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  1. NTU Theses and Dissertations Repository
  2. 管理學院
  3. 管理學院企業管理專班(Global MBA)
請用此 Handle URI 來引用此文件: http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/68461
完整後設資料紀錄
DC 欄位值語言
dc.contributor.advisor謝源弘(James Hsieh)
dc.contributor.authorYu-Chun Tsaien
dc.contributor.author蔡宇淳zh_TW
dc.date.accessioned2021-06-17T02:21:48Z-
dc.date.available2020-08-24
dc.date.copyright2020-08-24
dc.date.issued2020
dc.date.submitted2020-08-18
dc.identifier.citation1. IQVIA, The Global Use of Medicine in 2019 and Outlook to 2023, 2019
2. Marr, B., The 9 biggest technology trend that will transform medicine and healthcare in 2020. Forbes Nov 2019
3. Ushiyama F., Assessing the Research Productivity of the Pharmaceutical Industry: Pipeline Analysis, ISPIM Innovation Summit 2017
4. Miroudot, S. and C. Cadestin, “Services In GlobalValue Chains: From Inputs to Value-Creating Activities”, OECD Trade Policy Papers, No. 197, OECD Publishing, Paris, 2017
5. Schuhmacher A, Hinder M, Gassmann O., Value Creation in the Pharmaceutical Industry: The Critical Path to Innovation, Wiley-VCH 2016
6. Barak D. Richman et al., Pharmaceutical M A Activity: Effects on Prices, Innovation, and Competition, Loyola University Chicago Law Journal, 2017 787-819
7. https://www.fda.gov/drugs/buying-using-medicine-safely/generic-drugs
8. DiMasi AJ, Grabowski GH, Hansen WR, Innovation in the pharmaceutical industry: New estimates of R D costs, J Health Econ, 2016 May;47:20-33
9. EvaluatePharma, World Preview 2019, Outlook to 2024, 2019
10. Raghavendra J, Seetharaman J,. A study of decrease in R D spending in the pharmaceutical industry during post-recession. Int J of Aca Res Part B; 2012; 4(5), 29-47
11. Scannell, J., Blanckley, A., Boldon, H. et al. Diagnosing the decline in pharmaceutical R D efficiency. Nat Rev Drug Discov 11, 191–200, 2012
12. Deloitte, Ten years on Measuring the return from pharmaceutical innovation 2019 13. Deloitte, Life sciences regulatory: outlook 2020
14. Deloitte, External innovation: How biopharma companies are bolstering R D pipelines through deal-making 2019
15. KPMG, Venture pulse Q1 2020: Global analysis of venture funding, 2020
16. EvaluatePharma, Vantage 2020 Preview, 2019
17. CBinsight, The global CVC report, 2019
18. Deloitte, The rewards of regulatory change: Launching innovative biopharma in China Deloitte insight, 2019
19. DeFrancesco L., 1Q20 — biotech stocks nosedive, Nat Biotechnol. 2020 May;38(5):521-522 20. Hodgson J., Biotech's baby boom, Nat Biotechnol. 2019 May;37(5):502-512
dc.identifier.urihttp://tdr.lib.ntu.edu.tw/jspui/handle/123456789/68461-
dc.description.abstract在歐美國家的生計產業中,創投和企業創投是許多創新公司重要的資金來源︒近年來亞洲國家(尤其是大中華地區)急起直追, 過去十年內R&D支出呈現倍數成長︒本論文利用資料庫分析和跨國藥廠專業經理人/亞洲創投家的訪談,分析創投和企業創投在大中華地區目前的生態係和未來發展︒結果顯示企業創投正在大中華地區蓬勃發展中, 雖然和歐美國家相比,生態係仍在建構中,但再次顯示企業創投對醫療產業創新公司的重要性︒2020年全球正面臨心冠肺炎的考驗 (Covid-19),各種投資行為轉於保守態度,藉由本論文的研究,重新檢視企業創投在大中華地區的機會和風險,同時討論醫療產業未來五年的展望︒zh_TW
dc.description.abstractFinancial venture capital (VC) and corporate VC are among the most important source of funding of small companies in healthcare industry in Europe and USA. Countries in Asia are now catching up, especially in the greater China region, where R D expenditure was increasing tremendously in the last decade. In this thesis, we analyzed the ecosystem of venture capital as well as pharma-backed corporate VC investment in the greater China region compared to the US and Europe. We tried to identify the criteria of corporate VCs for making investment decisions by analyzing the investment portfolio from public available information and conducting interviews with investors from venture arm of big pharmaceutical companies and financial venture capitalists who had experiences in both US/EU and the greater China region. This thesis highlights the acceleration of corporate equity investing in the greater China region. The findings are consistent with data from Europe and USA where a recent analysis confirmed the critically important contribution of CVC and direct corporate investing for start-up and emerging biotech companies over the past 15 years, and importantly, the correlation between corporate investor involvement and successful ‘exit’ outcomes. As the Covid-19 pandemic hit worldwide, many VCs had become conservative in their investment. It is an appropriate timing to evaluate if the greater China region has more opportunities to be a preferred location for corporate investing in Asia and enable the translation of broader footprint of innovative science into new medicines in the next five years.en
dc.description.provenanceMade available in DSpace on 2021-06-17T02:21:48Z (GMT). No. of bitstreams: 1
U0001-1708202013551700.pdf: 5410978 bytes, checksum: e127d1f528b96f31217d938eb1e688e1 (MD5)
Previous issue date: 2020
en
dc.description.tableofcontentsAcknowledgement....................................................................I
Abstract ........................................................................ III
List of figures ................................................................. VII
List of tables.................................................................. VIII
1. Introduction ....................................................................1
2. Objective and research questions ................................................2
3. Methodology .....................................................................2
3.1. Quantitative analysis of CVC investment portfolio worldwide and in the greater China region using secondary data sources................................................................................................ 2
3.2. Qualitative research in investment criteria of CVC in healthcare industry in the greater China region using primary data source .......................................................................................... 3
4. Literature review ........................................................................................................................... 4
4.1. Introduction of healthcare industry ...................................................................................... 4
4.1.1. Overview of global trend in healthcare industry.......................................................... 4
4.1.2. Emerging of innovations to drive the healthcare industry .......................................... 4
4.1.3. Global market trend in healthcare industry .................................................................. 5
4.1.4. The major components of the pharmaceutical value chain ......................................... 8
4.1.5. Characteristics and current trends of the pharmaceutical industry ............................. 11
4.1.5.1. High-technology, capital intensive, long investment cycle, short patent protection, high-risk, and high-revenue ................................................................................. 11
4.1.5.2. Market trends and policy trends .......................................................................... 15
4.1.6. Key challenges and drivers of changing new R D models in pharmaceutical industry 19
4.2. Corporate and financial VC in the healthcare industry ..................................................... 24
4.2.1. Overview of financial VC investment ........................................................................ 24
4.2.2. Overview of corporate VC investment ....................................................................... 27
4.2.3. Corporate VC investment in biotech .......................................................................... 28
4.2.4. Corporate VC vs financial VC investment ................................................................. 29
4.3. Healthcare industry in the greater China region ................................................................ 30
4.3.1. VC/CVC investment in the greater China region ...................................................... 30
4.3.2. Regulatory transformation and pricing policy in China ............................................ 30
4.4. Covid-19 Pandemic: Impact in healthcare investment, good time or bad time? ............. 32
5. Results .......................................................................................................................................... 34
Part I: Analysis of top 10 CVC investment portfolio worldwide and in the greater China region 34
5.1. Key VC investments and players worldwide vs the greater China region ...................... 34
5.1.1. Global transaction deal analysis.................................................................................. 34
5.1.2. Investment analysis ...................................................................................................... 34
5.1.2.1. Key invested region ................................................................................................. 34
5.1.2.2. The stage of investment ....................................................................................... 37
5.1.2.3. Business model (investment field) ........................................................................ 40
5.1.2.4. The therapeutic area of investment........................................................................ 42
5.1.2.5. Deal volume analysis.............................................................................................. 43
5.1.3. Investor analysis........................................................................................................... 43
5.1.3.1. Top 100 Biotech VC/CVC companies worldwide ............................................... 45
5.1.3.2. Healthcare PE/VC investors in the greater China region ..................................... 49
5.2. CVC investments in the greater China region ................................................................... 52
5.2.1. Case study of MNC corporate venture arm investing in the greater China region.. 53
Lilly Asia Ventures ..................................................................................................................... 53
Johnson Johnson Innovation – JJDC, Inc. (JJDC) ................................................................ 54
Celgene (acquired by Bristol-Myers Squibb in 2019) .............................................................. 54
AstraZeneca ................................................................................................................................. 55
5.2.2. Key Chinese Pharma/biotech focus area .................................................................... 56
5.2.2.1. Chimeric antigen receptor-based cell therapies .................................................... 56
5.2.2.2. Cancer (target therapy, immunotherapy) .............................................................. 57
5.2.2.3. AI-based healthcare ................................................................................................ 58
Part II: Qualitative research in corporate VC and financial VC in pharmaceutical industry ..... 59
5.3.1. Selection of interviewees............................................................................................. 59
5.3.2. Aim of interviews ........................................................................................................ 59
5.3.3. Structure of interviews................................................................................................. 59
5.3.4. Summary of interviewees ............................................................................................ 60
5.4. Result of interviews ............................................................................................................. 61
5.4.1. Interviews from Novartis corporate venture capital .................................................. 61
5.4.1.2. Objective of CVC investment ................................................................................ 62
5.4.1.3. Risk evaluation of CVC investment ...................................................................... 63
5.4.1.4. Deal segments, valuation, and competition .......................................................... 64
5.4.1.5. Business development experience in the greater China region ........................... 65
5.4.1.6. Opportunities and obstacles of CVC investment in the greater China region .... 66
5.4.2. Interviews from financial venture capital ................................................................... 68
5.4.2.1. Emerging trends of healthcare industry in the greater China region ................... 68
5.4.2.2. Opportunities and obstacles of healthcare investment in the greater China region .................................................................................................................................................. 69
6. Discussion and limitation ........................................................................................................... 71
7. Conclusion and recommendation ............................................................................................... 73
8. Reference ..................................................................................................................................... 75
dc.language.isoen
dc.subject企業創投zh_TW
dc.subject醫療產業zh_TW
dc.subjecthealthcare industryen
dc.subjectcorporate venture capitalen
dc.title大中華地區醫藥產業企業創投生態系與未來展望zh_TW
dc.titleThe Ecosystem and Outlooks of Healthcare Corporate Venture Capital in the Greater China Regionen
dc.typeThesis
dc.date.schoolyear108-2
dc.description.degree碩士
dc.contributor.coadvisor許文馨(Audrey Hsu)
dc.contributor.oralexamcommittee謝冠雄(Edward Hsieh)
dc.subject.keyword企業創投,醫療產業,zh_TW
dc.subject.keywordcorporate venture capital,healthcare industry,en
dc.relation.page75
dc.identifier.doi10.6342/NTU202003737
dc.rights.note有償授權
dc.date.accepted2020-08-19
dc.contributor.author-college管理學院zh_TW
dc.contributor.author-dept企業管理碩士專班zh_TW
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