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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 蕭朱杏(Chuhsing Kate Hsiao) | |
dc.contributor.author | Wei-Ping Chen | en |
dc.contributor.author | 陳瑋萍 | zh_TW |
dc.date.accessioned | 2021-06-17T01:55:46Z | - |
dc.date.available | 2017-09-13 | |
dc.date.copyright | 2017-09-13 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-07-21 | |
dc.identifier.citation | AABB. (2012). Association Bulletin #12-03 - Strategies to Monitor, Limit, or Prevent Iron Deficiency in Blood Donors [Press release]. Retrieved from http://www.aabb.org/programs/publications/bulletins/Pages/ab12-03.aspx?PF=1
AABB. (2016). Management of Iron Deficiency Associated with Blood Donation [Press release]. Retrieved from https://www.aabb.org/advocacy/statements/Documents/statement161117.pdf Abdullah, S. M. (2011). The effect of repeated blood donations on the iron status of male Saudi blood donors. Blood Transfusion, 9(2), 167-171. doi:10.2450/2010.0040-10 ACC/SCN. (1992). 2nd Report on the World Nutrition Situation − Volume I: Global and regional results. Retrieved from https://www.unscn.org/web/archives_resources/files/rwns2_1.pdf Baart, A. M., van Noord, P. A. H., Vergouwe, Y., Moons, K. G. M., Swinkels, D. W., Wiegerinck, E. T., . . . Atsma, F. (2013). High prevalence of subclinical iron deficiency in whole blood donors not deferred for low hemoglobin. Transfusion, 53(8), 1670-1677. doi:10.1111/j.1537-2995.2012.03956.x Bates, H. (1980). How to detect iron deficiency before anemia develops. Laboratory Pathfinder, 1, 17-22. Bessman, J. D., Gilmer, P. R., & Gardner, F. H. (1983). Improved classification of anemias by MCV and RDW. American journal of clinical pathology, 80(3), 322-326. Birgegdrd, G., Hogmn, C., & Johamson, A. (1980). Serum Ferritin in the Regulation of Iron Therapy in Blood Donors. Vox Sanguinis, 38, 29-35. Brownlie, T., Utermohlen, V., & Hinton, P. S. (2004). Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women. Am J Clin Nutr, 79. Bryant, B. J., Yau, Y. Y., & Arceo, S. M. (2013). Ascertainment of Iron Deficiency and Depletion in Blood Donors through Screening Questions for Pica and Restless Legs Syndrome. Transfusion, 53(8), 1637-1644. doi:10.1111/trf.12061 Cable, R. G., Glynn, S. A., Kiss, J. E., Mast, A. E., Steele, W. R., Murphy, E. L., . . . for the, N. R. E. D. S., II. (2012). Iron Deficiency in Blood Donors: The REDS-II Donor Iron Status Evaluation (RISE) Study. Transfusion, 52(4), 702-711. doi:10.1111/j.1537-2995.2011.03401.x Cook, J., & Skikne, B. (1989). Iron deficiency: definition and diagnosis. Journal of internal medicine, 226(5), 349-355. Cook, J., Skikne, B., & Lynch, S. (1980). Serum ferritin in the evaluation of anemia. Radioimmunoassay of Hormones, Proteins and Enzymes. Amsterdam: Excerpta Medica, 239-248. Coulter, B. (2010). Beckman Coulter ferritin [Press release] Crichton, R. R. (1971). Ferritin: structure, synthesis and function. New England Journal of Medicine, 284(25), 1413-1422. Fairbanks, V. F., Fahey, J. L., & Beutler, E. (1971). Clinical disorders of iron metabolism: Saunders. Goldman, M., Uzicanin, S., & Osmond, L. (2017). A large national study of ferritin testing in Canadian blood donors. Transfusion, 57(3), 564-570. doi:10.1111/trf.13956 Goldman, M., Uzicanin, S., & Scalia, V. (2014). Iron deficiency in Canadian blood donors. Transfusion, 54(3 Pt 2), 775-779. doi:10.1111/trf.12380 Gonzalez, M. L., Maia, S., & Mesquita, P. (2013). Study of serum ferritin in donors of two red blood cells units collected by apheresis. Transfus Apher Sci, 49(2), 238-243. doi:10.1016/j.transci.2013.06.001 Guyton, A. C., & Hall, J. E. (2006). Textbook of Medical Physiology ver.17. Koulaouzidis, A., Cottier, R., & Bhat, S. (2009). A ferritin level >50 microg/L is frequently consistent with iron deficiency. Eur J Intern Med, 20(2), 168-170. doi:10.1016/j.ejim.2007.09.024 Krause, J. R., & Stolc, V. (1979). Serum ferritin and bone marrow iron stores: I. Correlation with absence of iron in biopsy specimens. American journal of clinical pathology, 72(5), 817-820. Looker, A. C., Dallman, P. R., & Carroll, M. D. (1997). Prevalence of Iron Deficiency in the United States. JAMA, 277(12). Magnussen, K., & Ladelund, S. (2015). Handling low hemoglobin and iron deficiency in a blood donor population: 2 years' experience. Transfusion, 55(10), 2473-2478. doi:10.1111/trf.13152 McPherson, R. A., & Pincus, M. R. (2016). Henry's clinical diagnosis and management by laboratory methods: Elsevier Health Sciences. Miller, J. L. (2013). Iron deficiency anemia: a common and curable disease. Cold Spring Harb Perspect Med, 3(7). doi:10.1101/cshperspect.a011866 Mozaheb, Z., Khayami, M., & Sayadpoor, D. (2011). Iron Balance in Regular Blood Donors. Transfus Med Hemother, 38(3), 190-194. doi:10.1159/000328812 Murray-Kolb, L. E., & Beard, J. L. (2007). Iron treatment normalizes cognitive functioning in young women. Am J Clin Nutr, 85. Page, E. A., Coppock, J. E., & Harrison, J. F. (2010). Study of iron stores in regular plateletpheresis donors. Transfus Med, 20(1), 22-29. doi:10.1111/j.1365-3148.2009.00979.x Pan, W. (2001). Akaikes Information Criterion in Generalized Estimating Equations. Rigas, A. S., Sørensen, C. J., Pedersen, O. B., Petersen, M. S., Thørner, L. W., Kotzé, S., . . . Ullum, H. (2014). Predictors of iron levels in 14,737 Danish blood donors: results from the Danish Blood Donor Study. Transfusion, 54(3pt2), 789-796. doi:10.1111/trf.12518 Sciences, N. A. o. (2001). Iron Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC). Silva, M. A. d., Souza, R. A. V. d., & Carlos, A. M. (2012). Etiology of anemia of blood donor candidates deferred by hematologic screening. Rev Bras Hematol Hemoter, 34(5), 356-360. doi:10.5581/1516-8484.20120092 Skikne, B., & Cook, J. (1981). Serum ferritin in the evaluation of iron status. Lab Management, 19, 31-35. Spencer, B. R., Kleinman, S., & Wright, D. J. (2013). Restless legs syndrome, pica, and iron status in blood donors. Transfusion, 53(8), 1645-1652. doi:10.1111/trf.12260 Vaucher, P., Druais, P.-L., & Waldvogel, S. (2012). Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial. CMAJ : Canadian Medical Association Journal, 184(11), 1247-1254. doi:10.1503/cmaj.110950 Verdon, F., Burnand, B., Stubi, C. F., Bonard, C., Graff, M., Michaud, A., . . . Herzig, L. (2003). Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial. Bmj, 326(7399), 1124. WHO, W. H. O. (2016). World Blood Donor Day 2016: Blood connects us all. Retrieved from http://www.who.int/campaigns/world-blood-donor-day/2016/en/ Yip, R., & Dallman, P. (1988). The roles of inflammation and iron deficiency as causes of anemia. The American journal of clinical nutrition, 48(5), 1295-1300. 全國法規資料庫. (2006). 捐血者健康標準. Retrieved from http://law.moj.gov.tw/LawClass/LawAll.aspx?PCode= L0020125 潘文涵等. (2009). 台灣人飲食與健康之趨勢:1993-1996 與 2005-2008 兩次營養健康調查之比較. Retrieved from http://obesity.hpa.gov.tw/PDA/researchList.aspx?cid=163 衛生福利部國民健康署. (2006). 健康久久網站. Retrieved from http://health99.hpa.gov.tw/OnlinkHealth/Onlink_BMI.aspx 蕭寧馨等. (1999). 國民營養健康狀況變遷調查 1993-1996 國人鐵營養狀況與缺鐵盛行率 1993-1994. 臺灣營養學會雜誌, 24卷(1期). 醫療財團法人台灣血液基金會. (2016a). 台灣捐血事業簡介 [Press release] 醫療財團法人台灣血液基金會. (2016b). 認識分離術捐血 [Press release] 醫療財團法人台灣血液基金會. (2016c). 醫療財團法人台灣血液基金會105年年報 [Press release] | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/67881 | - |
dc.description.abstract | 鐵是人體必需的營養素,根據聯合國的報告,缺鐵是開發中國家與富裕國家相同面對的營養與公共衛生問題。近年來,捐血可能會因血液的流失,造成捐血者貧血的議題已受到美國血庫協會的重視。台灣血液基金會於2009年至2013年,曾實施每5個月監測分離術血小板捐血者的鐵蛋白值,累積的資料尚未做統整分析,值得做進一步的研究。
本研究藉由收集5,127位進行鐵蛋白值監測個案的性別、年齡、鐵蛋白值、BMI、血紅素值及平均紅血球體積數據,計算其敘述統計(如平均值、標準誤、中位數)以了解這些資料的分布概況,並以t檢定(t test)比較男女各變項平均值的差異;再以性別與年齡50歲分層,比較不同的捐血頻率¬是否對鐵蛋白的影響有差異。若依照台灣血液基金會之規定,將2次鐵蛋白檢測的時間範圍限制在150~160天的間隔,再依間隔中間的捐血次數將所有個案資料分為0次、1~3次、4~6次、7~9次及10次以上共五組,比較五組的「前」「後」測鐵蛋白改變量有無差異,結果發現高捐血頻率組的鐵蛋白改變量最大。之後又針對高頻率(半年捐血10次以上組)捐血者進行縱貫分析,發現長期持續的高頻率捐血的確造成體內鐵蛋白顯著下降,且初始鐵蛋白的高低對鐵蛋白的改變量亦有差異。本研究續以多元回歸分析探討,進一步以廣義估計式建立本研究的重複測量結果預測鐵蛋白,統計分析使用SAS(9.4版)及SAS EG(6.1版)統計軟體執行個案敘述統計及推論統計分析。 本研究分別以鐵蛋白改變量及鐵蛋白建立兩種模式。結果發現性別、捐血頻率、初始鐵蛋白及BMI都是鐵蛋白顯著預測因子(p值皆<0.05)。 本研究發現本國的血小板捐血者在近半年的捐血間隔下,捐血次數越高,鐵蛋白值下降越多。而這種高頻率的血小板捐血者,持續捐一年後的體內鐵蛋白仍會下降,但下降情況趨緩;多元迴歸模式分析結果顯示,性別、捐血頻率、初始鐵蛋白及BMI對血小板捐血人的鐵蛋白有顯著影響,未來應可適度利用來建立捐血者之的體內鐵蛋白質的預測,以初步評估捐血人是否適合進行捐血。 | zh_TW |
dc.description.abstract | Iron is a necessary nutrient for the human body, according to the United Nations report, iron deficiency is a public health problem in many countries. In recent years, the iron-deficiency anemia due to blood donation has attracted great attention. From 2009 to 2013, Taiwan Blood Service Foundation conducted a program to monitor the ferritin levels of platelet blood donors. This huge dataset had not yet been analyzed.
In this study, we collected 5,127 cases whose ferritin levels have been monitored more than twice with an interval of detection in 150-160 days. The summary statistics, such as mean value, standard error and median, were then calculated for variables including sex, age, BMI, ferritin value, hemoglobin value and mean corpuscular volume. The difference between mean values of different genders was compared with t test. The blood donations frequency was categorized into five groups: 0 times, 1 to 3 times, 4 to 6 times, 7 to 9 times and more than 10 times. The result indicates that the group with the highest frequency (more than 10 times) has the lowest ferritin level. In this study, two multiple regression models with Generalized estimating equation (GEE) were explored, i.e. the ferritin changes model and the ferritin model. The multiple regression analysis with GEE identified that gender, donation frequency, initial ferritin value and BMI were all significant predictors for ferritin level (all p’s<0.05). All data were analyzed for descriptive and statistical analysis using the Statistical Analysis System (SAS). This study identifies that the higher the frequency of blood donation, the more the decline in ferritin. Such decreasing pattern remains for the high frequency group even after a year, but with a slower rate, if they continue to donate. Furthermore, to predict future ferritin level, the gender, donation frequency, initial ferritin value and BMI could be used to predict future ferritin levels, and serve as information for whether the blood donation will further induce the deficiency. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T01:55:46Z (GMT). No. of bitstreams: 1 ntu-106-R04847022-1.pdf: 2424245 bytes, checksum: f29028c1ae6e7c72454329752655b27b (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 口試委員審定書 i
中文摘要 ii 英文摘要 iv 第一章 導論 1 第一節 實習單位特色與簡介 1 第二節 研究背景 3 第三節 文獻回顧 6 第四節 研究目的與研究議題 7 第五節 研究倫理 8 第二章 研究資料與分析方法 9 第一節 資料來源 9 第二節 年齡與性別的影響 10 第三節 個案篩選流程 12 第四節 統計分析方法 14 第三章 結果 16 第一節 個案敘述統計 16 第二節 以捐血頻率做橫斷面分析 20 第三節 以持續捐血天數做分析 22 第四節 收案時鐵蛋白高低不同的分組分析 24 第五節 鐵蛋白改變量的影響因子分析 26 第六節 鐵蛋白預測模式建立與分析 29 第四章 討論 32 第一節 研究結論 32 第二節 是否達成實習目的 33 第三節 對於實務實習單位的建議與回饋 34 第四節 相關政策上的意涵或政策建議 34 附錄 36 參考文獻 41 | |
dc.language.iso | zh-TW | |
dc.title | 探討血小板捐血人的長期鐵蛋白變化趨勢 | zh_TW |
dc.title | A Longitudinal Study of Ferritin Change in Apheresis Platelet Donors | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 陳韻元(Yun-Yuan Chen) | |
dc.contributor.oralexamcommittee | 林東燦,楊銘欽,林菀俞 | |
dc.subject.keyword | 鐵蛋白,血紅素,平均紅血球體積,捐血頻率,廣義估計式, | zh_TW |
dc.subject.keyword | ferritin,hemoglobin,mean corpuscular volume,blood donation frequency,generalized estimating equation, | en |
dc.relation.page | 44 | |
dc.identifier.doi | 10.6342/NTU201701729 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2017-07-24 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 公共衛生碩士學位學程 | zh_TW |
顯示於系所單位: | 公共衛生碩士學位學程 |
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