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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 鍾孝文(Hsiao-Wen Chung) | |
dc.contributor.author | Chi-Wei Chang | en |
dc.contributor.author | 張琦偉 | zh_TW |
dc.date.accessioned | 2021-06-17T01:34:22Z | - |
dc.date.available | 2022-08-20 | |
dc.date.copyright | 2017-08-20 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-08-02 | |
dc.identifier.citation | 1. Milnor, W.R., Hemodynamics1982, Baltimore: Williams & Wilkins.
2. Postel-Vinay, N. and I.S.o. Hypertension, A century of arterial hypertension, 1896-19961996: John Wiley & Sons. 3. MacMahon, S., et al., Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet, 1990. 335(8692): p. 765-74. 4. Staessen, J.A., et al., Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials. Lancet, 2000. 355(9207): p. 865-72. 5. McEniery, C.M., et al., Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol, 2005. 46(9): p. 1753-60. 6. Schillaci, G., et al., Age-specific relationship of aortic pulse wave velocity with left ventricular geometry and function in hypertension. Hypertension, 2007. 49(2): p. 317-21. 7. Matsui, Y., et al., Association between home arterial stiffness index and target organ damage in hypertension: Comparison with pulse wave velocity and augmentation index. Atherosclerosis, 2011. 219(2): p. 637-42. 8. McCall, D.O., et al., The relationship between microvascular endothelial function and carotid-radial pulse wave velocity in patients with mild hypertension. Clin Exp Hypertens, 2010. 32(7): p. 474-9. 9. Covic, A., et al., Aortic pulse wave velocity and arterial wave reflections predict the extent and severity of coronary artery disease in chronic kidney disease patients. J Nephrol, 2005. 18(4): p. 388-96. 10. Koyoshi, R., et al., Clinical significance of flow-mediated dilation, brachial intima-media thickness and pulse wave velocity in patients with and without coronary artery disease. Circ J, 2012. 76(6): p. 1469-75. 11. Hsu, P.F., et al., Differential effects of age on carotid augmentation index and aortic pulse wave velocity in end-stage renal disease patients. J Chin Med Assoc, 2008. 71(4): p. 166-73. 12. Kis, E., et al., Pulse wave velocity in end-stage renal disease: influence of age and body dimensions. Pediatr Res, 2008. 63(1): p. 95-8. 13. Hirata, K., M. Kawakami, and M.F. O'Rourke, Pulse wave analysis and pulse wave velocity: a review of blood pressure interpretation 100 years after Korotkov. Circ J, 2006. 70(10): p. 1231-9. 14. Cameron, J.D., B.P. McGrath, and A.M. Dart, Use of radial artery applanation tonometry and a generalized transfer function to determine aortic pressure augmentation in subjects with treated hypertension. Journal of the American College of Cardiology, 1998. 32(5): p. 1214-1220. 15. Young, T. The Croonian Lecture. On the Functions of the Heart and Arteries. in Abstracts of the Papers Printed in the Philosophical Transactions of the Royal Society of London. 1800. The Royal Society. 16. Milnor, W.R., Hemodynamics. 2 ed1989. 95-97. 17. Avolio, A.P., et al., Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation, 1983. 68(1): p. 50-8. 18. Wada, T., et al., Correlation of ultrasound-measured common carotid artery stiffness with pathological findings. Arterioscler Thromb, 1994. 14(3): p. 479-82. 19. van Popele, N.M., et al., Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke, 2001. 32(2): p. 454-60. 20. Cohn, J.N., Arterial compliance to stratify cardiovascular risk: more precision in therapeutic decision making. Am J Hypertens, 2001. 14(8 Pt 2): p. 258S-263S. 21. Laurent, S., et al., Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J, 2006. 27(21): p. 2588-605. 22. Blacher, J., et al., Impact of aortic stiffness on survival in end-stage renal disease. Circulation, 1999. 99(18): p. 2434-2439. 23. Shoji, T., et al., Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease. Journal of the American Society of Nephrology, 2001. 12(10): p. 2117-2124. 24. Mattace-Raso, F.U., et al., Arterial stiffness and risk of coronary heart disease and stroke the rotterdam study. Circulation, 2006. 113(5): p. 657-663. 25. Laurent, S., et al., Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke, 2003. 34(5): p. 1203-1206. 26. Cruickshank, K., et al., Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation, 2002. 106(16): p. 2085-90. 27. Laurent, S., et al., Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension, 2001. 37(5): p. 1236-1241. 28. Meaume, S., et al., Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age. Arterioscler Thromb Vasc Biol, 2001. 21(12): p. 2046-50. 29. Nichols, W.W., M.F. O'Rourke, and C. Vlachopoulos, McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles2011: Hodder Arnold. 30. Yasmin and M.J. Brown, Similarities and differences between augmentation index and pulse wave velocity in the assessment of arterial stiffness. QJM, 1999. 92(10): p. 595-600. 31. Wilkinson, I.B., et al., Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis. J Hypertens, 1998. 16(12 Pt 2): p. 2079-84. 32. Wilkinson, I.B., et al., Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia. J Am Coll Cardiol, 2002. 39(6): p. 1005-11. 33. Nurnberger, J., et al., Augmentation index is associated with cardiovascular risk. J Hypertens, 2002. 20(12): p. 2407-14. 34. Wang, Y.-Y.L., et al., Past, Present, and Future of the Pulse Examination (脈診 mài zhen). Journal of Traditional and Complementary Medicine, 2012. 2(3): p. 164. 35. Wang, Y.Y.L., et al., Theory and Applications of the Harmonic Analysis of Arterial Pressure Pulse Waves. Journal of Medical and Biological Engineering, 2010. 30(3): p. 125-131. 36. Crilly, M., et al., Repeatability of central aortic blood pressures measured non-invasively using radial artery applanation tonometry and peripheral pulse wave analysis. Blood Press, 2007. 16(4): p. 262-9. 37. Kips, J., et al., The use of diameter distension waveforms as an alternative for tonometric pressure to assess carotid blood pressure. Physiological measurement, 2010. 31(4): p. 543. 38. Hsiu, H., et al., Effects of cold stimulation on the harmonic structure of the blood pressure and photoplethysmography waveforms. Photomedicine and laser surgery, 2012. 30(2): p. 77-84. 39. Allen, J., Photoplethysmography and its application in clinical physiological measurement. Physiological measurement, 2007. 28(3): p. R1. 40. Avolio, A.P., M. Butlin, and A. Walsh, Arterial blood pressure measurement and pulse wave analysis--their role in enhancing cardiovascular assessment. Physiol Meas, 2010. 31(1): p. R1-47. 41. Crilly, M.A., et al., Repeatability of SphygmoCor pulse wave analysis in assessing arterial wave reflection in pregnancy using applanation tonometry. Hypertens Pregnancy, 2014. 42. Kuo, Y.C., et al., Losing harmonic stability of arterial pulse in terminally ill patients. Blood Pressure Monitoring, 2004. 9(5): p. 255-258. 43. Bland, J.M. and D.G. Altman, Statistical-Methods for Assessing Agreement between 2 Methods of Clinical Measurement. Lancet, 1986. 1(8476): p. 307-310. 44. Fleiss, J.L., Front Matter, in The Design and Analysis of Clinical Experiments1999, John Wiley & Sons, Inc. p. i-xiv. 45. Portney, L.G. and M.P. Watkins, Foundations of Clinical Research: Applications to Practice2009: Pearson/Prentice Hall. 46. Scolletta, S., et al., Assessment of left ventricular function by pulse wave analysis in critically ill patients. Intensive Care Med, 2013. 39(6): p. 1025-33. 47. Rajendra Acharya, U., et al., Heart rate variability: a review. Med Biol Eng Comput, 2006. 44(12): p. 1031-51. 48. Akselrod, S., et al., Hemodynamic regulation: investigation by spectral analysis. Am J Physiol, 1985. 249(4 Pt 2): p. H867-75. 49. O'Rourke, M.F., A. Pauca, and X.J. Jiang, Pulse wave analysis. Br J Clin Pharmacol, 2001. 51(6): p. 507-22. 50. Stamler, J., J.D. Neaton, and D.N. Wentworth, Blood pressure (systolic and diastolic) and risk of fatal coronary heart disease. Hypertension, 1989. 13(5 Suppl): p. I2-12. 51. Wang, Y.Y., et al., Resonance. The missing phenomenon in hemodynamics. Circ Res, 1991. 69(1): p. 246-9. 52. Wang, Y.Y.L., et al., Pressure wave propagation in arteries. Ieee Engineering in Medicine and Biology Magazine, 1997. 16(1): p. 51-56. 53. Wang, Y.Y.L., et al., Pressure pulse velocity is related to the longitudinal elastic properties of the artery. Physiological Measurement, 2004. 25(6): p. 1397-1403. 54. Wang, Y.Y.L., et al., The ventricular-arterial coupling system can be analyzed by the eigenwave modes of the whole arterial system. Applied Physics Letters, 2008. 92(15). 55. Wang, Y.Y.L., et al., Analysis of transverse wave as a propagation mode for the pressure pulse in large arteries. Journal of Applied Physics, 2007. 102(6). 56. Lin Wang, Y.-Y. and W.-K. Wang, A hemodynamics model to study the collective behavior of the ventricular-arterial system. Journal of Applied Physics, 2013. 113(2): p. 024702-024702-6. 57. Wang, Y.-Y.L., et al., Examining the response pressure along a fluid-filled elastic tube to comprehend Frank’s arterial resonance model. Journal of Biomechanics, 2015. 58. Lin Wang, Y.Y. and W.K. Wang, Anatomy of arterial systems reveals that the major function of the heart is not to emit waves associated with the axial blood motion. The Journal of physiology, 2014. 592(2): p. 409-409. 59. Lin Wang, Y.Y. and W.K. Wang, From a basic principle of evolution to the heart rate of mammals. J Physiol, 2015. 593(9): p. 2241-2. 60. Jan, M.-Y., et al., The Physical Conditions of Different Organs Are Reflected Specifically in the Pressure Pulse Spectrum of the Peripheral Artery. Cardiovascular Engineering, 2003. 3(1): p. 21-29. 61. Hsu, T.L., et al., Pulse analysis as a possible real-time biomarker complementary to SGPT and SGOT for monitoring acute hepatotoxicity. Toxicology Mechanisms and Methods, 2003. 13(3): p. 181-186. 62. Wang, W.K., et al., Pulse spectrum analysis of chemical factory workers with abnormal blood test. American Journal of Chinese Medicine, 1996. 24(2): p. 199-203. 63. Lu, W.A., Y.Y.L. Wang, and W.K. Wang, Pulse analysis of patients with severe liver problems - Studying pulse spectrums to determine the effects on other organs. Ieee Engineering in Medicine and Biology Magazine, 1999. 18(1): p. 73-75. 64. Chen, C.Y., et al., Spectral-Analysis of Radial Pulse in Patients with Acute, Uncomplicated Myocardial-Infarction. Japanese Heart Journal, 1993. 34(2): p. 131-143. 65. Wang, S.H., et al., Effects of Antihypertensive Drugs on Specific Harmonic Indices of the Pulse Waveform in Normotensive Wistar Kyoto Rats. Clinical and Experimental Hypertension, 2012. 34(1): p. 74-78. 66. Sheng-Hung, W., et al. Effects of Captopril on Specific Harmonic Indexes of the Peripheral Pressure Pulse Waveform. in Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on. 2010. 67. Wang, Y.Y.L., J.I. Sheu, and W.K. Wang, Alterations of Pulse by Chinese Herb Medicine. American Journal of Chinese Medicine, 1992. 20(2): p. 181-190. 68. Wang, W.K., et al., Pulse spectrum study on the effect of Sie-Zie-Tang and Radix Aconiti. American Journal of Chinese Medicine, 1997. 25(3-4): p. 357-366. 69. Wang, W.K., T.L. Hsu, and Y.Y.L. Wang, Liu-Wei-Dihuang: A study by pulse analysis. American Journal of Chinese Medicine, 1998. 26(1): p. 73-82. 70. Wang, W.K., et al., Influence of spleen meridian herbs on the harmonic spectrum of the arterial pulse. American Journal of Chinese Medicine, 2000. 28(2): p. 279-289. 71. Wang, W.K., et al., Evaluation of herbal formulas by pulse analysis method. Acta Pharmacologica Sinica, 2003. 24(2): p. 145-151. 72. Wang, W.K., et al., Collective Effect of a Chinese Formula - a Study of Xiao-Jian-Zhong-Tang. American Journal of Chinese Medicine, 1995. 23(3-4): p. 299-304. 73. Wang, W.K., et al., Effect of acupuncture at Tai-Tsih (K-3) on the pulse spectrum. American Journal of Chinese Medicine, 1996. 24(3-4): p. 305-313. 74. Wang, W.K., et al., Effect of Acupuncture at Tsu-San-Li (St-36) on the Pulse Spectrum. American Journal of Chinese Medicine, 1995. 23(2): p. 121-130. 75. Wang, W.K., et al., Effect of acupuncture at Hsien-Ku (St-43) on the pulse spectrum and a discussion of the evidence for the frequency structure of Chinese medicine. American Journal of Chinese Medicine, 2000. 28(1): p. 41-55. 76. Chang, C.-W. and W.-K. Wang, Reliability assessment for pulse wave measurement using artificial pulse generator. Journal of medical engineering & technology, 2015. 39(3): p. 177-184. 77. Crilly, M., et al., Repeatability of the measurement of augmentation index in the clinical assessment of arterial stiffness using radial applanation tonometry. Scand J Clin Lab Invest, 2007. 67(4): p. 413-22. 78. Holland, D.J., et al., Pulse wave analysis is a reproducible technique for measuring central blood pressure during hemodynamic perturbations induced by exercise. Am J Hypertens, 2008. 21(10): p. 1100-6. 79. Frimodt-Moller, M., et al., Reproducibility of pulse-wave analysis and pulse-wave velocity determination in chronic kidney disease. Nephrol Dial Transplant, 2008. 23(2): p. 594-600. 80. Miyatani, M., et al., Test-retest reliability of pulse wave velocity in individuals with chronic spinal cord injury. J Spinal Cord Med, 2012. 35(5): p. 400-5. 81. Vivodtzev, I., et al., Arterial stiffness by pulse wave velocity in COPD: reliability and reproducibility. Eur Respir J, 2013. 42(4): p. 1140-1142. 82. Chae, Y.M. and J.K. Park, The relationship between brachial ankle pulse wave velocity and complement 1 inhibitor. J Korean Med Sci, 2009. 24(5): p. 831-6. 83. Li, P., et al., Determinants of brachial-ankle pulse wave velocity in chinese patients with rheumatoid arthritis. Clin Dev Immunol, 2013. 2013: p. 342869. 84. Yang, C.S., Inhibition of carcinogenesis by tea. Nature, 1997. 389(6647): p. 134-5. 85. Stangl, V., M. Lorenz, and K. Stangl, The role of tea and tea flavonoids in cardiovascular health. Mol Nutr Food Res, 2006. 50(2): p. 218-228. 86. Sumpio, B.E., et al., Green tea, the “Asian paradox,” and cardiovascular disease. Journal of the American College of Surgeons, 2006. 202(5): p. 813-825. 87. Song, J., et al., Tea and cognitive health in late life: current evidence and future directions. J Nutr Health Aging, 2012. 16(1): p. 31-4. 88. Duffy, S.J., et al., Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation, 2001. 104(2): p. 151-6. 89. Hodgson, J.M., et al., Regular ingestion of black tea improves brachial artery vasodilator function. Clin Sci (Lond), 2002. 102(2): p. 195-201. 90. Alexopoulos, N., et al., The acute effect of green tea consumption on endothelial function in healthy individuals. Eur J Cardiovasc Prev Rehabil, 2008. 15(3): p. 300-5. 91. Potenza, M.A., et al., EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR. Am J Physiol Endocrinol Metab, 2007. 292(5): p. E1378-87. 92. Lorenz, M., et al., A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem, 2004. 279(7): p. 6190-5. 93. Iadecola, C., Regulation of the Cerebral Microcirculation during Neural Activity - Is Nitric-Oxide the Missing Link. Trends in Neurosciences, 1993. 16(6): p. 206-214. 94. Iadecola, C., Nitric oxide: Roles in neurovascular regulation and ischemic brain injury. Nitric Oxide, 2012. 27: p. S3. 95. Kuriyama, S., et al., Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA, 2006. 296(10): p. 1255-65. 96. Nakachi, K., et al., Preventive effects of drinking green tea on cancer and cardiovascular disease: epidemiological evidence for multiple targeting prevention. Biofactors, 2000. 13(1-4): p. 49-54. 97. Wang, W.K., et al., The prandial effect on the pulse spectrum. American Journal of Chinese Medicine, 1996. 24(1): p. 93-98. 98. Hsu, T.L., et al., Similarity Between Coffee Effects and Qi-Stimulating Events. Journal of Alternative and Complementary Medicine, 2008. 14(9): p. 1145-1150. 99. Chang, C.-W. and W.-K. Wang, Reliability assessment for pulse wave measurement using artificial pulse generator. Journal of medical engineering & technology, 2015(0): p. 1-8. 100. Myers, M.G., Effects of caffeine on blood pressure. Arch Intern Med, 1988. 148(5): p. 1189-93. 101. Chin, J.M., et al., Caffeine content of brewed teas. J Anal Toxicol, 2008. 32(8): p. 702-4. 102. Yokogoshi, H., et al., Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci Biotechnol Biochem, 1995. 59(4): p. 615-8. 103. Yoto, A., et al., Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J Physiol Anthropol, 2012. 31: p. 28. 104. Hodgson, J.M., et al., Effects on blood pressure of drinking green and black tea. J Hypertens, 1999. 17(4): p. 457-63. 105. Hodgson, J.M., et al., Short-term effects of polyphenol-rich black tea on blood pressure in men and women. Food Funct, 2013. 4(1): p. 111-5. 106. Quinlan, P., J. Lane, and L. Aspinall, Effects of hot tea, coffee and water ingestion on physiological responses and mood: the role of caffeine, water and beverage type. Psychopharmacology (Berl), 1997. 134(2): p. 164-173. 107. Jan, M.Y., et al., The importance of pulsatile microcirculation in relation to hypertension - Studying the relationship between abdominal aortic blood pressure and renal cortex flux. Ieee Engineering in Medicine and Biology Magazine, 2000. 19(3): p. 106-111. 108. Chao, P.T., et al., Evaluating microcirculation by pulsatile laser Doppler signal. Physics in Medicine and Biology, 2006. 51(4): p. 845-854. 109. Young, S.T., et al., Specific frequency properties of renal and superior mesenteric arterial beds in rats. Cardiovasc Res, 1989. 23(6): p. 465-7. 110. Wang, Y.Y.L., et al., The ventricular-arterial coupling system can be analyzed by the eigenwave modes of the whole arterial system. Applied Physics Letters, 2008. 92(15): p. -. 111. Hsiu, H., et al., Acute microcirculatory responses induced by skin-surface vibration stimulation at a frequency near the heart rate. Biorheology, 2012. 49(1): p. 15-25. 112. Hsiu, H., et al., Effects of acupuncture on the harmonic components of the radial arterial blood-pressure waveform in stroke patients. Biorheology, 2013. 50(1-2): p. 69-81. 113. Jochmann, N., et al., The efficacy of black tea in ameliorating endothelial function is equivalent to that of green tea. Br J Nutr, 2008. 99(4): p. 863-8. 114. Bolduc, V., et al., Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr-/-:hApoB+/+ mice and improves cerebral blood flow. Am J Physiol Heart Circ Physiol, 2012. 302(6): p. H1330-9. 115. Choi, Y.B., et al., Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats. Brain research, 2004. 1019(1): p. 47-54. 116. Lee, H., J.H. Bae, and S.R. Lee, Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils. J Neurosci Res, 2004. 77(6): p. 892-900. 117. Rahman, R.M., et al., (−)-Epigallocatechin gallate as an intervention for the acute treatment of cerebral ischemia. Neurosci Lett, 2005. 382(3): p. 227-230. 118. Egashira, N., et al., Involvement of GABAA receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice. J Pharmacol Sci, 2007. 105(2): p. 211-214. 119. Egashira, N., et al., Neuroprotective effect of γ-glutamylethylamide (theanine) on cerebral infarction in mice. Neurosci Lett, 2004. 363(1): p. 58-61. 120. Kakuda, T., et al., Protective effect of γ-glutamylethylamide (theanine) on ischemic delayed neuronal death in gerbils. Neurosci Lett, 2000. 289(3): p. 189-192. 121. Cai, F., et al., Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1. Mediators of inflammation, 2006. 2006. 122. Larsson, S.C., J. Virtamo, and A. Wolk, Black tea consumption and risk of stroke in women and men. Ann Epidemiol, 2013. 23(3): p. 157-60. 123. Shen, L., et al., Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies. J Zhejiang Univ Sci B, 2012. 13(8): p. 652-62. 124. Pinto, N.B., et al., Neuroprotective properties of the standardized extract from Camellia sinensis (green tea) and its main bioactive components, epicatechin and epigallocatechin gallate, in the 6-OHDA model of Parkinson’s disease. 125. Shiraki, M., et al., Antioxidative and antimutagenic effects of theaflavins from black tea. Mutation Research Letters, 1994. 323(1): p. 29-34. 126. Adhikary, B., et al., Black tea and theaflavins assist healing of indomethacin-induced gastric ulceration in mice by antioxidative action. Evidence-Based Complementary and Alternative Medicine, 2010. 2011. 127. Aneja, R., et al., Theaflavin, a black tea extract, is a novel anti-inflammatory compound. Critical care medicine, 2004. 32(10): p. 2097-2103. 128. Vidyasagar, R., et al., The effect of black tea and caffeine on regional cerebral blood flow measured with arterial spin labeling. J Cereb Blood Flow Metab, 2013. 33(6): p. 963-8. 129. Mathew, R.J., D.L. Barr, and M.L. Weinman, Caffeine and cerebral blood flow. Br J Psychiatry, 1983. 143: p. 604-8. 130. Drouin, A., et al., Catechin treatment improves cerebrovascular flow-mediated dilation and learning abilities in atherosclerotic mice. Am J Physiol Heart Circ Physiol, 2011. 300(3): p. H1032-43. 131. Wang, W.K., et al., Alteration of pulse in human subjects by three Chinese herbs. Am J Chin Med, 1994. 22(2): p. 197-203. 132. Van der Pijl, P., L. Chen, and T. Mulder, Human disposition of L-theanine in tea or aqueous solution. Journal of Functional Foods, 2010. 2(4): p. 239-244. 133. Fredholm, B.B., et al., Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological reviews, 1999. 51(1): p. 83-133. 134. Lee, M.-J., et al., Pharmacokinetics of tea catechins after ingestion of green tea and (−)-epigallocatechin-3-gallate by humans formation of different metabolites and individual variability. Cancer Epidemiology Biomarkers & Prevention, 2002. 11(10): p. 1025-1032. 135. Mitchell, G.F., et al., Changes in arterial stiffness and wave reflection with advancing age in healthy men and women the Framingham Heart Study. Hypertension, 2004. 43(6): p. 1239-1245. 136. Wang, S.-H., et al. Age-related changes in specific harmonic indices of pressure pulse waveform. in 13th International Conference on Biomedical Engineering. 2009. Springer. 137. Sherebrin, M. and R. Sherebrin, Frequency analysis of the peripheral pulse wave detected in the finger with a photoplethysmograph. Ieee Transactions on Biomedical Engineering, 1990. 37(3): p. 313-317. 138. Olafiranye, O., et al., Harmonic Analysis of Noninvasively Recorded Arterial Pressure Waveforms in Healthy Bonnet Macaques (Macaca radiata). Journal of the American Association for Laboratory Animal Science, 2011. 50(1): p. 79-83. 139. Malliani, A., et al., Cardiovascular neural regulation explored in the frequency domain. Circulation, 1991. 84(2): p. 482-492. 140. Pagani, M., et al., Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circulation research, 1986. 59(2): p. 178-193. 141. Akselrod, S., et al., Hemodynamic regulation: investigation by spectral analysis. American Journal of Physiology-Heart and Circulatory Physiology, 1985. 249(4): p. H867-H875. 142. Bernardi, L., et al., Autonomic control of skin microvessels: assessment by power spectrum of photoplethysmographic waves. Clinical Science, 1996. 90(5): p. 345-355. 143. Khanoka, B., et al., Sympathetically induced spontaneous fluctuations of the photoplethysmographic signal. Medical and Biological Engineering and Computing, 2004. 42(1): p. 80-85. 144. Chan, G.S., et al., Spontaneous fluctuations in the peripheral photoplethysmographic waveform: roles of arterial pressure and muscle sympathetic nerve activity. American Journal of Physiology-Heart and Circulatory Physiology, 2012. 302(3): p. H826-H836. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/67487 | - |
dc.description.abstract | 動脈壓力波分析相關研究已經發展了數十年,也為此開發許多動脈壓力波量測儀器。然而,到目前為止缺乏一系列完整評估的系統和標準的流程,對動脈壓力波量測儀器進行諧頻分析之驗證,包括評估儀器本身的可靠度、同一操作者的量測的再現性,不同操作者的一致性等。因此,本論文有三個主要的目標:第一,我們目標建立模擬動脈壓力波的仿體系統,去評估動脈壓力波量測儀本身的可靠度;第二,我們目標在於建立一標準的臨床程序,去評估動脈壓力波量測儀的操作者內、操作間的可靠度。我們用動脈壓力波分析儀TD01C(米安科技,台灣)做為一個範例,來驗證我們前兩個目標的可行性;第三,我們執行一喝茶效應的臨床測試,藉此觀察動脈壓力波量測與諧頻分析,是否能有效的用來監測血循環狀態的變化,並且用來評估功能性食品或保健食品的功效。
在第一階段的研究,我們會建立一模擬動脈壓力波的仿體系統,用來製造週期性的壓力波,並且用DP103壓力感測器(Validyne,加州,美國)去驗證週期性輸出的可靠度。接著,我們會用此模擬動脈壓力波的仿體系統系統,來評估TD01C重複量測的再現性與多台儀器間的一致性。我們會用諧頻分析、變異係數、組內相關係數(ICC)、以及布蘭德-奧特曼圖(Bland-Altman plot)來評定TD01C的可靠程度。實驗的結果證明:1. 模擬動脈壓力波的仿體是一個可靠的評估系統用來驗證動脈壓力波量測儀本身的可靠度(ICC>0.95,p<0.001)。2.證明TD01C本身有可靠的再現性((ICCs of test–re-test reliability>0.95, p<0.001; CVs all<3%).) 3.實驗結果確認了用模擬動脈壓力波的仿體系統評估動脈壓力波量測儀本身的可靠度是一個可執行、可操作的方法。 實驗的第二步,我們使用TD01C對健康的受測者進行臨床測試,評估以TD01C量測橈動脈動脈壓力波時,同一操作者重複量測的再現性或不同操作者間量測的一致性。我們用諧頻分析方法來定量,探索連續量測所得動脈壓力波之諧頻的可靠度。組內相關係數和Bland-Altman圖被用來定量、驗證動脈壓力波量測儀的穩定程度。22個受測者(平均年齡45±14 歲; 14男和8女) 被招募進行可靠度測試──包含操作者內與操作者間量測。實驗的結果顯示:TD01C在同一操作者的重複量測實驗上有很好的再現性(ICCs>0.9, p<0.001);TD01C在不同操作者的連續量測中很好的一致性(ICCs 介於 0.83-0.96, p<0.001)。在Bland-Altman圖中,超過90% 諧頻,連續兩次量測的差值落在兩倍標準差範圍內。總結的來說,用TD01C來量測動脈壓力波是一可操作且可靠的方法,適合在臨床試驗中用來描繪動脈系統的狀態特徵。 第三步,本研究進行一項臨床測試來觀測飲茶對血循環的影響。我們用TD01C來量測橈動脈的動脈壓力波,並且用血壓計HEM-6051 (Omron, Japan)來量測血壓。我們接著用諧頻分析來評估動脈系統狀態的改變。研究結果顯示:飲用立頓紅茶、三峽蜜香紅茶、三峽碧螺春綠茶,都能增強動脈壓力波中高頻的成分(從第6到第11諧頻) 我們推論茶能夠增進腦部血循環,並因此推論茶葉具有保護神經的效果。 總結來說,TD01C系統經過仿體與臨床驗證其可靠度後,其儀器可靠度達到有臨床詮釋效力的標準。再加上飲茶實驗透過TD01C能夠觀察到動脈系統不同的狀態特徵,這顯示TD01C在心血管系統的臨床研究與應用上有很大的潛力,值得進行更多後續的研究。 | zh_TW |
dc.description.abstract | Pulse wave analysis (PWM) has been studied for many decades and many pressure measuring instruments were developed for this purpose. However, there was no complete assessment system and standard protocol to quantify the intrinsic reliability, intra-observer repeatability, and inter-observer reproducibility for clinical evaluation of a pressure measuring instrument. Therefore, there are three main purposes of this study. First, we aimed to assess intrinsic reliabilities of devices for pulse wave measurement using artificial pulse generator. Second, this study was aimed to establish a standard protocol for clinical test and to quantitatively assess the reliability of pulse wave analysis system, including intra-observer reliability, and inter-observer reliability. We used Pulse wave analyzer TD01C (MII-ANN Technology, Taiwan) as an example to validate the feasibility of previous two purposes. Third, we performed a clinical test of tea consumption to demonstrate pulse wave analysis could be useful in monitoring the circulation and to evaluate the effect of functional food or health product.
In the first step of the study, we build up an artificial pulse generator system to create a periodic pulse wave and DP103pressure transducer (Validyne, CA, USA) was used to test the stability of the periodic output. We then used the pulse generator system for evaluating the test–re-test and inter-device reliability of the TD01C system. We used harmonic analysis (HA), the coefficient of variation (CV), intra-class correlation coefficient (ICC) and Bland-Altman plot to determine the degree of reliability of the TD01C system. The artificial pulse generator system was proved stable to evaluate intrinsic reliabilities of devices for PWM (ICCs>0.95, p<0.001). TD01C was proved reliable for repeated measurements (ICCs of test–re-test reliability>0.95, p<0.001; CVs all<3%). The report confirmed the feasibility of intrinsic reliability assessment of devices for PWM using an artificial pulse generator system. The second step of the study, we used the TD01C system to perform a clinical test on healthy subjects and tested TD01C’s intra-observer and inter-observer reliability in PWM of the radial pulse wave. We conducted assessments using HA and investigated the stabilities of harmonics in successive measurements. ICC and Bland-Altman plot was used to verify the level of the stabilities. Twenty-two subjects (mean age 45±14 years; 14 males and 8 females) were enrolled for both the reliability assessments of intra-observer and of inter-observer. The report presented excellent repeatability (Intraclass correlation coefficients, ICCs>0.9, p<0.001) for intra-observer assessment and high reproducibility (ICCs range from 0.83-0.96, p<0.001) for inter-observer assessment. In the Bland-Altman plots, more than 90% of harmonics fell within two standard deviations of the mean difference. Consequently, PWM using TD01C system is a feasible and reliable method to assess hemodynamic characteristic in a clinical test. Third, the study performed a clinical test to investigate the effect of tea consumption on brain circulation. The radial pulse wave was measured by the TD01C system and blood pressure was measured with blood pressure monitor HEM-6051 (Omron, Japan). We used HA to evaluated circulation change. The report confirmed that consumption of Lipton black tea, Sanxia black tea, and Sanxia green tea all increased higher harmonic components (from sixth to tenth harmonic components of radial blood pulse). We conclude that tea could increase cerebral blood flow and thus the possible mechanism of tea-mediated neuroprotective effect is not only by the neuroprotective compounds of tea but also by increasing the brain perfusion. In summary, the TD01C measuring system, which was validated by the phantom test and clinical test, reached the reliability for clinical interpretation. In addition to its ability to identify the different characteristics for different status of the arterial system, there is great potential to apply the TD01C system on the cardiovascular research and is worthy to carry out more investigation. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T01:34:22Z (GMT). No. of bitstreams: 1 ntu-106-D99945007-1.pdf: 3933770 bytes, checksum: 623397178a913741969b54e0de3fe1b8 (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 致謝 3
中文摘要 4 ABSTRACT 6 目錄 8 圖次 10 表次 11 第一章 緒論 11 1.1 研究背景與動機 11 1.2 研究目的 12 1.3 論文架構 13 第二章 文獻探討 14 2.1 現代醫學下的動脈壓力波分析─指標與定量 14 2.2 中醫脈診─動脈壓力波的質性描述 15 2.3 徑向共振理論與正交化的指標 16 2.3.1徑向振動方程式的推導 17 2.3.2 徑向振動方程式理論解 23 2.3.3正交化的指標 25 第三章 動脈壓力波量測儀──儀器可靠度之測定 28 3.1 簡介 28 3.2 實驗材料與方法 28 3.2.1 實驗設備 28 3.2.2 實驗程序 30 3.2.3 儀器排除條款 34 3.2.4 統計分析 34 3.3 實驗結果與討論 35 3.3.1仿體系統穩定度驗證 35 3.3.2 動脈壓力波量測儀──量測再現性驗證 37 3.3.3 動脈壓力波量測儀,TD01C儀器間一致性實驗 39 3.3.4 小結 41 第四章 動脈壓力波量測儀──臨床可靠度之測定 44 4.1簡介 44 4.2 實驗材料與方法 45 4.2.1 實驗設備 45 4.2.2 實驗程序 45 4.2.3 訊號擷取與諧頻分析 46 4.2.4 評估同一操作者量測的再現性 47 4.2.5 評估不同操作者量測的一致性 47 4.2.6 統計分析 47 4.3 實驗結果與討論 48 4.3.1 同一操作者量測再現性的評估結果 48 4.3.2 不同操作者量測的一致性的評估結果 50 4.3.3 小結 52 第五章 動脈壓力波量測──以飲茶做為臨床實例 54 5.1簡介 54 5.2 實驗材料與方法 54 5.2.1 實驗程序 54 5.2.2 紅茶與溫水對照實驗 56 5.2.3 紅茶與綠茶對照實驗 58 5.3 實驗結果與討論 60 5.3.1 紅茶與溫水對照實驗 60 5.3.2 紅茶與綠茶對照實驗 63 5.3.3 茶葉對動脈壓力波之諧頻影響的生理意義 66 第六章 結論與未來工作 68 6.1結論 68 6.2 未來工作 69 附錄 71 參考文獻 73 | |
dc.language.iso | zh-TW | |
dc.title | 動脈壓力波之諧頻分析可靠度驗證與其臨床應用──以茶為例 | zh_TW |
dc.title | Reliability validation of harmonic analysis of blood pressure wave measurement and its clinical application, taking tea consumption for example | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-2 | |
dc.description.degree | 博士 | |
dc.contributor.coadvisor | 王唯工(Wei-Kung Wang) | |
dc.contributor.oralexamcommittee | 周迺寬(Nai-Kuan Chou),林啟萬(Chii-Wann Lin),林玉英(Yuh-Ying Lin),田維誠(Wei-Cheng Tian),詹明宜(Ming-Yie Jan) | |
dc.subject.keyword | 動脈壓力波分析,橈動脈壓力波,諧頻分析,可靠度,飲茶,血循環, | zh_TW |
dc.subject.keyword | ulse wave analysis,radial pulse wave,harmonic analysis,reliability,tea consumption,circulation, | en |
dc.relation.page | 80 | |
dc.identifier.doi | 10.6342/NTU201701717 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2017-08-02 | |
dc.contributor.author-college | 電機資訊學院 | zh_TW |
dc.contributor.author-dept | 生醫電子與資訊學研究所 | zh_TW |
顯示於系所單位: | 生醫電子與資訊學研究所 |
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