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|dc.contributor.advisor||郭育良(Yue-Liang Leon Guo)|
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|dc.description.abstract||According to World Health Organization estimated, the global prevalence of diabetes mellitus in adults (DM) was 8.5% in 2014. A total of 3.7 million deaths related to high blood glucose levels in 2012, and 43% of these deaths was under the age of 70. DM is a leading cause of complications in many parts of body that impact meaningfully on quality of life and also increases the overall risk of dying prematurely. The complications include cardiovascular diseases, blindness, kidney failure and lower limb amputation. Higher blood glucose levels during pregnancy increases the risk of fetal death and other complications.
In this serial study, we applied the sixth-month questionnaire of Taiwan Birth Cohort Study (TBCS) and National Health Insurance Database (NHIRD)- Longitudinal Health Insurance Database 2005 (LHID-2005) as data source of health outcome and covariates, and air monitoring data from Taiwan Environmental Protection Administration as exposure data source to do following studies. 1.) Investigate the association between air pollution exposure and gestational diabetes mellitus (GDM) 2.) Assess the effect of air pollution exposure on developing type 2 diabetes mellitus in pregnant women 3) Evaluate the risk of diabetic retinopathy occurrence for exposure air pollution in diabetics
The main findings of this serial study were as following: 1) Nitrogen oxide exposure during the first and second trimester is associated GDM occurrence. 2) The risk of developing type 2 DM is greater in pregnant women who had been diagnosed as having GDM during pregnancy. Although, air pollution exposure is not statistically significant associated with developing postpartum type 2 DM, Exposure to traffic-related air pollutants, pregnant women with GDM have higher risk of postpartum type 2 DM. 3) In diabetics, exposure to particulate matter air pollutants is significantly related to diabetic retinopathy occurrence.
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Previous issue date: 2020
List of Figures IX
List of Tables X
Chapter 1. Introduction 1
Chapter 2. Literature Review 4
Chapter 3. Materials and Methods 7
Part I. 10
Exposure assessment 10
Statistical analysis 13
Part II. 15
Study population 15
Cases and controls 15
Exposure Assessment 16
Statistical Analysis 18
Part III. 19
Study population 19
Cases and controls 19
Exposure Assessment 20
Statistical Analysis 22
Chapter 4. Results 24
Part I. 24
Part II. 27
Part III. 29
Chapter 5. Discussion 31
Part I. 31
Part II. 39
Part III. 44
Chapter 6. Conclusion 52
Publication List 60
|dc.title||The association between air pollution exposure and diabetes mellitus and its complications||en|
|dc.subject.keyword||Air Pollution,Nitric Oxide,Particulate Matter,Gestational Diabetes Mellitus,Diabetes Mellitus,Diabetic Retinopathy,||en|
|Appears in Collections:||環境與職業健康科學研究所|
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