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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 方啟泰 | |
| dc.contributor.author | Kuan-Yin Lin | en |
| dc.contributor.author | 林冠吟 | zh_TW |
| dc.date.accessioned | 2021-06-17T04:24:25Z | - |
| dc.date.available | 2018-08-31 | |
| dc.date.copyright | 2018-08-31 | |
| dc.date.issued | 2018 | |
| dc.date.submitted | 2018-08-15 | |
| dc.identifier.citation | 1. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017; 390(10100): 1211-59.
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Lee YL, Lin KY, Cheng CY, et al. Evolution of hepatitis A virus seroprevalence among HIV-positive adults in Taiwan. PloS One 2017; 12(10): e0186338. 11. Kourkounti S, Paparizos V, Leuow K, Paparizou E, Antoniou C. Adherence to hepatitis A virus vaccination in HIV-infected men who have sex with men. International Journal of STD & AIDS 2015; 26(12): 852-6. 12. Advisory Committee on Immunization Practices. Recommended adult immunization schedule: United States, 2012. Annals of Internal Medicine 2012; 156(3): 211-7. 13. HAVRIX: Full Prescription Information (Package Insert). GlaxoSmithKline Biologicals, 2017. 14. VAQTA: Full Prescription Information (Package Insert). MERCK&Co, 2017. 15. Shire NJ, Welge JA, Sherman KE. Efficacy of inactivated hepatitis A vaccine in HIV-infected patients: a hierarchical bayesian meta-analysis. Vaccine 2006; 24(3): 272-9. 16. Lin KY, Hsieh SM, Sun HY, et al. 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Comparative effectiveness of two doses versus three doses of hepatitis A vaccine in human immunodeficiency virus-infected and -uninfected men who have sex with men. Hepatology 2013; 57(5): 1734-41. 25. Tortajada C, de Olalla PG, Diez E, et al. Hepatitis A among men who have sex with men in Barcelona, 1989-2010: insufficient control and need for new approaches. BMC Infectious Diseases 2012; 12: 11. 26. Lin KY, Chen GJ, Lee YL, et al. Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review. World Journal of Gastroenterology 2017; 23(20): 3589-606. 27. Tjon GM, Coutinho RA, van den Hoek A, et al. High and persistent excretion of hepatitis A virus in immunocompetent patients. Journal of Medical Virology 2006; 78(11): 1398-405. 28. Zucman D, Farfour E, Mazaux L, et al. How to face the outbreak of viral hepatitis A in men-who-have-sex-with-men in France without vaccines? Clinical Infectious Diseases 2017; 65(6): 1053-54. 29. Zamir C, Rishpon S, Zamir D, Leventhal A, Rimon N, Ben-Porath E. Control of a community-wide outbreak of hepatitis A by mass vaccination with inactivated hepatitis A vaccine. European Journal of Clinical Microbiology & Infectious Diseases 2001; 20(3): 185-7. 30. Cheng A, Chang SY, Sun HY, et al. Long-term durability of responses to 2 or 3 doses of hepatitis A vaccination in human immunodeficiency virus-positive adults on antiretroviral therapy. The Journal of Infectious Diseases 2017; 215(4): 606-13. Supplementary references 1. Lin KY, Hsieh SM, Sun HY, et al. Serologic responses and effectiveness of hepatitis A vaccination among human immunodeficiency virus-positive individuals during the outbreak of acute hepatitis A. Hepatology 2018; 68(1): 22-31. 2. Taiwan CDC. Guidelines for diagnosis and treatment of HIV/AIDS. 2013. Available at: http://www.cdc.gov.tw/uploads/files/201310/1e64c227-32fc-49ab-8bfc-9484ec50c4f3.pdf (accessed August 1, 2018). 3. The L. Syphilis: an ancient disease in a modern era. Lancet 2017; 389(10078): 1492. 4. Wu HH, Shen YT, Chiou CS, Fang CT, Lo YC. Shigellosis outbreak among MSM living with HIV: a case-control study in Taiwan, 2015-2016. Sexually Transmitted Infections 2018. doi: 10.1136/sextrans-2017-053410. 5. Wu HJ, Chang CC, Fang CT. Scaling-up pre-exposure prophylaxis (PrEP) as a strategy to eliminate HIV transmission among men who have sex with men (MSM): a modeling study. The 21th International AIDS Conference. Durban, South Africa. 18–22 July 2016. . 6. Lee YL, Lin KY, Cheng CY, et al. Evolution of hepatitis A virus seroprevalence among HIV-positive adults in Taiwan. PloS One 2017; 12(10): e0186338. 7. Lin KY, Chen GJ, Lee YL, et al. Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review. World Journal of Gastroenterology 2017; 23(20): 3589-606. 8. Lee YL, Chen GJ, Chen NY, et al. Less severe but prolonged course of acute hepatitis A in HIV-positive patients than HIV-negative patients during an outbreak: A multicenter observational study. Clinical Infectious Diseases 2018. doi: 10.1093/cid/ciy328. 9. Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Philadelphia, PA:Elsevier/Saunders, 2015. 10. Tjon GM, Coutinho RA, van den Hoek A, et al. High and persistent excretion of hepatitis A virus in immunocompetent patients. Journal of Medical Virology 2006; 78(11): 1398-405. 11. HAVRIX: Full Prescription Information (Package Insert). GlaxoSmithKline Biologicals, 2017. 12. VAQTA: Full Prescription Information (Package Insert). MERCK&Co, 2017. 13. Lin KY, Hsieh SM, Sheng WH, et al. Comparable serologic responses to 2 different combinations of inactivated HAV vaccines in HIV-positive patients during the acute hepatitis A outbreak in Taiwan. The Journal of Infectious Diseases 2018; 218(5): 734-8. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/70218 | - |
| dc.description.abstract | 背景：自2015年起，急性A型肝炎於男男間性行為者之間再度爆發流行 。而台灣此次發生之大規模急性A型肝炎疫情，主要影響者為愛滋病毒感染之男男間性行為者。本研究旨在於台灣急性A型肝炎爆發流行期間，探討A型肝炎疫苗應用在群體層面上之效果。方法：因應急性A型肝炎爆發流行，台灣發起至少施打一劑A型肝炎疫苗的接種措施。我們先進行一項1:4的巢式病例對照研究以估算A型肝炎疫苗於愛滋病毒感染之男男間性行為者個人層面上之效果。再藉此進行一項針對男男間性行為者A型肝炎傳播之數理模型研究，根據其是否愛滋病毒感染分層，並將模型與台灣2015年6月至2017年12月間的疫情資料做校正，以評估A型肝炎疫苗接種措施於男男間性行為者群體層面上之效果。結果：於前瞻研究期間內，共收案1470位初始A肝抗體陰性之愛滋病毒感染者，其中共有55位為罹患急性A型肝炎之病例，其成功配對於220位未罹患急性A型肝炎之病例。於愛滋病毒感染之男男間性行為者，施打一劑及兩劑A型肝炎疫苗之個人層面預防效果分別為96.1%及97.8%。在數理模型與疫情資料做校正後，我們估算傳播係數為2.47 month-1，因此相對應的基礎再生數(R0)在愛滋病毒感染者及未感染者分別為8.2與4.1。當假設數理模型未進行A型肝炎疫苗的接種措施時，則疫情會在第21個月達到高峰，並共有7410位急性A型肝炎感染者；而當假設數理模型有進行A型肝炎疫苗的接種措施時，則疫情會在第14個月達到高峰，並共有1303位急性A型肝炎感染者。因此能估算出A型肝炎疫苗接種措施於男男間性行為者群體層面上之效果為82.4%。結論：於愛滋病毒感染之男男間性行為者施打A型肝炎疫苗，能有效的遏止急性A型肝炎爆發流行。 | zh_TW |
| dc.description.abstract | Background: Outbreaks of acute hepatitis A among men who have sex with men (MSM) have reemerged since 2015. We aimed to investigate the population-level effectiveness of the hepatitis A virus (HAV) vaccination campaign during a large outbreak mainly affecting HIV-positive MSM in Taiwan. Methods: In response to the outbreak, a vaccination campaign mainly for HIV-positive MSM was implemented with administration of at least 1 dose of HAV vaccine. The individual-level effectiveness of HAV vaccine among HIV-positive individuals was first ascertained by a nested case-control study. A mathematical model of HAV transmission was then developed among MSM to estimate population-level effectiveness of the vaccination campaign. The model was risk-structured according to the HIV status and calibrated with the epidemic curve of acute hepatitis A in Taiwan during June 2015 to December 2017. Findings: Among 1,470 initially HAV-seronegative HIV-positive individuals in a prospective cohort, 55 case patients of acute hepatitis A were matched to 220 controls. Single-dose and 2-dose HAV vaccination provided an individual-level protection of 96.1% and 97.8% among HIV-positive MSM vaccinees, respectively. With model fitting to the whole epidemic curve, we estimated a transmission rate of 2.47 month-1 for HAV. The corresponding reproduction number (R0) were 8.2 and 4.1 for HIV-positive and HIV-negative MSM, respectively. In the simulated counterfactual scenario without the HAV vaccination campaign, the outbreak would peak in month 21 with a total of 7,410 incident cases. With the vaccination campaign, the epidemic peaked in month 14 with 1,303 incident cases, resulting in a population-level effectiveness of 82.4% among all MSM. Interpretation: HAV vaccination for MSM is a highly effective strategy to curb the hepatitis A outbreak in this high-risk population. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T04:24:25Z (GMT). No. of bitstreams: 1 ntu-107-R04847039-1.pdf: 1808077 bytes, checksum: a41977352363613480be2df567d50fdb (MD5) Previous issue date: 2018 | en |
| dc.description.tableofcontents | 碩士論文審定書 (I)
謝辭 (II) 中文摘要 (III) Abstract (V) 目錄 (VII) Introduction (1) Methods (3) Results (7) Discussion (10) References (14) Tables (19) Figures (21) Supplementary Appendix (25) Supplementary Table (32) Supplementary Figure (38) Supplementary Reference (40) | |
| dc.language.iso | en | |
| dc.subject | 糞口傳染 | zh_TW |
| dc.subject | 疫苗接種 | zh_TW |
| dc.subject | 男男間性行為 | zh_TW |
| dc.subject | 數理模型 | zh_TW |
| dc.subject | 病毒性肝炎 | zh_TW |
| dc.subject | mathematical model | en |
| dc.subject | faecal-oral transmission | en |
| dc.subject | men who have sex with men | en |
| dc.subject | immunization | en |
| dc.subject | viral hepatitis | en |
| dc.title | 2015-2017台灣急性A型肝炎爆發流行期間A型肝炎疫苗接種在男男間性行為者之效果 | zh_TW |
| dc.title | Effectiveness of Hepatitis A Vaccination among Men Who Have Sex With Men during an Acute Hepatitis A Outbreak in Taiwan, 2015-2017 | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 106-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 洪健清 | |
| dc.contributor.oralexamcommittee | 林先和,劉定萍 | |
| dc.subject.keyword | 病毒性肝炎,糞口傳染,疫苗接種,男男間性行為,數理模型, | zh_TW |
| dc.subject.keyword | viral hepatitis,faecal-oral transmission,immunization,men who have sex with men,mathematical model, | en |
| dc.relation.page | 42 | |
| dc.identifier.doi | 10.6342/NTU201802970 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2018-08-15 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 公共衛生碩士學位學程 | zh_TW |
| Appears in Collections: | 公共衛生碩士學位學程 | |
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