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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 詹東榮(Tong-Rong Jan) | |
dc.contributor.author | Min-Chun Chung | en |
dc.contributor.author | 鍾姄 | zh_TW |
dc.date.accessioned | 2021-05-17T09:17:55Z | - |
dc.date.available | 2017-07-27 | |
dc.date.available | 2021-05-17T09:17:55Z | - |
dc.date.copyright | 2012-07-27 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-07-19 | |
dc.identifier.citation | References
Abdelhalim, M.A., Jarrar, B.M., 2011. Gold nanoparticles administration induced prominent inflammatory, central vein intima disruption, fatty change and Kupffer cells hyperplasia. Lipids Health Dis 10, 133. Black, R.A., 2002. Tumor necrosis factor-alpha converting enzyme. Int J Biochem Cell Biol 34, 1-5. Blank, F., Gerber, P., Rothen-Rutishauser, B., Sakulkhu, U., Salaklang, J., De Peyer, K., Gehr, P., Nicod, L.P., Hofmann, H., Geiser, T., Petri-Fink, A., Von Garnier, C., 2011. Biomedical nanoparticles modulate specific CD4+ T cell stimulation by inhibition of antigen processing in dendritic cells. Nanotoxicology 5, 606-621. Boverhof, D.R., David, R.M., 2010. Nanomaterial characterization: considerations and needs for hazard assessment and safety evaluation. Anal Bioanal Chem 396, 953-961. Boya, P., Kroemer, G., 2008. Lysosomal membrane permeabilization in cell death. Oncogene 27, 6434-6451. Bulte, J.W., Douglas, T., Witwer, B., Zhang, S.C., Strable, E., Lewis, B.K., Zywicke, H., Miller, B., van Gelderen, P., Moskowitz, B.M., Duncan, I.D., Frank, J.A., 2001. Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 19, 1141-1147. Buyukhatipoglu, K., Clyne, A.M., 2011. Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation. J Biomed Mater Res A 96, 186-195. Chan, W.H., Shiao, N.H., Lu, P.Z., 2006. CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrial-dependent pathways and inhibition of survival signals. Toxicol Lett 167, 191-200. Chauvet, N., Palin, K., Verrier, D., Poole, S., Dantzer, R., Lestage, J., 2001. Rat microglial cells secrete predominantly the precursor of interleukin-1beta in response to lipopolysaccharide. Eur J Neurosci 14, 609-617. Chen, Y., Guzik, S., Sumner, J.P., Moreland, J., Koretsky, A.P., 2011. Magnetic manipulation of actin orientation, polymerization, and gliding on myosin using superparamagnetic iron oxide particles. Nanotechnology 22, 065101. Cho, W.S., Cho, M., Kim, S.R., Choi, M., Lee, J.Y., Han, B.S., Park, S.N., Yu, M.K., Jon, S., Jeong, J., 2009. Pulmonary toxicity and kinetic study of Cy5.5-conjugated superparamagnetic iron oxide nanoparticles by optical imaging. Toxicol Appl Pharmacol 239, 106-115. Choi, J., Zheng, Q., Katz, H.E., Guilarte, T.R., 2010. Silica-based nanoparticle uptake and cellular response by primary microglia. Environ Health Perspect 118, 589-595. Chouly, C., Pouliquen, D., Lucet, I., Jeune, J.J., Jallet, P., 1996. Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution. J Microencapsul 13, 245-255. Draheim, H.J., Prinz, M., Weber, J.R., Weiser, T., Kettenmann, H., Hanisch, U.K., 1999. Induction of potassium channels in mouse brain microglia: cells acquire responsiveness to pneumococcal cell wall components during late development. Neuroscience 89, 1379-1390. Engberink, R.D., van der Pol, S.M., Walczak, P., van der Toorn, A., Viergever, M.A., Dijkstra, C.D., Bulte, J.W., de Vries, H.E., Blezer, E.L., 2010. Magnetic resonance imaging of monocytes labeled with ultrasmall superparamagnetic particles of iron oxide using magnetoelectroporation in an animal model of multiple sclerosis. Mol Imaging 9, 268-277. Forgac, M., 1989. Structure and function of vacuolar class of ATP-driven proton pumps. Physiol Rev 69, 765-796. Garden, G.A., Moller, T., 2006. Microglia biology in health and disease. J Neuroimmune Pharmacol 1, 127-137. Grazioli, L., Bondioni, M.P., Romanini, L., Frittoli, B., Gambarini, S., Donato, F., Santoro, L., Colagrande, S., 2009. Superparamagnetic iron oxide-enhanced liver MRI with SHU 555 A (RESOVIST): New protocol infusion to improve arterial phase evaluation--a prospective study. J Magn Reson Imaging 29, 607-616. Gupta, A.K., Gupta, M., 2005. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26, 3995-4021. Gustafsson, A., Lindstedt, E., Elfsmark, L.S., Bucht, A., 2011. Lung exposure of titanium dioxide nanoparticles induces innate immune activation and long-lasting lymphocyte response in the Dark Agouti rat. J Immunotoxicol 8, 111-121. Hamm, B., Staks, T., Taupitz, M., Maibauer, R., Speidel, A., Huppertz, A., Frenzel, T., Lawaczeck, R., Wolf, K.J., Lange, L., 1994. Contrast-enhanced MR imaging of liver and spleen: first experience in humans with a new superparamagnetic iron oxide. J Magn Reson Imaging 4, 659-668. Hautot, D., Pankhurst, Q.A., Morris, C.M., Curtis, A., Burn, J., Dobson, J., 2007. Preliminary observation of elevated levels of nanocrystalline iron oxide in the basal ganglia of neuroferritinopathy patients. Biochim Biophys Acta 1772, 21-25. Hentze, H., Lin, X.Y., Choi, M.S., Porter, A.G., 2003. Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin. Cell Death Differ 10, 956-968. Hinton, A., Bond, S., Forgac, M., 2009. V-ATPase functions in normal and disease processes. Pflugers Arch 457, 589-598. Hsiao, J.K., Chu, H.H., Wang, Y.H., Lai, C.W., Chou, P.T., Hsieh, S.T., Wang, J.L., Liu, H.M., 2008. Macrophage physiological function after superparamagnetic iron oxide labeling. NMR Biomed 21, 820-829. Hu, Y.L., Gao, J.Q., 2010. Potential neurotoxicity of nanoparticles. Int J Pharm 394, 115-121. Huber, D.L., 2005. Synthesis, properties, and applications of iron nanoparticles. Small 1, 482-501. Hutter, E., Boridy, S., Labrecque, S., Lalancette-Hebert, M., Kriz, J., Winnik, F.M., Maysinger, D., 2010. Microglial response to gold nanoparticles. ACS Nano 4, 2595-2606. Imai, Y., Kohsaka, S., 2002. Intracellular signaling in M-CSF-induced microglia activation: role of Iba1. Glia 40, 164-174. Ito, A., Shinkai, M., Honda, H., Kobayashi, T., 2005. Medical application of functionalized magnetic nanoparticles. J Biosci Bioeng 100, 1-11. Jackson, H., Muhammad, O., Daneshvar, H., Nelms, J., Popescu, A., Vogelbaum, M.A., Bruchez, M., Toms, S.A., 2007. Quantum dots are phagocytized by macrophages and colocalize with experimental gliomas. Neurosurgery 60, 524-529; discussion 529-530. Jan, E., Byrne, S.J., Cuddihy, M., Davies, A.M., Volkov, Y., Gun'ko, Y.K., Kotov, N.A., 2008. High-content screening as a universal tool for fingerprinting of cytotoxicity of nanoparticles. ACS Nano 2, 928-938. Ji, K.A., Yang, M.S., Jeong, H.K., Min, K.J., Kang, S.H., Jou, I., Joe, E.H., 2007. Resident microglia die and infiltrated neutrophils and monocytes become major inflammatory cells in lipopolysaccharide-injected brain. Glia 55, 1577-1588. Johnson-Lyles, D.N., Peifley, K., Lockett, S., Neun, B.W., Hansen, M., Clogston, J., Stern, S.T., McNeil, S.E., 2010. Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction. Toxicol Appl Pharmacol 248, 249-258. Kanazawa, H., Ohsawa, K., Sasaki, Y., Kohsaka, S., Imai, Y., 2002. Macrophage/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway. J Biol Chem 277, 20026-20032. Kim, S.U., de Vellis, J., 2005. Microglia in health and disease. J Neurosci Res 81, 302-313. Kirik, O.V., Sukhorukova, E.G., Korzhevskii, D.E., 2010. [Calcium-binding Iba-1/AIF-1 protein in rat brain cells]. Morfologiia 137, 5-8. Klionsky, D.J., Emr, S.D., 2000. Autophagy as a regulated pathway of cellular degradation. Science 290, 1717-1721. Kohler, C., 2007. Allograft inflammatory factor-1/Ionized calcium-binding adapter molecule 1 is specifically expressed by most subpopulations of macrophages and spermatids in testis. Cell Tissue Res 330, 291-302. Levesque, S., Taetzsch, T., Lull, M.E., Kodavanti, U., Stadler, K., Wagner, A., Johnson, J.A., Duke, L., Kodavanti, P., Surace, M.J., Block, M.L., 2011. Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity. Environ Health Perspect 119, 1149-1155. Li, J.J., Muralikrishnan, S., Ng, C.T., Yung, L.Y., Bay, B.H., 2010. Nanoparticle-induced pulmonary toxicity. Exp Biol Med (Maywood) 235, 1025-1033. Liong, M., Lu, J., Kovochich, M., Xia, T., Ruehm, S.G., Nel, A.E., Tamanoi, F., Zink, J.I., 2008. Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano 2, 889-896. Liu, D., Wu, W., Chen, X., Wen, S., Zhang, X., Ding, Q., Teng, G., Gu, N., 2012. Conjugation of paclitaxel to iron oxide nanoparticles for tumor imaging and therapy. Nanoscale 4, 2306-2310. Liu, G., Men, P., Harris, P.L., Rolston, R.K., Perry, G., Smith, M.A., 2006. Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance. Neurosci Lett 406, 189-193. Liu, Y., Jiao, F., Qiu, Y., Li, W., Lao, F., Zhou, G., Sun, B., Xing, G., Dong, J., Zhao, Y., Chai, Z., Chen, C., 2009. The effect of Gd@C82(OH)22 nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity. Biomaterials 30, 3934-3945. Long, T.C., Saleh, N., Tilton, R.D., Lowry, G.V., Veronesi, B., 2006. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity. Environ Sci Technol 40, 4346-4352. Long, T.C., Tajuba, J., Sama, P., Saleh, N., Swartz, C., Parker, J., Hester, S., Lowry, G.V., Veronesi, B., 2007. Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro. Environ Health Perspect 115, 1631-1637. Lunov, O., Syrovets, T., Buchele, B., Jiang, X., Rocker, C., Tron, K., Nienhaus, G.U., Walther, P., Mailander, V., Landfester, K., Simmet, T., 2010a. The effect of carboxydextran-coated superparamagnetic iron oxide nanoparticles on c-Jun N-terminal kinase-mediated apoptosis in human macrophages. Biomaterials 31, 5063-5071. Lunov, O., Syrovets, T., Rocker, C., Tron, K., Nienhaus, G.U., Rasche, V., Mailander, V., Landfester, K., Simmet, T., 2010b. Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes. Biomaterials 31, 9015-9022. Luo P.Q. 2011 Master thesis: The study of novel alumina nanomaterials on microglia phagocytosis suppression. Institute of Microbiology & Immunology, Chung Shan Medical University, Taichung, Taiwan. Luzio, J.P., Pryor, P.R., Bright, N.A., 2007. Lysosomes: fusion and function. Nat Rev Mol Cell Biol 8, 622-632. Ma, J.S., Kim, W.J., Kim, J.J., Kim, T.J., Ye, S.K., Song, M.D., Kang, H., Kim, D.W., Moon, W.K., Lee, K.H., 2010. Gold nanoparticles attenuate LPS-induced NO production through the inhibition of NF-kappaB and IFN-beta/STAT1 pathways in RAW264.7 cells. Nitric Oxide 23, 214-219. Ma, X., Wu, Y., Jin, S., Tian, Y., Zhang, X., Zhao, Y., Yu, L., Liang, X.J., 2011. Gold nanoparticles induce autophagosome accumulation through size-dependent nanoparticle uptake and lysosome impairment. ACS Nano 5, 8629-8639. Maysinger, D., Behrendt, M., Lalancette-Hebert, M., Kriz, J., 2007. Real-time imaging of astrocyte response to quantum dots: in vivo screening model system for biocompatibility of nanoparticles. Nano Lett 7, 2513-2520. Metz, S., Bonaterra, G., Rudelius, M., Settles, M., Rummeny, E.J., Daldrup-Link, H.E., 2004. Capacity of human monocytes to phagocytose approved iron oxide MR contrast agents in vitro. Eur Radiol 14, 1851-1858. Minagar, A., Shapshak, P., Fujimura, R., Ownby, R., Heyes, M., Eisdorfer, C., 2002. The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J Neurol Sci 202, 13-23. Mishima, T., Iwabuchi, K., Fujii, S., Tanaka, S.Y., Ogura, H., Watano-Miyata, K., Ishimori, N., Andoh, Y., Nakai, Y., Iwabuchi, C., Ato, M., Kitabatake, A., Tsutsui, H., Onoe, K., 2008. Allograft inflammatory factor-1 augments macrophage phagocytotic activity and accelerates the progression of atherosclerosis in ApoE-/- mice. Int J Mol Med 21, 181-187. Mistry, A., Stolnik, S., Illum, L., 2009. Nanoparticles for direct nose-to-brain delivery of drugs. Int J Pharm 379, 146-157. Morishige, T., Yoshioka, Y., Tanabe, A., Yao, X., Tsunoda, S., Tsutsumi, Y., Mukai, Y., Okada, N., Nakagawa, S., 2010. Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B. Biochem Biophys Res Commun 392, 160-165. Mou, Y., Chen, B., Zhang, Y., Hou, Y., Xie, H., Xia, G., Tang, M., Huang, X., Ni, Y., Hu, Q., 2011. Influence of synthetic superparamagnetic iron oxide on dendritic cells. Int J Nanomedicine 6, 1779-1786. Naqvi, S., Samim, M., Abdin, M., Ahmed, F.J., Maitra, A., Prashant, C., Dinda, A.K., 2010. Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress. Int J Nanomedicine 5, 983-989. Nishanth, R.P., Jyotsna, R.G., Schlager, J.J., Hussain, S.M., Reddanna, P., 2011. Inflammatory responses of RAW 264.7 macrophages upon exposure to nanoparticles: role of ROS-NFkappaB signaling pathway. Nanotoxicology 5, 502-516. Nunes, A., Al-Jamal, K.T., Kostarelos, K., 2012. Therapeutics, imaging and toxicity of nanomaterials in the central nervous system. J Control Release. Oberdörster, G., Stone, V., Donaldson, K., 2007. Toxicology of nanoparticles: a historical perspective. Nanotoxicology 1, 2-25. Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., Cox, C., 2004. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16, 437-445. Ohsawa, K., Imai, Y., Kanazawa, H., Sasaki, Y., Kohsaka, S., 2000. Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J Cell Sci 113 ( Pt 17), 3073-3084. Park, E.J., Kim, H., Kim, Y., Yi, J., Choi, K., Park, K., 2010. Inflammatory responses may be induced by a single intratracheal instillation of iron nanoparticles in mice. Toxicology 275, 65-71. Patro, N., Nagayach, A., Patro, I.K., 2010. Iba1 expressing microglia in the dorsal root ganglia become activated following peripheral nerve injury in rats. Indian J Exp Biol 48, 110-116. Pisanic, T.R., 2nd, Blackwell, J.D., Shubayev, V.I., Finones, R.R., Jin, S., 2007. Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. Biomaterials 28, 2572-2581. Prinz, M., Kann, O., Draheim, H.J., Schumann, R.R., Kettenmann, H., Weber, J.R., Hanisch, U.K., 1999. Microglial activation by components of gram-positive and -negative bacteria: distinct and common routes to the induction of ion channels and cytokines. J Neuropathol Exp Neurol 58, 1078-1089. Qu, G., Zhang, C., Yuan, L., He, J., Wang, Z., Wang, L., Liu, S., Jiang, G., 2012. Quantum dots impair macrophagic morphology and the ability of phagocytosis by inhibiting the Rho-associated kinase signaling. Nanoscale 4, 2239-2244. Radomski, A., Jurasz, P., Alonso-Escolano, D., Drews, M., Morandi, M., Malinski, T., Radomski, M.W., 2005. Nanoparticle-induced platelet aggregation and vascular thrombosis. Br J Pharmacol 146, 882-893. Saftig, P., Klumperman, J., 2009. Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Nat Rev Mol Cell Biol 10, 623-635. Saijo, K., Glass, C.K., 2011. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 11, 775-787. Sanz, J.M., Di Virgilio, F., 2000. Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells. J Immunol 164, 4893-4898. Sayin, B., Somavarapu, S., Li, X.W., Sesardic, D., Senel, S., Alpar, O.H., 2009. TMC-MCC (N-trimethyl chitosan-mono-N-carboxymethyl chitosan) nanocomplexes for mucosal delivery of vaccines. Eur J Pharm Sci 38, 362-369. Schladt, T.D., Schneider, K., Schild, H., Tremel, W., 2011. Synthesis and bio-functionalization of magnetic nanoparticles for medical diagnosis and treatment. Dalton Trans 40, 6315-6343. Shen, C.C., Liang, H.J., Wang, C.C., Liao, M.H., T.R., J., 2011a. A role of cellular glutathione in the differential effects of iron oxide nanoparticles on antigen-specific T cell cytokine expression. Int J Nanomedicine 6. Shen, C.C., Wang, C.C., Liao, M.H., Jan, T.R., 2011b. A single exposure to iron oxide nanoparticles attenuates antigen-specific antibody production and T-cell reactivity in ovalbumin-sensitized BALB/c mice. Int J Nanomedicine 6, 1229-1235. Silva, A.C., Oliveira, T.R., Mamani, J.B., Malheiros, S.M., Malavolta, L., Pavon, L.F., Sibov, T.T., Amaro, E., Jr., Tannus, A., Vidoto, E.L., Martins, M.J., Santos, R.S., Gamarra, L.F., 2011. Application of hyperthermia induced by superparamagnetic iron oxide nanoparticles in glioma treatment. Int J Nanomedicine 6, 591-603. Silva, G.A., 2008. Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS. BMC Neurosci 9 Suppl 3, S4. Singh, N., Jenkins, G.J., Asadi, R., Doak, S.H., 2010. Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION). Nano Rev 1. Soenen, S.J., Nuytten, N., De Meyer, S.F., De Smedt, S.C., De Cuyper, M., 2010. High intracellular iron oxide nanoparticle concentrations affect cellular cytoskeleton and focal adhesion kinase-mediated signaling. Small 6, 832-842. Song, L., Lee, C., Schindler, C., 2011. Deletion of the murine scavenger receptor CD68. J Lipid Res 52, 1542-1550. Spuch, C., Saida, O., Navarro, C., 2012. Advances in the treatment of neurodegenerative disorders employing nanoparticles. Recent Pat Drug Deliv Formul 6, 2-18. Stanley, A.C., Lacy, P., 2010. Pathways for cytokine secretion. Physiology (Bethesda) 25, 218-229. Stow, J.L., Low, P.C., Offenhauser, C., Sangermani, D., 2009. Cytokine secretion in macrophages and other cells: pathways and mediators. Immunobiology 214, 601-612. Terada, K., Yamada, J., Hayashi, Y., Wu, Z., Uchiyama, Y., Peters, C., Nakanishi, H., 2010. Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia. Glia 58, 114-124. Trombetta, E.S., Ebersold, M., Garrett, W., Pypaert, M., Mellman, I., 2003. Activation of lysosomal function during dendritic cell maturation. Science 299, 1400-1403. Tsai, C.Y., Lu, S.L., Hu, C.W., Yeh, C.S., Lee, G.B., Lei, H.Y., 2012. Size-dependent attenuation of TLR9 signaling by gold nanoparticles in macrophages. J Immunol 188, 68-76. Vancompernolle, K., Van Herreweghe, F., Pynaert, G., Van de Craen, M., De Vos, K., Totty, N., Sterling, A., Fiers, W., Vandenabeele, P., Grooten, J., 1998. Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity. FEBS Lett 438, 150-158. Villiers, C., Freitas, H., Couderc, R., Villiers, M.B., Marche, P., 2010. Analysis of the toxicity of gold nano particles on the immune system: effect on dendritic cell functions. J Nanopart Res 12, 55-60. Wang, B., Feng, W.Y., Wang, M., Shi, J.W., Zhang, F., Ouyang, H., Zhao, Y.L., Chai, Z.F., Huang, Y.Y., Xie, Y.N., Wang, H.F., Wang, J., 2007. Transport of intranasally instilled fine Fe2O3 particles into the brain: micro-distribution, chemical states, and histopathological observation. Biol Trace Elem Res 118, 233-243. Wang, B., Feng, W.Y., Zhu, M.T., Wang, M., Gu, Y., Ouyang, H., Wang, H., Li, M., Zhao, Y., Chai, Z.F., Wang, H., 2009. Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice. J. Nanopart. Res. 11, 41–53. Wang, J., Chen, B., Jin, N., Xia, G., Chen, Y., Zhou, Y., Cai, X., Ding, J., Li, X., Wang, X., 2011a. The changes of T lymphocytes and cytokines in ICR mice fed with Fe3O4 magnetic nanoparticles. Int J Nanomedicine 6, 605-610. Wang, S., Kurepa, J., Smalle, J.A., 2011b. Ultra-small TiO(2) nanoparticles disrupt microtubular networks in Arabidopsis thaliana. Plant Cell Environ 34, 811-820. Wang, Y., Wang, B., Zhu, M.T., Li, M., Wang, H.J., Wang, M., Ouyang, H., Chai, Z.F., Feng, W.Y., Zhao, Y.L., 2011c. Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure. Toxicol Lett 205, 26-37. Warheit, D.B., Webb, T.R., Sayes, C.M., Colvin, V.L., Reed, K.L., 2006. Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area. Toxicol Sci 91, 227-236. Weber, S.M., Levitz, S.M., 2001. Chloroquine antagonizes the proinflammatory cytokine response to opportunistic fungi by alkalizing the fungal phagolysosome. J Infect Dis 183, 935-942. Weinstein, J.S., Varallyay, C.G., Dosa, E., Gahramanov, S., Hamilton, B., Rooney, W.D., Muldoon, L.L., Neuwelt, E.A., 2010. Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review. J Cereb Blood Flow Metab 30, 15-35. Wu, X., Tan, Y., Mao, H., Zhang, M., 2010. Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells. Int J Nanomedicine 5, 385-399. Xie, J., Huang, J., Li, X., Sun, S., Chen, X., 2009. Iron oxide nanoparticle platform for biomedical applications. Curr Med Chem 16, 1278-1294. Yang, C.Y., Tai, M.F., Lin, C.P., Lu, C.W., Wang, J.L., Hsiao, J.K., Liu, H.M., 2011. Mechanism of cellular uptake and impact of ferucarbotran on macrophage physiology. PLoS One 6, e25524. Yang, D., Zhao, Y., Guo, H., Li, Y., Tewary, P., Xing, G., Hou, W., Oppenheim, J.J., Zhang, N., 2010a. [Gd@C(82)(OH)(22)](n) nanoparticles induce dendritic cell maturation and activate Th1 immune responses. ACS Nano 4, 1178-1186. Yang, X., Liu, J., He, H., Zhou, L., Gong, C., Wang, X., Yang, L., Yuan, J., Huang, H., He, L., Zhang, B., Zhuang, Z., 2010b. SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells. Part Fibre Toxicol 7, 1. Yang, Y., Qu, Y., Lu, X., 2010c. Global gene expression analysis of the effects of gold nanoparticles on human dermal fibroblasts. J Biomed Nanotechnol 6, 234-246. Yang, Z., Liu, Z.W., Allaker, R.P., Reip, P., Oxford, J., Ahmad, Z., Ren, G., 2010d. A review of nanoparticle functionality and toxicity on the central nervous system. J R Soc Interface 7 Suppl 4, S411-422. Yeh, C.H., Hsiao, J.K., Wang, J.L., Sheu, F., 2010. Immunological impact of magnetic nanoparticles (Ferucarbotran) on murine peritoneal macrophages. J Nanopart Res 12, 151–160. Yen, H.J., Hsu, S.H., Tsai, C.L., 2009. Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. Small 5, 1553-1561. Yu, M.K., Jeong, Y.Y., Park, J., Park, S., Kim, J.W., Min, J.J., Kim, K., Jon, S., 2008. Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo. Angew Chem Int Ed Engl 47, 5362-5365. Zdolsek, J.M., Olsson, G.M., Brunk, U.T., 1990. Photooxidative damage to lysosomes of cultured macrophages by acridine orange. Photochem Photobiol 51, 67-76. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/6777 | - |
dc.description.abstract | 氧化鐵奈米粒子普遍應用於中樞核磁共振成像的對比劑。微膠細胞為中樞神經系統中主要的免疫細胞,具有監督外來抗原入侵及引起適當炎症反應以消滅外來病原之功能。本研究的主旨在於探討當中樞感染與小鼠初代微膠細胞大量活化下,氧化鐵奈米粒子對其免疫功能是否造成影響。實驗結果顯示氧化鐵奈米粒子濃度低於每毫升100 微克的鐵(100 μg of Fe/mL)時,對小鼠微膠細胞並無細胞毒性,微膠細胞會快速將氧化鐵奈米粒子吞入細胞內,同時抑制微膠細胞的活化、吞噬能力、interleukin-1β (IL-1β)的分泌與IL-1β converting enzyme (ICE) 的活性,但tumor necrosis factor-α (TNF-α) 與TNF-α converting enzyme (TACE) 卻不受影響。此外,被攝入的氧化鐵奈米粒子會進入微膠細胞內的溶體,同時造成溶體鹼化與膜通透性上升,並抑制溶體分解蛋白質的能力及cathepsin B酵素的活性。進一步探討氧化鐵奈米粒子抑制免疫功能與溶體受損間的關係,顯示氧化鐵奈米粒子抑制cathepsin B的活性而減少ICE活性與IL-1β的分泌。綜合上述,本研究結果指出氧化鐵奈米粒子會抑制微膠細胞防禦性免疫功能,且傷害溶體正常功能,顯示氧化鐵奈米粒子抑制微膠細胞對抗病原感染能力。 | zh_TW |
dc.description.abstract | Superparamagnetic iron oxide nanoparticles have been employed as magnetic resonance imaging contrast agents for a variety of diagnostic applications, including the imaging of the central nervous system (CNS). As the central resident immune cells with macrophage-like functions, microglia are the dominant cells responsible for managing foreign materials invading the CNS. The objective of this study was to investigate the potential effect of iron oxide nanoparticles on functional activities of primary murine microglia stimulated with lipopolysaccharide (LPS). The results showed that iron oxide nanoparticles at concentrations < 100 μg of Fe/mL did not cause cytotoxicity. Confocal imaging revealed that iron oxide nanoparticles were rapidly and markedly engulfed by microglia. Iron oxide nanoparticles inhibited the expression of the activation marker ionized calcium-binding adaptor molecule-1 and the phagocytic activity of LPS-stimulated microglia. In addition, iron oxide nanoparticles inhibited secretion of interleukin (IL)-1β and IL-1β converting enzyme (ICE) activity, whereas tumor necrosis factor (TNF)-α secretion and TNF-α converting enzyme (TACE) activity were unaltered. Furthermore, internalized iron oxide nanoparticles were accumulated in lysosomes. Iron oxide nanoparticles also impaired lysosome proteolytic and cathepsin B activity, and increased lysosomal membrane permeability and alkalinization. These results suggest that the iron oxide nanoparticles may inhibit the cathepsin B activity, which subsequently suppress the activation of ICE and the secretion of IL-1β. Collectively, the present study demonstrated that iron oxide nanoparticles markedly attenuated the activation and functional activities of LPS-stimulated microglia, suggesting an impaired defense capacity of microglia against gram-negative bacteria. | en |
dc.description.provenance | Made available in DSpace on 2021-05-17T09:17:55Z (GMT). No. of bitstreams: 1 ntu-101-R99629005-1.pdf: 4641913 bytes, checksum: fab8e12d7ee864e040492a96971b5953 (MD5) Previous issue date: 2012 | en |
dc.description.tableofcontents | Content
口試委員審定書..........................................I 致謝....................................................II 中文摘要................................................III Abstract................................................IV Content.................................................V Figures.................................................VIII Abbreviation............................................IX Chapter 1 Introduction....................................1 1.1 Background of nanoparticles and iron oxide nanoparticles.........................................1 1.2 Toxicity of nanoparticles.............................2 1.3 Effects of nanoparticles on immune cells..............3 1.4 The potential toxicity of nanoparticles to the central nervous system (CNS)..................................4 1.5 Microglia.............................................6 1.6 Immunological impacts of nanoparticles on microglia...7 1.7 Objective of the study................................8 Chapter 2 Materials and Methods..........................10 2.1 Chemicals and reagents...............................10 2.2 Culture of primary murine microglial cells...........11 2.3 Internalization of iron oxide nanoparticles and colocalized with lysosome............................12 2.4 Measurement of cell viability by MTT assay...........12 2.5 Detection of microglial activation marker expression.13 2.6 Analysis of phagocytic activity......................13 2.7 Measurement of cytokines by ELISA....................14 2.8 Measurement of IL-1βconverting enzyme activity using enzymatic assay......................................15 2.9 Measurement of TNF-α converting enzyme activity using enzymatic assay......................................15 2.10 Analysis of amount of total lysosomes...............16 2.11 Measurement of lysosomal membrane permeability......16 2.12 Measurement of lysosomal pH.........................17 2.13 Measurement of proteolytic activity.................17 2.14 Measurement of cathepsin B activity.................17 2.15 Statistical analysis................................18 Chapter 3 Results........................................19 3.1 Uptake of iron oxide nanoparticles by LPS-stimulated microglia............................................19 3.2 No cytotoxic effect of iron oxide nanoparticles on LPS- stimulated microglia.................................21 3.3 Iron oxide nanoparticles inhibited the activation of LPS-stimulated microglia.............................22 3.4 Iron oxide nanoparticles inhibited the phagocytic activity of LPS-stimulated microglia.................24 3.5 Iron oxide nanoparticles differentially affected the secretion of proinflammatory cytokines in LPS- stimulated microglia.................................26 3.6 Iron oxide nanoparticles differentially affected the activity of ICE and TACE in LPS-stimulated microglia.27 3.7 The distribution of iron oxide nanoparticles in lysosomes of LPS-stimulated microglia................28 3.8 Iron oxide nanoparticles increased the amount of lysosomes in LPS-stimulated microglia................29 3.9 Iron oxide nanoparticles increased lysosomal membrane permeability in LPS-stimulated microglia.............31 3.10 Iron oxide nanoparticles induced lysosomal alkalinization in LPS-stimulated microglia...........33 3.11 Iron oxide nanoparticles inhibited lysosomal degradation capacity in LPS-stimulated microglia.....35 3.12 Iron oxide nanoparticles inhibited cathepsin B activity in LPS-stimulated microglia.................37 Chapter 4 Discussion.....................................39 References...............................................44 | |
dc.language.iso | en | |
dc.title | 氧化鐵奈米粒子對脂多醣活化小鼠微膠細胞功能之作用 | zh_TW |
dc.title | The Effect of Iron Oxide Nanoparticles on the Functionality of Murine Microglia Stimulated with Lipopolysaccharide | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 梁弘人,林俊宏,簡茂盛,林辰栖 | |
dc.subject.keyword | 介白素,氧化鐵奈米粒子,脂多醣,溶體,微膠細胞, | zh_TW |
dc.subject.keyword | interleukin, iron oxide nanoparticles,lipopolysaccharide,lysosome,microglia, | en |
dc.relation.page | 55 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2012-07-20 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
顯示於系所單位: | 獸醫學系 |
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