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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 王根樹(Gen-Shuh Wang) | |
dc.contributor.author | Yi-Tung Shen | en |
dc.contributor.author | 沈怡彤 | zh_TW |
dc.date.accessioned | 2021-06-17T02:44:53Z | - |
dc.date.available | 2021-12-31 | |
dc.date.copyright | 2020-08-27 | |
dc.date.issued | 2020 | |
dc.date.submitted | 2020-08-18 | |
dc.identifier.citation | Amjad, H., Hashmi, I., Rehman, M. S. U., Ali Awan, M., Ghaffar, S., Khan, Z. (2013). Cancer and non-cancer risk assessment of trihalomethanes in urban drinking water supplies of Pakistan. Ecotoxicology and Environmental Safety, 91, 25-31. doi:https://doi.org/10.1016/j.ecoenv.2013.01.008 Andelman, J. B. (1985). Inhalation exposure in the home to volatile organic contaminants of drinking-water. Science of the Total Environment, 47(DEC), 443-460. doi:10.1016/0048-9697(85)90349-3 Azar, A., Trochimowicz, H., Maxfield, M. (1972). Review of lead studies in animals carried out at Haskell Laboratory: Two year feeding study and response to hemorrhage study. Paper presented at the Environmental health aspects of lead: Proceedings International Symposium. Basu, M., Gupta, S. K., Singh, G., Mukhopadhyay, U. (2011a). Multi-route risk assessment from trihalomethanes in drinking water supplies. Environmental Monitoring and Assessment, 178(1), 121-134. doi:10.1007/s10661-010-1677-z Basu, M., Gupta, S. K., Singh, G., Mukhopadhyay, U. (2011b). Multi-route risk assessment from trihalomethanes in drinking water supplies. Environ Monit Assess, 178(1-4), 121-134. doi:10.1007/s10661-010-1677-z Black, B. D., Harrington, G. W., Singer, P. C. (1996). Reducing cancer risks by improving organic carbon removal. Journal‐American Water Works Association, 88(6), 40-52. Bolyard, M., Fair, P. S., Hautman, D. P. (1992). Occurrence of chlorate in hypochlorite solutions used for drinking water disinfection. Environmental Science Technology, 26(8), 1663-1665. doi:10.1021/es00032a028 Boorman, G. A. (1999). Drinking water disinfection byproducts: review and approach to toxicity evaluation. Environmental Health Perspectives, 107(suppl 1), 207-217. Cantor, K. P., Lynch, C. F., Hildesheim, M. E., Dosemeci, M., Lubin, J., Alavanja, M., Craun, G. (1998). Drinking water source and chlorination byproducts I. Risk of bladder cancer. Epidemiology, 21-28. Cantor, K. P., Lynch, C. R., Hildesheim, M. E., Dosemeci, M., Lubin, J., Alavanja, M., Craun, G. (1999). Drinking water source and chlorination byproducts in iowa, iii. Risk of brain cancer. American Journal of Epidemiology, 150(6), 552-560. Chang, C. C., Ho, S. C., Wang, L. Y., Yang, C. Y. (2007). Bladder cancer in Taiwan: relationship to trihalomethane concentrations present in drinking-water supplies. J Toxicol Environ Health A, 70(20), 1752-1757. doi:10.1080/15287390701459031 Chang, H. H., Tung, H. H., Chao, C. C., Wang, G. S. (2010). Occurrence of haloacetic acids (HAAs) and trihalomethanes (THMs) in drinking water of Taiwan. Environmental Monitoring and Assessment, 162(1), 237-250. doi:10.1007/s10661-009-0792-1 Chen, C. J., Chen, C. W., Wu, M. M., Kuo, T. L. (1992). Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking-water. British Journal of Cancer, 66(5), 888-892. doi:10.1038/bjc.1992.380 Chen, C. J., Hsueh, Y. M., Lai, M. S., Shyu, M. P., Chen, S. Y., Wu, M. M., . . . Tai, T. Y. (1995). Increased prevalence of hypertension and long-term arsenic exposure. Hypertension, 25(1), 53-60. doi:10.1161/01.Hyp.25.1.53 Chen, C. L., Hsu, L. I., Chiou, H. Y., Hsueh, Y. M., Chen, S. Y., Wu, M. M., . . . Blackfoot Dis Study, G. (2004). Ingested arsenic, cigarette smoking, and lung cancer risk - A follow-up study in arseniasis-endemic areas in Taiwan. Jama-Journal of the American Medical Association, 292(24), 2984-2990. doi:10.1001/jama.292.24.2984 Chen, Y., Megosh, L. C., Gilmour, S. K., Sawicki, J. A., O'Brien, T. G. (2000). K6/ODC transgenic mice as a sensitive model for carcinogen identification. Toxicology Letters, 116(1-2), 27-35. doi:10.1016/s0378-4274(00)00196-x Chowdhury, S., Champagne, P. (2009). Risk from exposure to trihalomethanes during shower: Probabilistic assessment and control. Science of the Total Environment, 407(5), 1570-1578. doi:https://doi.org/10.1016/j.scitotenv.2008.11.025 Chowdhury, S., Rodriguez, M. J., Sadiq, R. (2011). Disinfection byproducts in Canadian provinces: associated cancer risks and medical expenses. J Hazard Mater, 187(1-3), 574-584. doi:10.1016/j.jhazmat.2011.01.085 Council of the European Union. (2015). Council Directive 9883EC on the quality of water intended for human consumption. DeAngelo, A. B., George, M. H., Kilburn, S. R., Moore, T. M., Wolf, D. C. (1998). Carcinogenicity of Potassium Bromate Administered in the Drinking Water to Male B6C3F1 Mice and F344/N Rats. Toxicologic pathology, 26(5), 587-594. doi:10.1177/019262339802600501 Doyle, T. J., Zheng, W., Cerhan, J. R., Hong, C. P., Sellers, T. A., Kushi, L. H., Folsom, A. R. (1997). The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa: a prospective cohort study. American Journal of Public Health, 87(7), 1168-1176. doi:10.2105/ajph.87.7.1168 Fakour, H., Lo, S.-L., Lin, T.-F. (2016). Impacts of Typhoon Soudelor (2015) on the water quality of Taipei, Taiwan. Scientific Reports, 6(1), 25228. doi:10.1038/srep25228 Gan, W., Guo, W., Mo, J., He, Y., Liu, Y., Liu, W., . . . Yang, X. (2013). The occurrence of disinfection by-products in municipal drinking water in China's Pearl River Delta and a multipathway cancer risk assessment. Sci Total Environ, 447, 108-115. doi:10.1016/j.scitotenv.2012.12.091 Ged, E. C., Boyer, T. H. (2014). Effect of seawater intrusion on formation of bromine-containing trihalomethanes and haloacetic acids during chlorination. Desalination, 345, 85-93. doi:https://doi.org/10.1016/j.desal.2014.04.021 Giller, S., le Curieux, F., Erb, F., Marzin, D. (1997). Comparative genotoxicity of halogenated acetic acids found in drinking water. Mutagenesis, 12(5), 321-328. doi:10.1093/mutage/12.5.321 Haag, W. R. (1981). On the disappearance of chlorine in sea-water. Water Res, 15(7), 937-940. Hayashi, H., Kanisawa, M., Yamanaka, K., Ito, T., Udaka, N., Ohji, H., . . . Kitamura, H. (1998). Dimethylarsinic acid, a main metabolite of inorganic arsenics, has tumorigenicity and progression effects in the pulmonary tumors of A/J mice. Cancer Letters, 125(1), 83-88. doi:https://doi.org/10.1016/S0304-3835(97)00484-9 Health Canada. (2019). Guidelines for Canadian Drinking Water Quality. Herren-Freund, S. L., Pereira, M. A., Khoury, M. D., Olson, G. (1987). The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. Toxicology and Applied Pharmacology, 90(2), 183-189. doi:https://doi.org/10.1016/0041-008X(87)90325-5 Hsu, C.-H., Jeng, W.-L., Chang, R.-M., Chien, L.-C., Han, B.-C. (2001). Estimation of Potential Lifetime Cancer Risks for Trihalomethanes from Consuming Chlorinated Drinking Water in Taiwan. Environmental Research, 85(2), 77-82. doi:https://doi.org/10.1006/enrs.2000.4102 Huff, J., Lunn, R. M., Waalkes, M. P., Tomatis, L., Infante, P. F. (2007). Cadmium-induced cancers in animals and in humans. Int J Occup Environ Health, 13(2), 202-212. doi:10.1179/oeh.2007.13.2.202 Integrated Risk Information System. (2020). Retrieved from https://www.epa.gov/iris International Agency for Research on Cancer. (2020). Retrieved from https://www.iarc.fr/ Jensen, C. S., Menné, T., Lisby, S., Kristiansen, J., Veien, N. K. (2003). Experimental systemic contact dermatitis from nickel: a dose–response study. Contact Dermatitis, 49(3), 124-132. doi:10.1111/j.0105-1873.2003.00157.x King, W. D., Marrett, L. D. (1996). Case-control study of bladder cancer and chlorination by-products in treated water (Ontario, Canada). Cancer Causes Control, 7(6), 596-604. doi:10.1007/BF00051702 Koller, L. D., Kerkvliet, N. I., Exon, J. H. (1985). Neoplasia induced in male rats fed lead acetate, ethyl urea, and sodium nitrite. Toxicologic pathology, 13(1), 50-57. KUROKAWA, Y., MATSUSHIMA, Y., TAKAMURA, N., IMAZAWA, T., HAYASHI, Y. (1987). Relationship between the duration of treatment and the incidence of renal cell tumors in male F344 rats administered potassium bromate. Japanese Journal of Cancer Research GANN, 78(4), 358-364. Leavens, T. L., Blount, B. C., DeMarini, D. M., Madden, M. C., Valentine, J. L., Case, M. W., . . . Pegram, R. A. (2007). Disposition of bromodichloromethane in humans following oral and dermal exposure. Toxicological Sciences, 99(2), 432-445. doi:10.1093/toxsci/kfm190 Lee, L. J.-H., Chan, C.-C., Chung, C.-W., Ma, Y.-C., Wang, G.-S., Wang, J.-D. (2002). Health risk assessment on residents exposed to chlorinated hydrocarbons contaminated in groundwater of a hazardous waste site. Journal of Toxicology and Environmental Health Part A, 65(3-4), 219-235. Lee, S. C., Guo, H., Lam, S. M. J., Lau, S. L. A. (2004). Multipathway risk assessment on disinfection by-products of drinking water in Hong Kong. Environmental Research, 94(1), 47-56. doi:https://doi.org/10.1016/S0013-9351(03)00067-7 Lin, T. F., Hoang, S. W. (2000). Inhalation exposure to THMs from drinking water in south Taiwan. Science of the Total Environment, 246(1), 41-49. doi:10.1016/s0048-9697(99)00420-9 Little, J. C. (1992). Applying the 2-resistance theory to contaminant volatilization in showers. Environmental Science Technology, 26(7), 1341-1349. doi:10.1021/es00031a010 Liu, C. W., Lin, K. H., Kuo, Y. M. (2003). Application of factor analysis in the assessment of groundwater quality in a blackfoot disease area in Taiwan. Science of the Total Environment, 313(1-3), 77-89. doi:10.1016/s0048-9697(02)00683-6 McMichael, A. J., Woodruff, R. E., Hales, S. (2006). Climate change and human health: present and future risks. The Lancet, 367(9513), 859-869. doi:https://doi.org/10.1016/S0140-6736(06)68079-3 Ministry of Health and Welfare, R. o. C., ,. (2008). Compilation of Exposure Factors. Ministry of Health and Welfare, R. o. C., ,. (2013). Nutrition and Health Survey in Taiwan. Ministry of Health, L. a. W., Japan. (2015). Drinking Water Quality Standards. Ministry of the Interior, R. o. C., ,. (2019). Abridged Life Table in Taiwan. Morimoto, K., Koizumi, A. (1983). Trihalomethanes induce sister chromatid exchanges in human lymphocytes in vitro and mouse bone marrow cells in vivo. Environmental Research, 32(1), 72-79. Morris, R. D., Audet, A. M., Angelillo, I. F., Chalmers, T. C., Mosteller, F. (1992). Chlorination, chlorination by-products, and cancer: a meta-analysis. American Journal of Public Health, 82(7), 955-963. doi:10.2105/ajph.82.7.955 Moser, V. C., Phillips, P. M., McDaniel, K. L., MacPhail, R. C. (1999). Behavioral Evaluation of the Neurotoxicity Produced by Dichloroacetic Acid in Rats11Portions of this research were presented at the annual Society of Toxicology meeting (The Toxiologist 13:252; 1993) and at the ILSI Workshop on Disinfection By-Products, 1995. Neurotoxicology and Teratology, 21(6), 719-731. doi:https://doi.org/10.1016/S0892-0362(99)00029-X Munch, D. J., Hautman, D. P. (1995). Method 551.1: Determination of chlorination disinfection byproducts, chlorinated solvents, and halogenated pesticides/herbicides in drinking water by liquid-liquid extraction and gas chromatography with electron-capture detection. Methods for the Determination of organic compounds in drinking water. Nakajima, M., Kitazawa, M., Oba, K., Kitagawa, Y., Toyoda, Y. (1989). Effect of route of administration in the micronucleus test with potassium bromate. Mutation Research/Genetic Toxicology, 223(4), 399-402. doi:https://doi.org/10.1016/0165-1218(89)90095-5 National Health and Medical Research Council. (2017). Australian Drinking Water Guidelines 6. Nazir, M., Khan, F. I. (2006). Human health risk modeling for various exposure routes of trihalomethanes (THMs) in potable water supply. Environmental Modelling Software, 21(10), 1416-1429. doi:https://doi.org/10.1016/j.envsoft.2005.06.009 Nordberg, G. F. (2009). Historical perspectives on cadmium toxicology. Toxicology and Applied Pharmacology, 238(3), 192-200. doi:https://doi.org/10.1016/j.taap.2009.03.015 NRC. (2009). Science and Decisions: Advancing Risk Assessment. Washington, DC: The National Academies Press. NTP. (2008). Toxicology and carcinogenesis studies of sodium dichromate dihydrate (Cas No. 7789-12-0) in F344/N rats and B6C3F1 mice (drinking water studies). Natl Toxicol Program Tech Rep Ser(546), 1-192. Nuckols, J. R., Ashley, D. L., Lyu, C., Gordon, S. M., Hinckley, A. F., Singer, P. (2005). Influence of tap water quality and household water use activities on indoor air and internal dose levels of trihalomethanes. Environmental Health Perspectives, 113(7), 863-870. doi:10.1289/ehp.7141 Office of Environmental Health Hazard Assessment. (2020). Retrieved from https://oehha.ca.gov/ Patz, J. A., Campbell-Lendrum, D., Holloway, T., Foley, J. A. (2005). Impact of regional climate change on human health. Nature, 438(7066), 310-317. doi:10.1038/nature04188 PEREIRA, M. A. (1996). Carcinogenic activity of dichloroacetic acid and trichloroacetic acid in the liver of female b6c3f1 mice. Toxicological Sciences, 31(2), 192-199. doi:10.1093/toxsci/31.2.192 Perry, H. M., Jr., Kopp, S. J., Perry, E. F., Erlanger, M. W. (1989). Hypertension and associated cardiovascular abnormalities induced by chronic barium feeding. J Toxicol Environ Health, 28(3), 373-388. doi:10.1080/15287398909531356 Rahman, M. B., Cowie, C., Driscoll, T., Summerhayes, R. J., Armstrong, B. K., Clements, M. S. (2014). Colon and rectal cancer incidence and water trihalomethane concentrations in New South Wales, Australia. BMC Cancer, 14(1), 445. doi:10.1186/1471-2407-14-445 Richardson, S. D., DeMarini, D. M., Kogevinas, M., Fernandez, P., Marco, E., Lourencetti, C., . . . McKague, A. B. (2010). What’s in the pool? A comprehensive identification of disinfection by-products and assessment of mutagenicity of chlorinated and brominated swimming pool water. Environmental Health Perspectives, 118(11), 1523-1530. Risk Assessment Information System. (2020). Retrieved from https://rais.ornl.gov/ Rook, J. J., JJ, R. (1974). Formation of haloforms during chlorination of natural waters. Rossman, T. G., Uddin, A. N., Burns, F. J. (2004). Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicology and Applied Pharmacology, 198(3), 394-404. doi:10.1016/j.taap.2003.10.016 Ruddick, J., Villeneuve, D., Chu, I., Valli, V. (1983). A teratological assessment of four trihalomethanes in the rat. Journal of Environmental Science Health Part B, 18(3), 333-349. Schroeder, H. A., Mitchener, M., Nason, A. P. (1970). Zirconium, niobium, antimony, vanadium and lead in rats: life term studies. The Journal of nutrition, 100(1), 59-68. Schwartz, J. (1991). LEAD, BLOOD-PRESSURE, AND CARDIOVASCULAR-DISEASE IN MEN AND WOMEN. Environmental Health Perspectives, 91, 71-75. doi:10.2307/3430985 Smith, M., Randall, J., Read, E., Stober, J. (1989). Teratogenic activity of trichloroacetic acid in the rat. Teratology, 40(5), 445-451. Smith, M., Randall, J., Read, E., Stober, J. (1992). Developmental toxicity of dichloroacetate in the rat. Teratology, 46(3), 217-223. Steinmaus, C., Yuan, Y., Bates, M. N., Smith, A. H. (2003). Case-control study of bladder cancer and drinking water arsenic in the Western United States. American Journal of Epidemiology, 158(12), 1193-1201. doi:10.1093/aje/kwg281 Stern, A. H. (2010). A quantitative assessment of the carcinogenicity of hexavalent chromium by the oral route and its relevance to human exposure. Environmental Research, 110(8), 798-807. doi:10.1016/j.envres.2010.08.002 Taiwan Water Corporation. (2020). Hushan Water Environmental Education Park. Retrieved from https://hushan.water.gov.tw/index.aspx Tseng, W. P. (1977). Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic. Environmental Health Perspectives, 19(AUG), 109-119. doi:10.2307/3428460 Tseng, W. P., Chu, H. M., How, S. W., Fong, J. M., Lin, C. S., Yeh, S. (1968). Prevalence of Skin Cancer in an Endemic Area of Chronic Arsenicism in Taiwan2. JNCI: Journal of the National Cancer Institute, 40(3), 453-463. doi:10.1093/jnci/40.3.453 TWEPA. (2009). Drinking Water Quality Standards. United States Environmental Protection Agency. (2020). Retrieved from https://www3.epa.gov/ceampubl/learn2model/part-two/onsite/esthenry.html USEPA. (1992). Guidelines for Exposure Assessment. USEPA. (1999). Alternative Disinfectants and Oxidants Guidance Manual (EPA 815-R-99-014). Washington, DC. USEPA. (2005a). Guidelines for Carcinogen Risk Assessment. USEPA. (2005b). Human Health Risk Assessment Protocol. USEPA. (2005c). Human Health Risk Assessment Protocol (HHRAP)for Hazardous Waste Combustion Facilities, Final. USEPA. (2009). National Primary Drinking Water Regulations. USEPA. (2011). Exposure factors handbook. USEPA. (2019). Guidelines for Human Exposure Assessment. Uyak, V. (2006). Multi-pathway risk assessment of trihalomethanes exposure in Istanbul drinking water supplies. Environment International, 32(1), 12-21. doi:https://doi.org/10.1016/j.envint.2005.03.005 Wang, G. S., Deng, Y. C., Lin, T. F. (2007). Cancer risk assessment from trihalomethanes in drinking water. Science of the Total Environment, 387(1-3), 86-95. doi:10.1016/j.scitotenv.2007.07.029 Wang, W., Ye, B., Yang, L., Li, Y., Wang, Y. (2007). Risk assessment on disinfection by-products of drinking water of different water sources and disinfection processes. Environment International, 33(2), 219-225. doi:https://doi.org/10.1016/j.envint.2006.09.009 Wei, M., Wanibuchi, H., Yamamoto, S., Li, W., Fukushima, S. (1999). Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats. Carcinogenesis, 20(9), 1873-1876. doi:10.1093/carcin/20.9.1873 WHO. (2003). Chromium in Drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. WHO. (2004). Trichloroacetic Acid in Drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. WHO. (2005a). Bromate in Drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. WHO. (2005b). Dichloroacetic Acid in Drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. WHO. (2005c). Trihalomethanes in Drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. WHO. (2011a). Arsenic in Drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. WHO. (2011b). Lead in Drinking-water. Background document for development of WHO Guidelines for Drinking-water Quality. WHO. (2017). Guidelines for drinking-water quality: fourth edition incorporating the first addendum. Wigg, N. R., Vimpani, G. V., McMichael, A. J., Baghurst, P. A., Robertson, E. F., Roberts, R. J. (1988). Port-pirie cohort study - childhood blood lead and neuropsychological development at age 2 years. Journal of Epidemiology and Community Health, 42(3), 213-219. doi:10.1136/jech.42.3.213 Wilkes, C. R., Small, M. J., Andelman, J. B., Giardino, N. J., Marshall, J. (1992). Inhalation exposure model for volatile chemicals from indoor uses of water. Atmospheric Environment Part a-General Topics, 26(12), 2227-2236. doi:10.1016/0960-1686(92)90412-e Xu, X., Mariano, T. M., Laskin, J. D., Weisel, C. P. (2002). Percutaneous absorption of trihalomethanes, haloacetic acids, and haloketones. Toxicology and Applied Pharmacology, 184(1), 19-26. doi:10.1006/taap.2002.9494 Xu, X., Weisel, C. P. (2003). Inhalation exposure to haloacetic acids and haloketones during showering. Environmental Science Technology, 37(3), 569-576. doi:10.1021/es025747 Yang, G. Q., Wang, S. Z., Zhou, R. H., Sun, S. Z. (1983). Endemic selenium intoxication of humans in China. Am J Clin Nutr, 37(5), 872-881. doi:10.1093/ajcn/37.5.872 陳文祥, 游., 吳美炷. (2015). 吉貝淨水場溴酸鹽改善實場驗證. 自來水會刊雜誌, 34卷(2期總號134), 頁27-37. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/68971 | - |
dc.description.abstract | 乾淨且安全的飲用水對我們的日常生活至關重要,喝水、洗衣、洗澡等不同人為活動都會接觸到水中的汙染物質。因此,本研究的主要目的是評估透過口服攝入、吸入及皮膚吸收等途徑暴露到飲用水中不同污染物的累積癌症風險。另一方面,由於氣候變遷的影響,極端降雨事件更加頻繁地發生,已有研究證實颱風期間自來水中的三鹵甲烷濃度升高,藉此,本研究的第二個目的是探討在颱風期間因暴露於較高濃度的三鹵甲烷而增加的癌症風險。 本研究使用的數據來自環保署飲用水水質資料庫自2002年1月至2019年12月的水質數據以及2019年2月至2019年10月所收集的樣本分析結果。根據汙染物質的檢測率和可得的毒理資料,共計選擇八種金屬(砷、鉛、硒、鉻、鎘、鋇、銻和鎳)及七種消毒副產物(氯仿、溴二氯甲烷、二溴氯甲烷、溴仿、二氯乙酸、三氯乙酸和溴酸鹽)作為研究對象,並參照美國環境保護署的風險評估指南和臺灣人民的生活習慣,使用Crystal Ball軟體進行蒙地卡羅模擬,計算平均每日劑量、終生癌症風險及危害指數。 研究結果發現,在臺灣各地區及離島的飲用水中,這十五種污染物的累積癌症風險皆高於10-6,也就是美國環境保護署定義的可接受風險。其中,風險最高者是來自離島的飲用水,癌症風險為1.38×10-4,主要因為其總三鹵甲烷濃度較其他地區為高。而全臺灣飲用水的累積危害指數皆遠低於美國環保署訂定的可忽略危害基準。另外,颱風情境下所衍生的終生三鹵甲烷癌症風險與一般情境差異不大,主要原因為每年五天的高暴露時間與終生暴露相比沒有太大的影響。 整體言之,儘管有其他水中污染物未涵蓋在此次評估中,但累積癌症風險已高於10-6,代表值得關注飲用水中同時出現的污染物對健康效應的影響。另外,雖然颱風期間的高暴露對終生癌症風險整體影響低,但是仍應控制飲用水中的濁度和天然有機物濃度,以預防短時間高暴露可能造成的健康危害。 | zh_TW |
dc.description.abstract | Safe drinking water is essential to our daily life since it is inevitable that people expose to contaminants in drinking water through multiple exposure routes every day. As a result, the main purpose of this study is to investigate the cumulative cancer risks of co-occurring contaminants in drinking water through oral ingestion, inhalation, and dermal absorption exposures in Taiwan. On the other hand, due to the effects of climate change, typhoons and extreme weather events are occurring more frequently in past decades, resulting in much higher concentrations of trihalomethanes (THMs) in the treated water during the typhoon period. Therefore, the second purpose of this study is to elucidate the lifetime cancer risk resulting from exposure to higher concentrations of THMs during typhoon seasons. The water quality data used in this study were obtained from the database of the Environmental Protection Administration of Taiwan from January 2002 to December 2019 and the analytical results of collected samples from February 2019 to October 2019. Based on the occurrence data and the available cancer potency information, eight metals (arsenic, lead, selenium, chromium, cadmium, barium, antimony, and nickel) and seven disinfection byproducts (chloroform, bromodichloromethane, dibromochloromethane, bromoform, dichloroacetic acid, trichloroacetic acid, and bromate) were chosen for investigation. Based on the United States Environmental Protection Agency (USEPA) risk assessment guidelines and the lifestyles of residents in Taiwan, the equations and the parameters for calculation of risk assessment were simulated using Monte Carlo simulations with Crystal Ball software. The results of cumulative cancer risks of these fifteen contaminants from drinking water in northern, central, southern, eastern, and offshore islands of Taiwan were all higher than 10-6, the acceptable risk level defined by USEPA. The highest cancer risk of 1.38×10-4 was in drinking water from offshore islands because the total THM concentration was higher than that in the other areas. All of the results of the hazard index in Taiwan were much lower than 1, the negligible hazard level defined by USEPA. Moreover, the increased cancer risk of exposure to THMs in the typhoon scenario was not apparent for the results of lifetime cancer risk because the five days of exposure duration per year is considerably short when compared to our lifetime. In conclusion, the cumulative cancer risks from exposure to multiple contaminants in drinking water were higher than 10-6 although there were other water contaminants not included in the assessment. These results suggested that risk assessment should concern about the cumulative health impacts of co-occurring contaminants in drinking water. Besides, it is also necessary to prevent the high exposure to THMs in typhoon seasons by controlling the turbidity and natural organic matters in drinking water, which were the precursors of THMs, during the typhoon. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T02:44:53Z (GMT). No. of bitstreams: 1 U0001-1708202001244000.pdf: 2441500 bytes, checksum: 0da769981fac9bd1dfb8fff54c9e57e3 (MD5) Previous issue date: 2020 | en |
dc.description.tableofcontents | 中文摘要 i Abstract ii Contents iv List of Figures vi List of Tables vii Chapter 1 Introduction 1 1.1 Background 1 1.2 Objectives 2 Chapter 2 Literature Review 3 2.1 Drinking water quality standards 3 2.2 Disinfection byproducts (DBPs) 4 2.3 Overview of risk assessment 5 2.3-1 Hazard identification 5 2.3-2 Dose-response assessment 14 2.3-3 Exposure assessment 17 2.3-4 Risk characterization 19 2.4 Impacts of extreme weather events 19 2.5 Risk assessment of disinfection byproducts in different countries 20 Chapter 3 Materials and Methods 22 3.1 Study framework 22 3.2 Sample collections 23 3.3 On-site analysis 24 3.4 Laboratory analysis 25 3.4-1 Non-purgeable dissolved organic carbon (NPDOC) analysis 25 3.4-2 Trihalomethanes (THMs) analysis 26 3.5 Data source 28 3.6 Exposure assessment 29 3.6-1 Oral ingestion 30 3.6-2 Inhalation 31 3.6-3 Dermal 34 3.7 Risk characterization 36 3.7-1 Quantitative estimation of potential for noncancer effects 36 3.7-2 Quantitative estimation of cancer risk 37 Chapter 4 Results and Discussions 38 4.1 Concentrations of contaminants in distribution system 38 4.2 Species distributions of THMs and HAA5 in drinking water of Taiwan 56 4.3 Multiple pathway evaluations of cancer risks for THMs 59 4.4 Cumulative cancer risk 62 4.4-1 Lifetime cancer risk 62 4.4-2 Yearly cancer risk 65 4.5 Cumulative noncancer health effects 68 4.6 Impacts of extreme weather events 71 4.7 Uncertainty analysis 72 Chapter 5 Conclusions 73 Reference 74 | |
dc.language.iso | en | |
dc.title | 臺灣飲用水中多重汙染物之致癌風險評估 | zh_TW |
dc.title | Risk Assessment of DBPs and other Contaminants in Drinking Water of Taiwan | en |
dc.type | Thesis | |
dc.date.schoolyear | 108-2 | |
dc.description.degree | 碩士 | |
dc.contributor.advisor-orcid | 王根樹(0000-0002-1832-472X) | |
dc.contributor.oralexamcommittee | 康世芳(Shyh-Fang Kang),林財富(Tsair-Fuh Lin),吳涵涵(Charlene Wu) | |
dc.contributor.oralexamcommittee-orcid | ,吳涵涵(0000-0002-1407-7397) | |
dc.subject.keyword | 風險評估,三鹵甲烷,消毒副產物,重金屬,颱風, | zh_TW |
dc.subject.keyword | risk assessment,trihalomethanes,disinfection byproducts,heavy metals,typhoon scenario, | en |
dc.relation.page | 86 | |
dc.identifier.doi | 10.6342/NTU202003651 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2020-08-18 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 環境與職業健康科學研究所 | zh_TW |
顯示於系所單位: | 環境與職業健康科學研究所 |
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