請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/67592
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 童世煌(Shih-Huang Tung) | |
dc.contributor.author | Hsiao-Wei Chung | en |
dc.contributor.author | 鐘筱崴 | zh_TW |
dc.date.accessioned | 2021-06-17T01:39:14Z | - |
dc.date.available | 2020-08-02 | |
dc.date.copyright | 2017-08-02 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-07-30 | |
dc.identifier.citation | 1.Anton, F. Process and apparatus for preparing artificial threads. U.S. Patent 1,975,504, October 2, 1934.
2.Fashandi, H.; Karimi, M., Pore formation in polystyrene fiber by superimposing temperature and relative humidity of electrospinning atmosphere. Polymer 2012, 53 (25), 5832-5849. 3.Chen, P.-Y.; Tung, S.-H., One-Step Electrospinning To Produce Nonsolvent-Induced Macroporous Fibers with Ultrahigh Oil Adsorption Capability. Macromolecules 2017, 50 (6), 2528-2534. 4.Fong, H.; Liu, W.; Wang, C.-S.; Vaia, R. A., Generation of electrospun fibers of nylon 6 and nylon 6-montmorillonite nanocomposite. Polymer 2002, 43 (3), 775-780. 5.Gibson, P.; Schreuder-Gibson, H.; Rivin, D., Transport properties of porous membranes based on electrospun nanofibers. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2001, 187, 469-481. 6.Tsai, P. P.; Schreuder-Gibson, H.; Gibson, P., Different electrostatic methods for making electret filters. Journal of Electrostatics 2002, 54 (3–4), 333-341. 7.Buchko, C. J.; Kozloff, K. M.; Martin, D. C., Surface characterization of porous, biocompatible protein polymer thin films. Biomaterials 2001, 22 (11), 1289-1300. 8.Bognitzki, M.; Czado, W.; Frese, T.; Schaper, A.; Hellwig, M.; Steinhart, M.; Greiner, A.; Wendorff, J. H., Nanostructured Fibers via Electrospinning. Advanced Materials 2001, 13 (1), 70-72. 9.Bognitzki, M.; Frese, T.; Steinhart, M.; Greiner, A.; Wendorff, J. H.; Schaper, A.; Hellwig, M., Preparation of fibers with nanoscaled morphologies: Electrospinning of polymer blends. Polymer Engineering & Science 2001, 41 (6), 982-989. 10.Kenawy, E.-R.; Bowlin, G. L.; Mansfield, K.; Layman, J.; Simpson, D. G.; Sanders, E. H.; Wnek, G. E., Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. Journal of Controlled Release 2002, 81 (1), 57-64. 11.Yoshimoto, H.; Shin, Y. M.; Terai, H.; Vacanti, J. P., A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 2003, 24 (12), 2077-2082. 12.Zong, X.; Kim, K.; Fang, D.; Ran, S.; Hsiao, B. S.; Chu, B., Structure and process relationship of electrospun bioabsorbable nanofiber membranes. Polymer 2002, 43 (16), 4403-4412. 13.Boland, E. D.; Wnek, G. E.; Simpson, D. G.; Pawlowski, K. J.; Bowlin, G. L., Tailoring tissue engineering scaffolds using electrostatic processing techniques: a study of poly(glycolic acid) electrospinning. Journal of Macromolecular Science, Part A 2001, 38 (12), 1231-1243. 14.Li, W. J.; Laurencin, C. T.; Caterson, E. J.; Tuan, R. S.; Ko, F. K., Electrospun nanofibrous structure: A novel scaffold for tissue engineering. Journal of Biomedical Materials Research 2002, 60 (4), 613-621. 15.Anton, F. Method and apparatus for spinning. U.S. Patent 2,160,962, June 6, 1939. 16.Anton, F. Artificial thread and method of producing same. U.S. Patent 2,187,306, January 16, 1940. 17.Anton, F. Production of artificial fibers from fiber forming liquids. U.S. patent 2,323,025, June 29, 1943. 18.Anton, F. Method and apparatus for spinning. U.S. Patent 2,349,950, May 30, 1944. 19.Darrell, H. R.; Iksoo, C., Nanometre diameter fibres of polymer, produced by electrospinning. Nanotechnology 1996, 7 (3), 216. 20.Doshi, J.; Reneker, D. H., Electrospinning process and applications of electrospun fibers. Journal of Electrostatics 1995, 35 (2), 151-160. 21.Reneker, D. H.; Yarin, A. L.; Fong, H.; Koombhongse, S., Bending instability of electrically charged liquid jets of polymer solutions in electrospinning. Journal of Applied Physics 2000, 87 (9), 4531-4547. 22.Shin, Y. M.; Hohman, M. M.; Brenner, M. P.; Rutledge, G. C., Experimental characterization of electrospinning: the electrically forced jet and instabilities. Polymer 2001, 42 (25), 09955-09967. 23.Deitzel, J. M.; Kleinmeyer, J. D.; Hirvonen, J. K.; Beck Tan, N. C., Controlled deposition of electrospun poly(ethylene oxide) fibers. Polymer 2001, 42 (19), 8163-8170. 24.Fang, X.; Reneker, D. H., DNA fibers by electrospinning. Journal of Macromolecular Science, Part B 1997, 36 (2), 169-173. 25.Taylor, G., Electrically Driven Jets. Proceedings of the Royal Society of London. A. Mathematical and Physical Sciences 1969, 313 (1515), 453. 26.Buchko, C. J.; Chen, L. C.; Shen, Y.; Martin, D. C., Processing and microstructural characterization of porous biocompatible protein polymer thin films. Polymer 1999, 40 (26), 7397-7407. 27.Fong, H.; Chun, I.; Reneker, D. H., Beaded nanofibers formed during electrospinning. Polymer 1999, 40 (16), 4585-4592. 28.Hajra, M. G.; Mehta, K.; Chase, G. G., Effects of humidity, temperature, and nanofibers on drop coalescence in glass fiber media. Separation and Purification Technology 2003, 30 (1), 79-88. 29.Norris, I. D.; Shaker, M. M.; Ko, F. K.; MacDiarmid, A. G., Electrostatic fabrication of ultrafine conducting fibers: polyaniline/polyethylene oxide blends. Synthetic Metals 2000, 114 (2), 109-114. 30.Han, S. O.; Son, W. K.; Cho, D.; Youk, J. H.; Park, W. H., Preparation of porous ultra-fine fibres via selective thermal degradation of electrospun polyetherimide/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibres. Polymer Degradation and Stability 2004, 86 (2), 257-262. 31.Kim, C. H.; Jung, Y. H.; Kim, H. Y.; Lee, D. R.; Dharmaraj, N.; Choi, K. E., Effect of collector temperature on the porous structure of electrospun fibers. Macromolecular Research 2006, 14 (1), 59-65. 32.You, Y.; Youk, J. H.; Lee, S. W.; Min, B.-M.; Lee, S. J.; Park, W. H., Preparation of porous ultrafine PGA fibers via selective dissolution of electrospun PGA / PLA blend fibers. Materials Letters 2006, 60 (6), 757-760. 33.Elford, W. J., Principles governing the preparation of membranes having graded porosities. The properties of 'gradocol' membranes as ultrafilters. Transactions of the Faraday Society 1937, 33 (0), 1094-1104. 34.Ferry, J. D., Ultrafilter Membranes and Ultrafiltration. Chemical Reviews 1936, 18 (3), 373-455. 35.Martinova, D. L. a. L., Formation mechanism of porous polycaprolactone nanofibers prepared by electrospinning. In Proceedings of the 42nd IUPAC Congress, Glasgow, Scotland, August 2009. 36.Qi, Z.; Yu, H.; Chen, Y.; Zhu, M., Highly porous fibers prepared by electrospinning a ternary system of nonsolvent/solvent/poly(l-lactic acid). Materials Letters 2009, 63 (3–4), 415-418. 37.Khil, M. S.; Bhattarai, S. R.; Kim, H. Y.; Kim, S. Z.; Lee, K. H., Novel fabricated matrix via electrospinning for tissue engineering. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2005, 72B (1), 117-124. 38.Choi, S.-S.; Lee, Y. S.; Joo, C. W.; Lee, S. G.; Park, J. K.; Han, K.-S., Electrospun PVDF nanofiber web as polymer electrolyte or separator. Electrochimica Acta 2004, 50 (2), 339-343. 39.Kim, J. H.; Park, B. J.; Han, Y. W., Evaluation of fatigue characteristics for adhesively-bonded composite stepped lap joint. Composite Structures 2004, 66 (1–4), 69-75. 40.Ma, P. X.; Zhang, R., Synthetic nano‐scale fibrous extracellular matrix. Journal of Biomedical Materials Research 1999, 46 (1), 60-72. 41.Peng, M.; Li, D.; Shen, L.; Chen, Y.; Zheng, Q.; Wang, H., Nanoporous Structured Submicrometer Carbon Fibers Prepared via Solution Electrospinning of Polymer Blends. Langmuir 2006, 22 (22), 9368-9374. 42.A. Greiner, J. H. W., Electrospinning: a fascinating method for the preparation of ultrathin fibres. Angewandte Chemie International Edition 2007, 46, 5670-5703. 43.Rezabeigi, E.; Sta, M.; Swain, M.; McDonald, J.; Demarquette, N. R.; Drew, R. A. L.; Wood-Adams, P. M., Electrospinning of porous polylactic acid fibers during nonsolvent induced phase separation. Journal of Applied Polymer Science 2017, 134 (20). 44.Casper, C. L.; Stephens, J. S.; Tassi, N. G.; Chase, D. B.; Rabolt, J. F., Controlling Surface Morphology of Electrospun Polystyrene Fibers: Effect of Humidity and Molecular Weight in the Electrospinning Process. Macromolecules 2004, 37 (2), 573-578. 45.Li, C.-L.; Wang, D.-M.; Deratani, A.; Quémener, D.; Bouyer, D.; Lai, J.-Y., Insight into the preparation of poly(vinylidene fluoride) membranes by vapor-induced phase separation. Journal of Membrane Science 2010, 361 (1–2), 154-166. 46.Lu, P.; Xia, Y., Maneuvering the Internal Porosity and Surface Morphology of Electrospun Polystyrene Yarns by Controlling the Solvent and Relative Humidity. Langmuir 2013, 29 (23), 7070-7078. 47.Megelski, S.; Stephens, J. S.; Chase, D. B.; Rabolt, J. F., Micro- and Nanostructured Surface Morphology on Electrospun Polymer Fibers. Macromolecules 2002, 35 (22), 8456-8466. 48.Nezarati, R. M.; Eifert, M. B.; Cosgriff-Hernandez, E., Effects of Humidity and Solution Viscosity on Electrospun Fiber Morphology. Tissue Engineering. Part C, Methods 2013, 19 (10), 810-819. 49.Park, J.-Y.; Lee, I.-H., Relative Humidity Effect on the Preparation of Porous Electrospun Polystyrene Fibers. Journal of Nanoscience and Nanotechnology 2010, 10 (5), 3473-3477. 50.Srinivasarao, M.; Collings, D.; Philips, A.; Patel, S., Three-Dimensionally Ordered Array of Air Bubbles in a Polymer Film. Science 2001, 292 (5514), 79. 51.Wu, J.; Wang, N.; Wang, L.; Dong, H.; Zhao, Y.; Jiang, L., Electrospun Porous Structure Fibrous Film with High Oil Adsorption Capacity. ACS Applied Materials & Interfaces 2012, 4 (6), 3207-3212. 52.Chang, H. H.; Beltsios, K.; Chen, Y. H.; Lin, D. J.; Cheng, L. P., Effects of cooling temperature and aging treatment on the morphology of nano‐ and micro‐porous poly(ethylene‐co‐vinyl alcohol) membranes by thermal induced phase separation method. Journal of Applied Polymer Science 2014, 131 (12). 53.McCann, J. T.; Marquez, M.; Xia, Y., Highly Porous Fibers by Electrospinning into a Cryogenic Liquid. Journal of the American Chemical Society 2006, 128 (5), 1436-1437. 54.Katsogiannis, K. A. G.; Vladisavljević, G. T.; Georgiadou, S., Porous electrospun polycaprolactone (PCL) fibres by phase separation. European Polymer Journal 2015, 69, 284-295. 55.Wei, Z.; Zhang, Q.; Wang, L.; Wang, X.; Long, S.; Yang, J., Porous electrospun ultrafine fibers via a liquid–liquid phase separation method. Colloid and Polymer Science 2013, 291 (5), 1293-1296. 56.Schaub, N. J.; Britton, T.; Rajachar, R.; Gilbert, R. J., Engineered Nanotopography on Electrospun PLLA Microfibers Modifies RAW 264.7 Cell Response. ACS Applied Materials & Interfaces 2013, 5 (20), 10173-10184. 57.Matthews, J. A.; Wnek, G. E.; Simpson, D. G.; Bowlin, G. L., Electrospinning of Collagen Nanofibers. Biomacromolecules 2002, 3 (2), 232-238. 58.Venugopal, J.; Low, S.; Choon, A. T.; Ramakrishna, S., Interaction of cells and nanofiber scaffolds in tissue engineering. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2008, 84B (1), 34-48. 59.Kumbar, S. G.; James, R.; Nukavarapu, S. P.; Laurencin, C. T., Electrospun nanofiber scaffolds: engineering soft tissues. Biomedical Materials 2008, 3 (3), 034002. 60.Burger, C.; Hsiao, B. S.; Chu, B., Nanofibrous materials and their applications. Annual Review of Materials Research 2006, 36 (1), 333-368. 61.Bhardwaj, N.; Kundu, S. C., Electrospinning: A fascinating fiber fabrication technique. Biotechnology Advances 2010, 28 (3), 325-347. 62.Langer, R.; Vacanti, J., Tissue engineering. Science 1993, 260 (5110), 920-926. 63.Kidoaki, S.; Kwon, I. K.; Matsuda, T., Mesoscopic spatial designs of nano- and microfiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques. Biomaterials 2005, 26 (1), 37-46. 64.Huang, L.; Nagapudi, K.; P.Apkarian, R.; Chaikof, E. L., Engineered collagen–PEO nanofibers and fabrics. Journal of Biomaterials Science, Polymer Edition 2001, 12 (9), 979-993. 65.Boland, E. D.; Telemeco, T. A.; Simpson, D. G.; Wnek, G. E.; Bowlin, G. L., Utilizing acid pretreatment and electrospinning to improve biocompatibility of poly(glycolic acid) for tissue engineering. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2004, 71B (1), 144-152. 66.Kelly J Shields, M. J. B., Gary L Bowlin, Jennifer S Wayne, Mechanical properties and cellular proliferation of electrospun collagen type II. Tissue Engineering 2004, 10 (9-19), 1510-1517. 67.Stankus, J. J.; Guan, J.; Wagner, W. R., Fabrication of biodegradable elastomeric scaffolds with sub‐micron morphologies. Journal of Biomedical Materials Research Part A 2004, 70A (4), 603-614. 68.Lee, S.; Leach, M. K.; Redmond, S. A.; Chong, S. Y. C.; Mellon, S. H.; Tuck, S. J.; Feng, Z.-Q.; Corey, J. M.; Chan, J. R., A culture system to study oligodendrocyte myelination-processes using engineered nanofibers. Nature methods 2012, 9 (9), 917-922. 69.Wang, H. B.; Mullins, M. E.; Cregg, J. M.; McCarthy, C. W.; Gilbert, R. J., Varying the diameter of aligned electrospun fibers alters neurite outgrowth and Schwann cell migration. Acta Biomaterialia 2010, 6 (8), 2970-2978. 70.He, L.; Liao, S.; Quan, D.; Ma, K.; Chan, C.; Ramakrishna, S.; Lu, J., Synergistic effects of electrospun PLLA fiber dimension and pattern on neonatal mouse cerebellum C17.2 stem cells. Acta Biomaterialia 2010, 6 (8), 2960-2969. 71.Daud, M. F. B.; Pawar, K. C.; Claeyssens, F.; Ryan, A. J.; Haycock, J. W., An aligned 3D neuronal-glial co-culture model for peripheral nerve studies. Biomaterials 2012, 33 (25), 5901-5913. 72.Binder, C.; Milleret, V.; Hall, H.; Eberli, D.; Lühmann, T., Influence of micro and submicro poly(lactic‐glycolic acid) fibers on sensory neural cell locomotion and neurite growth. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2013, 101 (7), 1200-1208. 73.Qu, J.; Wang, D.; Wang, H.; Dong, Y.; Zhang, F.; Zuo, B.; Zhang, H., Electrospun silk fibroin nanofibers in different diameters support neurite outgrowth and promote astrocyte migration. Journal of Biomedical Materials Research Part A 2013, 101A (9), 2667-2678. 74.Liu, Y.; Ji, Y.; Ghosh, K.; Clark, R. A. F.; Huang, L.; Rafailovich, M. H., Effects of fiber orientation and diameter on the behavior of human dermal fibroblasts on electrospun PMMA scaffolds. Journal of Biomedical Materials Research Part A 2009, 90A (4), 1092-1106. 75.Hsu, Y. M.; Chen, C. N.; Chiu, J. J.; Chang, S. H.; Wang, Y. J., The effects of fiber size on MG63 cells cultured with collagen based matrices. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2009, 91B (2), 737-745. 76.Badami, A. S.; Kreke, M. R.; Thompson, M. S.; Riffle, J. S.; Goldstein, A. S., Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly(lactic acid) substrates. Biomaterials 2006, 27 (4), 596-606. 77.Saino, E.; Focarete, M. L.; Gualandi, C.; Emanuele, E.; Cornaglia, A. I.; Imbriani, M.; Visai, L., Effect of Electrospun Fiber Diameter and Alignment on Macrophage Activation and Secretion of Proinflammatory Cytokines and Chemokines. Biomacromolecules 2011, 12 (5), 1900-1911. 78.Christopherson, G. T.; Song, H.; Mao, H.-Q., The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation. Biomaterials 2009, 30 (4), 556-564. 79.Murugan, R.; Ramakrishna, S., Nano-featured scaffolds for tissue engineering: a review of spinning methodologies. Tissue Eng. 2006, 12 (3), 435-47. 80.Pant, H. R.; Neupane, M. P.; Pant, B.; Panthi, G.; Oh, H.-J.; Lee, M. H.; Kim, H. Y., Fabrication of highly porous poly (ɛ-caprolactone) fibers for novel tissue scaffold via water-bath electrospinning. Colloids and Surfaces B: Biointerfaces 2011, 88 (2), 587-592. 81.Leong, M. F.; Chian, K. S.; Mhaisalkar, P. S.; Ong, W. F.; Ratner, B. D., Effect of electrospun poly(D,L‐lactide) fibrous scaffold with nanoporous surface on attachment of porcine esophageal epithelial cells and protein adsorption. Journal of Biomedical Materials Research Part A 2009, 89A (4), 1040-1048. 82.Moroni, L.; Licht, R.; de Boer, J.; de Wijn, J. R.; van Blitterswijk, C. A., Fiber diameter and texture of electrospun PEOT/PBT scaffolds influence human mesenchymal stem cell proliferation and morphology, and the release of incorporated compounds. Biomaterials 2006, 27 (28), 4911-4922. 83.Smith, L. A.; Ma, P. X., Nano-fibrous scaffolds for tissue engineering. Colloids and Surfaces B: Biointerfaces 2004, 39 (3), 125-131. 84.Dash, T. K.; Konkimalla, V. B., Poly-є-caprolactone based formulations for drug delivery and tissue engineering: A review. Journal of Controlled Release 2012, 158 (1), 15-33. 85.Lu, X.; Wang, C.; Wei, Y., One‐Dimensional Composite Nanomaterials: Synthesis by Electrospinning and Their Applications. Small 2009, 5 (21), 2349-2370. 86.Go, D. P.; Harvie, D. J. E.; Tirtaatmadja, N.; Gras, S. L.; O'Connor, A. J., A Simple, Scalable Process for the Production of Porous Polymer Microspheres by Ink‐Jetting Combined with Thermally Induced Phase Separation. Particle & Particle Systems Characterization 2014, 31 (6), 685-698. 87.Najafabadi, A. H.; Tamayol, A.; Annabi, N.; Ochoa, M.; Mostafalu, P.; Akbari, M.; Nikkhah, M.; Rahimi, R.; Dokmeci, M. R.; Sonkusale, S.; Ziaie, B.; Khademhosseini, A., Biodegradable Nanofibrous Polymeric Substrates for Generating Elastic and Flexible Electronics. Advanced Materials 2014, 26 (33), 5823-5830. 88.Agarwal, S.; Wendorff, J. H.; Greiner, A., Use of electrospinning technique for biomedical applications. Polymer 2008, 49 (26), 5603-5621. 89.Lim, T. C.; Kotaki, M.; Yong, T. K. J.; Yang, F.; Fujihara, K.; Ramakrishna, S., Recent Advances In Tissue Engineering Applications Of Electrospun Nanofibers. Materials Technology 2004, 19 (1), 20-27. 90.Ma, Z.; Kotaki, M.; Inai, R.; Ramakrishna, S., Potential of nanofiber matrix as tissue-engineering scaffolds. Tissue Eng. 2005, 11 (1-2), 101-9. 91.Sill, T. J.; von Recum, H. A., Electrospinning: Applications in drug delivery and tissue engineering. Biomaterials 2008, 29 (13), 1989-2006. 92.Choi, J. S.; Lee, S. J.; Christ, G. J.; Atala, A.; Yoo, J. J., The influence of electrospun aligned poly(ɛ-caprolactone)/collagen nanofiber meshes on the formation of self-aligned skeletal muscle myotubes. Biomaterials 2008, 29 (19), 2899-2906. 93.Liang, D.; Hsiao, B. S.; Chu, B., Functional electrospun nanofibrous scaffolds for biomedical applications. Advanced Drug Delivery Reviews 2007, 59 (14), 1392-1412. 94.Andriano, K. P.; Pohjonen, T.; Törmälä, P., Processing and characterization of absorbable polylactide polymers for use in surgical implants. Journal of Applied Biomaterials 1994, 5 (2), 133-140. 95.Bodmeier, R.; Oh, K. H.; Chen, H., The effect of the addition of low molecular weight poly(dl-lactide) on drug release from biodegradable poly(dl-lactide) drug delivery systems. International Journal of Pharmaceutics 1989, 51 (1), 1-8. 96.Cerral, P.; Tricoli, M.; Lelli, L.; Guerra, G. D.; Sbarbati Del Guerra, R.; Cascone, M. G.; Giusti, P., Block copolymers of L-lactide and poly(ethylene glycol) for biomedical applications. Journal of Materials Science: Materials in Medicine 1994, 5 (6), 308-313. 97.Coffin, M. D.; McGinity, J. W., Biodegradable Pseudolatexes: The Chemical Stability of Poly(D,L-Lactide) and Poly (ε-Caprolactone) Nanoparticles in Aqueous Media. Pharmaceutical Research 1992, 9 (2), 200-205. 98.Fambri, L.; Pegoretti, A.; Mazzurana, M.; Migliaresi, C., Biodegradable fibres. Journal of Materials Science: Materials in Medicine 1994, 5 (9), 679-683. 99.Kenley, R. A.; Lee, M. O.; Mahoney, T. R.; Sanders, L. M., Poly(lactide-co-glycolide) decomposition kinetics in vivo and in vitro. Macromolecules 1987, 20 (10), 2398-2403. 100.Li, S. M.; Garreau, H.; Vert, M., Structure-property relationships in the case of the degradation of massive aliphatic poly-(α-hydroxy acids) in aqueous media. Journal of Materials Science: Materials in Medicine 1990, 1 (3), 123-130. 101.Therin, M.; Christel, P.; Li, S.; Garreau, H.; Vert, M., In vivo degradation of massive poly(α-hydroxy acids): Validation of In vitro findings. Biomaterials 1992, 13 (9), 594-600. 102.Gupta, B.; Revagade, N.; Hilborn, J., Poly(lactic acid) fiber: An overview. Progress in Polymer Science 2007, 32 (4), 455-482. 103.Rezabeigi, E.; Wood-Adams, P. M.; Drew, R. A. L., Production of porous polylactic acid monoliths via nonsolvent induced phase separation. Polymer 2014, 55 (26), 6743-6753. 104.Rezabeigi, E.; Wood-Adams, P. M.; Drew, R. A. L., Isothermal ternary phase diagram of the polylactic acid-dichloromethane-hexane system. Polymer 2014, 55 (14), 3100-3106. 105.Tang, M.; Dong, Y.; Stevens, M. M.; Williams, C. K., Tailoring Polylactide Degradation: Copolymerization of a Carbohydrate Lactone and S,S-Lactide. Macromolecules 2010, 43 (18), 7556-7564. 106.Sumanasinghe, R. D.; Haslauer, C. M.; Pourdeyhimi, B.; Loboa, E. G., Melt spun microporous fibers using poly(lactic acid) and sulfonated copolyester blends for tissue engineering applications. Journal of Applied Polymer Science 2010, 117 (6), 3350-3361. 107.Tamayol, A.; Akbari, M.; Annabi, N.; Paul, A.; Khademhosseini, A.; Juncker, D., Fiber-based tissue engineering: Progress, challenges, and opportunities. Biotechnology Advances 2013, 31 (5), 669-687. 108.Barnes, C. P.; Sell, S. A.; Boland, E. D.; Simpson, D. G.; Bowlin, G. L., Nanofiber technology: Designing the next generation of tissue engineering scaffolds. Advanced Drug Delivery Reviews 2007, 59 (14), 1413-1433. 109.Yang, F.; Murugan, R.; Wang, S.; Ramakrishna, S., Electrospinning of nano/micro scale poly(l-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 2005, 26 (15), 2603-2610. 110.You, Y.; Min, B. M.; Lee, S. J.; Lee, T. S.; Park, W. H., In vitro degradation behavior of electrospun polyglycolide, polylactide, and poly(lactide‐co‐glycolide). Journal of Applied Polymer Science 2005, 95 (2), 193-200. 111.Lee, Y. H.; Lee, J. H.; An, I.-G.; Kim, C.; Lee, D. S.; Lee, Y. K.; Nam, J.-D., Electrospun dual-porosity structure and biodegradation morphology of Montmorillonite reinforced PLLA nanocomposite scaffolds. Biomaterials 2005, 26 (16), 3165-3172. 112.Zeng, J.; Xu, X.; Chen, X.; Liang, Q.; Bian, X.; Yang, L.; Jing, X., Biodegradable electrospun fibers for drug delivery. Journal of Controlled Release 2003, 92 (3), 227-231. 113.Li, J.; Shi, X.; Gao, F.; Liu, L.; Chen, R.; Chen, C.; Zhang, Z., Filtration of fine particles in atmospheric aerosol with electrospinning nanofibers and its size distribution. Science China Technological Sciences 2014, 57 (2), 239-243. 114.Wang, Z.; Pan, Z., Preparation of hierarchical structured nano-sized/porous poly(lactic acid) composite fibrous membranes for air filtration. Applied Surface Science 2015, 356, 1168-1179. 115.Engelberg, I.; Kohn, J., Physico-mechanical properties of degradable polymers used in medical applications: A comparative study. Biomaterials 1991, 12 (3), 292-304. 116.Middleton, J. C.; Tipton, A. J., Synthetic biodegradable polymers as orthopedic devices. Biomaterials 2000, 21 (23), 2335-2346. 117.Nair, L. S.; Laurencin, C. T., Biodegradable polymers as biomaterials. Progress in Polymer Science 2007, 32 (8), 762-798. 118.Woodruff, M. A.; Hutmacher, D. W., The return of a forgotten polymer—Polycaprolactone in the 21st century. Progress in Polymer Science 2010, 35 (10), 1217-1256. 119.Koutroumanis, K. P.; Holdich, R. G.; Georgiadou, S., Synthesis and micellization of a pH-sensitive diblock copolymer for drug delivery. International Journal of Pharmaceutics 2013, 455 (1), 5-13. 120.Laouini, A.; Koutroumanis, K. P.; Charcosset, C.; Georgiadou, S.; Fessi, H.; Holdich, R. G.; Vladisavljević, G. T., pH-Sensitive Micelles for Targeted Drug Delivery Prepared Using a Novel Membrane Contactor Method. ACS Applied Materials & Interfaces 2013, 5 (18), 8939-8947. 121.Gentsch, R.; Boysen, B.; Lankenau, A.; Börner, H. G., Single‐Step Electrospinning of Bimodal Fiber Meshes for Ease of Cellular Infiltration. Macromolecular Rapid Communications 2010, 31 (1), 59-64. 122.Reneker, D. H.; Kataphinan, W.; Theron, A.; Zussman, E.; Yarin, A. L., Nanofiber garlands of polycaprolactone by electrospinning. Polymer 2002, 43 (25), 6785-6794. 123.Shin, M.; Ishii, O.; Sueda, T.; Vacanti, J. P., Contractile cardiac grafts using a novel nanofibrous mesh. Biomaterials 2004, 25 (17), 3717-3723. 124.Fujihara, K.; Kotaki, M.; Ramakrishna, S., Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers. Biomaterials 2005, 26 (19), 4139-4147. 125.Li, W.-J.; Tuli, R.; Huang, X.; Laquerriere, P.; Tuan, R. S., Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomaterials 2005, 26 (25), 5158-5166. 126.Goldstein, J. I.; Newbury, D. E.; Echlin, P.; Joy, D. C.; Lyman, C. E.; Lifshin, E.; Sawyer, L.; Michael, J. R., Scanning Electron Microscopy and X-ray Microanalysis. 3rd ed.; Springer Science & BusinessMedia: New York, 2003. 127.Ritter, H. L.; Drake, L. C., Pressure Porosimeter and Determination of Complete Macropore-Size Distributions. Industrial & Engineering Chemistry Analytical Edition 1945, 17 (12), 782-786. 128.Drake, L. C., Pore-Size Distribution in Porous Materials. Industrial & Engineering Chemistry 1949, 41 (4), 780-785. 129.Lin, D.-J.; Chang, C.-L.; Huang, F.-M.; Cheng, L.-P., Effect of salt additive on the formation of microporous poly(vinylidene fluoride) membranes by phase inversion from LiClO4/Water/DMF/PVDF system. Polymer 2003, 44 (2), 413-422. 130.Marcus, Y., The properties of solvents. 1st ed.; Wiley: New York 1998. 131.Smallwood, I. M., Handbook of Organic Solvent Properties. 1st ed.; Butterworth-Heinemann: Oxford, 1996. 132.Riddick, J. A.; Bunger, W. B.; Sakano, T. K., Organic solvents: physical properties and methods of purification. 4th ed.; Wiley: New York, 1986. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/67592 | - |
dc.description.abstract | 連續性纖維的製程不勝枚舉,其中電紡絲技術屬於簡單的方式。電紡絲纖維尺寸通常可由微米小至奈米等級,具有高比表面積的性質,若能在電紡絲纖維上製造出孔洞,就能再進一步提高纖維的比表面積。一般而言,透過改變電紡絲環境中的濕度能製造出纖維上的孔洞,但是這種孔洞的深度淺,只生於表面,效果十分有限。
本實驗利用聚乳酸(PLA)和聚己內酯(PCL)製備高分子電紡絲纖維,搭配溶劑三氯甲烷(CF)和氯苯(CB)、非溶劑二甲基亞碸(DMSO),成功透過非溶劑誘導相分離法(nonsolvent-induced phase separation, NIPS)於三相系統中獲得一系列不同孔洞型態的電紡纖維,調配非溶劑含量的比例,纖維上的孔洞有明顯的變化,PLA系列的纖維孔洞大小可由50奈米變化至1200奈米,而PCL系列的纖維孔洞大小可由500奈米變化至3200奈米。我們也發現,無論是PLA還是PCL高分子孔洞纖維,使用沸點較高的CB作為溶劑,該系統的電紡纖維表面孔洞會比CF系統大。 另外,我們也利用其他不同的溶劑與非溶劑組合,嘗試找出能製備孔洞纖維的最佳條件,進一步發現溶劑除了要能與非溶劑互溶,沸點亦不能接近或高於非溶劑;而非溶劑除了沸點高之外,還要具備與水互溶的特性,才有利於產生孔洞纖維。 | zh_TW |
dc.description.abstract | The electrospinning is a simple way to fabricate fibers in a continuous manner, which generates fibers with a high specific surface area due to the small diameters ranging from nanometers to several micrometers. To further increase the specific surface area, one can create pores on the electrospinning fibers. The humidity of environment can be used to produce pores on the fibers through the condensation of moisture, but the pores formed by this way only occur on the surface and are generally small and shallow. Therefore, the increase of the specific surface area of fibers by raising the humidity is limited.
In this study, biocompatible poly (lactic acid) (PLA) and polycaprolactone (PCL) were used for preparing electrospinning polymer fibers. Chloroform (CF) or chlorobenzene (CB) was used as solvent, and dimethyl sulfoxide (DMSO) was chosen as nonsolvent. The polymers were dissolved in the mixture of the solvent and nonsolvent, and the ternary systems were successfully electrospun into a series of porous fibers by nonsolvent-induced phase separation (NIPS). The pore size and the pore morphology are changed significantly by adjusting the ratio of the nonsolvent in the mixtures. The pore size of the PLA fibers is 50 to 1200 nm and that of the PCL fibers is 500 to 3200 nm. The higher boiling point CB as solvent causes larger pores than CF in both PLA and PCL fibers. More importantly, the pores not only form on the surface, but can penetrate into the fibers for the mixtures with appropriate amount of the nonsolvent. We also utilized the combinations of other solvents and nonsolvents to establish the principles for producing porous fibers. We found that to successfully produce porous fibers, the solvents and the nonsolvents must be miscible and the boiling point of the solvents must be lower than the nonsolvents. In addition, a good miscibility of the nonsolvents with water favors the pore formation. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T01:39:14Z (GMT). No. of bitstreams: 1 ntu-106-R04549010-1.pdf: 5630133 bytes, checksum: 9f28cfa42f5590fc2d1836aa72154905 (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 口試委員審定書 i
誌謝 ii 摘要 iii Abstract iv 目錄 vi 圖目錄 ix 表目錄 xi 第一章 緒論 1 1.1 簡介 1 1.2 研究動機 2 第二章 文獻回顧 3 2.1 電紡絲技術 3 2.1.1電紡絲概述 3 2.1.2電紡絲過程 4 2.1.3 電紡絲模式 5 2.1.4 影響電紡絲的參數 6 2.2孔洞纖維與相分離技術 7 2.2.1 電紡絲孔洞纖維 7 2.2.2 相分離技術發展 8 2.3 生醫材料與孔洞纖維 12 2.3.1 電紡絲纖維於生醫之應用 12 2.3.2 常見生物可降解材料PLA 15 2.3.3 常見生物可降解材料PCL 17 第三章 實驗方法與儀器 18 3.1 實驗藥品 18 3.2 實驗步驟 20 3.2.1 三相圖繪製 20 3.2.2 電紡絲溶液配置方法 20 3.2.3 電紡裝置架設與參數設定 21 3.2.4 纖維截面製備 22 3.3 實驗儀器與原理 23 3.3.1 場發射掃描式電子顯微鏡 23 3.3.2 白金濺鍍機 24 3.3.3 壓汞測孔機 25 3.3.4 纖維直徑測量 26 第四章 結果與討論 27 4.1以PLA製備孔洞纖維 27 4.1.1 高分子溶液濃度與可電紡性 27 4.1.2 PLA/CB/DMSO系統:調控非溶劑比例之影響 29 4.1.3 PLA/CF/DMSO系統:調控非溶劑比例之影響 34 4.1.4 濕度之影響 39 4.1.5 孔洞形成機制 41 4.1.6 添加鹽類之影響 46 4.1.7 不同溶劑之影響 48 4.2以PCL製備孔洞纖維 51 4.2.1 高分子溶液濃度與可電紡性 51 4.2.2 PCL/CF/DMSO系統:調控非溶劑比例之影響 53 4.2.3 PCL/CB/DMSO系統:調控非溶劑比例之影響 57 4.2.4 濕度之影響 61 4.2.5 孔洞形成機制 63 4.2.6 不同溶劑之影響 66 4.2.7 不同非溶劑之影響 69 4.3比較PCL孔洞纖維與PLA孔洞纖維之差異 72 第五章 結論 74 第六章 參考文獻 75 | |
dc.language.iso | zh-TW | |
dc.title | 結合非溶劑誘導相分離與電紡絲技術製備生物可降解孔洞纖維 | zh_TW |
dc.title | Preparation of Biodegradable Porous Fibers by Combining Nonsolvent-Induced Phase Separation and Electrospinning Method | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 鄭如忠(Ru-Jong Jeng),葉樹開(Shu-Kai Yeh),賴偉淇(Wei-Chi Lai) | |
dc.subject.keyword | 電紡絲,非溶劑誘導相分離,生物可降解高分子,孔洞纖維,聚乳酸,聚己內酯, | zh_TW |
dc.subject.keyword | Electrospinning,nonsolvent-induced phase separation,Biodegradable polymer,Porous fibers,PLA,PCL, | en |
dc.relation.page | 89 | |
dc.identifier.doi | 10.6342/NTU201702222 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2017-07-31 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
顯示於系所單位: | 高分子科學與工程學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-106-1.pdf 目前未授權公開取用 | 5.5 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。