濕式靜電紡絲製備聚乳酸纖維型態之研究

Abstract

在本研究中，我們透過濕式靜電紡絲來探討靜電紡絲的纖維結構。利用不同的蒐集溶劑，從靜電紡絲纖維的直徑及表面和內部孔洞資訊，來驗證靜電紡絲纖維形成的機制，並針對靜電訪絲纖維進入不同蒐集溶劑的結構形成做進一步的分析及討論。 我們先針對靜電紡絲在不同工作距離下皮層是否已經形成，並且針對不同工作進入蒐集溶劑後的結構作探討。我們發現在工作距離15公分之後，靜電紡絲纖維形狀已經固定，內外部結構也都確定下來，所以不論使用什麼當作蒐集溶劑都不會對靜電紡絲纖維結構有影響。而在靜電紡絲纖維形狀尚未確定就進入蒐集溶劑中：以水當作蒐集溶劑時，靜電紡絲纖維會停留在液面不會進入溶劑中，靜電紡絲的纖維結構在碰到水及沒碰到水的部分會有明顯差異，前者表面會有孔洞、內部也是由許多靠近外圍的孔洞構成；後者表面則是平滑沒有孔洞、內部也是緻密而沒有孔洞的結構。以酒精當作蒐集溶劑時，靜電紡絲纖維可以完全沒入溶劑中，而靜電紡絲纖維表面結構在不同的工作距離下，會隨著水引發相分離的程度，具有不同大小的孔洞，內部結構在形狀為固定前，則是會有許多細小且均勻分布的孔洞，這是因為氯仿和酒精可以完全互溶。

In this study, we tried to discuss the electrospinning fiber structure through the wet electrospinning process. By using different collected solvents, we were able to verify the mechanism for formation the electrospinning fiber from the fiber’s diameter and information of its inner and surface pores. In addition, we analyzed the structures of electrospun fiber by using different collected solvent. First, we investigated whether the skin was formed under different working distance, and discussed the structure of them after entering collected solvent. We found that if the working distance was over 15 cm, the shape of the electrospun fiber was fixed, as well as the interior and exterior structure. Hence, no matter what kind of collected solvents have been used, it has no effect on the structures of the electrospun fiber. As for those entering collecting solvent before the shape was fixed: When water was used as a collecting solvent, the electrospun fiber remained on the surface of the liquid instead of entering the solvent. The structure of the electrospun fiber on near-water side and far-water side had significant differences. The former had porous surface and the interior structure was constructed of pores to the surface; the latter had smooth non-porous surface and its interior structure was dense and also non-porous. When alcohol was used as a collecting solvent, the electrospun fiber could sink into the liquid. The surface of the electrospun fibers consisted of different sizes of pores under different working distance, resulting from the extant of phase separation induced by water. The interior structure was made of tiny and equally distributed pores, due to the fact that chloroform is compatible with alcohol.