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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 沈湯龍(Tang-Long Shen) | |
| dc.contributor.author | Hsiang-Yi Hsu | en |
| dc.contributor.author | 徐向毅 | zh_TW |
| dc.date.accessioned | 2021-06-17T03:16:25Z | - |
| dc.date.available | 2023-07-06 | |
| dc.date.copyright | 2018-07-06 | |
| dc.date.issued | 2018 | |
| dc.date.submitted | 2018-07-04 | |
| dc.identifier.citation | Reference
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/69464 | - |
| dc.description.abstract | Antrodia cinnamomea (Syn. Taiwanofungus camphoratus and A. camphorata), an endemic medical fungus of Taiwan, grows on the inside of a tree hollow of the endemic broad-leaved tree, Cinnamomum kanehirae Hayata. Antrodia cinnamomea bears a number of bioactive compounds that exhibit beneficial effects to human health, such as immunomodulation, liver protection, and anti-cancer activity. Here, the dish-cultured A. cinnamomea fruiting body was subjected to analyze its morphological characteristics and major compounds. Moreover, the ethanol-extract of the dish-cultured A. cinnamomea fruiting body inhibited the in vitro growth of various human cancer cell lines, including liver cancer cell (Hep G2), breast carcinoma cell (MDA-MB-231, SkBr3 and MCF-7), lung cancer (H-1975, H-1650, H-292, A549), and neuroblastoma SK-N-SH. Nonetheless, the dish-cultured A. cinnamomea fruiting body extract did not show apparent toxicity to normal cell line, H9C2 a myoblast cell line. Furthermore, the in vivo study using nude mice showed that the oral administration of the dish-cultured A. cinnamomea fruiting body extract enables modulating the immune system as a result of increases in cytokine secretion, M1 macrophage (CD86+ CD11b+) activity, B cell (CD19+) population, and dendritic cells (CD11c+), whereas a decrease in M2 macrophage (CD206+ CD11b+) polarity, by which the dish-cultured A. cinnamomea fruiting body extract confers to its anti-tumor activity. This study implicated that the anti-tumor effect of the dish-cultured A. cinnamomea fruiting body is attributed by it immunomodulatory activities. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T03:16:25Z (GMT). No. of bitstreams: 1 ntu-107-R04633021-1.pdf: 3299433 bytes, checksum: fa6b6c8076d534923f69dbd1d2ee876e (MD5) Previous issue date: 2018 | en |
| dc.description.tableofcontents | 目 錄
口試委員會審定書………………………………………………………………………………………….. Ⅰ 中文摘要…………………………………………………………………………………………………………. Ⅳ Abstracts.…………………………………………………………………………………………………………. Ⅴ Introduction…………………………………………………………………………………………………….... 1 Material and Methods…………………………….…………………………………………………. 4 Strain cultivation………….……………………………………………………………………. 4 Strain and sequencing…………………...………………………………………………….. 4 Solid state cultivation……………………………………………………………………… 5 Liquid state cultivation…………………………………………………………………… 5 Metabolomics analysis………………………………………………………………………. 6 HPLC analysis………………………………………………………………………………… 6 LC-MS analysis……………………………………………………………………………… 6 Cell functional assay………………………………………………………………………….. 7 Cell lines and culture……………………………………………………………………. 7 MTT assay……………………………………………………………………………………. 7 Cell migration assay…………………………………………………………………….. 8 Soft agar assay…………………………………………………………………………….. 9 In vivo assay……………………………………………………………………………………. 9 In vivo xenograft studies…………………………………………………………….. 9 Flow cytometry………………………………………………………………………….. 10 ELISA……………………………………………………………………........................ 11 Immunohistochemistry………………………………………………………………. 12 Results…………………………………………………………………………………………………….. 12 Identification of solid state A. cinnamomea...…...……………………………….. 12 Metabolite profile of solid state A. cinnamomea fruiting body………………. 13 Cell bioactivity of extracts of solid state A. cinnamomea fruiting body………. 14 Cell toxicity…………………………………………………………………………………………….. 14 Inhibition of in vitro tumorigenicity……………………………………………………….. 15 Inhibition of in vivo tumor growth…………………………………………................. 15 Toxicity of dish-cultured A. cinnamomea fruiting body………………………….. 17 Immunomodulation of solid state fruiting body in normal mice……………. 17 Discussion……………………………………………………………………………………………………….. 18 References………………………………………………………………………………………………………. 23 Figures and Tables…………………………………………………………………………………………… 39 Supplementary……………………………………………………………………………………………….. 41 | |
| dc.language.iso | en | |
| dc.subject | 免疫調節 | zh_TW |
| dc.subject | 腫瘤抑制 | zh_TW |
| dc.subject | 子實體萃取物 | zh_TW |
| dc.subject | 皿培式牛樟芝 | zh_TW |
| dc.subject | Dish-cultured Antrodia cinnamomea | en |
| dc.subject | fruiting body extract | en |
| dc.subject | anti-tumor | en |
| dc.subject | immunomodulation | en |
| dc.title | 探討皿培式牛樟芝萃取物在抗腫瘤和免疫調節的功效 | zh_TW |
| dc.title | Investigation of anti-tumor and immunomodulatory effects of dish-cultured fruiting body extract of Antrodia cinnamomea | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 106-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 翁豐嶽,曲芳華,鐘文鑫,曾顯雄 | |
| dc.subject.keyword | 皿培式牛樟芝,子實體萃取物,腫瘤抑制,免疫調節, | zh_TW |
| dc.subject.keyword | Dish-cultured Antrodia cinnamomea, fruiting body extract,anti-tumor,immunomodulation, | en |
| dc.relation.page | 50 | |
| dc.identifier.doi | 10.6342/NTU201801279 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2018-07-04 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 植物病理與微生物學研究所 | zh_TW |
| 顯示於系所單位： | 植物病理與微生物學系 | |
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