. Li, G. Du and J. Chen. 2012. A bile salt hydrolase gene of Lactobacillus plantarum BBE7 with high cholesterol-removing activity. Eur. Food Res. Technol. 235: 419-427. Duary, R. K., V. K. Batish and S. Grover. 2012. Relative gene expression of bile salt hydrolase and surface proteins in two putative indigenous Lactobacillus plantarum strains under in vitro gut conditions. Mol. Biol. Rep. 39: 2541-2552. Dubois, M., K. Gilles, J. K. Hamilton, P. A. Rebers and F. Smith. 1951. A colorimetric method for the determination of sugars. Nature. 168: 167. Elkins, C. A. and D. C. Savage. 2003. CbsT2 from Lactobacillus johnsonii 100-100 is a transport protein of the major facilitator superfamily that facilitates bile acid antiport. J. Mol. Microbiol. Biotechnol. 6: 76–87. Elkins, C. A., S. A. Moser and D. C. Savage. 2001. Genes encoding bile salt hydrolases and conjugated bile salt transporters in Lactobacillus johnsonii 100-100 and other Lactobacillus species. Microbiology. 147: 3403-3412. Fernandez, A., J. Ogawa, S. Penaud, S. Boudebbouze, D. Ehrlich, M. van de Guchte and E. Maguin. 2008. Rerouting of pyruvate metabolism during acid adaptation in Lactobacillus bulgaricus. Proteomics. 8: 3154-3163. Fiocco, D., V. Capozzi, P. Goffin, P. Hols and G. Spano. 2007. Improved adaptation to heat, cold, and solvent tolerance in Lactobacillus plantarum. Appl. Microbiol. Biotechnol. 77: 909-915. Francis, K. P. and G. S. Stewart. 1997. Detection and speciation of bacteria through PCR using universal major cold-shock protein primer oligomers. J. Ind. Microbiol. Biotechnol. 19: 286-293. Franks, F. 1995. Protein destabilization at low temperatures. Adv. Protein Chem. 46: 105-139. Grill, J. P., C. Cayuela, J. M. Antoine and F. Schneider. 2000. Isolation and characterization of a Lactobacillus amylovorus mutant depleted in conjugated bile salt hydrolase activity: relation between activity and bile salt resistance. J. Appl. Microbiol. 89: 553-563. Gruenwedel, D.W. and C. H. Hsu. 1969. Salt effects on the denaturation of DNA. Biopolymers. 7: 557-570. Guerzoni, M. E., R. Lanciotti and P. S. Cocconcelli. 2001. Alteration in cellular fatty acid composition as a response to salt, acid, oxidative and thermal stresses in Lactobacillus helveticus. Microbiology. 147: 2255–2264. Hamon, E., P. Horvatovich, E. Izquierdo, F. Bringel, E. Marchioni, D. Aoudé-Werner and S. Ennahar. 2011. Comparative proteomic analysis of Lactobacillus plantarum for the identification of key proteins in bile tolerance. BMC Microbiol. 11: 63. Heuman, D. M., R. S. Bajaj and Q. Lin. 1996. Adsorption of mixtures of bile salt taurine conjugates to lecithin-cholesterol membranes: implications for bile salt toxicity and cytoprotection. J. Lipid Res. 37: 562-573. Hidalgo-Cantabrana, C., B. Sánchez, C. Milani, M. Ventura, A. Margolles and P. Ruas-Madiedo. 2014. Genomic overview and biological functions of exopolysaccharide biosynthesis in Bifidobacterium spp. Appl. Environ. Microbiol. 80: 9-18. Hofmann, A. F. and A. Roda. 1984. Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem. J. Lipid Res. 25: 1477-1489. Hofmann, A. F. and K. J. Mysels. 1992. Bile acid solubility and precipitation in vitro and in vivo: the role of conjugation, pH, and Ca2+ ions. J. Lipid Res. 33: 617-626. Hsieh, H. H., S. Y. Wang, T. L. Chen, Y. L. Huang and M. J. Chen. 2012. Effects of cow's and goat's milk as fermentation media on the microbial ecology of sugary kefir grains. Int. J. Food Microbiol. 157: 73-81. Huffer, S., M. E. Clark, J. C. Ning, H. W. Blanch and D. S. Clark. 2011. Role of alcohols in growth, lipid composition, and membrane fluidity of yeasts, bacteria, and archaea. Appl. Environ. Microbiol. 77: 6400-6408. Imlay, J. A. and S. Linn. 1988. DNA damage and oxygen radical toxicity. Science. 240: 1302–1309. Ingham, C. J., M. Beerthuyzen and J. van Hylckama Vlieg. 2008. Population heterogeneity of Lactobacillus plantarum WCFS1 microcolonies in response to and recovery from acid stress. Appl. Environ. Microbiol. 74: 7750-7758. Ingram, L. O. 1976. Adaptation of membrane lipids to alcohols. J. Bacteriol. 125: 670–678. Jones, T. H., K. M. Vail and L. M. McMullen. 2013. Filament formation by foodborne bacteria under sublethal stress. Int. J. Food Microbiol. 165: 97-110. Kandell, R. L. and Bernstein, C. 1991. Bile salt/acid induction of DNA damage in bacterial and mammalian cells: implications for colon cancer. Nutr. Cancer. 16: 227-238. Kaneuchi, C., M. Seki and K. Komagata. 1988. Taxonomic Study of Lactobacillus mali Carr and Davis 1970 and Related Strains: Validation of Lactobacillus mali Carr and Davis 1970 over Lactobacillus yamanashiensis Nonomura 1983. Int. J. Syst. Bacteriol. 38: 269-272. Kim, S. W. and N. W. Dunn. 1997. Identification of a cold shock gene in lactic acid bacteria and the effect of cold shock on cryotolerance. Curr. Microbiol. 35: 59-63. Kim, W. S., L. Perl, J. H. Park, J. E.Tandianus and N. W. Dunn. 2001. Assessment of stress response of the probiotic Lactobacillus acidophilus. Curr. Microbiol. 43: 346-350. Ko, R., L. T. Smith and G. M. Smith. 1994. Glycine betaine confers enhanced osmotolerance and cryotolerance on Listeria monocytogenes. J. Bacteriol. 176: 426-431. Kohanski, M. A., D. J. Dwyer, B. Hayete, C. A. Lawrence and J. J. Collins. 2007. A common mechanism of cellular death induced by bactericidal antibiotics. Cell. 130: 797–810. Koponen, J., K. Laakso, K. Koskenniemi, M. Kankainen, K. Savijoki, T. A. Nyman, W. M. de Vos, S. Tynkkynen, N. Kalkkinen, P. Varmanen. 2012. Effect of acid stress on protein expression and phosphorylation in Lactobacillus rhamnosus GG. J. Proteom. 75: 1357-1374. Koskenniemi, K., K. Laakso, J. Koponen, M. Kankainen, D. Greco, P. Auvinen, K. Savijoki, T. A. Nyman, A. Surakka, T. Salusjärvi, W. M. de Vos, S. Tynkkynen, N. Kalkkinen and P. Varmanen. 2011. Proteomics and transcriptomics characterization of bile stress response in probiotic Lactobacillus rhamnosus GG. Mol. Cell Proteomics. 10: M110.002741. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227: 680-685. Laplace, J. M., N. Sauvageot, A. Hartke and Y. Auffray. 1999. Characterization of Lactobacillus collinoides response to heat, acid and ethanol treatments. Appl. Microbiol. Biotechnol. 51: 659-663. Laureys, D. and L. De Vuyst. 2014. Microbial species diversity, community dynamics, and metabolite kinetics of water kefir fermentation. Appl. Environ. Microbiol. 80: 2564-2572. Lechner, S., U. Muller-Ladner, K. Schlottmann, B. Jung, M. McClelland, J. Ruschoff, J. Welsh, J. Scholmerich, and F. Kullmann. 2002. Bile acids mimic oxidative stress induced upregulation of thioredoxin reductase in colon cancer cell lines. Carcinogenesis. 23: 1281-1288. Lee, J. Y., E. A. Pajarillo, M. J. Kim, J. P. Chae and D. K. Kang. 2013. Proteomic and transcriptional analysis of Lactobacillus johnsonii PF01 during bile salt exposure by iTRAQ shotgun proteomics and quantitative RT-PCR. J. Proteome Res. 12: 432-443. Lee, K., H. G. Lee, K. Pi and Y. J. Choi. 2008. The effect of low pH on protein expression by the probiotic bacterium Lactobacillus reuteri. Proteomics. 8: 1624-1630. Lee, S. Y. 2004. Microbial safety of pickled fruits and vegetables and hurdle technology. Int. J. Food Saf. 4: 21-32. Lemay, M. J., N. Rodrigue, C. Gariépy and L. Saucier. 2000. Adaptation of Lactobacillus alimentarius to environmental stresses. Int. J. Food Microbiol. 55: 249-253. Lepage, G. and C. C. Roy. 1986. Direct transesterification of all classes of lipids in a one-step reaction. J. Lipid Res. 27: 114-120. Leverrier, P., D. Dimova, V. Pichereau, Y. Auffray, P. Boyaval and G. Jan. 2003. Susceptibility and adaptive response to bile salts in Propionibacterium freudenreichii: physiological and proteomic analysis. Appl. Environ. Microbiol. 69: 3809-3818. Li, S., R. Huang, N. P. Shah, X. Tao, Y. Xiong and H. Wei. 2014. Antioxidant and antibacterial activities of exopolysaccharides from Bifidobacterium bifidum WBIN03 and Lactobacillus plantarum R315. J. Dairy Sci. 97: 7334-7343. Lin, Y. C., Y. T. Chen, H. H. Hsieh and M. J. Chen. 2016. Effect of Lactobacillus mali APS1 and L. kefiranofaciens M1 on obesity and glucosehomeostasis in diet-induced obese mice. J. Funct. Foods. 23: 580-589. Looijesteijn, P. J., and J. Hugenholtz. 1999. Uncoupling of growth and exopolysaccharide production by Lactococcus lactis subsp. cremoris NIZO B40 and optimization of its synthesis. J. Biosci. Bioeng. 88: 178-182. Lorca, G. L. and G. F. Valdez. 2001. A low-pH-inducible, stationary-phase acid tolerance response in Lactobacillus acidophilus CRL 639. Curr. Microbiol. 42: 21-25. Louis, P., H. G. Trüper and E. A. Galinski. 1994. Survival of Escherichia coli during drying and storage in the presence of compatible solutes. Appl. Microbiol. Biotechnol. 41: 684-688. Low, D., J. A. Ahlgren, D. Horne, D. J. McMahon, C. J. Oberg and J. R. Broadbent. 1998. Role of Streptococcus thermophilus MR-1C capsular exopolysaccharide in cheese moisture retention. Appl. Environ. Microbiol. 64: 2147-2151. Magalhães, G., K. T., V. de M. Pereira, D. R. Dias and R. F. Schwan. 2010. Microbial communities and chemical changes during fermentation of sugary Brazilian kefir. World J. Microbiol. Biotechnol. 26: 1241-1250. Marceau, A., M. Zagorec and M. Champomier-Verges. 2002. Analysis of Lactobacillus sakei adaptation to its environment by a proteomic approach. Sci. Aliments. 22: 97-105. Marshall-Jones, Z. V., M. L. Baillon, J. M. Croft and R. F. Butterwick. 2006. Effects of Lactobacillus acidophilus DSM13241 as a probiotic in healthy adult cats. Am. J. Vet. Res. 67: 1005-1012. Meury, J. 1988. Glycine betaine reverses the effects of osmotic stress on DNA replication and cellular division in Escherichia coli. Arch. Microbiol. 149: 232-239. Nakimbugwe, D., B. Masschalck, G. Anim, and C. W. Michiels. 2006. Inactivation of gram-negative bacteria in milk and banana juice by hen egg white and lambda lysozyme under high hydrostatic pressure. Int. J. Food Microbiol. 112: 19–25. Narberhaus, F. 2002. Alpha-crystallin-type heat shock proteins: socializing minichaperones in the context of a multichaperone network. Microbiol. Mol. Biol. Rev. 66: 64-93. Palmfeldt, J. and B. Hahn-Hägerdal. 2000. Influence of culture pH on survival of Lactobacillus reuteri subjected to freeze-drying. Int. J. Food Microbiol. 55: 235-238. Panoff, J. M., B. Thammavongs and M. Guéguen. 2000. Cryoprotectants lead to phenotypic adaptation to freeze-thaw stress in Lactobacillus delbrueckii ssp. bulgaricus CIP 101027T. Cryobiology. 40: 264-269. Panoff, J. M., B. Thammavongs, J. M. Laplace, A. Hartke, P. Boutibonnes and Y. Auffray. 1995. Cryotolerance and Cold Adaptation in Lactococcus lactis Subsp. lactis IL1403. Cryobiology. 32: 516-520. Papadimitriou, K., Á. Alegría, P. A. Bron, M. de Angelis, M. Gobbetti, M. Kleerebezem, J. A. Lemos , D. M. Linares , P. Ross, C. Stanton, F. Turroni, D. van Sinderen, P. Varmanen, M. Ventura, M. Zúñiga, E. Tsakalidou and J. Kok. 2016. Stress Physiology of Lactic Acid Bacteria. Microbiol. Mol. Biol. Rev. 80: 837-890. Payne, C. M., C. Crowley, D. Washo, H. Bernstein, C. Bernstein and M. Briel. 1998. The stress-response proteins poly(ADP-ribose) polymerase and NF-kappaB protect against bile salt-induced apoptosis. Cell Death Differ. 5: 623-636. Pfeiler, E. A. and T. R. Klaenhammer. 2009. Role of Transporter Proteins in Bile Tolerance of Lactobacillus acidophilus. Appl. Environ. Microbiol. 75: 6013–6016. Pfeiler, E. A., M. A. Azcarate-Peril and T. R. Klaenhammer. 2007. Characterization of a novel bile-inducible operon encoding a two-component regulatory system in Lactobacillus acidophilus. J. Bacteriol. 189: 4624-4634. Piddock, L. J. 2006. Multidrug-resistance efflux pumps - not just for resistance. Nat. Rev. Microbiol. 4: 629-636. Pieterse, B., R. J. Leer, F. H. Schuren and M. J. van der Werf. 2005. Unravelling the multiple effects of lactic acid stress on Lactobacillus plantarum by transcription profiling. Microbiology. 151:3881-3894. Piper, P. W. 1993. Molecular events associated with acquisition of heat tolerance by the yeast Saccharomyces cerevisiae. FEMS Microbiol. Rev. 11: 339-355. Piper, P. W., C. Ortiz-Calderon, C. Holyoak, P. Coote and M. Cole. 1997. Hsp30, the integral plasma membrane heat shock protein of Saccharomyces cerevisiae, is a stress-inducible regulator of plasma membrane H(+)-ATPase. Cell Stress Chaperones. 2: 12-24. Powell, A. A., J. M. LaRue, A. K. Batta and J. D. Martinez. 2001. Bile acid hydrophobicity is correlated with induction of apoptosis and/or growth arrest in HCT116 cells. Biochem. J. 356: 481-486. Rajagopalan, N. and S. Lindenbaum. 1982. The binding of Ca2+ to taurine and glycine-conjugated bile salt micelles. Biochim. Biophys. Acta. 711: 66-74. Robinson, R. K. 1987. Survival of Lactobacillus acidophilus in fermented products. S. Afr. J. Dairy Sci. 19: 25-27. Roth, W. G., M. P. Leckie and D. N. Dietzler. 1985a. Osmotic stress drastically inhibits active transport of carbohydrates by Escherichia coli. Biochem. Biophys. Res. Commun. 126: 434- 441. Roth, W. G., S. E. Porter, M. P. Leckie, B. E. Porter and D. N. Dietzler. 1985b. Restoration of cell volume and the reversal of carbohydrate transport and growth inhibition of osmotically upshocked Escherichia coli. Biochem. Biophys. Res. Commun. 126: 442-449. Ruas-Madiedo, P., J. Hugenholtz and P. Zoon. 2002. An overview of the functionality of exopolysaccharides produced by lactic acid bacteria. Int. Dairy J.12: 163-171. Ruiz, L., A. Margolles and B. Sanchez. 2013. Bile resistance mechanisms in Lactobacillus and Bifidobacterium. Front Microbiol. 4: 396. Russel, N. J. and N. Fukanage. 1990. A comparison of thermal adaptation of membrane lipids in psychrophilic and thermophilic bacteria. FEMS Microbiol. Rev. 75:171-182. Ryan, P. M., R. P. Ross, G. F. Fitzgerald, N. M. Caplice and C. Stanton. 2015. Sugar-coated: exopolysaccharide producing lactic acid bacteria for food and human health applications. Food Funct. 6: 679-693. Saarela, M., M. Rantala, K. Hallamaa, L. Nohynek, I. Virkajärvi and J. Mättö. 2004. Stationary‐phase acid and heat treatments for improvement of the viability of probiotic lactobacilli and bifidobacteria. J. Appl. Microbiol. 96: 1205-1214. Sanchez, B., L. Ruiz, M. Gueimonde, P. Ruas-Madiedo, and A. Margolles. 2013. Adaptation of bifidobacteria to the gastrointestinal tract and functional consequences. Pharmacol. Res. 69: 127-136. Sandrin, T. R., J. E. Goldstein and S. Schumaker. 2013. MALDI TOF MS profiling of bacteria at the strain level: a review. Mass Spectrom. Rev. 32: 188-217. Sanhueza, E., E. Paredes-Osses, C. L. González and A. García. 2015. Effect of pH in the survival of Lactobacillus salivarius strain UCO_979C wild type and the pH acid acclimated variant. Electron. J. Biotechnol. 18: 343-346. Sanyal, A. J., M. L. Shiffman, J. I. Hirsch and E. W. Moore. 1991. Premicellar taurocholate enhances ferrous iron uptake from all regions of rat small intestine Gastroenterology. 101: 382-389. Sauer, S. and M. Kliem. 2010. Mass spectrometry tools for the classification and identification of bacteria. Nat. Rev. Microbiol. 8: 74-82. Schmidt, G., C. Hertel and W. P. Hammes. 1999. Molecular characterisation of the dnaK operon of Lactobacillus sakei LTH681. Syst. Appl. Microbiol. 22: 321-328. Schott, A. S., J. Behr, J. Quinn and R. F. Vogel. 2016. MALDI-TOF Mass Spectrometry Enables a Comprehensive and Fast Analysis of Dynamics and Qualities of Stress Responses of Lactobacillus paracasei subsp. paracasei F19. PLoS. ONE. 11: e0165504. Sedewitz, B., K. H. Schleifer and F. Götz. 1984. Purification and biochemical characterization of pyruvate oxidase from Lactobacillus plantarum. J. Bacteriol. 160: 273–278. Selma, M. V., M. C. Salmeron, M. Valero and P. S. Fernandez. 2006. Efficacy of pulsed electric fields for Listeria monocytogenes inactivation and control in horchata. J. Food Saf. 26: 137-149. Seto, A., Y. Saito, M. Matsushige, H. Kobayashi, Y. Sasaki, N. Tonouchi, T. Tsuchida, F. Yoshinaga, K. Ueda and T. Beppu. 2006. Effective cellulose production by a coculture of Gluconacetobacter xylinus and Lactobacillus mali. Appl. Microbiol. Biotechnol. 73: 915-921. Shao, Y., S. Gao, H. Guo and H. Zhang. 2014. Influence of culture conditions and preconditioning on survival of Lactobacillus delbrueckii subspecies bulgaricus ND02 during lyophilization. J. Dairy Sci. 97: 1270-1280. Singh, S. and R. Shalini. 2016. Effect of Hurdle Technology in Food Preservation: A Review. Crit. Rev. Food Sci. Nutr. 56: 641-649. Singhal, N., M. Kumar, P. K. Kanaujia and J. S. Virdi. 2015. MALDI-TOF mass spectrometry: an emerging technology for microbial identification and diagnosis. Front Microbiol. 6: 791. Sokol, R. J., B. M. Winklhofer-Roob, M. W. Devereaux and Jr. J. M. McKim. 1995. Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids. Gastroenterology. 109: 1249-1256. Stentz, R., C. Loizel, C. Mallert and M. Zagorec. 2000. Development of genetic tools for Lactobacillus sakei: disruption of the beta-galactosidase gene and use of lacZ as a reporter gene To study regulation of the putative copper ATPase, AtkB. Appl. Environ. Microbiol. 66: 4272-4278. Stock, J. B., B. Rauch and S. Roseman. 1977. Periplasmic space in Salmonella typhimurium and Escherichia coli. J. Biol. Chem. 252: 7850-7861. Stolz, P., G. Bocker, W. P. Hammes and R. F. Vogel. 1995. Utilization of electron acceptors by lactobacilli isolated from sourdough. Z Lebensm Unters Forsch. 201: 402–410. Storz, G. and R. Hengge. 2010. Bacterial stress responses. American Society for Microbiology Press. Washington, DC, USA. Streit, F., G. Corrieu and C. Béal. 2007. Acidification improves cryotolerance of Lactobacillus delbrueckii subsp. bulgaricus CFL1. J. Biotechnol. 128: 659-667. Streit, F., J. Delettre, G. Corrieu and C. Beal. 2008. Acid adaptation of Lactobacillus delbrueckii subsp. bulgaricus induces physiological responses at membrane and cytosolic levels that improves cryotolerance. J. Appl. Microbiol. 105: 1071-1080. Sturme, M. H., J. Nakayama, D. Molenaar, Y. Murakami, R. Kunugi, T. Fujii, E. E. Vaughan, M. Kleerebezem and W. M. de Vos. 2005. An agr-like two-component regulatory system in Lactobacillus plantarum is involved in production of a novel cyclic peptide and regulation of adherence. J. Bacteriol. 187: 5224-5235. Sturme, M. H., M. Kleerebezem, J. Nakayama, A. D. Akkermans, E. E. Vaughan and W. M. de Vos. 2002. Cell to cell communication by autoinducing peptides in gram-positive bacteria. Antonie Van Leeuwenhoek. 81: 233-243. Suokko, A., M. Poutanen, K. Savijoki, N. Kalkkinen and P. Varmanen. 2008. ClpL is essential for induction of thermotolerance and is potentially part of the HrcA regulon in Lactobacillus gasseri. Proteomics. 8: 1029-1041. Tanigawa, K., H. Kawabata and K. Watanabe. 2010. Identification and Typing of Lactococcus lactis by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry. Appl. Environ. Microbiol. 76: 4055-4062. Taranto, M. P., M. L. Fernandez Murga, G. Lorca and G. F. de Valdez. 2003. Bile salts and cholesterol induce changes in the lipid cell membrane of Lactobacillus reuteri. J. Appl. Microbiol. 95: 86-91. Teixeira, P., H. Castro, C. Moha’csi-Farkas1and R. Kirby. 1997. Identification of sites of injury in Lactobacillus bulgaricus during heat stress. J. Appl. Microbiol. 83: 219-226. Teramoto, K., H. Sato, L. Sun, M. Torimura and H. Tao. 2007. A simple intact protein analysis by MALDI-MS for characterization of ribosomal proteins of two genome-sequenced lactic acid bacteria and verification of their amino acid sequences. J. Proteome Res. 6: 3899-3907. Thammavongs, B., D. Corroler, J. M. Panoff, Y. Auffray and P. Boutibonnes. 1996. Physiological response of Enterococcus faecalis JH2-2 to cold shock: growth at low temperatures and freezing/thawing challenge. Lett. Appl. Microbiol. 23: 398-402. Torino, M. I., M. P. Taranto, F. Sesma and G. F. de Valdez. 2001. Heterofermentative pattern and exopolysaccharide production by Lactobacillus helveticus ATCC 15807 in response to environmental pH. J. Appl. Microbiol. 91: 846-852. Tsakalidou, E. and K. Papadimitriou. 2011. Stress Responses of Lactic Acid Bacteria. Springer-Verlag New York Inc. New York, NY, USA. Ullrich, M. 2009. Bacterial Polysaccharides: Current Innovations and Future Trends. Caister Academic Press, Poole, UK. van de Guchte, M., P. Serror, C. Chervaux, T. Smokvina, S. D. Ehrlich and E. Maguin. 2002. Stress responses in lactic acid bacteria. Antonie van Leeuwenhoek. 82: 187-216. Walker, D. C., H. S. Girgis and T. R. Klaenhammer. 1999. The groESL Chaperone Operon of Lactobacillus johnsonii. Appl. Environ. Microbiol. 65: 3033-3041. Walker, J. E., M. Saraste and N. J. Gay. 1984. The UNC operon nucleotide sequence, regulation and structure of ATP-synthase. Biochim. Biophys. Acta. 768: 164-200. Walter, R. P., J. G. Morris and D. B. Kell. 1987. The roles of osmotic stress and water activity in the inhibition of the growth, glycolysis and glucose phosphotransferase system of Clostridium pasteurianum. J. Gen. Microbiol. 133:259-266. Wang, G., S. Yin, H. An, S. Chen and Y. Hao. 2011. Coexpression of bile salt hydrolase gene and catalase gene remarkably improves oxidative stress and bile salt resistance in Lactobacillus casei. J. Ind. Microbiol. Biotechnol. 38: 985-990. Wang, Y., G. Corrieu and C. Béal. 2005a. Fermentation pH and temperature influence the cryotolerance of Lactobacillus acidophilus RD758. J. Dairy Sci. 88: 21-29. Wang, Y., J. Delettre, A. Guillot, G. Corrieu and C. Béal. 2005b. Influence of cooling temperature and duration on cold adaptation of Lactobacillus acidophilus RD758. Cryobiology. 50: 294-307. Weitzel, G., U. Pilatus and L. Rensing. 1987. The cytoplasmic pH, ATP content and total protein synthesis rate during heat-shock protein inducing treatments in yeast. Exp. Cell Res. 170: 64-79. Whitehead, K., J. Versalovic, S. Roos and R. A. Britton. 2008. Genomic and Genetic Characterization of the Bile Stress Response of Probiotic Lactobacillus reuteri ATCC 55730. Appl. Environ. Microbiol. 74: 1812-1819. Wong, S., B. M. Kabeir, S. Mustafa, R. Mohamad, A. S. M. Hussin and M. Y. Manap. 2010. Viability of Bifidobacterium Pseudocatenulatum G4 after spray-Drying and Freeze-Drying. Microbiol. Insights. 3: 37-43. Wouters, J. A., B. Jeynov, F. M. Rombouts, W. M. de Vos, O. P. Kuipers and T. Abee. 1999. Analysis of the role of 7 kDa cold-shock proteins of Lactococcus lactis MG1363 in cryoprotection. Microbiology. 145: 3185-3194. Wouters, J. A., F. M. Rombouts, O. P. Kuipers, W. M. de Vos and T. Abee. 2000. The Role of Cold-Shock Proteins in Low-Temperature Adaptation of Food-Related Bacteria. Syst. Appl. Microbiol. 23: 165-173. Wu, C., G. He and J. Zhang. 2014. Physiological and proteomic analysis of Lactobacillus casei in response to acid adaptation. J. Ind. Microbiol. Biotechnol. 41: 1533-1540. Wu, M.H., T. M. Pan, Y. J. Wu, S. J. Chang, M. S. Chang and C. Y. Hu. 2010. Exopolysaccharide activities from probiotic bifidobacterium: Immunomodulatory effects (on J774A.1 macrophages) and antimicrobial properties. Int. J. Food Microbiol. 144: 104-110. Wu, V. C. H. and D. Y. C. Fung. 2001. Evaluation of Thin Agar Layer Method for Recovery of Heat‐Injured Foodborne Pathogens. J. Food Sci. 66: 580-583. Yamanaka, K., L. Fang and M. Inouye. 1998. The CspA family in Escherichia coli: multiple gene duplication for stress adaptation. Mol. Microbiol. 27: 247-255. Yang, F., C. Hou, X. Zeng and S. Qiao. 2015. The use of lactic Acid bacteria as a probiotic in Swine diets. Pathogens. 4: 34-45. Yanokura, E., K. Oki, H. Makino, M. Modesto, B. Pot, P. Mattarelli, B. Biavati and K.Watanabe. 2015. Subspeciation of Bifidobacterium longum by multilocus approaches and amplified fragment length polymorphism: Description of B. longum subsp. suillum subsp. nov., isolated from the faeces of piglets. Syst. Appl. Microbiol. 38: 305-314. Zink, R., C. Walker, G. Schmidt, M. Elli, D. Pridmore and R. Reniero. 2000. Impact of multiple stress factors on the survival of dairy lactobacilli. Sci. Aliments. 20: 119-126. Zuljan, F. A., G. D. Repizo, S. H. Alarcon and C. Magni. 2014. α-Acetolactate synthase of Lactococcus lactis contributes to pH homeostasis in acid stress conditions. Int. J. Food Microbiol. 188: 99-107. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/70377 | - |
dc.description.abstract | Lactobacillus mali APS1為自糖液克弗爾粒中分離出,一具潛力的益生菌株,其已被證實具有免疫調節、抗結腸炎和抗肥胖等諸多機能性。而益生菌之益生特質的發揮與其活菌數息息相關,然而益生菌產品生產及使用過程中,菌體將面臨各式各樣的環境壓力,如冷、熱、酸和膽鹽,這些環境壓力都將造成菌體菌數大幅減少,而影響機能性的發揮。因此,微生物為了抵抗環境壓力的威脅,演化出一套防禦系統,幫助菌體適應這些致死或次致死的環境,而本研究即為探Lactobacillus mali APS1於不同壓力下,如冷、熱、酸和膽鹽等環境中之適應性反應的表現和存活率變化。
首先在L. mali APS1壓力敏感性結果顯示, L. mali APS1之冷、熱、酸和膽鹽之次致死和致死環境分別為10°C和-20°C、42°C和52°C、pH 3.5和pH 2.0以及0.1% 和2.0%膽鹽濃度。冷、熱和膽鹽適應處理可誘導L. mali APS1之同源壓力耐受性,而冷和膽鹽適應可對L. mali APS1於熱致死挑戰下提供交叉保護的效果,而冷和熱適應亦可提供L. mali APS1於膽鹽致死挑戰下一定交叉保護作用,另酸和膽鹽適應可增加L. mali APS1於冷致死挑戰下之存活率。此外,酸和冷適應之L. mali APS1經冷凍乾燥處理後存活率顯著高於熱及膽鹽適應組 (p < 0.05) 。胞外多醣體產量各適應組與未適應組間無顯著差異 (p > 0.05) ,而經後續致死挑戰後存活率較高的適應處理組別,在掃描式電子顯微鏡觀察下可觀察到較少細胞損壞的情形,而在蛋白質體分析部分,各處理組間和未適應組以迷你膠體電泳分析之蛋白質條帶無發現明顯差異,但透過基質輔助雷射脫附離子化飛行時間質譜儀 (matrix-assisted laser desorption/ionization time-of-flight mass spectrometer, MALDI-TOF MS) 之分析,可觀察到各處理組間部份訊號變化,而各組進一步以主成分分析 (Principal Component Analysis, PCA) ,發現可將適應組和未適應組進行分群。 綜上所述,本研究發現次致死適應可作為提升L. mali APS1於致死環境壓力下存活表現之可能策略,此外,根據菌體形態和蛋白質體分析結果,發現經適應之L. mali APS1可被誘導壓力適應反應,幫助菌體維持生存能力和細胞完整性。 | zh_TW |
dc.description.abstract | Lactobacillus mali APS1, a potential probiotic strain isolated from sugar kefir grains, has been proven its functionalities about immune-regulation, anti-colitis, and anti-obesity. Live probiotics with certain amount of number are essential for healthy beneficial. However, probiotics encounter critical environmental stress such as cold, heat, acid and bile salts, which dramatically decrease the survival and functionality of probiotics. Therefore, bacteria evolve a system defensing to help them adapting to lethal or sublethal condition. Thus, the objective of this study was to investigate the adaptive responses and viability of L. mali APS1 to various environmental stresses, such as cold, heat, acid, and bile salts.
The stress susceptibility results showed that the sublethal and lethal condition of acid, bile salt, heat and cold for L. mali APS1 were 10°C and -20°C, 42°C and 52°C, pH 3.5 and pH 2.0, and 0.1% and 2%, respectively. The subsequent lethal challenge survival results showed that sublethal adaptation of L. mali APS1 to cold, heat and bile salts could induce homologous tolerance. Adaptation to cold and bile provided cross-protection against heat challenge (52°C). Adaptation to cold and heat improved the resistance to bile salt stress (2%). Adaptation to acid and bile increased survival of L. mali APS1 under cold lethal challenge. Besides, after freeze drying, survival of cold and acid adapted cells was significantly higher than heat and bile adapted cells (p < 0.05). Exopolysaccharides production of all stress-adapted and non-adapted cells have no significant difference (p > 0.05). Adapted cells with higher survival were observed minor cell damage after subsequent lethal challenge by scaning electron microscopy (SEM). For proteomics analysis, no significant difference was observed in Mini SDS-PAGE results, but signal change was detected from matrix-assisted laser desorption/ionization time-of-flight mass spectrometer(MALDI-TOF MS) between adapted and non-adapted cells and further grouped by principle component analysis (PCA). In conclusion, this study revealed that sublethal adaptation could be a possible strategy to improve survival of L. mali APS1 in lethal stress condition. Besides, according to morphological and proteomics analysis results, it was found that some adaptive response could be induced to maintain survival and integrity of adapted L. mali APS1. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T04:26:53Z (GMT). No. of bitstreams: 1 ntu-107-R05626023-1.pdf: 3496974 bytes, checksum: dd60acc476d32c38a32b3df82bcb4ca7 (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 誌謝 i
中文摘要 ii Abstract iv 目 錄 vi 圖目錄 xi 表目錄 xii 緒 言 xiii 壹、 文獻探討 1 一、 Lactobacillus mali APS1之分離與機能性 1 (一) 菌株分離 1 (二) 菌種特性 1 (三) 菌株機能性 2 二、 乳酸菌適應性壓力反應 (adaptive stress response) 3 (一) L. mali菌株可能面臨的環境壓力 3 1. pH值 4 2. 溫度 5 3. 膽鹽 5 4. 滲透壓 8 5. 氧化壓力 8 6. 營養來源 9 7. 其他因子 9 (二) 適應性壓力反應 10 (三) 酸適應處理對菌體存活之影響 11 (四) 膽鹽適應處理對菌體存活之影響 11 (五) 冷適應處理對菌體存活之影響 12 (六) 熱適應處理對菌體存活之影響 12 (七) 適應性壓力反應機制 17 (八) 酸適應反應機制 17 1. 維持胞內pH值恆定 18 2. 改變代謝路徑 18 3. 誘發壓力蛋白及伴護蛋白的表現 19 4. 改變細胞膜脂肪酸組成 20 (九) 膽鹽適應反應機制 20 1. 膽鹽外排系統 20 2. 膽鹽水解酶 21 3. 改變細胞外層結構 21 4. 表現壓力蛋白 22 (十) 冷適應反應機制 23 1. 修飾細胞膜脂肪酸組成 23 2. 調控相容性溶質濃度 24 3. 誘發與熱壓力反應相關蛋白質及冷誘導蛋白表現 24 (十一) 熱適應反應機制 24 1. 熱震蛋白 25 2. Clp多元複合物 25 3. 小熱震蛋白 26 4. 調節代謝酵素之表現 26 貳、 材料與方法 28 一、 實驗架構 28 二、 材料方法 29 (一) 菌株來源及保存 29 (二) 實驗菌液之製備 29 (三) L. mali APS1 對各式壓力之敏感性 30 (四) L. mali APS1 之壓力適應處理 30 (五) L. mali APS1 於後續不同致死環境壓力中之存活測定 30 (六) L. mali APS1冷凍乾燥處理 31 (七) L. mali APS1於冷凍乾燥後之存活實驗 31 (八) L. mali APS1胞外多醣體產量測定 31 (九) 以掃描式電子顯微鏡觀察L. mali APS1之樣品製備 32 (十) L. mali APS1菌體脂肪酸組成分析 33 1. 脂肪酸之萃取 33 2. 脂肪酸成分分析 33 (十一) 蛋白質表現分析 34 1. 菌體胞內粗蛋白萃取 34 2. 基質輔助雷射脫附離子化飛行時間質譜儀所需蛋白質之萃取 35 3. MALDI-TOF MS蛋白質分析 35 4. 蛋白質定量與濃度調整 36 5. 迷你膠體電泳分析 36 (十二) 菌數測定 39 (十三) 統計分析 39 參、 結果 40 第一節 : L. mali APS1於不同環境壓力下生長情形與耐受性表現 40 一、 L. mali APS1對不同壓力之敏感性 40 (一) L. mali APS1之冷敏感性 40 (二) L. mali APS1之熱敏感性 40 (三) L. mali APS1之酸敏感性 41 (四) L. mali APS1之膽鹽敏感性 41 二、 不同壓力適應處理L. mali APS1於後續致死壓力挑戰下存活表現結果 47 (一) 不同壓力適應處理對L. mali APS1於低溫環境下存活表現之影響 47 (二) 不同壓力適應處理對L. mali APS1於高溫環境下存活表現之影響 47 (三) 不同壓力適應處理對L. mali APS1於酸性環境下存活表現之影響 48 (四) 不同壓力適應處理對L. mali APS1於膽鹽環境下存活表現之影響 49 (五) 不同壓力適應處理對L. mali APS1經冷凍乾燥後存活表現之影響 55 第二節 次致死壓力適應對L. mali APS1生理特性之影響 57 一、 次致死壓力適應及致死壓力挑戰對L. mali APS1菌體型態之影響 57 (一) 未適應及壓力適應處理之L. mali APS1菌體型態觀察 57 (二) 未適應及壓力適應處理之L. mali APS1熱致死挑戰後菌體型態觀察 58 (三) 未適應及壓力適應處理之L. mali APS1酸致死挑戰後菌體型態觀察 58 (四) 未適應及壓力適應處理之L. mali APS1膽鹽致死挑戰後菌體型態觀察 59 二、 次致死壓力適應對L. mali APS1胞外多醣體產量之影響 65 三、 次致死壓力適應對L. mali APS1菌體蛋白質表現之影響 67 (一) 迷你膠體電泳分析 67 (二) MALDI-TOF MS質譜分析結果 67 (三) 將MALDI-TOF MS訊號波峰進行主成分分析之結果 68 肆、 討論 72 一、 L. mali APS1於不同環境壓力下之生長情形與耐受性表現 72 二、 次致死壓力適應對L. mali APS1生理特性之影響 77 伍、 結論 82 陸、 參考文獻 83 | |
dc.language.iso | zh-TW | |
dc.title | Lactobacillus mali APS1於不同壓力下存活與適應性反應之探討 | zh_TW |
dc.title | Investigation on the survival and adaptive responses of Lactobacillus mali APS1 under various stresses | en |
dc.type | Thesis | |
dc.date.schoolyear | 106-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 江明倫 | |
dc.contributor.oralexamcommittee | 周正俊,廖?成,王聖耀 | |
dc.subject.keyword | Lactobacillus mali APS1,次致死,壓力適應,交叉保護,基質輔助雷射脫附離子化飛行時間質譜儀, | zh_TW |
dc.subject.keyword | Lactobacillus mali APS1,sublethal,stress adaptation,cross-protection,MALDI-TOF MS, | en |
dc.relation.page | 103 | |
dc.identifier.doi | 10.6342/NTU201803121 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2018-08-14 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 動物科學技術學研究所 | zh_TW |
顯示於系所單位: | 動物科學技術學系 |
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