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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 徐源泰(Yuan-Tay Shyu) | |
dc.contributor.author | Yen-Ting Lai | en |
dc.contributor.author | 賴彥廷 | zh_TW |
dc.date.accessioned | 2021-06-17T02:28:39Z | - |
dc.date.available | 2022-08-24 | |
dc.date.copyright | 2017-08-24 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-08-17 | |
dc.identifier.citation | 參考文獻
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/68641 | - |
dc.description.abstract | 本研究旨在以高壓加工技術(High pressure process, HPP) 富化毛豆γ-胺基丁酸 (gamma-aminobutyric acid, GABA)含量,並探究最適高壓處理條件、儲放時間、儲放溫度及其抗憂鬱機能。以異硫氰酸苯酯(phenylisothiocyanate, PITC)試劑進行柱前衍生化,將毛豆以100-600 Mpa條件分別處理帶殼毛豆、莢殼、毛豆仁,並透過建立HPLC分析方法檢測GABA含量,以確認HPP加工技術的最佳富化處理條件。
由實驗結果可得知,高壓加工技術可有效增加毛豆中GABA含量之生成,200 MPa為富化毛豆GABA含量之最適高壓條件。經200 Mpa條件處理的毛豆,其GABA含量顯著高於對照組,帶殼毛豆可達436.05 mg/100g,莢殼可達524.65 mg/100g,毛豆仁於300 MPa條件下可達296.85 mg/100g。麩胺酸含量變化於高壓處理後在500和600 MPa條件時較高,而GABA在同高壓條件時含量較低,兩者趨勢呈反比,顯示麩胺酸受關鍵酵素作用而生成GABA,以致GABA生成量多時麩胺酸含量減少。麩醯胺酸含量於200 MPa條件下會隨高壓處理增加。 以最佳富化條件高壓後的毛豆莢殼水萃物餵食不可預期慢性壓力模式誘導的憂鬱小鼠,由尾部懸吊試驗可得知服用毛豆水萃物高劑量組(102.5 mg/kg bw)的小鼠於第一週至第四週皆較控制組、正控制組(市售含GABA 25.6 mg/kg bw)及毛豆水萃物低劑量組(25.6 mg/kg bw)等組別有最少的不動時間,顯示服用高劑量毛豆水萃物對減少小鼠憂鬱情形有顯著效果。由開放空間試驗的探索站立次數可得知,憂鬱小鼠服用較高劑量之水萃物會有明顯探索行為,顯示服用毛豆莢殼水萃物可減緩憂鬱之症狀。 | zh_TW |
dc.description.abstract | The objective o f this research way to investigate the influence of high pressure processing(HPP)on γ-aminobutyric acid enrichment in vegetable soybeans and its antidepressant effect, the optimum HPP condition,storage time and temperature were also studied. 100-600 MPa were used to treat the whole vegetable soybean, pod, and kernel. After the treatments, GABA extracted from different vegetable soybean positions, derived with phenylisothiocyanate(PITC), were analyzed by high performance liquid chromatography and examined in order to identify the best potential conditions of GABA production.
The results showed that HPP could effectively increase the content of GABA in soybean and the optimum conditions of HPP treatment were 200 MPa, the GABA content of the treated vegetable soybean was significantly higher than the control group. The GABA content in the whole vegetable soybean was 436.05 mg/100g, vegetable soybean pod was 524.65 mg/100g , vegetable soybean kernel was 296.85 mg/100g .After HPP, the content of glutamate was higher at 500 and 600 MPa, while the GABA contents was lower in the same high pressure condition,and the two trends were inversely proportional to the effect of glutamate acting on the key enzyme to produce GABA, this clearly shows that increasing the amount of GABA production but reducing the glutamate content. The unpredictable chronic mild stress-induced mice were fed with optimum conditions for high-pressure soybean pod water extract. The tail suspension test showed that the immobility time of the 102.5 mg/kg dose group was significantly shorter than that of the other groups. By the number of open field test to explore the number of standing , it could be learned that the mice with increased depression symptom taking higher doses of water extract could have a clear exploration of behavior, and namely taking water extract of soybean pod could slow down their symptoms of depression. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T02:28:39Z (GMT). No. of bitstreams: 1 ntu-106-R04628211-1.pdf: 2411735 bytes, checksum: fbbcd587e8b6c85439018f2a385369aa (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 目錄
中文摘要 II Abstract III 目錄 V 圖目錄 VIII 表目錄 X 第一章 前言 1 第二章 文獻回顧 2 第一節 毛豆 2 1.介紹 2 2.現況 2 3.營養成分與機能性 3 4.應用性 6 第二節 GABA介紹 7 1.特性 7 2. GABA生成代謝途徑 8 3. GABA製備技術 12 4.生理作用 15 第三節 Glutamate介紹 17 第四節 Glutamine介紹 19 第五節 高壓介紹 21 第六節 憂鬱症介紹 23 第七節 憂鬱症動物模式 25 1.介紹 25 2.行為絕望模式 26 第八節 研究動機與目的 28 第九節 試驗架構 28 第三章 材料與方法 30 第一節 試驗材料 30 第二節 試驗藥品 30 第三節 儀器與設備 31 第四節 HPLC分析 32 1.檢測方法確立 32 2.樣品萃取 33 3.樣品衍生化 34 4.高效能液相層析分析 34 第五節 高壓處理方法 36 第六節 動物實驗 36 1.劑量篩選 36 2.動物選擇 37 3.動物飼養 37 4. 行為分析軟體 43 第七節 統計分析 43 第四章 結果與討論 44 第一節 γ-胺基丁酸檢測方法確立 44 第二節 L-麩胺酸檢測方法確立 48 第三節 L-麩醯胺酸檢測方法確立 51 第四節 高壓處理對毛豆不同部位GABA含量之影響 54 第五節 高壓處理對毛豆不同部位glutamate含量之影響 61 第六節 毛豆以200 MPa處理後靜置5天內glutamine含量變化 65 第七節 毛豆水萃物對類憂鬱動物行為之影響 68 1.動物飼養與體重變化 68 2.蔗糖水試驗 69 3.尾部懸吊試驗 70 4.開放空間試驗 71 第五章 結論 76 參考文獻 78 | |
dc.language.iso | zh-TW | |
dc.title | 利用高壓加工技術提升毛豆γ-胺基丁酸含量及其抗憂鬱機能之研究 | zh_TW |
dc.title | Study of γ-Aminobutyric Acid Enrichment in Vegetable Soybeans by High Pressure Processing and its Antidepressant Effect | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 吳思節(Sz-Jie Wu) | |
dc.contributor.oralexamcommittee | 曾文聖,劉滿海,莊朝琪 | |
dc.subject.keyword | γ-胺基丁酸,毛豆,高壓加工技術,麩胺酸,尾部懸吊試驗,開放空間試驗,不可預期慢性壓力模式, | zh_TW |
dc.subject.keyword | γ-aminobutyric acid,vegetable soybean,high pressure process,glutamate,tail suspension test,open field test,unpredictable chronic mild stress, | en |
dc.relation.page | 88 | |
dc.identifier.doi | 10.6342/NTU201703803 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2017-08-18 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 園藝暨景觀學系 | zh_TW |
顯示於系所單位: | 園藝暨景觀學系 |
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