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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 詹長權 | |
dc.contributor.author | Yu-Yen Chin | en |
dc.contributor.author | 金俞延 | zh_TW |
dc.date.accessioned | 2021-06-17T00:46:47Z | - |
dc.date.available | 2013-03-02 | |
dc.date.copyright | 2012-03-02 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-12-27 | |
dc.identifier.citation | 1. 國立台灣大學, 97 年度空氣污染對沿海地區環境及居民健康影響之風險評估規劃第1 年計畫(Risk assessment on air pollution and health among residents near a petrochemical complex in Yunlin County), 2008, 雲林縣環境保護局.
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Lawther, P.J., Air pollution and health. In: The Theory and Practice of Public Health. Oxford University Press, London, 1975: p. 190-198. 65. 南亞塑膠工業股份有限公司環境工程中心, 六輕產品、產能調整計畫環境影響評估報告書, 2000. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/66620 | - |
dc.description.abstract | 背景與目的:研究已發現六輕工業區附近的居民有較高的惡性腫瘤、肝癌、及口腔癌的死亡率。然而,附近居民暴露於六輕工業區所排放的多環芳香烴所受到的影響目前仍不清楚,因此本研究透過測量一生物指標1-羥基芘來評估居民暴露於多環芳香烴之情形。
方法:本研究根據風向與距離選擇出三個研究地點:1)麥寮,為六輕工業區之所在地;2)台西,位於六輕工業區的下風處,且在工業區的半徑十公里以內;3)虎尾,位於六輕工業區的上風處,且距離工業區二十五公里以外。一共有392位來自這三個鄉鎮的三十五歲以上成年人參與此研究,並收集了他們的尿液樣本以及問卷資料。尿液樣本分析尿中1-羥基芘的方法是使用高效能液相層析儀,並以螢光偵測。 結果:以1-羥基芘的濃度來看,住在麥寮的居民有最高的1-羥基芘濃度,其次是台西的居民,最後是虎尾的居民(0.23±0.33 vs. 0.15±0.20 vs. 0.08±0.07 μmol/mol-creatinine) ,以ANOVA統計方式顯示此差異是顯著的 (p<0.01)。 在迴歸模式中,經過校正相關的干擾因子後,此區域效應對於1-羥基芘的濃度仍維持統計上的顯著意義,與虎尾居民相比,麥寮居民的1-羥基芘濃度高出1.89倍,而台西居民的1-羥基芘濃度高出1.43倍。而在非吸菸族群,1-羥基芘濃度的差異則更明顯,麥寮居民的1-羥基芘濃度高出虎尾居民2.19倍,而台西居民的1-羥基芘濃度高出虎尾居民1.76倍。 結論:居民的1-羥基芘濃度呈現與居住的地區有相關,顯示居住於該地區的民眾所暴露的多環芳香烴極可能是來自於六輕工業區。 | zh_TW |
dc.description.abstract | Background and Aims: Previous research has found residents living near the No.6 Naphtha Cracker Complex have higher mortality rates of malignant tumor, liver cancer, and oral cancer. However, the effect of exposure to polycyclic aromatic hydrocarbons (PAHs) emitted from this petrochemical complex on residents was still not clear. This study measured urinary 1-hydroxypyrene (1-OHP) as a biomarker to assess people’s exposure to PAHs emitted from the petrochemical complex.
Methods: Three towns were chosen as study sites based on wind direction and distance from the complex: 1) Mailiao, where the complex located; 2) Taisi, the downwind area within 10 km radius of the complex; 3) Huwei, the upwind area of 25 km away from the complex. We recruited 392 adults and collected their spot urine samples and questionnaire data. Urine samples were analyzed for 1-OHP by a High Performance Liquid Chromatography-Florescent method. Results: Residents living in Mailiao had the highest urinary 1-OHP concentration, followed by those in Taisi and those in Huwei (0.23±0.33 vs. 0.15±0.20 vs. 0.08±0.07 μmol/mol-creatinine) by ANOVA-test (p<0.01). After controlling the covariates in regression model, the zone effect on 1-OHP levels remained significant. The 1-OHP concentration of Mailiao was 1.89 times and Taisi was 1.43 times more than Huwei (p<0.01). In non-smoking group, the 1-hydroxypyrene differences were even more obvious that Mailiao was 2.14 times and Taisi was 1.70 times more than Huwei (p<0.01). Conclusions: Residents’ 1-OHP concentrations were significantly related to zone effect, indicating their proximity to a large industrial point source of PAHs. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T00:46:47Z (GMT). No. of bitstreams: 1 ntu-100-R98841003-1.pdf: 2903287 bytes, checksum: f3ee5ff967f7aeabe51f6c65dc78b099 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | Acknowledgement III
ABSTRACT IV 摘要 V Contents VI Table index VIII Figure index X CHAPTER 1 Objective 1 CHAPTER 2 Introduction 2 2.1 Assessment of health effect among workers and residents near petrochemical industries 2 2.2 The No.6 Naphtha Cracker Complex 4 2.3 The air pollutions and polycyclic aromatic hydrocarbons emitted from the petrochemical industry 8 2.4 The process related to the PAH emission in the petrochemical industry 13 2.5 The environmental monitoring and biological monitoring of PAHs 19 CHAPTER 3 Materials and Methods 27 3.1 Study design 27 3.2 Study site description 29 3.3 Study subjects 31 3.4 Collection and measurement of urinary 1-OHP 32 3.4.1 Urine collection and transport 32 3.4.2 Urinary 1-hydroxypyrene analysis 32 3.4.3 Experimental instruments and reagents for urinary 1-hydroxypyrene analysis 33 3.4.4 Urinary creatinine 35 3.5 Questionnaire survey 36 3.6 Statistical analysis 37 CHAPTER 4 Results 38 4.1 The description of study subjects 38 4.2 The urinary 1-hydroxypyrene concentration of study subjects 41 4.3 The linear regression analysis on urinary 1-hydroxypyrene concentration of all study subjects 45 4.4 The trend test for the 1-hydroxypyrene concentrations and the frequencies of variables 48 4.5 The linear regression analysis on urinary 1-hydroxypyrene concentration of non-smoking group 50 4.6 The correlations between each variable 53 4.7 The multiple linear regression analysis on urinary 1-hydroxypyrene concentration of all study subjects 56 4.8 The multiple linear regression analysis with significant contributors on urinary 1-hydroxypyrene concentration of all study subjects 58 4.9 The multiple linear regression analysis on urinary 1-hydroxypyrene concentration of non-smoking group 60 4.10 The multiple linear regression analysis of significant contributor on urinary 1-hydroxypyrene concentration of non-smoking group 62 CHAPTER 5 Discussion 64 CHAPTER 6 Conclusion 78 CHAPTER 7 Recommendation 79 References 81 Appendix 1. The process of factories in No.6 Naphtha Cracker Complex 86 Appendix 2. Questionnaire 91 | |
dc.language.iso | zh-TW | |
dc.title | 石化工業區對附近成年居民尿中1-羥基芘濃度的影響 | zh_TW |
dc.title | Influence of Petrochemical Complex on Adults’ Urinary
1-hydroxypyrene Levels | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 吳焜裕,胡素婉,許惠悰 | |
dc.subject.keyword | 石化工業,1-羥基芘,多環芳香烴, | zh_TW |
dc.subject.keyword | Petrochemical industry,1-hydroxypyrene (1-OHP),PAHs, | en |
dc.relation.page | 101 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-12-28 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 職業醫學與工業衛生研究所 | zh_TW |
顯示於系所單位: | 職業醫學與工業衛生研究所 |
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